Motif ID: Nkx6-3_Dbx2_Barx2

Z-value: 0.404

Transcription factors associated with Nkx6-3_Dbx2_Barx2:

Gene SymbolEntrez IDGene Name
Barx2 ENSMUSG00000032033.10 Barx2
Dbx2 ENSMUSG00000045608.6 Dbx2
Nkx6-3 ENSMUSG00000063672.6 Nkx6-3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dbx2mm10_v2_chr15_-_95655960_956559600.646.5e-05Click!


Activity profile for motif Nkx6-3_Dbx2_Barx2.

activity profile for motif Nkx6-3_Dbx2_Barx2


Sorted Z-values histogram for motif Nkx6-3_Dbx2_Barx2

Sorted Z-values for motif Nkx6-3_Dbx2_Barx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-3_Dbx2_Barx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 123 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_102589687 2.886 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr5_-_62766153 2.590 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr5_-_70842617 2.340 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr4_-_14621805 2.102 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chrX_+_170009892 1.615 ENSMUST00000180251.1
 Gm21887
predicted gene, 21887
chr13_+_94083490 1.326 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr15_-_8710409 1.270 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710734 1.238 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr4_+_136143497 1.202 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr10_-_110000219 1.086 ENSMUST00000032719.7
 Nav3
neuron navigator 3
chr3_-_116712644 1.053 ENSMUST00000029569.2
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chrX_-_143933204 1.036 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr13_-_105271039 1.033 ENSMUST00000069686.6
 Rnf180
ring finger protein 180
chr17_-_81649607 1.007 ENSMUST00000163680.2
ENSMUST00000086538.3
ENSMUST00000163123.1
 Slc8a1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr17_+_26715644 0.986 ENSMUST00000062519.7
ENSMUST00000144221.1
ENSMUST00000142539.1
ENSMUST00000151681.1
 Crebrf



CREB3 regulatory factor



chrX_-_143933089 0.969 ENSMUST00000087313.3
 Dcx
doublecortin
chr11_+_109543694 0.932 ENSMUST00000106696.1
 Arsg
arylsulfatase G
chr7_+_79273201 0.917 ENSMUST00000037315.6
 Abhd2
abhydrolase domain containing 2
chr13_-_105054895 0.896 ENSMUST00000063551.5
 Rgs7bp
regulator of G-protein signalling 7 binding protein
chr9_-_15301555 0.873 ENSMUST00000034414.8
 4931406C07Rik
RIKEN cDNA 4931406C07 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.3 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.4 2.9 GO:0019532 oxalate transport(GO:0019532)
0.6 2.5 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 2.5 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 2.0 GO:0021860 pyramidal neuron development(GO:0021860)
0.3 1.2 GO:1901642 purine nucleoside transmembrane transport(GO:0015860) purine-containing compound transmembrane transport(GO:0072530) nucleoside transmembrane transport(GO:1901642)
0.0 1.2 GO:0071398 cellular response to fatty acid(GO:0071398)
0.2 1.1 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.2 1.0 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.2 1.0 GO:1900170 prolactin signaling pathway(GO:0038161) negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.1 1.0 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.1 0.9 GO:0032570 response to progesterone(GO:0032570)
0.0 0.9 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 0.8 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.1 0.7 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.2 0.6 GO:0010871 negative regulation of receptor biosynthetic process(GO:0010871)
0.1 0.5 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 0.4 GO:0051661 maintenance of centrosome location(GO:0051661)
0.0 0.4 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.4 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 2.5 GO:0043205 fibril(GO:0043205)
0.1 2.5 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 1.2 GO:0030315 T-tubule(GO:0030315)
0.1 0.9 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 0.9 GO:0042581 specific granule(GO:0042581)
0.2 0.6 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.2 0.5 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 0.4 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.4 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.4 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.3 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.2 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.2 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.2 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.2 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.2 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.2 GO:0031430 pseudopodium(GO:0031143) M band(GO:0031430) sarcoplasmic reticulum membrane(GO:0033017)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.9 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 2.9 GO:0030552 cAMP binding(GO:0030552)
0.1 2.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.5 2.5 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.1 2.5 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 2.0 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.4 1.2 GO:0015217 ADP transmembrane transporter activity(GO:0015217) coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.0 1.2 GO:0005504 fatty acid binding(GO:0005504)
0.0 1.1 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.3 1.0 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.0 1.0 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.9 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.1 0.9 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.2 0.8 GO:0034235 GPI anchor binding(GO:0034235)
0.1 0.6 GO:0019960 C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132)
0.0 0.6 GO:0045296 cadherin binding(GO:0045296)
0.0 0.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.4 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.1 0.2 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.2 GO:0051378 primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378)