Motif ID: Nr6a1

Z-value: 0.572


Transcription factors associated with Nr6a1:

Gene SymbolEntrez IDGene Name
Nr6a1 ENSMUSG00000063972.7 Nr6a1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr6a1mm10_v2_chr2_-_38926217_389264540.232.1e-01Click!


Activity profile for motif Nr6a1.

activity profile for motif Nr6a1


Sorted Z-values histogram for motif Nr6a1

Sorted Z-values for motif Nr6a1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr6a1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_45530330 1.921 ENSMUST00000061986.5
 Shb
src homology 2 domain-containing transforming protein B
chr7_-_66427469 1.826 ENSMUST00000015278.7
 Aldh1a3
aldehyde dehydrogenase family 1, subfamily A3
chr7_+_30314810 1.644 ENSMUST00000054594.8
ENSMUST00000177078.1
ENSMUST00000176504.1
ENSMUST00000176304.1
 Syne4



spectrin repeat containing, nuclear envelope family member 4



chr1_+_131970589 1.438 ENSMUST00000027695.6
 Slc45a3
solute carrier family 45, member 3
chr5_-_137611372 1.248 ENSMUST00000054564.6
 Pcolce
procollagen C-endopeptidase enhancer protein
chr2_+_172472512 1.206 ENSMUST00000029007.2
 Fam209
family with sequence similarity 209
chr5_-_137610626 1.164 ENSMUST00000142675.1
 Pcolce
procollagen C-endopeptidase enhancer protein
chr5_-_137611429 1.114 ENSMUST00000031731.7
 Pcolce
procollagen C-endopeptidase enhancer protein
chr14_+_58072686 1.107 ENSMUST00000022545.7
 Fgf9
fibroblast growth factor 9
chr9_+_50603892 1.107 ENSMUST00000044051.4
 Timm8b
translocase of inner mitochondrial membrane 8B
chr10_+_128083273 1.098 ENSMUST00000026459.5
 Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr2_+_180071793 1.091 ENSMUST00000108901.1
 Mtg2
mitochondrial ribosome associated GTPase 2
chr6_+_83349446 0.940 ENSMUST00000136501.1
 Bola3
bolA-like 3 (E. coli)
chr11_-_69822144 0.925 ENSMUST00000045771.6
 Spem1
sperm maturation 1
chr7_-_105574324 0.910 ENSMUST00000081165.7
 Apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1
chr12_-_115790884 0.904 ENSMUST00000081809.5
 Ighv1-73
immunoglobulin heavy variable 1-73
chr9_-_96437434 0.821 ENSMUST00000070500.2
 BC043934
cDNA sequence BC043934
chr13_-_24761440 0.780 ENSMUST00000176890.1
ENSMUST00000175689.1
 Gmnn

geminin

chr17_+_26123514 0.773 ENSMUST00000025014.8
 Mrpl28
mitochondrial ribosomal protein L28
chr12_-_71136611 0.754 ENSMUST00000021486.8
ENSMUST00000166120.1
 Timm9

translocase of inner mitochondrial membrane 9

chr10_-_80855187 0.726 ENSMUST00000035775.8
 Lsm7
LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr4_+_13743424 0.715 ENSMUST00000006761.3
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr11_+_6560183 0.701 ENSMUST00000109722.2
 Ccm2
cerebral cavernous malformation 2
chr15_-_98165613 0.701 ENSMUST00000143400.1
 Asb8
ankyrin repeat and SOCS box-containing 8
chr1_+_151428612 0.688 ENSMUST00000065625.5
 Trmt1l
tRNA methyltransferase 1 like
chr4_+_123904832 0.663 ENSMUST00000030400.7
 Mycbp
c-myc binding protein
chr17_-_46645128 0.635 ENSMUST00000003642.6
 Klc4
kinesin light chain 4
chr12_+_3807017 0.618 ENSMUST00000020991.8
ENSMUST00000172509.1
 Dnmt3a

