Motif ID: Nkx6-2

Z-value: 0.698


Transcription factors associated with Nkx6-2:

Gene SymbolEntrez IDGene Name
Nkx6-2 ENSMUSG00000041309.11 Nkx6-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx6-2mm10_v2_chr7_-_139582790_139582808-0.449.5e-03Click!


Activity profile for motif Nkx6-2.

activity profile for motif Nkx6-2


Sorted Z-values histogram for motif Nkx6-2

Sorted Z-values for motif Nkx6-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 122 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_96467606 3.963 ENSMUST00000061739.8
 Pcp4
Purkinje cell protein 4
chr18_-_42899294 3.803 ENSMUST00000117687.1
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr3_+_55461758 3.765 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr17_-_29888570 3.743 ENSMUST00000171691.1
 Mdga1
MAM domain containing glycosylphosphatidylinositol anchor 1
chr1_+_194619815 3.410 ENSMUST00000027952.5
 Plxna2
plexin A2
chr5_-_131308076 3.242 ENSMUST00000160609.1
 Wbscr17
Williams-Beuren syndrome chromosome region 17 homolog (human)
chr5_-_131307848 3.019 ENSMUST00000086023.5
 Wbscr17
Williams-Beuren syndrome chromosome region 17 homolog (human)
chr1_+_66321708 2.843 ENSMUST00000114013.1
 Map2
microtubule-associated protein 2
chr2_+_22622183 2.648 ENSMUST00000028123.3
 Gad2
glutamic acid decarboxylase 2
chr1_-_126830632 2.596 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chr2_+_62664279 2.537 ENSMUST00000028257.2
 Gca
grancalcin
chr1_+_66322102 2.185 ENSMUST00000123647.1
 Map2
microtubule-associated protein 2
chr10_+_106470281 2.129 ENSMUST00000029404.9
ENSMUST00000169303.1
 Ppfia2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr15_+_99006056 1.988 ENSMUST00000079818.3
 Gm8973
predicted gene 8973
chr3_+_103575275 1.856 ENSMUST00000090697.4
 Syt6
synaptotagmin VI
chr4_-_91376433 1.810 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
 Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chr4_+_48049080 1.789 ENSMUST00000153369.1
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr4_-_97584612 1.734 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr5_+_19907502 1.668 ENSMUST00000101558.3
 Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr15_+_18818895 1.645 ENSMUST00000166873.2
 Cdh10
cadherin 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 GO:0021954 central nervous system neuron development(GO:0021954)
0.4 4.0 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.3 3.9 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.5 3.8 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
0.6 3.7 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.3 3.4 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.1 3.4 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.4 3.1 GO:2000809 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) positive regulation of synaptic vesicle clustering(GO:2000809)
1.0 3.0 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.7 2.6 GO:0006538 glutamate catabolic process(GO:0006538)
0.1 2.5 GO:0048240 sperm capacitation(GO:0048240)
0.0 2.0 GO:0048813 dendrite morphogenesis(GO:0048813)
0.6 1.8 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.0 1.5 GO:0051926 negative regulation of calcium ion transport(GO:0051926)
0.0 1.5 GO:0006342 chromatin silencing(GO:0006342)
0.1 1.3 GO:0070995 NADPH oxidation(GO:0070995)
0.2 1.2 GO:1903056 mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 1.2 GO:0072661 protein targeting to plasma membrane(GO:0072661)
0.0 1.2 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.3 1.1 GO:0050913 sensory perception of bitter taste(GO:0050913)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 5.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.4 4.0 GO:0005883 neurofilament(GO:0005883)
0.0 3.8 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 3.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 3.4 GO:0002116 semaphorin receptor complex(GO:0002116)
0.2 3.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.6 3.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 3.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 2.6 GO:0060077 inhibitory synapse(GO:0060077)
0.0 2.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.2 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 1.7 GO:0014704 intercalated disc(GO:0014704)
0.0 1.6 GO:0000786 nucleosome(GO:0000786)
0.0 1.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 1.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 1.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 1.2 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.2 GO:0005923 bicellular tight junction(GO:0005923)
0.1 1.1 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.7 GO:0005881 cytoplasmic microtubule(GO:0005881)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.6 5.0 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.3 3.8 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.2 3.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.5 3.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 3.1 GO:0005516 calmodulin binding(GO:0005516)
0.1 3.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.4 2.6 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 2.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 2.5 GO:0016504 peptidase activator activity(GO:0016504)
0.1 1.8 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 1.7 GO:0017080 sodium channel regulator activity(GO:0017080)
0.3 1.5 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 1.3 GO:0070402 NADPH binding(GO:0070402)
0.1 1.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 1.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.2 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.2 GO:0001540 beta-amyloid binding(GO:0001540)
0.4 1.1 GO:0008384 IkappaB kinase activity(GO:0008384)
0.2 0.9 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)