Motif ID: Nkx2-6

Z-value: 0.237


Transcription factors associated with Nkx2-6:

Gene SymbolEntrez IDGene Name
Nkx2-6 ENSMUSG00000044186.9 Nkx2-6



Activity profile for motif Nkx2-6.

activity profile for motif Nkx2-6


Sorted Z-values histogram for motif Nkx2-6

Sorted Z-values for motif Nkx2-6



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_91399984 0.814 ENSMUST00000102799.3
Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr10_+_52358767 0.617 ENSMUST00000180473.1
Gm26741
predicted gene, 26741
chr4_-_109665249 0.604 ENSMUST00000063531.4
Cdkn2c
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr4_+_62619515 0.484 ENSMUST00000084521.4
ENSMUST00000107424.1
Rgs3

regulator of G-protein signaling 3

chr1_+_179961110 0.397 ENSMUST00000076687.5
ENSMUST00000097450.3
Cdc42bpa

CDC42 binding protein kinase alpha

chr15_-_78773452 0.289 ENSMUST00000018313.5
Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr2_+_23069210 0.268 ENSMUST00000155602.1
Acbd5
acyl-Coenzyme A binding domain containing 5
chr1_+_179960472 0.267 ENSMUST00000097453.2
ENSMUST00000111117.1
Cdc42bpa

CDC42 binding protein kinase alpha

chr7_-_116031047 0.241 ENSMUST00000106612.1
Sox6
SRY-box containing gene 6
chr19_+_8802486 0.150 ENSMUST00000172175.1
Zbtb3
zinc finger and BTB domain containing 3
chr12_-_108702265 0.144 ENSMUST00000167978.1
ENSMUST00000021691.4
Degs2

degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase

chr10_+_100488289 0.112 ENSMUST00000164751.1
Cep290
centrosomal protein 290
chr1_+_156035392 0.111 ENSMUST00000111757.3
Tor1aip2
torsin A interacting protein 2
chr3_+_62419668 0.097 ENSMUST00000161057.1
Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr3_+_87525572 0.085 ENSMUST00000170036.1
ENSMUST00000117293.1
Etv3

ets variant gene 3

chr1_-_156034800 0.078 ENSMUST00000169241.1
Tor1aip1
torsin A interacting protein 1
chr2_-_121456693 0.062 ENSMUST00000110613.2
ENSMUST00000056312.3
Serinc4

serine incorporator 4

chr1_-_156034826 0.047 ENSMUST00000141878.1
ENSMUST00000123705.1
Tor1aip1

torsin A interacting protein 1

chr19_+_8819401 0.046 ENSMUST00000096753.3
Hnrnpul2
heterogeneous nuclear ribonucleoprotein U-like 2
chr9_-_10904766 0.019 ENSMUST00000160216.1
Cntn5
contactin 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.3 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.7 GO:0007097 nuclear migration(GO:0007097)
0.0 0.2 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.1 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.1 GO:0090435 protein localization to nuclear envelope(GO:0090435)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.1 GO:0042284 sphingolipid delta-4 desaturase activity(GO:0042284)
0.0 0.6 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.1 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)