Motif ID: Nr4a2

Z-value: 0.454


Transcription factors associated with Nr4a2:

Gene SymbolEntrez IDGene Name
Nr4a2 ENSMUSG00000026826.7 Nr4a2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr4a2mm10_v2_chr2_-_57124003_571240710.144.5e-01Click!


Activity profile for motif Nr4a2.

activity profile for motif Nr4a2


Sorted Z-values histogram for motif Nr4a2

Sorted Z-values for motif Nr4a2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr4a2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_26229707 1.539 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr8_+_68880491 1.226 ENSMUST00000015712.8
 Lpl
lipoprotein lipase
chr11_+_70657687 1.077 ENSMUST00000134087.1
ENSMUST00000170716.1
 Eno3

enolase 3, beta muscle

chr11_+_70657196 0.933 ENSMUST00000157027.1
ENSMUST00000072841.5
ENSMUST00000108548.1
ENSMUST00000126241.1
 Eno3



enolase 3, beta muscle



chrX_+_150589907 0.810 ENSMUST00000080884.4
 Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr5_+_111581422 0.794 ENSMUST00000064930.3
 C130026L21Rik
RIKEN cDNA C130026L21 gene
chr6_-_124814288 0.787 ENSMUST00000172132.2
 Tpi1
triosephosphate isomerase 1
chr10_-_40302186 0.769 ENSMUST00000099945.4
 Amd1
S-adenosylmethionine decarboxylase 1
chr9_-_32344237 0.663 ENSMUST00000034533.5
 Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
chrX_-_48513518 0.640 ENSMUST00000114945.2
ENSMUST00000037349.7
 Aifm1

apoptosis-inducing factor, mitochondrion-associated 1

chr13_+_94875600 0.607 ENSMUST00000022195.10
 Otp
orthopedia homolog (Drosophila)
chr17_+_29360923 0.591 ENSMUST00000024810.6
 Fgd2
FYVE, RhoGEF and PH domain containing 2
chr2_+_4976113 0.562 ENSMUST00000167607.1
ENSMUST00000115010.2
 Ucma

upper zone of growth plate and cartilage matrix associated

chr10_-_35711891 0.542 ENSMUST00000080898.2
 Amd2
S-adenosylmethionine decarboxylase 2
chr5_-_121527186 0.528 ENSMUST00000152270.1
 Mapkapk5
MAP kinase-activated protein kinase 5
chr18_+_86711059 0.501 ENSMUST00000068423.3
 Cbln2
cerebellin 2 precursor protein
chr11_-_52282564 0.500 ENSMUST00000086844.3
 Tcf7
transcription factor 7, T cell specific
chr13_+_93304066 0.491 ENSMUST00000109493.1
 Homer1
homer homolog 1 (Drosophila)
chr13_-_97747373 0.485 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chrX_-_73921917 0.466 ENSMUST00000114389.3
 Naa10
N(alpha)-acetyltransferase 10, NatA catalytic subunit
chr4_+_99955715 0.464 ENSMUST00000102783.4
 Pgm2
phosphoglucomutase 2
chr18_-_15063560 0.455 ENSMUST00000168989.1
 Kctd1
potassium channel tetramerisation domain containing 1
chr5_-_137613759 0.450 ENSMUST00000155251.1
ENSMUST00000124693.1
 Pcolce

procollagen C-endopeptidase enhancer protein

chr2_+_79707780 0.439 ENSMUST00000090760.2
ENSMUST00000040863.4
ENSMUST00000111780.2
 Ppp1r1c


protein phosphatase 1, regulatory (inhibitor) subunit 1C


chrX_-_73921930 0.425 ENSMUST00000033763.8
 Naa10
N(alpha)-acetyltransferase 10, NatA catalytic subunit
chr10_+_110920170 0.389 ENSMUST00000020403.5
 Csrp2
cysteine and glycine-rich protein 2
chrX_-_73921828 0.387 ENSMUST00000096316.3
ENSMUST00000114390.1
ENSMUST00000114391.3
ENSMUST00000114387.1
 Naa10



