Motif ID: Nr2f6

Z-value: 0.748


Transcription factors associated with Nr2f6:

Gene SymbolEntrez IDGene Name
Nr2f6 ENSMUSG00000002393.8 Nr2f6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr2f6mm10_v2_chr8_-_71381907_71381977-0.421.5e-02Click!


Activity profile for motif Nr2f6.

activity profile for motif Nr2f6


Sorted Z-values histogram for motif Nr2f6

Sorted Z-values for motif Nr2f6



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2f6

PNG image of the network

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Top targets:


Showing 1 to 20 of 138 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_137741601 2.897 ENSMUST00000119498.1
ENSMUST00000061789.7
 Nyap1

neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1

chr1_-_138847579 2.689 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr4_+_85205417 2.038 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr15_+_89532816 1.898 ENSMUST00000167173.1
 Shank3
SH3/ankyrin domain gene 3
chr17_-_35910032 1.847 ENSMUST00000141662.1
ENSMUST00000056034.6
ENSMUST00000077494.6
ENSMUST00000149277.1
ENSMUST00000061052.5
 Atat1




alpha tubulin acetyltransferase 1




chr4_+_85205120 1.795 ENSMUST00000107188.3
 Sh3gl2
SH3-domain GRB2-like 2
chr9_+_108392820 1.763 ENSMUST00000035234.4
 1700102P08Rik
RIKEN cDNA 1700102P08 gene
chr13_+_43370710 1.622 ENSMUST00000066804.4
 Sirt5
sirtuin 5
chr10_-_79984227 1.547 ENSMUST00000052885.7
 Tmem259
transmembrane protein 259
chr8_+_71469186 1.539 ENSMUST00000124745.1
ENSMUST00000138892.1
ENSMUST00000147642.1
 Dda1


DET1 and DDB1 associated 1


chr17_-_35909626 1.361 ENSMUST00000141132.1
 Atat1
alpha tubulin acetyltransferase 1
chr17_-_35132050 1.330 ENSMUST00000025249.6
 Apom
apolipoprotein M
chr10_-_79983970 1.319 ENSMUST00000124536.1
 Tmem259
transmembrane protein 259
chr7_+_64501687 1.247 ENSMUST00000032732.8
 Apba2
amyloid beta (A4) precursor protein-binding, family A, member 2
chr16_-_4624984 1.239 ENSMUST00000014445.6
 Pam16
presequence translocase-asssociated motor 16 homolog (S. cerevisiae)
chr7_+_30232310 1.208 ENSMUST00000108193.1
ENSMUST00000108192.1
 Polr2i

polymerase (RNA) II (DNA directed) polypeptide I

chr7_-_30232186 1.198 ENSMUST00000006254.5
 Tbcb
tubulin folding cofactor B
chr19_-_6921753 1.125 ENSMUST00000173635.1
 Esrra
estrogen related receptor, alpha
chr10_+_43524080 1.096 ENSMUST00000057649.6
 Gm9803
predicted gene 9803
chr11_+_101442440 1.026 ENSMUST00000107249.1
 Rpl27
ribosomal protein L27

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
1.1 3.2 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.2 2.9 GO:1904294 positive regulation of ERAD pathway(GO:1904294)
0.0 2.9 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.5 2.7 GO:0035262 gonad morphogenesis(GO:0035262)
0.1 2.1 GO:1900078 positive regulation of cellular response to insulin stimulus(GO:1900078)
0.4 1.9 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.1 1.6 GO:0010566 regulation of ketone biosynthetic process(GO:0010566)
0.0 1.6 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.1 1.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 1.4 GO:0051974 negative regulation of telomerase activity(GO:0051974)
0.0 1.4 GO:0060074 synapse maturation(GO:0060074)
0.4 1.3 GO:0050748 negative regulation of lipoprotein metabolic process(GO:0050748)
0.4 1.2 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.0 1.1 GO:0051865 protein autoubiquitination(GO:0051865)
0.2 0.9 GO:0009212 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) dTTP metabolic process(GO:0046075)
0.2 0.9 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 0.9 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 0.8 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.8 GO:0048268 clathrin coat assembly(GO:0048268)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.2 GO:0097427 microtubule bundle(GO:0097427)
0.0 1.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.6 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.5 1.4 GO:1990879 CST complex(GO:1990879)
0.3 1.3 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.2 1.2 GO:0031314 mitochondrial inner membrane presequence translocase complex(GO:0005744) extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1 1.2 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 1.1 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.0 GO:0016592 mediator complex(GO:0016592)
0.0 1.0 GO:0060170 ciliary membrane(GO:0060170)
0.0 1.0 GO:0022626 cytosolic ribosome(GO:0022626)
0.2 0.9 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.8 GO:0030131 clathrin adaptor complex(GO:0030131)
0.2 0.7 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.7 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.2 0.6 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.0 0.6 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.6 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.5 GO:0097440 apical dendrite(GO:0097440)
0.1 0.4 GO:0070826 paraferritin complex(GO:0070826)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.1 GO:0061733 peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0 2.0 GO:0005496 steroid binding(GO:0005496)
0.5 1.9 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 1.6 GO:0070403 NAD+ binding(GO:0070403)
0.0 1.5 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)
0.1 1.4 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 1.3 GO:0016209 antioxidant activity(GO:0016209)
0.0 1.2 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 1.2 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.9 GO:0043851 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)
0.1 0.8 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.8 GO:0050699 WW domain binding(GO:0050699)
0.0 0.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 0.7 GO:0031720 haptoglobin binding(GO:0031720)
0.0 0.7 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.2 0.6 GO:0019808 polyamine binding(GO:0019808)
0.1 0.6 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.1 0.6 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.6 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)