Motif ID: Nkx3-2

Z-value: 0.700


Transcription factors associated with Nkx3-2:

Gene SymbolEntrez IDGene Name
Nkx3-2 ENSMUSG00000049691.7 Nkx3-2



Activity profile for motif Nkx3-2.

activity profile for motif Nkx3-2


Sorted Z-values histogram for motif Nkx3-2

Sorted Z-values for motif Nkx3-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx3-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_89436736 2.558 ENSMUST00000146630.1
ENSMUST00000145753.1
 Pbxip1

pre B cell leukemia transcription factor interacting protein 1

chr1_+_172341197 2.433 ENSMUST00000056136.3
 Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr15_-_56694525 2.392 ENSMUST00000050544.7
 Has2
hyaluronan synthase 2
chr3_+_89436699 2.273 ENSMUST00000038942.3
ENSMUST00000130858.1
 Pbxip1

pre B cell leukemia transcription factor interacting protein 1

chr11_-_101987004 2.221 ENSMUST00000107173.2
ENSMUST00000107172.1
 Dusp3

dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)

chr15_-_88978958 2.168 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr16_+_41532851 2.058 ENSMUST00000078873.4
 Lsamp
limbic system-associated membrane protein
chr10_+_38965515 1.968 ENSMUST00000019992.5
 Lama4
laminin, alpha 4
chr8_+_45885479 1.932 ENSMUST00000034053.5
 Pdlim3
PDZ and LIM domain 3
chr10_+_94036001 1.515 ENSMUST00000020208.4
 Fgd6
FYVE, RhoGEF and PH domain containing 6
chr3_-_67463828 1.506 ENSMUST00000058981.2
 Lxn
latexin
chr2_-_104409992 1.498 ENSMUST00000149466.1
ENSMUST00000139015.1
 D430041D05Rik

RIKEN cDNA D430041D05 gene

chr2_+_10153563 1.374 ENSMUST00000026886.7
 Itih5
inter-alpha (globulin) inhibitor H5
chr2_-_164404606 1.312 ENSMUST00000109359.1
ENSMUST00000109358.1
ENSMUST00000103103.3
 Matn4


matrilin 4


chr18_+_5591860 1.295 ENSMUST00000025081.5
ENSMUST00000159390.1
 Zeb1

zinc finger E-box binding homeobox 1

chr4_-_147936713 1.201 ENSMUST00000105712.1
ENSMUST00000019199.7
 Plod1

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1

chr16_+_21204755 1.191 ENSMUST00000006112.6
 Ephb3
Eph receptor B3
chr6_-_125494754 1.181 ENSMUST00000032492.8
 Cd9
CD9 antigen
chr4_+_102421518 1.174 ENSMUST00000106904.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr15_-_37458523 1.099 ENSMUST00000116445.2
 Ncald
neurocalcin delta

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 3.1 GO:0010838 positive regulation of keratinocyte proliferation(GO:0010838)
0.6 2.9 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.8 2.4 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.1 2.2 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 2.1 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 2.1 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.4 1.6 GO:0033580 protein glycosylation at cell surface(GO:0033575) protein galactosylation at cell surface(GO:0033580) protein galactosylation(GO:0042125)
0.1 1.5 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.1 1.4 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.2 1.3 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.0 1.3 GO:0048678 response to axon injury(GO:0048678)
0.2 1.2 GO:0030913 paranodal junction assembly(GO:0030913)
0.1 1.2 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 1.2 GO:0018126 protein hydroxylation(GO:0018126)
0.1 1.2 GO:0007413 axonal fasciculation(GO:0007413)
0.2 1.1 GO:0070166 enamel mineralization(GO:0070166)
0.1 1.1 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.1 1.1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 1.1 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.2 1.0 GO:0009597 detection of virus(GO:0009597)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.4 GO:0097449 astrocyte projection(GO:0097449)
0.1 2.2 GO:0001772 immunological synapse(GO:0001772)
0.0 2.2 GO:0005901 caveola(GO:0005901)
0.1 2.0 GO:0005605 basal lamina(GO:0005605)
0.0 1.7 GO:0030018 Z disc(GO:0030018)
0.0 1.6 GO:0031985 Golgi cisterna(GO:0031985)
0.0 1.6 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.5 GO:0005581 collagen trimer(GO:0005581)
0.5 1.4 GO:0036125 mitochondrial fatty acid beta-oxidation multienzyme complex(GO:0016507) fatty acid beta-oxidation multienzyme complex(GO:0036125)
0.1 1.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.2 GO:0005604 basement membrane(GO:0005604)
0.1 0.9 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 0.7 GO:0031084 BLOC-2 complex(GO:0031084)
0.1 0.7 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.6 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 0.4 GO:0071920 cleavage body(GO:0071920)
0.1 0.4 GO:0097227 sperm annulus(GO:0097227)
0.1 0.4 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 2.4 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.8 2.4 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 2.2 GO:0033549 MAP kinase phosphatase activity(GO:0033549)
0.0 2.2 GO:0008565 protein transporter activity(GO:0008565)
0.1 1.9 GO:0008307 structural constituent of muscle(GO:0008307)
0.6 1.8 GO:0043912 D-lysine oxidase activity(GO:0043912)
0.3 1.6 GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276)
0.1 1.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.4 1.4 GO:0016508 long-chain-enoyl-CoA hydratase activity(GO:0016508) long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0 1.3 GO:0070888 E-box binding(GO:0070888)
0.3 1.2 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.2 1.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 1.2 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 1.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 1.1 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.1 GO:0005518 collagen binding(GO:0005518)
0.3 1.0 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 1.0 GO:0005178 integrin binding(GO:0005178)
0.2 0.8 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768)