N(alpha)-acetyltransferase 10, NatA catalytic subunit



chr1_+_137966529 0.374 ENSMUST00000182158.1
 A430106G13Rik
RIKEN cDNA A430106G13 gene
chr2_-_73911323 0.369 ENSMUST00000111996.1
ENSMUST00000018914.2
 Atp5g3

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)

chrX_-_142390334 0.338 ENSMUST00000112907.1
 Acsl4
acyl-CoA synthetase long-chain family member 4
chr3_+_14578609 0.334 ENSMUST00000029069.6
ENSMUST00000165922.2
 E2f5

E2F transcription factor 5

chr15_-_42676967 0.333 ENSMUST00000022921.5
 Angpt1
angiopoietin 1
chr7_-_100514800 0.330 ENSMUST00000054923.7
 Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr2_+_75832168 0.320 ENSMUST00000047232.7
ENSMUST00000111952.2
 Agps

alkylglycerone phosphate synthase

chr17_+_47737030 0.317 ENSMUST00000086932.3
 Tfeb
transcription factor EB
chr2_+_121295437 0.302 ENSMUST00000110639.1
 Map1a
microtubule-associated protein 1 A
chr11_-_100822525 0.299 ENSMUST00000107358.2
 Stat5b
signal transducer and activator of transcription 5B
chr1_+_63176818 0.295 ENSMUST00000129339.1
 Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr10_-_93589621 0.287 ENSMUST00000020203.6
 Snrpf
small nuclear ribonucleoprotein polypeptide F
chr4_-_36136463 0.283 ENSMUST00000098151.2
 Lingo2
leucine rich repeat and Ig domain containing 2
chr15_-_89425856 0.283 ENSMUST00000109313.2
 Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr18_-_56975333 0.281 ENSMUST00000139243.2
ENSMUST00000025488.8
 C330018D20Rik

RIKEN cDNA C330018D20 gene

chr2_-_101621033 0.266 ENSMUST00000090513.4
 B230118H07Rik
RIKEN cDNA B230118H07 gene
chr1_-_63176653 0.264 ENSMUST00000027111.8
ENSMUST00000168099.2
 Ndufs1

NADH dehydrogenase (ubiquinone) Fe-S protein 1

chr2_+_105668888 0.260 ENSMUST00000111086.4
ENSMUST00000111087.3
 Pax6

paired box gene 6

chr10_-_117224480 0.250 ENSMUST00000020382.6
 Yeats4
YEATS domain containing 4
chr8_+_70863127 0.234 ENSMUST00000050921.2
 A230052G05Rik
RIKEN cDNA A230052G05 gene
chr9_+_95637601 0.233 ENSMUST00000015498.8
 Pcolce2
procollagen C-endopeptidase enhancer 2
chr8_+_117095854 0.233 ENSMUST00000034308.8
ENSMUST00000167370.1
ENSMUST00000176860.1
 Bcmo1


beta-carotene 15,15'-monooxygenase


chr18_+_36664060 0.219 ENSMUST00000036765.7
 Eif4ebp3
eukaryotic translation initiation factor 4E binding protein 3
chr6_-_99096196 0.216 ENSMUST00000175886.1
 Foxp1
forkhead box P1
chr3_+_4211716 0.210 ENSMUST00000170943.1
 Gm8775
predicted gene 8775
chr13_+_118714678 0.209 ENSMUST00000022246.8
 Fgf10
fibroblast growth factor 10
chr11_-_70656467 0.192 ENSMUST00000131642.1
 Gm12319
predicted gene 12319
chr8_-_64733534 0.191 ENSMUST00000141021.1
 Sc4mol
sterol-C4-methyl oxidase-like
chr9_-_22002599 0.186 ENSMUST00000115336.2
ENSMUST00000044926.5
 Ccdc151

