Motif ID: Nkx2-3

Z-value: 1.151


Transcription factors associated with Nkx2-3:

Gene SymbolEntrez IDGene Name
Nkx2-3 ENSMUSG00000044220.12 Nkx2-3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-3mm10_v2_chr19_+_43612299_436123250.421.6e-02Click!


Activity profile for motif Nkx2-3.

activity profile for motif Nkx2-3


Sorted Z-values histogram for motif Nkx2-3

Sorted Z-values for motif Nkx2-3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_38783503 9.694 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr2_-_114013619 6.147 ENSMUST00000090275.4
 Gjd2
gap junction protein, delta 2
chr12_+_38783455 6.138 ENSMUST00000161980.1
ENSMUST00000160701.1
 Etv1

ets variant gene 1

chr2_+_73271925 6.138 ENSMUST00000090813.5
 Sp9
trans-acting transcription factor 9
chr3_+_55461758 5.819 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr16_-_23520579 5.420 ENSMUST00000089883.5
 Masp1
mannan-binding lectin serine peptidase 1
chrX_-_143933204 5.103 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr15_+_92597104 4.689 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4
chrX_-_143933089 4.432 ENSMUST00000087313.3
 Dcx
doublecortin
chr2_+_22622183 4.349 ENSMUST00000028123.3
 Gad2
glutamic acid decarboxylase 2
chr16_+_7069825 3.901 ENSMUST00000056416.7
 Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr18_-_31447383 3.774 ENSMUST00000025110.3
 Syt4
synaptotagmin IV
chr5_-_62766153 3.664 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr4_+_97777780 3.573 ENSMUST00000107062.2
ENSMUST00000052018.5
ENSMUST00000107057.1
 Nfia


nuclear factor I/A


chr1_+_66321708 3.474 ENSMUST00000114013.1
 Map2
microtubule-associated protein 2
chr15_+_92051153 3.353 ENSMUST00000169825.1
 Cntn1
contactin 1
chr17_+_3397189 3.328 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr1_+_66322102 3.288 ENSMUST00000123647.1
 Map2
microtubule-associated protein 2
chr6_-_6882068 3.287 ENSMUST00000142635.1
ENSMUST00000052609.8
 Dlx5

distal-less homeobox 5

chr18_+_69593361 3.285 ENSMUST00000114978.2
ENSMUST00000114977.1
 Tcf4

transcription factor 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 118 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 21.4 GO:0007638 mechanosensory behavior(GO:0007638)
0.5 9.5 GO:0021860 pyramidal neuron development(GO:0021860)
1.0 8.3 GO:2000809 positive regulation of synaptic vesicle clustering(GO:2000809)
0.7 7.9 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 6.4 GO:0001578 microtubule bundle formation(GO:0001578)
0.1 6.4 GO:0043488 regulation of mRNA stability(GO:0043488)
0.2 6.2 GO:0048670 regulation of collateral sprouting(GO:0048670)
0.1 6.1 GO:0007601 visual perception(GO:0007601)
0.2 5.8 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.8 5.4 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.6 4.9 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
1.1 4.3 GO:0006538 glutamate catabolic process(GO:0006538)
1.3 4.0 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
1.3 3.9 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.2 3.9 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.5 3.8 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1 3.6 GO:0060074 synapse maturation(GO:0060074)
0.6 3.5 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
1.1 3.3 GO:0060166 olfactory pit development(GO:0060166)
0.3 3.3 GO:0042118 endothelial cell activation(GO:0042118)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 6.9 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.8 6.8 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 6.7 GO:0045202 synapse(GO:0045202)
0.1 6.6 GO:0031225 anchored component of membrane(GO:0031225)
0.5 6.4 GO:0042788 polysomal ribosome(GO:0042788)
0.0 6.3 GO:0005874 microtubule(GO:0005874)
0.2 6.2 GO:0030673 axolemma(GO:0030673)
0.2 5.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
1.0 5.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 4.3 GO:0060077 inhibitory synapse(GO:0060077)
0.2 4.0 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.3 3.8 GO:0031045 dense core granule(GO:0031045)
0.0 3.6 GO:0030175 filopodium(GO:0030175)
0.2 3.5 GO:0005922 connexon complex(GO:0005922)
0.1 3.3 GO:0071565 nBAF complex(GO:0071565)
1.0 3.0 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 3.0 GO:0042641 actomyosin(GO:0042641)
0.0 2.9 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 2.9 GO:0016323 basolateral plasma membrane(GO:0016323)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.3 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.4 9.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.8 6.8 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 6.4 GO:0017091 AU-rich element binding(GO:0017091)
0.1 6.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.8 5.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.4 4.9 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.6 4.3 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.6 4.0 GO:0008046 axon guidance receptor activity(GO:0008046)
0.5 4.0 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.5 3.9 GO:0050693 LBD domain binding(GO:0050693)
0.0 3.9 GO:0003729 mRNA binding(GO:0003729)
0.1 3.8 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 3.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 3.5 GO:0070412 R-SMAD binding(GO:0070412)
0.8 3.3 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 3.3 GO:0071837 HMG box domain binding(GO:0071837)
0.0 3.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 3.2 GO:0042043 neurexin family protein binding(GO:0042043)
1.0 3.0 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)