Motif ID: Nr1i3

Z-value: 1.455


Transcription factors associated with Nr1i3:

Gene SymbolEntrez IDGene Name
Nr1i3 ENSMUSG00000005677.8 Nr1i3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr1i3mm10_v2_chr1_+_171213969_171214007-0.503.4e-03Click!


Activity profile for motif Nr1i3.

activity profile for motif Nr1i3


Sorted Z-values histogram for motif Nr1i3

Sorted Z-values for motif Nr1i3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr1i3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_32276400 8.320 ENSMUST00000020531.2
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr1_+_166254095 7.556 ENSMUST00000111416.1
 Ildr2
immunoglobulin-like domain containing receptor 2
chr4_-_137785371 5.782 ENSMUST00000133473.1
 Alpl
alkaline phosphatase, liver/bone/kidney
chr14_-_48667508 5.666 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr5_-_116422858 5.522 ENSMUST00000036991.4
 Hspb8
heat shock protein 8
chr9_+_65630552 5.433 ENSMUST00000055844.8
 Rbpms2
RNA binding protein with multiple splicing 2
chr1_-_163289214 4.919 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chr9_-_30922452 4.656 ENSMUST00000065112.6
 Adamts15
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15
chr1_+_87264345 4.602 ENSMUST00000118687.1
ENSMUST00000027472.6
 Efhd1

EF hand domain containing 1

chr7_-_103843154 4.350 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr17_+_47505117 4.228 ENSMUST00000183044.1
ENSMUST00000037333.10
 Ccnd3

cyclin D3

chr2_+_122147680 4.053 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr1_+_90203980 3.883 ENSMUST00000065587.4
ENSMUST00000159654.1
 Ackr3

atypical chemokine receptor 3

chr11_-_90002881 3.881 ENSMUST00000020864.8
 Pctp
phosphatidylcholine transfer protein
chr2_+_93642307 3.756 ENSMUST00000042078.3
ENSMUST00000111254.1
 Alx4

aristaless-like homeobox 4

chr11_-_3931960 3.735 ENSMUST00000109990.1
ENSMUST00000020710.4
ENSMUST00000109989.3
ENSMUST00000109991.1
ENSMUST00000109993.2
 Tcn2




transcobalamin 2




chr4_-_148087961 3.383 ENSMUST00000030865.8
 Agtrap
angiotensin II, type I receptor-associated protein
chr7_-_30973464 3.356 ENSMUST00000001279.8
 Lsr
lipolysis stimulated lipoprotein receptor
chr1_+_135729147 3.354 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr7_-_30973367 3.301 ENSMUST00000108116.3
 Lsr
lipolysis stimulated lipoprotein receptor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 682 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 13.9 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
2.5 12.7 GO:0015671 oxygen transport(GO:0015671)
3.1 9.4 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.2 8.1 GO:0070206 protein trimerization(GO:0070206)
0.1 8.0 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.5 7.1 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.2 6.8 GO:0046677 response to antibiotic(GO:0046677)
0.2 6.2 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.4 6.1 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.5 5.8 GO:0060539 diaphragm development(GO:0060539)
1.9 5.7 GO:0015889 cobalamin transport(GO:0015889)
1.4 5.7 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.3 5.6 GO:0038092 nodal signaling pathway(GO:0038092)
0.1 5.6 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.6 5.5 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.2 5.4 GO:0006783 heme biosynthetic process(GO:0006783)
0.4 5.1 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.8 5.0 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.8 5.0 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.5 4.9 GO:0048664 neuron fate determination(GO:0048664)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 271 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 33.8 GO:0005740 mitochondrial envelope(GO:0005740)
0.0 32.0 GO:0070062 extracellular exosome(GO:0070062)
0.1 24.9 GO:0005667 transcription factor complex(GO:0005667)
0.1 20.8 GO:0031012 extracellular matrix(GO:0031012)
0.3 15.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
1.6 12.7 GO:0005833 hemoglobin complex(GO:0005833)
0.2 11.5 GO:0005604 basement membrane(GO:0005604)
0.2 10.9 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
1.6 9.4 GO:0061689 tricellular tight junction(GO:0061689)
0.2 8.5 GO:0005581 collagen trimer(GO:0005581)
0.5 8.2 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.1 7.9 GO:0000922 spindle pole(GO:0000922)
0.5 7.4 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 6.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 6.6 GO:0005657 replication fork(GO:0005657)
0.4 6.5 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 6.4 GO:0005925 focal adhesion(GO:0005925)
0.1 6.0 GO:0044853 plasma membrane raft(GO:0044853)
0.1 5.9 GO:0015934 large ribosomal subunit(GO:0015934)
0.1 5.7 GO:0016328 lateral plasma membrane(GO:0016328)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 423 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 14.4 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.3 13.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 13.2 GO:0071837 HMG box domain binding(GO:0071837)
2.5 12.7 GO:0005344 oxygen transporter activity(GO:0005344)
0.5 9.4 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.2 7.7 GO:0050840 extracellular matrix binding(GO:0050840)
1.9 7.5 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.5 7.4 GO:0001054 RNA polymerase I activity(GO:0001054)
0.2 7.3 GO:0005518 collagen binding(GO:0005518)
0.4 7.2 GO:0017049 GTP-Rho binding(GO:0017049)
0.5 7.1 GO:0008430 selenium binding(GO:0008430)
0.3 7.1 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 6.6 GO:0005178 integrin binding(GO:0005178)
0.4 6.2 GO:0005044 scavenger receptor activity(GO:0005044)
0.9 6.1 GO:0031419 cobalamin binding(GO:0031419)
0.2 6.1 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 6.0 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.2 5.3 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.8 5.1 GO:0001758 retinal dehydrogenase activity(GO:0001758)