Motif ID: Nkx2-5

Z-value: 0.846


Transcription factors associated with Nkx2-5:

Gene SymbolEntrez IDGene Name
Nkx2-5 ENSMUSG00000015579.4 Nkx2-5



Activity profile for motif Nkx2-5.

activity profile for motif Nkx2-5


Sorted Z-values histogram for motif Nkx2-5

Sorted Z-values for motif Nkx2-5



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-5

PNG image of the network

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Top targets:


Showing 1 to 20 of 98 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_31949571 8.133 ENSMUST00000064016.5
 Gpr17
G protein-coupled receptor 17
chr15_-_88978958 8.106 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr1_+_172341197 4.686 ENSMUST00000056136.3
 Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr15_-_54919961 3.543 ENSMUST00000167541.2
ENSMUST00000041591.9
ENSMUST00000173516.1
 Enpp2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr8_-_46294592 3.538 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr12_+_37880700 3.268 ENSMUST00000040500.7
 Dgkb
diacylglycerol kinase, beta
chr12_+_74297474 3.254 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr8_+_124793061 3.082 ENSMUST00000041106.7
 Trim67
tripartite motif-containing 67
chr15_-_54920115 2.704 ENSMUST00000171545.1
 Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr6_-_101377342 2.518 ENSMUST00000151175.1
 Pdzrn3
PDZ domain containing RING finger 3
chr4_+_103619580 2.415 ENSMUST00000106827.1
 Dab1
disabled 1
chr14_+_80000292 2.182 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr19_+_26753588 2.060 ENSMUST00000177116.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr5_-_124327883 1.779 ENSMUST00000031344.6
 Mphosph9
M-phase phosphoprotein 9
chr7_+_128246812 1.757 ENSMUST00000164710.1
ENSMUST00000070656.5
 Tgfb1i1

transforming growth factor beta 1 induced transcript 1

chr3_+_52268337 1.725 ENSMUST00000053764.5
 Foxo1
forkhead box O1
chr5_-_124327812 1.722 ENSMUST00000184951.1
 Mphosph9
M-phase phosphoprotein 9
chr1_-_66817536 1.697 ENSMUST00000068168.3
ENSMUST00000113987.1
 Kansl1l

KAT8 regulatory NSL complex subunit 1-like

chrX_-_75416533 1.530 ENSMUST00000033542.4
 Mtcp1
mature T cell proliferation 1
chr2_-_173276144 1.519 ENSMUST00000139306.1
 Pmepa1
prostate transmembrane protein, androgen induced 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 8.1 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.9 8.1 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.9 6.2 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
1.6 4.7 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.2 3.5 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.1 3.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.5 3.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 3.1 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.1 2.7 GO:0007528 neuromuscular junction development(GO:0007528)
0.8 2.4 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.1 2.2 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.2 2.1 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.7 2.0 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.2 1.7 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.5 1.5 GO:0002331 pre-B cell allelic exclusion(GO:0002331) signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.3 1.5 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 1.5 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 1.5 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 1.5 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.1 1.4 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.1 GO:0005901 caveola(GO:0005901)
0.4 5.0 GO:0097449 astrocyte projection(GO:0097449)
0.0 3.5 GO:0005814 centriole(GO:0005814)
0.0 2.5 GO:0031594 neuromuscular junction(GO:0031594)
0.0 2.4 GO:0005903 brush border(GO:0005903)
0.1 2.1 GO:0071564 npBAF complex(GO:0071564)
0.1 2.0 GO:0035861 site of double-strand break(GO:0035861)
0.0 2.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 2.0 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 1.7 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.1 1.5 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 1.5 GO:1990391 DNA repair complex(GO:1990391)
0.0 1.5 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.2 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.2 GO:0000786 nucleosome(GO:0000786)
0.0 1.1 GO:0001772 immunological synapse(GO:0001772)
0.1 1.0 GO:0005915 zonula adherens(GO:0005915)
0.0 1.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 0.9 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.1 GO:0008565 protein transporter activity(GO:0008565)
1.6 6.2 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.0 5.1 GO:0004930 G-protein coupled receptor activity(GO:0004930)
1.6 4.7 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 4.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 3.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.3 3.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.4 3.2 GO:0048495 Roundabout binding(GO:0048495)
0.1 2.9 GO:0016414 O-octanoyltransferase activity(GO:0016414)
0.1 2.4 GO:0042169 SH2 domain binding(GO:0042169)
0.0 2.2 GO:0045296 cadherin binding(GO:0045296)
0.0 2.1 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.2 2.0 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 1.7 GO:0001223 transcription coactivator binding(GO:0001223)
0.2 1.5 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 1.5 GO:0004677 DNA-dependent protein kinase activity(GO:0004677) 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0 1.5 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.2 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 1.1 GO:0038191 neuropilin binding(GO:0038191)