coiled-coil domain containing 151

chr9_-_106656081 0.185 ENSMUST00000023959.7
 Grm2
glutamate receptor, metabotropic 2
chr1_+_131910458 0.180 ENSMUST00000062264.6
 Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr7_+_125603420 0.178 ENSMUST00000033000.6
 Il21r
interleukin 21 receptor
chr2_-_163417092 0.171 ENSMUST00000127038.1
 Oser1
oxidative stress responsive serine rich 1
chr8_-_46211284 0.171 ENSMUST00000034049.4
 Slc25a4
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
chrX_+_7579666 0.168 ENSMUST00000115740.1
ENSMUST00000115739.1
 Foxp3

forkhead box P3

chr10_+_94147982 0.164 ENSMUST00000105290.2
 Nr2c1
nuclear receptor subfamily 2, group C, member 1
chr8_-_119840522 0.164 ENSMUST00000168698.1
ENSMUST00000034285.6
 Cotl1

coactosin-like 1 (Dictyostelium)

chrX_-_150589844 0.159 ENSMUST00000112725.1
ENSMUST00000112720.1
 Apex2

apurinic/apyrimidinic endonuclease 2

chr2_+_59160838 0.158 ENSMUST00000102754.4
ENSMUST00000168631.1
ENSMUST00000123908.1
 Pkp4


plakophilin 4


chr3_-_95133989 0.150 ENSMUST00000172572.2
ENSMUST00000173462.2
 Scnm1

sodium channel modifier 1

chr10_+_42502197 0.144 ENSMUST00000105499.1
 Snx3
sorting nexin 3
chr7_+_120635176 0.137 ENSMUST00000033176.5
 Uqcrc2
ubiquinol cytochrome c reductase core protein 2
chr1_+_167618246 0.136 ENSMUST00000111380.1
 Rxrg
retinoid X receptor gamma
chr4_-_42581621 0.134 ENSMUST00000178742.1
 Gm10592
predicted gene 10592
chr4_-_150914401 0.128 ENSMUST00000105675.1
 Park7
Parkinson disease (autosomal recessive, early onset) 7
chr2_-_155945282 0.122 ENSMUST00000040162.2
 Gdf5
growth differentiation factor 5
chr10_+_53337686 0.122 ENSMUST00000046221.6
ENSMUST00000163319.1
 Pln

phospholamban

chr10_-_99759658 0.121 ENSMUST00000056085.4
 Csl
citrate synthase like
chr4_-_141623799 0.120 ENSMUST00000038661.7
 Slc25a34
solute carrier family 25, member 34
chr15_-_98607611 0.105 ENSMUST00000096224.4
 Adcy6
adenylate cyclase 6
chr1_-_87573825 0.104 ENSMUST00000068681.5
 Ngef
neuronal guanine nucleotide exchange factor
chr2_-_129699833 0.102 ENSMUST00000028883.5
 Pdyn
prodynorphin
chr13_-_92131494 0.098 ENSMUST00000099326.3
ENSMUST00000146492.1
 Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr15_+_25940846 0.091 ENSMUST00000110438.1
 Fam134b
family with sequence similarity 134, member B
chr2_+_61593077 0.089 ENSMUST00000112495.1
ENSMUST00000112501.2
 Tank

TRAF family member-associated Nf-kappa B activator

chr13_-_97747399 0.071 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr3_+_84925476 0.065 ENSMUST00000107675.1
 Fbxw7
F-box and WD-40 domain protein 7
chr2_+_158794807 0.057 ENSMUST00000029186.7
ENSMUST00000109478.2
ENSMUST00000156893.1
 Dhx35


