Motif ID: Nkx2-9

Z-value: 0.532


Transcription factors associated with Nkx2-9:

Gene SymbolEntrez IDGene Name
Nkx2-9 ENSMUSG00000058669.7 Nkx2-9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-9mm10_v2_chr12_-_56613270_566132910.105.9e-01Click!


Activity profile for motif Nkx2-9.

activity profile for motif Nkx2-9


Sorted Z-values histogram for motif Nkx2-9

Sorted Z-values for motif Nkx2-9



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-9

PNG image of the network

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Top targets:


Showing 1 to 20 of 115 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_71963713 3.077 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chr12_-_56536895 2.438 ENSMUST00000001536.8
 Nkx2-1
NK2 homeobox 1
chr6_+_66896397 1.894 ENSMUST00000043148.6
ENSMUST00000114228.1
ENSMUST00000114227.1
ENSMUST00000114226.1
ENSMUST00000114225.1
ENSMUST00000114224.1
 Gng12





guanine nucleotide binding protein (G protein), gamma 12





chr3_+_122419772 1.726 ENSMUST00000029766.4
 Bcar3
breast cancer anti-estrogen resistance 3
chr6_+_135362931 1.682 ENSMUST00000032330.9
 Emp1
epithelial membrane protein 1
chr6_+_66896480 1.513 ENSMUST00000114222.1
 Gng12
guanine nucleotide binding protein (G protein), gamma 12
chr15_-_88978958 1.393 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr11_+_88718442 1.312 ENSMUST00000138007.1
 C030037D09Rik
RIKEN cDNA C030037D09 gene
chr5_-_62765618 1.245 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr8_-_46294592 1.147 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr18_+_73859366 1.127 ENSMUST00000120033.1
ENSMUST00000179472.1
ENSMUST00000119239.1
 Mro


maestro


chr7_-_142576492 1.099 ENSMUST00000140716.1
 H19
H19 fetal liver mRNA
chr13_+_72632597 1.055 ENSMUST00000172353.1
 Irx2
Iroquois related homeobox 2 (Drosophila)
chr12_+_24572276 1.045 ENSMUST00000085553.5
 Grhl1
grainyhead-like 1 (Drosophila)
chr9_-_54647199 1.039 ENSMUST00000128163.1
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr17_+_34263209 1.038 ENSMUST00000040828.5
 H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr11_+_117849223 0.991 ENSMUST00000081387.4
 Birc5
baculoviral IAP repeat-containing 5
chr6_-_101377342 0.950 ENSMUST00000151175.1
 Pdzrn3
PDZ domain containing RING finger 3
chr11_+_117849286 0.911 ENSMUST00000093906.4
 Birc5
baculoviral IAP repeat-containing 5
chr16_+_30065333 0.866 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 2.4 GO:0021759 globus pallidus development(GO:0021759)
0.3 1.9 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.1 1.7 GO:0032060 bleb assembly(GO:0032060)
0.1 1.7 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.3 1.4 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.1 1.1 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.1 1.1 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.3 1.0 GO:0002339 B cell selection(GO:0002339)
0.2 1.0 GO:0002934 desmosome organization(GO:0002934)
0.0 1.0 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.3 0.9 GO:0021557 oculomotor nerve development(GO:0021557) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.0 0.9 GO:0045454 cell redox homeostasis(GO:0045454)
0.3 0.8 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.2 0.8 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.2 0.8 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.2 0.7 GO:0036292 DNA rewinding(GO:0036292)
0.2 0.7 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.1 0.7 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 0.6 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.1 0.6 GO:0042940 D-amino acid transport(GO:0042940)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.6 1.9 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.0 1.4 GO:0005901 caveola(GO:0005901)
0.0 1.2 GO:0005844 polysome(GO:0005844)
0.1 1.0 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.7 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.7 GO:0043596 nuclear replication fork(GO:0043596)
0.0 0.6 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.6 GO:0097440 apical dendrite(GO:0097440)
0.0 0.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.3 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.2 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.2 GO:0042629 mast cell granule(GO:0042629)
0.0 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.1 GO:0071439 clathrin complex(GO:0071439)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.4 GO:0042301 phosphate ion binding(GO:0042301)
0.2 2.4 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0 1.9 GO:0043027 Ran GTPase binding(GO:0008536) cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 1.5 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 1.5 GO:0008565 protein transporter activity(GO:0008565)
0.1 1.0 GO:0015643 toxic substance binding(GO:0015643)
0.1 1.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 1.0 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.9 GO:0008432 JUN kinase binding(GO:0008432)
0.2 0.8 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.1 0.8 GO:0034711 inhibin binding(GO:0034711)
0.0 0.8 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.8 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.8 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.8 GO:0005109 frizzled binding(GO:0005109)
0.1 0.7 GO:0036310 annealing helicase activity(GO:0036310)
0.0 0.7 GO:0005044 scavenger receptor activity(GO:0005044)
0.2 0.6 GO:0019153 protein-disulfide reductase (glutathione) activity(GO:0019153)
0.1 0.6 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)
0.1 0.6 GO:0001515 opioid peptide activity(GO:0001515)