DNA methyltransferase 3A

chr4_+_123904907 0.618 ENSMUST00000106202.3
 Mycbp
c-myc binding protein
chr9_+_98296556 0.613 ENSMUST00000035031.6
ENSMUST00000112935.1
 Nmnat3

nicotinamide nucleotide adenylyltransferase 3

chr11_-_60811228 0.587 ENSMUST00000018744.8
 Shmt1
serine hydroxymethyltransferase 1 (soluble)
chr3_+_138526174 0.549 ENSMUST00000029803.7
 Eif4e
eukaryotic translation initiation factor 4E
chr12_+_3807076 0.537 ENSMUST00000174817.1
 Dnmt3a
DNA methyltransferase 3A
chr8_+_75109528 0.535 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr19_+_46707443 0.533 ENSMUST00000003655.7
 As3mt
arsenic (+3 oxidation state) methyltransferase
chr5_-_136986829 0.521 ENSMUST00000034953.7
ENSMUST00000085941.5
 Znhit1

zinc finger, HIT domain containing 1

chr8_-_109693235 0.518 ENSMUST00000034164.4
 Ist1
increased sodium tolerance 1 homolog (yeast)
chr15_-_98165560 0.506 ENSMUST00000123922.1
 Asb8
ankyrin repeat and SOCS box-containing 8
chr18_-_77767752 0.490 ENSMUST00000048192.7
 Haus1
HAUS augmin-like complex, subunit 1
chr2_+_173737492 0.477 ENSMUST00000067530.4
 Vapb
vesicle-associated membrane protein, associated protein B and C
chr10_-_43540945 0.471 ENSMUST00000147196.1
ENSMUST00000019932.3
 1700021F05Rik

RIKEN cDNA 1700021F05 gene

chr5_-_30073554 0.466 ENSMUST00000026846.6
 Tyms
thymidylate synthase
chrX_-_36991724 0.404 ENSMUST00000152291.1
 Sept6
septin 6
chr4_+_43632185 0.386 ENSMUST00000107874.2
 Npr2
natriuretic peptide receptor 2
chr4_-_134552122 0.383 ENSMUST00000060435.6
 Sepn1
selenoprotein N, 1
chr9_+_73102398 0.382 ENSMUST00000174203.2
ENSMUST00000034737.6
ENSMUST00000173734.2
ENSMUST00000167514.1
 Gm20509
Khdc3


predicted gene 20509
KH domain containing 3, subcortical maternal complex member


chr9_-_50603792 0.365 ENSMUST00000000175.4
 Sdhd
succinate dehydrogenase complex, subunit D, integral membrane protein
chr2_+_157424255 0.344 ENSMUST00000029175.7
ENSMUST00000092576.4
 Src

Rous sarcoma oncogene

chr11_+_120677226 0.325 ENSMUST00000129644.2
ENSMUST00000151160.1
 Aspscr1

alveolar soft part sarcoma chromosome region, candidate 1 (human)

chr4_+_155562348 0.321 ENSMUST00000030939.7
 Nadk
NAD kinase
chr2_+_32606946 0.282 ENSMUST00000113290.1
 St6galnac6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr17_+_33629078 0.278 ENSMUST00000166627.1
ENSMUST00000073570.5
ENSMUST00000170225.1
 Zfp414


