Motif ID: Nr4a3

Z-value: 0.377


Transcription factors associated with Nr4a3:

Gene SymbolEntrez IDGene Name
Nr4a3 ENSMUSG00000028341.3 Nr4a3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr4a3mm10_v2_chr4_+_48045144_480451600.183.1e-01Click!


Activity profile for motif Nr4a3.

activity profile for motif Nr4a3


Sorted Z-values histogram for motif Nr4a3

Sorted Z-values for motif Nr4a3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr4a3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrY_-_1245685 0.850 ENSMUST00000143286.1
ENSMUST00000137048.1
ENSMUST00000069309.7
ENSMUST00000139365.1
 Uty



ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome



chr19_-_4334001 0.707 ENSMUST00000176653.1
 Kdm2a
lysine (K)-specific demethylase 2A
chr16_+_10545390 0.642 ENSMUST00000115827.1
ENSMUST00000038145.6
ENSMUST00000150894.1
 Clec16a


C-type lectin domain family 16, member A


chr15_+_25773985 0.577 ENSMUST00000125667.1
 Myo10
myosin X
chrY_-_1245753 0.575 ENSMUST00000154004.1
 Uty
ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
chr5_+_66968559 0.498 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr16_-_4523056 0.466 ENSMUST00000090500.3
ENSMUST00000023161.7
 Srl

sarcalumenin

chr4_+_43578921 0.387 ENSMUST00000030190.8
 Rgp1
RGP1 retrograde golgi transport homolog (S. cerevisiae)
chr15_-_76918010 0.372 ENSMUST00000048854.7
 Zfp647
zinc finger protein 647
chr15_+_100761741 0.370 ENSMUST00000023776.6
 Slc4a8
solute carrier family 4 (anion exchanger), member 8
chr17_-_35909626 0.328 ENSMUST00000141132.1
 Atat1
alpha tubulin acetyltransferase 1
chr18_-_60624304 0.319 ENSMUST00000097566.3
 Synpo
synaptopodin
chr2_-_163417092 0.318 ENSMUST00000127038.1
 Oser1
oxidative stress responsive serine rich 1
chr19_+_46152505 0.315 ENSMUST00000026254.7
 Gbf1
golgi-specific brefeldin A-resistance factor 1
chrX_+_73675500 0.310 ENSMUST00000171398.1
 Slc6a8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr7_+_102267795 0.301 ENSMUST00000033289.4
 Stim1
stromal interaction molecule 1
chr4_-_126202583 0.289 ENSMUST00000106142.1
ENSMUST00000169403.1
ENSMUST00000130334.1
 Thrap3


thyroid hormone receptor associated protein 3


chr2_-_33468493 0.252 ENSMUST00000113156.1
ENSMUST00000028125.5
ENSMUST00000126442.1
 Zbtb43


zinc finger and BTB domain containing 43


chr11_+_70657687 0.235 ENSMUST00000134087.1
ENSMUST00000170716.1
 Eno3

enolase 3, beta muscle

chr19_-_45998479 0.231 ENSMUST00000045396.7
 9130011E15Rik
RIKEN cDNA 9130011E15 gene
chr6_-_112946754 0.230 ENSMUST00000113169.2
 Srgap3
SLIT-ROBO Rho GTPase activating protein 3
chr7_-_98162318 0.216 ENSMUST00000107112.1
 Capn5
calpain 5
chr6_-_28421680 0.212 ENSMUST00000090511.3
 Gcc1
golgi coiled coil 1
chr7_-_79842287 0.205 ENSMUST00000049004.6
 Anpep
alanyl (membrane) aminopeptidase
chr6_+_91156772 0.205 ENSMUST00000143621.1
 Hdac11
histone deacetylase 11
chr5_+_111581422 0.202 ENSMUST00000064930.3
 C130026L21Rik
RIKEN cDNA C130026L21 gene
chr12_-_84194007 0.193 ENSMUST00000110294.1
 Elmsan1
ELM2 and Myb/SANT-like domain containing 1
chr11_+_116657106 0.192 ENSMUST00000116318.2
 Gm11744
predicted gene 11744
chr12_+_4082574 0.186 ENSMUST00000020986.7
 Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr9_+_75071386 0.183 ENSMUST00000155282.2
 Myo5a
myosin VA
chr7_+_30712209 0.181 ENSMUST00000005692.6
ENSMUST00000170371.1
 Atp4a

