Motif ID: Nkx6-1_Evx1_Hesx1

Z-value: 0.680

Transcription factors associated with Nkx6-1_Evx1_Hesx1:

Gene SymbolEntrez IDGene Name
Evx1 ENSMUSG00000005503.8 Evx1
Hesx1 ENSMUSG00000040726.8 Hesx1
Nkx6-1 ENSMUSG00000035187.8 Nkx6-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx6-1mm10_v2_chr5_-_101665195_101665226-0.134.6e-01Click!


Activity profile for motif Nkx6-1_Evx1_Hesx1.

activity profile for motif Nkx6-1_Evx1_Hesx1


Sorted Z-values histogram for motif Nkx6-1_Evx1_Hesx1

Sorted Z-values for motif Nkx6-1_Evx1_Hesx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-1_Evx1_Hesx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_84417359 7.929 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr5_-_62766153 6.747 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrX_-_143933204 6.393 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chrX_-_143933089 5.501 ENSMUST00000087313.3
 Dcx
doublecortin
chr11_-_98053415 5.355 ENSMUST00000017544.2
 Stac2
SH3 and cysteine rich domain 2
chr15_+_18818895 5.241 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr16_-_97170707 4.821 ENSMUST00000056102.7
 Dscam
Down syndrome cell adhesion molecule
chr2_-_79456750 4.690 ENSMUST00000041099.4
 Neurod1
neurogenic differentiation 1
chr9_-_55919605 4.416 ENSMUST00000037408.8
 Scaper
S phase cyclin A-associated protein in the ER
chr7_+_126776939 4.351 ENSMUST00000038614.5
ENSMUST00000170882.1
ENSMUST00000106359.1
ENSMUST00000106357.1
ENSMUST00000145762.1
ENSMUST00000132643.1
ENSMUST00000106356.1
 Ypel3






yippee-like 3 (Drosophila)






chr7_+_126950518 4.108 ENSMUST00000106335.1
ENSMUST00000146017.1
 Sez6l2

seizure related 6 homolog like 2

chr1_+_72284367 4.000 ENSMUST00000027380.5
ENSMUST00000141783.1
 Tmem169

transmembrane protein 169

chr1_-_155417394 3.895 ENSMUST00000111775.1
ENSMUST00000111774.1
 Xpr1

xenotropic and polytropic retrovirus receptor 1

chr2_+_116067213 3.661 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr15_-_8710409 3.513 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710734 3.501 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr9_+_113812547 3.496 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chr7_+_126950687 3.400 ENSMUST00000106333.1
 Sez6l2
seizure related 6 homolog like 2
chr17_+_3397189 3.349 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr5_+_19907502 3.265 ENSMUST00000101558.3
 Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 190 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 11.9 GO:0021860 pyramidal neuron development(GO:0021860)
0.9 8.7 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.4 8.7 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
1.8 7.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.0 6.2 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.8 6.0 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
1.6 4.8 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
1.2 4.7 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.9 4.4 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.2 4.3 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 4.2 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 4.0 GO:0031032 actomyosin structure organization(GO:0031032)
0.6 3.7 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 3.7 GO:0006342 chromatin silencing(GO:0006342)
0.6 3.5 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 3.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.1 3.4 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.3 2.9 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.9 2.8 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1 2.8 GO:0001886 endothelial cell morphogenesis(GO:0001886)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.1 GO:0030425 dendrite(GO:0030425)
0.1 7.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.4 7.0 GO:0043205 fibril(GO:0043205)
0.0 6.6 GO:0060076 excitatory synapse(GO:0060076)
1.1 5.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 4.8 GO:0000790 nuclear chromatin(GO:0000790)
0.2 3.8 GO:0005614 interstitial matrix(GO:0005614)
0.0 3.6 GO:0036477 somatodendritic compartment(GO:0036477)
1.2 3.5 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
1.1 3.4 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 3.3 GO:0031672 A band(GO:0031672)
0.0 3.3 GO:0030426 growth cone(GO:0030426)
0.0 3.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 3.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 2.7 GO:0030673 axolemma(GO:0030673)
0.1 2.7 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 2.7 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 2.6 GO:0030139 endocytic vesicle(GO:0030139)
0.0 2.6 GO:0070382 exocytic vesicle(GO:0070382)
0.1 2.4 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 129 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 11.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 9.4 GO:0005096 GTPase activator activity(GO:0005096)
1.1 8.7 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 7.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 7.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
1.4 7.0 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.8 6.2 GO:0001618 virus receptor activity(GO:0001618)
0.0 5.4 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.9 5.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 4.8 GO:0070412 R-SMAD binding(GO:0070412)
0.2 3.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.4 3.4 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.2 2.8 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.7 2.7 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 2.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 2.7 GO:0001968 fibronectin binding(GO:0001968)
0.4 2.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 2.3 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.2 2.2 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 2.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)