zinc finger protein 414


chr1_+_171329376 0.276 ENSMUST00000111299.1
ENSMUST00000064950.4
 Dedd

death effector domain-containing

chr2_+_32606979 0.259 ENSMUST00000113289.1
ENSMUST00000095044.3
 St6galnac6

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

chr10_-_79916912 0.235 ENSMUST00000045628.7
ENSMUST00000171416.1
 R3hdm4

R3H domain containing 4

chr6_+_42245907 0.216 ENSMUST00000031897.5
 Gstk1
glutathione S-transferase kappa 1
chr15_-_73184840 0.209 ENSMUST00000044113.10
 Ago2
argonaute RISC catalytic subunit 2
chr14_+_12189943 0.143 ENSMUST00000119888.1
 Ptprg
protein tyrosine phosphatase, receptor type, G
chr9_-_121839460 0.129 ENSMUST00000135986.2
 Ccdc13
coiled-coil domain containing 13
chr9_-_119157055 0.123 ENSMUST00000010795.4
 Acaa1b
acetyl-Coenzyme A acyltransferase 1B
chr5_+_136987019 0.117 ENSMUST00000004968.4
 Plod3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr17_+_72918298 0.092 ENSMUST00000024857.6
 Lbh
limb-bud and heart
chr7_+_128265675 0.078 ENSMUST00000118169.1
ENSMUST00000142841.1
 Slc5a2

solute carrier family 5 (sodium/glucose cotransporter), member 2

chr19_-_5688149 0.069 ENSMUST00000068169.5
 Pcnxl3
pecanex-like 3 (Drosophila)
chr4_-_123904826 0.044 ENSMUST00000181292.1
 Gm26606
predicted gene, 26606
chr14_+_76488436 0.042 ENSMUST00000101618.2
 Tsc22d1
TSC22 domain family, member 1
chr1_+_171329015 0.031 ENSMUST00000111300.1
 Dedd
death effector domain-containing

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0060166 olfactory pit development(GO:0060166)
0.5 1.4 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.4 1.1 GO:0009177 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.3 2.3 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.3 1.1 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.2 0.8 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.2 1.6 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.2 0.5 GO:0009838 abscission(GO:0009838)
0.2 0.6 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.1 1.2 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.1 0.4 GO:0014873 response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
0.1 0.5 GO:0044830 modulation by host of viral RNA genome replication(GO:0044830)
0.1 0.3 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.1 1.1 GO:0060484 lung-associated mesenchyme development(GO:0060484)
0.1 0.5 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.1 0.3 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 1.1 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.1 0.5 GO:0009404 toxin metabolic process(GO:0009404)
0.1 0.3 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.1 0.9 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 0.7 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
0.0 0.5 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.2 GO:0035087 siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.0 0.5 GO:0071549 cellular response to dexamethasone stimulus(GO:0071549)
0.0 0.9 GO:0045739 positive regulation of DNA repair(GO:0045739)
0.0 0.9 GO:0030317 sperm motility(GO:0030317)
0.0 0.5 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.8 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 0.7 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 0.4 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.4 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.2 1.6 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.2 0.9 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.1 1.1 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 0.4 GO:0005940 septin ring(GO:0005940)
0.1 0.7 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.1 0.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.5 GO:0090543 Flemming body(GO:0090543)
0.1 0.8 GO:0034518 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.1 0.4 GO:0045179 apical cortex(GO:0045179)
0.1 0.5 GO:0070652 HAUS complex(GO:0070652)
0.1 1.2 GO:0001741 XY body(GO:0001741)
0.0 0.5 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.5 GO:0042555 MCM complex(GO:0042555)
0.0 1.9 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.0 1.1 GO:0005604 basement membrane(GO:0005604)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.4 1.8 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.2 0.6 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) serine binding(GO:0070905)
0.2 0.6 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.1 1.2 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.1 1.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.4 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.1 0.3 GO:0003951 NAD+ kinase activity(GO:0003951)
0.1 3.5 GO:0016504 peptidase activator activity(GO:0016504)
0.1 0.4 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 1.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 0.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 0.5 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 0.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 1.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.3 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.9 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.5 GO:0005542 folic acid binding(GO:0005542)
0.0 1.3 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 1.2 GO:0030792 methylarsonite methyltransferase activity(GO:0030792)
0.0 0.2 GO:0015035 glutathione peroxidase activity(GO:0004602) protein disulfide oxidoreductase activity(GO:0015035)