ATPase, H+/K+ exchanging, gastric, alpha polypeptide

chr6_+_113531675 0.179 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr11_+_115475645 0.175 ENSMUST00000035240.6
 Armc7
armadillo repeat containing 7
chr4_+_99955715 0.172 ENSMUST00000102783.4
 Pgm2
phosphoglucomutase 2
chr7_+_45897429 0.171 ENSMUST00000140243.1
 Tmem143
transmembrane protein 143
chr4_-_129227883 0.170 ENSMUST00000106051.1
 C77080
expressed sequence C77080
chr16_+_10545339 0.166 ENSMUST00000066345.7
ENSMUST00000115824.3
ENSMUST00000155633.1
 Clec16a


C-type lectin domain family 16, member A


chr7_-_126475082 0.163 ENSMUST00000032978.6
 Sh2b1
SH2B adaptor protein 1
chr12_-_93929102 0.163 ENSMUST00000180321.1
 Gm9726
predicted gene 9726
chr9_-_64341145 0.162 ENSMUST00000120760.1
ENSMUST00000168844.2
 Dis3l

DIS3 mitotic control homolog (S. cerevisiae)-like

chr8_+_124793061 0.160 ENSMUST00000041106.7
 Trim67
tripartite motif-containing 67
chr4_+_134396320 0.156 ENSMUST00000105869.2
 Pafah2
platelet-activating factor acetylhydrolase 2
chr2_-_180273488 0.149 ENSMUST00000108891.1
 Cables2
CDK5 and Abl enzyme substrate 2
chr1_+_75435930 0.145 ENSMUST00000037796.7
ENSMUST00000113584.1
ENSMUST00000145166.1
ENSMUST00000143730.1
ENSMUST00000133418.1
ENSMUST00000144874.1
ENSMUST00000140287.1
 Gmppa






GDP-mannose pyrophosphorylase A






chr15_-_102516806 0.132 ENSMUST00000169162.1
ENSMUST00000023812.2
ENSMUST00000165174.1
ENSMUST00000169367.1
ENSMUST00000169377.1
 Map3k12




mitogen-activated protein kinase kinase kinase 12




chr9_-_119578981 0.128 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr8_+_124793013 0.126 ENSMUST00000167588.1
 Trim67
tripartite motif-containing 67
chr6_+_91157373 0.125 ENSMUST00000155007.1
 Hdac11
histone deacetylase 11
chr9_+_22003035 0.123 ENSMUST00000115331.2
ENSMUST00000003493.7
 Prkcsh

protein kinase C substrate 80K-H

chrX_-_71492799 0.123 ENSMUST00000037391.5
ENSMUST00000114586.2
ENSMUST00000114587.2
 Cd99l2


CD99 antigen-like 2


chrX_+_150589907 0.122 ENSMUST00000080884.4
 Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr4_+_137993016 0.119 ENSMUST00000105830.2
ENSMUST00000084215.5
ENSMUST00000058133.3
ENSMUST00000139759.1
 Eif4g3



eukaryotic translation initiation factor 4 gamma, 3



chr2_-_167492826 0.117 ENSMUST00000109211.2
ENSMUST00000057627.9
 Spata2

spermatogenesis associated 2

chr9_-_22085391 0.117 ENSMUST00000179422.1
ENSMUST00000098937.3
ENSMUST00000177967.1
ENSMUST00000180180.1
 Ecsit



ECSIT homolog (Drosophila)



