Motif ID: Nkx2-5
Z-value: 0.846
Transcription factors associated with Nkx2-5:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nkx2-5 | ENSMUSG00000015579.4 | Nkx2-5 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 8.1 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) |
| 1.6 | 4.7 | GO:0051933 | amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935) |
| 0.9 | 8.1 | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus(GO:0002862) |
| 0.9 | 6.2 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 0.8 | 2.4 | GO:0021577 | hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) |
| 0.7 | 2.0 | GO:0032915 | positive regulation of transforming growth factor beta2 production(GO:0032915) |
| 0.5 | 1.5 | GO:0002331 | pre-B cell allelic exclusion(GO:0002331) signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884) |
| 0.5 | 3.2 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
| 0.3 | 1.5 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.2 | 1.0 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
| 0.2 | 2.1 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.2 | 1.1 | GO:0030242 | pexophagy(GO:0030242) |
| 0.2 | 1.7 | GO:0071732 | cellular response to nitric oxide(GO:0071732) |
| 0.2 | 3.5 | GO:0097154 | GABAergic neuron differentiation(GO:0097154) |
| 0.2 | 1.0 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.2 | 0.6 | GO:0021698 | cerebellar cortex structural organization(GO:0021698) |
| 0.2 | 0.5 | GO:0002636 | positive regulation of germinal center formation(GO:0002636) |
| 0.1 | 1.4 | GO:0051791 | medium-chain fatty acid metabolic process(GO:0051791) |
| 0.1 | 3.3 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.1 | 3.1 | GO:2000060 | positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060) |
| 0.1 | 0.4 | GO:0071873 | response to norepinephrine(GO:0071873) |
| 0.1 | 1.1 | GO:0060907 | positive regulation of macrophage cytokine production(GO:0060907) |
| 0.1 | 0.8 | GO:0070601 | centromeric sister chromatid cohesion(GO:0070601) |
| 0.1 | 1.0 | GO:0007379 | segment specification(GO:0007379) |
| 0.1 | 1.5 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.1 | 1.0 | GO:0007190 | activation of adenylate cyclase activity(GO:0007190) |
| 0.1 | 0.4 | GO:0007128 | meiotic prophase I(GO:0007128) prophase(GO:0051324) meiotic cell cycle phase(GO:0098762) meiosis I cell cycle phase(GO:0098764) |
| 0.1 | 1.2 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.1 | 0.3 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) |
| 0.1 | 1.1 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.1 | 0.5 | GO:0016480 | negative regulation of transcription from RNA polymerase III promoter(GO:0016480) |
| 0.1 | 2.7 | GO:0007528 | neuromuscular junction development(GO:0007528) |
| 0.1 | 2.2 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
| 0.0 | 1.5 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.0 | 0.9 | GO:0014067 | negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067) |
| 0.0 | 0.1 | GO:0097623 | potassium ion export across plasma membrane(GO:0097623) |
| 0.0 | 1.5 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
| 0.0 | 0.3 | GO:0071361 | cellular response to zinc ion(GO:0071294) cellular response to ethanol(GO:0071361) |
| 0.0 | 1.0 | GO:0031365 | N-terminal protein amino acid modification(GO:0031365) |
| 0.0 | 0.3 | GO:2001197 | regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197) |
| 0.0 | 0.9 | GO:0015991 | energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662) |
| 0.0 | 1.2 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.0 | 0.5 | GO:0006829 | zinc II ion transport(GO:0006829) |
| 0.0 | 1.1 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.0 | 1.2 | GO:0006334 | nucleosome assembly(GO:0006334) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 5.0 | GO:0097449 | astrocyte projection(GO:0097449) |
| 0.2 | 0.8 | GO:0044316 | cone cell pedicle(GO:0044316) |
| 0.1 | 1.5 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.1 | 2.1 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 0.8 | GO:0031415 | NatA complex(GO:0031415) |
| 0.1 | 0.9 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.1 | 1.0 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.1 | 0.4 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.1 | 8.1 | GO:0005901 | caveola(GO:0005901) |
| 0.1 | 2.0 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.0 | 1.2 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 3.5 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 1.5 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.0 | 1.5 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 2.5 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 1.1 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 1.2 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 0.9 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 0.4 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.0 | 0.3 | GO:0045180 | basal cortex(GO:0045180) |
| 0.0 | 1.0 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 0.2 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.0 | 1.7 | GO:0000123 | histone acetyltransferase complex(GO:0000123) |
| 0.0 | 2.4 | GO:0005903 | brush border(GO:0005903) |
| 0.0 | 1.2 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 0.1 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 0.5 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 0.9 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.0 | 2.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 2.0 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 4.7 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
| 1.6 | 6.2 | GO:0004528 | phosphodiesterase I activity(GO:0004528) |
| 0.4 | 3.2 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.3 | 3.3 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.2 | 1.0 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.2 | 2.0 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.2 | 1.5 | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591) |
| 0.2 | 0.8 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.1 | 0.5 | GO:0080084 | RNA polymerase III type 1 promoter DNA binding(GO:0001030) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III type 3 promoter DNA binding(GO:0001032) 5S rDNA binding(GO:0080084) |
| 0.1 | 1.7 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.1 | 1.1 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.1 | 0.9 | GO:0016920 | pyroglutamyl-peptidase activity(GO:0016920) |
| 0.1 | 1.5 | GO:0004677 | DNA-dependent protein kinase activity(GO:0004677) 1-phosphatidylinositol-3-kinase activity(GO:0016303) |
| 0.1 | 0.3 | GO:0016934 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 0.1 | 2.9 | GO:0016414 | O-octanoyltransferase activity(GO:0016414) |
| 0.1 | 1.0 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.1 | 0.4 | GO:0051425 | PTB domain binding(GO:0051425) |
| 0.1 | 8.1 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.1 | 0.6 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.1 | 2.4 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 2.2 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 1.5 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 2.1 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 0.2 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
| 0.0 | 0.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.9 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.0 | 1.3 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 4.1 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 1.1 | GO:0033549 | MAP kinase phosphatase activity(GO:0033549) |
| 0.0 | 5.1 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 0.0 | 1.1 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.0 | 0.5 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 1.2 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 0.2 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.0 | 0.3 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 3.5 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 0.5 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 1.0 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
