Motif ID: Nr2f1_Nr4a1

Z-value: 1.555

Transcription factors associated with Nr2f1_Nr4a1:

Gene SymbolEntrez IDGene Name
Nr2f1 ENSMUSG00000069171.7 Nr2f1
Nr4a1 ENSMUSG00000023034.6 Nr4a1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr2f1mm10_v2_chr13_-_78196373_78196440-0.647.1e-05Click!
Nr4a1mm10_v2_chr15_+_101266839_101266859-0.251.5e-01Click!


Activity profile for motif Nr2f1_Nr4a1.

activity profile for motif Nr2f1_Nr4a1


Sorted Z-values histogram for motif Nr2f1_Nr4a1

Sorted Z-values for motif Nr2f1_Nr4a1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2f1_Nr4a1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_119578981 11.671 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr1_+_12718496 10.909 ENSMUST00000088585.3
 Sulf1
sulfatase 1
chr11_+_70657196 9.318 ENSMUST00000157027.1
ENSMUST00000072841.5
ENSMUST00000108548.1
ENSMUST00000126241.1
 Eno3



enolase 3, beta muscle



chr4_+_99955715 8.524 ENSMUST00000102783.4
 Pgm2
phosphoglucomutase 2
chr1_+_166254095 8.220 ENSMUST00000111416.1
 Ildr2
immunoglobulin-like domain containing receptor 2
chr11_+_70657687 8.082 ENSMUST00000134087.1
ENSMUST00000170716.1
 Eno3

enolase 3, beta muscle

chr13_+_98354234 7.957 ENSMUST00000105098.3
 Foxd1
forkhead box D1
chr5_+_111581422 7.219 ENSMUST00000064930.3
 C130026L21Rik
RIKEN cDNA C130026L21 gene
chr10_+_128194446 7.002 ENSMUST00000044776.6
 Gls2
glutaminase 2 (liver, mitochondrial)
chr3_-_138131356 6.877 ENSMUST00000029805.8
 Mttp
microsomal triglyceride transfer protein
chr10_-_78464853 6.554 ENSMUST00000105385.1
 Pdxk
pyridoxal (pyridoxine, vitamin B6) kinase
chr6_-_119544282 6.427 ENSMUST00000119369.1
ENSMUST00000178696.1
 Wnt5b

wingless-related MMTV integration site 5B

chr18_+_57142782 6.229 ENSMUST00000139892.1
 Megf10
multiple EGF-like-domains 10
chr7_-_109616548 6.183 ENSMUST00000077909.1
ENSMUST00000084738.3
 St5

suppression of tumorigenicity 5

chr18_-_60624304 6.079 ENSMUST00000097566.3
 Synpo
synaptopodin
chr3_+_146500071 5.998 ENSMUST00000119130.1
 Gng5
guanine nucleotide binding protein (G protein), gamma 5
chr12_-_110978981 5.850 ENSMUST00000135131.1
ENSMUST00000043459.6
ENSMUST00000128353.1
 Ankrd9


ankyrin repeat domain 9


chr13_-_74350206 5.803 ENSMUST00000022062.7
 Sdha
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr11_-_100822525 5.796 ENSMUST00000107358.2
 Stat5b
signal transducer and activator of transcription 5B
chr19_+_53529100 5.694 ENSMUST00000038287.6
 Dusp5
dual specificity phosphatase 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 359 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.0 15.9 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.2 15.2 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.3 14.7 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.1 12.5 GO:0006006 glucose metabolic process(GO:0006006)
4.0 12.1 GO:0042822 vitamin B6 metabolic process(GO:0042816) pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823)
3.9 11.7 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) membrane depolarization during SA node cell action potential(GO:0086046)
0.4 9.2 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
1.4 8.4 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
2.7 8.0 GO:0072076 nephrogenic mesenchyme development(GO:0072076)
0.9 8.0 GO:0006105 succinate metabolic process(GO:0006105)
2.6 7.9 GO:0045204 MAPK export from nucleus(GO:0045204)
0.2 7.7 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
1.3 7.6 GO:0043654 recognition of apoptotic cell(GO:0043654)
1.5 7.5 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.3 7.5 GO:0016578 histone deubiquitination(GO:0016578)
0.3 7.4 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.4 6.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 6.5 GO:0051384 response to glucocorticoid(GO:0051384)
1.1 6.3 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
1.5 6.2 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 161 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.8 GO:0031012 extracellular matrix(GO:0031012)
0.1 17.5 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 17.0 GO:0005759 mitochondrial matrix(GO:0005759)
3.1 15.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 15.3 GO:0005667 transcription factor complex(GO:0005667)
0.3 12.8 GO:0098803 respiratory chain complex(GO:0098803)
0.1 10.5 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 10.3 GO:0005730 nucleolus(GO:0005730)
0.0 10.2 GO:0015629 actin cytoskeleton(GO:0015629)
0.6 10.0 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 8.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
2.8 8.4 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.5 7.9 GO:0031528 microvillus membrane(GO:0031528)
0.9 7.3 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.4 7.0 GO:0045259 proton-transporting ATP synthase complex(GO:0045259)
0.6 6.9 GO:0070069 cytochrome complex(GO:0070069)
0.4 6.7 GO:0005844 polysome(GO:0005844)
0.3 6.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 6.5 GO:0000118 histone deacetylase complex(GO:0000118)
1.3 6.3 GO:0005861 troponin complex(GO:0005861)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 249 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 15.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
1.7 15.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
2.8 13.8 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.3 13.4 GO:0005109 frizzled binding(GO:0005109)
4.0 12.1 GO:0031403 lithium ion binding(GO:0031403)
0.1 10.7 GO:0003924 GTPase activity(GO:0003924)
1.4 10.0 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.8 10.0 GO:0008301 DNA binding, bending(GO:0008301)
0.8 9.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 8.6 GO:0001047 core promoter binding(GO:0001047)
2.7 8.0 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 7.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.4 7.8 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 7.7 GO:0070410 co-SMAD binding(GO:0070410)
0.2 6.9 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.3 6.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 6.8 GO:0051082 unfolded protein binding(GO:0051082)
0.2 6.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 6.6 GO:0005518 collagen binding(GO:0005518)
0.2 6.4 GO:0033549 MAP kinase phosphatase activity(GO:0033549)