DEAH (Asp-Glu-Ala-His) box polypeptide 35


chrX_+_6415736 0.053 ENSMUST00000143641.3
 Shroom4
shroom family member 4
chr15_-_102516806 0.050 ENSMUST00000169162.1
ENSMUST00000023812.2
ENSMUST00000165174.1
ENSMUST00000169367.1
ENSMUST00000169377.1
 Map3k12




mitogen-activated protein kinase kinase kinase 12




chr16_+_44139821 0.042 ENSMUST00000159514.1
ENSMUST00000161326.1
ENSMUST00000063520.8
ENSMUST00000063542.7
 Naa50



N(alpha)-acetyltransferase 50, NatE catalytic subunit



chr2_+_105668935 0.025 ENSMUST00000142772.1
 Pax6
paired box gene 6
chr11_+_3650253 0.023 ENSMUST00000096441.3
 Morc2a
microrchidia 2A
chr4_+_136357423 0.019 ENSMUST00000182167.1
 Gm17388
predicted gene, 17388
chr15_-_89425795 0.017 ENSMUST00000168376.1
 Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr2_-_26237368 0.010 ENSMUST00000036187.8
 Qsox2
quiescin Q6 sulfhydryl oxidase 2
chr9_-_64737623 0.006 ENSMUST00000169058.1
 Rab11a
RAB11a, member RAS oncogene family
chr9_-_13446753 0.002 ENSMUST00000167906.2
 Gm17571
predicted gene, 17571
chr6_+_3993776 0.001 ENSMUST00000031673.5
 Gngt1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0006597 spermine biosynthetic process(GO:0006597)
0.3 1.2 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.3 0.8 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.3 1.3 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.1 0.3 GO:0030210 heparin biosynthetic process(GO:0030210) Tie signaling pathway(GO:0048014)
0.1 0.8 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.3 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
0.1 0.6 GO:1903624 regulation of apoptotic DNA fragmentation(GO:1902510) regulation of DNA catabolic process(GO:1903624)
0.1 0.3 GO:2000277 positive regulation of oxidative phosphorylation uncoupler activity(GO:2000277)
0.1 0.7 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.1 0.5 GO:0090400 stress-induced premature senescence(GO:0090400)
0.1 0.3 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918)
0.1 0.2 GO:0032829 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) negative regulation of interleukin-2 biosynthetic process(GO:0045085) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0 0.1 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.0 0.6 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.0 0.3 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.1 GO:0035811 negative regulation of urine volume(GO:0035811)
0.0 0.2 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.4 GO:0048875 chemical homeostasis within a tissue(GO:0048875)
0.0 0.7 GO:0010107 potassium ion import(GO:0010107)
0.0 0.1 GO:0060591 chondroblast differentiation(GO:0060591)
0.0 2.0 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.0 0.2 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.2 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.1 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 0.1 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.3 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.4 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.1 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0 0.1 GO:0086023 adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.0 0.2 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.4 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.0 0.2 GO:0046628 positive regulation of insulin receptor signaling pathway(GO:0046628)
0.0 0.0 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 0.2 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.6 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.3 0.8 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.2 1.2 GO:0042627 chylomicron(GO:0042627)
0.2 1.3 GO:0031415 NatA complex(GO:0031415)
0.1 0.3 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.0 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.3 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.5 GO:0032156 septin cytoskeleton(GO:0032156)
0.0 0.4 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 0.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 0.1 GO:0032009 early phagosome(GO:0032009)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.6 GO:0016235 aggresome(GO:0016235)
0.0 1.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.2 GO:0030057 desmosome(GO:0030057)
0.0 0.4 GO:0043034 costamere(GO:0043034)
0.0 0.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.3 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0019808 polyamine binding(GO:0019808)
0.3 1.3 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189) peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.2 2.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 0.6 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 0.7 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.8 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 1.2 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.5 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 0.8 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 0.3 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.1 0.4 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 0.2 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.1 0.2 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.4 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.1 GO:0044388 tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478) small protein activating enzyme binding(GO:0044388) cupric ion binding(GO:1903135) cuprous ion binding(GO:1903136) glyoxalase (glycolic acid-forming) activity(GO:1990422)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.2 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.0 0.3 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.2 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.3 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.3 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.1 GO:0036122 BMP binding(GO:0036122)
0.0 0.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 0.7 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.3 GO:0003746 translation elongation factor activity(GO:0003746)