Motif ID: Nr1h2

Z-value: 1.230


Transcription factors associated with Nr1h2:

Gene SymbolEntrez IDGene Name
Nr1h2 ENSMUSG00000060601.6 Nr1h2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr1h2mm10_v2_chr7_-_44553901_445539550.731.5e-06Click!


Activity profile for motif Nr1h2.

activity profile for motif Nr1h2


Sorted Z-values histogram for motif Nr1h2

Sorted Z-values for motif Nr1h2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr1h2

PNG image of the network

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Top targets:


Showing 1 to 20 of 114 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_97417730 14.700 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr4_-_53159885 13.545 ENSMUST00000030010.3
 Abca1
ATP-binding cassette, sub-family A (ABC1), member 1
chr6_+_90462562 11.183 ENSMUST00000032174.5
 Klf15
Kruppel-like factor 15
chr8_-_84773381 9.653 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr2_+_102658640 7.695 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr7_+_97453204 7.146 ENSMUST00000050732.7
ENSMUST00000121987.1
 Kctd14

potassium channel tetramerisation domain containing 14

chr11_+_55098104 7.007 ENSMUST00000000608.7
 Gm2a
GM2 ganglioside activator protein
chr10_-_109823585 6.773 ENSMUST00000161582.1
 Nav3
neuron navigator 3
chr1_-_164458345 6.466 ENSMUST00000027863.7
 Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr7_+_112953955 5.365 ENSMUST00000182858.1
 Rassf10
Ras association (RalGDS/AF-6) domain family (N-terminal) member 10
chr17_-_79715034 4.757 ENSMUST00000024894.1
 Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
chr3_+_62419668 4.474 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr5_-_124327883 4.051 ENSMUST00000031344.6
 Mphosph9
M-phase phosphoprotein 9
chr3_+_90514435 3.814 ENSMUST00000048138.6
ENSMUST00000181271.1
 S100a13

S100 calcium binding protein A13

chr19_-_5845471 3.641 ENSMUST00000174287.1
ENSMUST00000173672.1
 Neat1

nuclear paraspeckle assembly transcript 1 (non-protein coding)

chr2_-_113829069 3.538 ENSMUST00000024005.7
 Scg5
secretogranin V
chr5_-_120588613 3.429 ENSMUST00000046426.8
 Tpcn1
two pore channel 1
chr5_+_123015010 3.386 ENSMUST00000121652.1
ENSMUST00000051016.4
 Orai1

ORAI calcium release-activated calcium modulator 1

chr13_-_12461432 3.348 ENSMUST00000143693.1
ENSMUST00000144283.1
ENSMUST00000099820.3
ENSMUST00000135166.1
 Lgals8



lectin, galactose binding, soluble 8



chr11_+_93996082 3.198 ENSMUST00000041956.7
 Spag9
sperm associated antigen 9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 14.7 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
3.4 13.5 GO:0055099 regulation of Cdc42 protein signal transduction(GO:0032489) response to high density lipoprotein particle(GO:0055099) platelet dense granule organization(GO:0060155)
0.8 11.2 GO:0072010 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.7 9.7 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.8 9.0 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
1.3 7.7 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
1.4 7.0 GO:0006689 ganglioside catabolic process(GO:0006689) oligosaccharide catabolic process(GO:0009313)
2.2 6.5 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
1.6 4.8 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.2 4.5 GO:0001886 endothelial cell morphogenesis(GO:0001886)
1.3 4.0 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
1.3 3.8 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.2 3.6 GO:0030575 nuclear body organization(GO:0030575)
0.2 3.5 GO:0016486 peptide hormone processing(GO:0016486)
0.2 3.4 GO:0002115 store-operated calcium entry(GO:0002115)
0.1 3.4 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.6 3.3 GO:0002317 plasma cell differentiation(GO:0002317)
0.4 3.2 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.9 2.8 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
0.6 2.6 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 13.5 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 11.8 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.2 7.7 GO:0030673 axolemma(GO:0030673)
0.1 7.4 GO:0005776 autophagosome(GO:0005776)
0.0 6.9 GO:0005874 microtubule(GO:0005874)
0.9 6.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 6.4 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 4.6 GO:0030141 secretory granule(GO:0030141)
0.0 4.4 GO:0005635 nuclear envelope(GO:0005635)
0.5 3.6 GO:0042382 paraspeckles(GO:0042382)
0.0 3.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 2.6 GO:0043196 varicosity(GO:0043196)
0.6 2.5 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.4 2.5 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 2.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.4 2.3 GO:0008091 spectrin(GO:0008091)
0.5 2.1 GO:0001533 cornified envelope(GO:0001533)
0.1 2.0 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 1.8 GO:0005814 centriole(GO:0005814)
0.4 1.7 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.9 GO:0042803 protein homodimerization activity(GO:0042803)
4.5 13.5 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188)
0.0 10.4 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 8.2 GO:0044212 transcription regulatory region DNA binding(GO:0044212)
1.9 7.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.4 7.0 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.6 6.5 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
1.0 4.8 GO:0070330 aromatase activity(GO:0070330)
1.3 4.0 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.6 3.8 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 3.5 GO:0051082 unfolded protein binding(GO:0051082)
1.1 3.4 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.3 3.4 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.3 3.2 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 3.2 GO:0051213 dioxygenase activity(GO:0051213)
0.0 3.1 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 3.0 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.9 2.8 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.0 2.7 GO:0030246 carbohydrate binding(GO:0030246)
0.1 2.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)