Motif ID: Nkx3-1

Z-value: 0.632


Transcription factors associated with Nkx3-1:

Gene SymbolEntrez IDGene Name
Nkx3-1 ENSMUSG00000022061.8 Nkx3-1



Activity profile for motif Nkx3-1.

activity profile for motif Nkx3-1


Sorted Z-values histogram for motif Nkx3-1

Sorted Z-values for motif Nkx3-1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx3-1

PNG image of the network

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Top targets:


Showing 1 to 20 of 150 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_164269371 3.128 ENSMUST00000145412.1
ENSMUST00000033749.7
 Pir

pirin

chr9_+_78191966 2.892 ENSMUST00000034903.5
 Gsta4
glutathione S-transferase, alpha 4
chr4_-_140774196 2.819 ENSMUST00000026381.6
 Padi4
peptidyl arginine deiminase, type IV
chr9_-_20976762 2.346 ENSMUST00000054197.5
 S1pr2
sphingosine-1-phosphate receptor 2
chr10_-_13324160 2.326 ENSMUST00000105545.4
 Phactr2
phosphatase and actin regulator 2
chr19_+_20601958 2.081 ENSMUST00000087638.3
 Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr13_+_51408618 2.037 ENSMUST00000087978.3
 S1pr3
sphingosine-1-phosphate receptor 3
chr1_-_163289214 1.909 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chrX_+_150547375 1.904 ENSMUST00000066337.6
ENSMUST00000112715.1
 Alas2

aminolevulinic acid synthase 2, erythroid

chrX_-_75875101 1.898 ENSMUST00000114059.3
 Pls3
plastin 3 (T-isoform)
chrX_-_75874536 1.757 ENSMUST00000033547.7
 Pls3
plastin 3 (T-isoform)
chr4_-_132757162 1.704 ENSMUST00000030709.8
 Smpdl3b
sphingomyelin phosphodiesterase, acid-like 3B
chr10_-_13324250 1.546 ENSMUST00000105543.1
 Phactr2
phosphatase and actin regulator 2
chr10_+_94514825 1.543 ENSMUST00000065060.5
 Tmcc3
transmembrane and coiled coil domains 3
chr10_-_12861735 1.540 ENSMUST00000076817.4
 Utrn
utrophin
chr8_+_114133557 1.516 ENSMUST00000073521.5
ENSMUST00000066514.6
 Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7

chr17_+_56304313 1.475 ENSMUST00000113035.1
ENSMUST00000113039.2
ENSMUST00000142387.1
 Uhrf1


ubiquitin-like, containing PHD and RING finger domains, 1


chr9_-_124493793 1.462 ENSMUST00000178787.1
 Gm21836
predicted gene, 21836
chr8_+_114133635 1.452 ENSMUST00000147605.1
ENSMUST00000134593.1
 Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7

chr3_-_104818539 1.436 ENSMUST00000106774.1
ENSMUST00000106775.1
ENSMUST00000166979.1
ENSMUST00000136148.1
 Mov10



Moloney leukemia virus 10




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.4 GO:0060348 bone development(GO:0060348)
1.0 3.0 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034)
0.1 2.9 GO:0030224 monocyte differentiation(GO:0030224)
0.3 2.8 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.8 2.3 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.5 2.1 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.3 2.0 GO:1901550 regulation of endothelial cell development(GO:1901550) regulation of establishment of endothelial barrier(GO:1903140)
0.1 2.0 GO:0070986 left/right axis specification(GO:0070986)
0.1 1.9 GO:0048664 neuron fate determination(GO:0048664)
0.1 1.9 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.2 1.7 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 1.7 GO:0006730 one-carbon metabolic process(GO:0006730)
0.5 1.5 GO:0007525 somatic muscle development(GO:0007525)
0.2 1.5 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.1 1.5 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.1 1.4 GO:0006379 mRNA cleavage(GO:0006379)
0.0 1.4 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.2 1.3 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.2 1.2 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.1 1.2 GO:0018344 protein geranylgeranylation(GO:0018344)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.7 GO:0032420 stereocilium(GO:0032420)
0.0 2.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.4 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 2.0 GO:0005882 intermediate filament(GO:0005882)
0.1 1.5 GO:0070938 contractile ring(GO:0070938)
0.0 1.5 GO:0000791 euchromatin(GO:0000791)
0.2 1.2 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 1.1 GO:0097342 ripoptosome(GO:0097342)
0.1 1.1 GO:0042611 MHC protein complex(GO:0042611)
0.0 1.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.3 1.0 GO:0097447 dendritic tree(GO:0097447)
0.1 1.0 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 1.0 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 1.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.9 GO:0032839 dendrite cytoplasm(GO:0032839)
0.2 0.7 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.2 0.7 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.0 0.6 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 0.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 4.4 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.3 3.1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
1.0 3.0 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.1 2.9 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.5 2.8 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 2.3 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 2.2 GO:0016594 glycine binding(GO:0016594)
0.3 2.1 GO:0001758 retinal dehydrogenase activity(GO:0001758) 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.1 1.9 GO:0071837 HMG box domain binding(GO:0071837)
0.1 1.8 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.2 1.7 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.5 1.5 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.1 1.5 GO:0017166 vinculin binding(GO:0017166)
0.0 1.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 1.4 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 1.3 GO:0016151 nickel cation binding(GO:0016151)
0.1 1.2 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 1.1 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 1.1 GO:0042605 peptide antigen binding(GO:0042605)
0.1 1.0 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)