chr11_+_74649462 0.115 ENSMUST00000092915.5
ENSMUST00000117818.1
 Cluh

clustered mitochondria (cluA/CLU1) homolog

chr2_-_165283599 0.114 ENSMUST00000155289.1
 Slc35c2
solute carrier family 35, member C2
chr19_+_44989073 0.113 ENSMUST00000026225.8
 Sema4g
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr4_+_131873608 0.112 ENSMUST00000053819.3
 Srsf4
serine/arginine-rich splicing factor 4
chr6_-_76497631 0.110 ENSMUST00000097218.5
 Gm9008
predicted pseudogene 9008
chr11_-_100822525 0.105 ENSMUST00000107358.2
 Stat5b
signal transducer and activator of transcription 5B
chr7_-_28598140 0.101 ENSMUST00000108283.1
ENSMUST00000040531.8
 Pak4
Samd4b
p21 protein (Cdc42/Rac)-activated kinase 4
sterile alpha motif domain containing 4B
chr2_+_158794807 0.101 ENSMUST00000029186.7
ENSMUST00000109478.2
ENSMUST00000156893.1
 Dhx35


DEAH (Asp-Glu-Ala-His) box polypeptide 35


chr19_-_37207293 0.092 ENSMUST00000132580.1
ENSMUST00000079754.4
ENSMUST00000136286.1
ENSMUST00000126188.1
ENSMUST00000126781.1
 Cpeb3




cytoplasmic polyadenylation element binding protein 3




chr4_+_116075269 0.090 ENSMUST00000030471.8
 Lrrc41
leucine rich repeat containing 41
chr7_-_127345314 0.088 ENSMUST00000060783.5
 Zfp768
zinc finger protein 768
chr11_-_61494173 0.087 ENSMUST00000101085.2
ENSMUST00000079080.6
ENSMUST00000108714.1
 Mapk7


mitogen-activated protein kinase 7


chr2_+_157279026 0.086 ENSMUST00000116380.2
 Rpn2
ribophorin II
chr11_+_70657196 0.081 ENSMUST00000157027.1
ENSMUST00000072841.5
ENSMUST00000108548.1
ENSMUST00000126241.1
 Eno3



enolase 3, beta muscle



chr17_+_29360923 0.074 ENSMUST00000024810.6
 Fgd2
FYVE, RhoGEF and PH domain containing 2
chr7_+_45896941 0.073 ENSMUST00000069772.7
ENSMUST00000107716.1
 Tmem143

transmembrane protein 143

chr4_+_134397380 0.067 ENSMUST00000105870.1
 Pafah2
platelet-activating factor acetylhydrolase 2
chr2_+_59160838 0.065 ENSMUST00000102754.4
ENSMUST00000168631.1
ENSMUST00000123908.1
 Pkp4


plakophilin 4


chr2_+_157279065 0.063 ENSMUST00000029171.5
 Rpn2
ribophorin II
chrX_-_150589844 0.061 ENSMUST00000112725.1
ENSMUST00000112720.1
 Apex2

apurinic/apyrimidinic endonuclease 2

chr6_+_91156665 0.058 ENSMUST00000041736.4
 Hdac11
histone deacetylase 11
chr7_-_19715395 0.049 ENSMUST00000032555.9
ENSMUST00000093552.5
 Tomm40

translocase of outer mitochondrial membrane 40 homolog (yeast)

chr11_+_70764209 0.043 ENSMUST00000060444.5
 Zfp3
zinc finger protein 3
chr4_-_126202757 0.043 ENSMUST00000080919.5
 Thrap3
thyroid hormone receptor associated protein 3
chr8_+_119862239 0.042 ENSMUST00000034287.8
 Klhl36
kelch-like 36
chr4_-_43578824 0.038 ENSMUST00000030189.7
 Gba2
glucosidase beta 2
chr17_+_34605855 0.035 ENSMUST00000037489.8
 Agpat1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr6_-_113531575 0.031 ENSMUST00000032425.5
 Emc3
ER membrane protein complex subunit 3
chr3_-_138131356 0.030 ENSMUST00000029805.8
 Mttp
microsomal triglyceride transfer protein
chr8_-_123894736 0.030 ENSMUST00000034453.4
 Acta1
actin, alpha 1, skeletal muscle
chr11_-_115267236 0.028 ENSMUST00000106554.1
 Grin2c
glutamate receptor, ionotropic, NMDA2C (epsilon 3)
chr7_+_130865835 0.025 ENSMUST00000075181.4
ENSMUST00000048180.5
 Plekha1

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

chr13_-_41847482 0.024 ENSMUST00000072012.3
 Adtrp
androgen dependent TFPI regulating protein
chr17_-_35910032 0.018 ENSMUST00000141662.1
ENSMUST00000056034.6
ENSMUST00000077494.6
ENSMUST00000149277.1
ENSMUST00000061052.5
 Atat1




alpha tubulin acetyltransferase 1




chr3_-_59210881 0.018 ENSMUST00000040622.1
 P2ry13
purinergic receptor P2Y, G-protein coupled 13
chr4_+_126058557 0.017 ENSMUST00000035497.4
 Oscp1
organic solute carrier partner 1
chr3_-_104818539 0.013 ENSMUST00000106774.1
ENSMUST00000106775.1
ENSMUST00000166979.1
ENSMUST00000136148.1
 Mov10



Moloney leukemia virus 10



chr6_+_41546730 0.009 ENSMUST00000103299.1
 Trbc2
T cell receptor beta, constant 2
chr2_+_79707780 0.009 ENSMUST00000090760.2
ENSMUST00000040863.4
ENSMUST00000111780.2
 Ppp1r1c


protein phosphatase 1, regulatory (inhibitor) subunit 1C


chr8_-_120668121 0.007 ENSMUST00000034277.7
 Emc8
ER membrane protein complex subunit 8
chr15_-_79141197 0.005 ENSMUST00000169604.1
 1700088E04Rik
RIKEN cDNA 1700088E04 gene
chr17_-_73950172 0.002 ENSMUST00000024866.4
 Xdh
xanthine dehydrogenase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0014873 response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
0.2 1.2 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.1 0.8 GO:1901524 regulation of autophagosome maturation(GO:1901096) regulation of macromitophagy(GO:1901524) negative regulation of macromitophagy(GO:1901525)
0.1 0.3 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.1 0.3 GO:0070973 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.7 GO:0033184 positive regulation of histone ubiquitination(GO:0033184)
0.1 0.2 GO:0045204 MAPK export from nucleus(GO:0045204)
0.1 0.3 GO:0032237 activation of store-operated calcium channel activity(GO:0032237)
0.0 0.1 GO:0086017 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) Purkinje myocyte action potential(GO:0086017) membrane depolarization during SA node cell action potential(GO:0086046)
0.0 0.1 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
0.0 0.1 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.0 0.1 GO:0070375 ERK5 cascade(GO:0070375)
0.0 0.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.1 GO:0015786 UDP-glucose transport(GO:0015786)
0.0 0.2 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.0 0.1 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.0 0.2 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.0 0.1 GO:0060903 positive regulation of meiosis I(GO:0060903)
0.0 0.4 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.1 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.2 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.2 GO:0036376 sodium ion export from cell(GO:0036376)
0.0 0.3 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.2 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 0.0 GO:0006680 glucosylceramide catabolic process(GO:0006680)
0.0 0.3 GO:0072337 modified amino acid transport(GO:0072337)
0.0 0.3 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0031983 vesicle lumen(GO:0031983)
0.1 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.3 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 0.3 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 0.7 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.2 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.2 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0 0.2 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116)
0.0 0.1 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.1 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.0 0.1 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.4 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.1 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.4 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.1 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.2 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.0 GO:0004348 glucosylceramidase activity(GO:0004348)
0.0 0.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.2 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)