Motif ID: Nrf1

Z-value: 3.305


Transcription factors associated with Nrf1:

Gene SymbolEntrez IDGene Name
Nrf1 ENSMUSG00000058440.8 Nrf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nrf1mm10_v2_chr6_+_30047979_300480490.299.8e-02Click!


Activity profile for motif Nrf1.

activity profile for motif Nrf1


Sorted Z-values histogram for motif Nrf1

Sorted Z-values for motif Nrf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nrf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_79682304 7.966 ENSMUST00000166603.1
 Cdc34
cell division cycle 34
chr7_-_29281977 7.440 ENSMUST00000098604.4
ENSMUST00000108236.3
 Spint2

serine protease inhibitor, Kunitz type 2

chr15_+_88751649 6.317 ENSMUST00000041297.8
 Zbed4
zinc finger, BED domain containing 4
chr9_+_21616230 5.700 ENSMUST00000174008.1
 Smarca4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr10_+_79682169 5.404 ENSMUST00000020550.5
 Cdc34
cell division cycle 34
chr14_+_59625281 5.360 ENSMUST00000053949.5
 Shisa2
shisa homolog 2 (Xenopus laevis)
chr9_+_21616166 5.354 ENSMUST00000034707.8
ENSMUST00000098948.3
 Smarca4

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

chr1_+_24005505 4.810 ENSMUST00000181961.1
 Gm26524
predicted gene, 26524
chr17_+_34894515 4.789 ENSMUST00000052778.8
 Zbtb12
zinc finger and BTB domain containing 12
chr11_-_69921329 4.512 ENSMUST00000108613.3
ENSMUST00000043419.3
ENSMUST00000070996.4
 Eif5a


eukaryotic translation initiation factor 5A


chr19_+_41911851 4.410 ENSMUST00000011896.6
 Pgam1
phosphoglycerate mutase 1
chr7_+_24507006 4.339 ENSMUST00000176880.1
 Zfp428
zinc finger protein 428
chr13_-_53286052 4.332 ENSMUST00000021918.8
 Ror2
receptor tyrosine kinase-like orphan receptor 2
chr2_+_157560078 4.329 ENSMUST00000153739.2
ENSMUST00000173595.1
ENSMUST00000109526.1
ENSMUST00000173839.1
ENSMUST00000173041.1
ENSMUST00000173793.1
ENSMUST00000172487.1
ENSMUST00000088484.5
 Nnat







neuronatin







chr16_+_90727490 4.327 ENSMUST00000181232.1
 Gm17518
predicted gene, 17518
chr17_-_75551838 4.269 ENSMUST00000112507.3
 Fam98a
family with sequence similarity 98, member A
chr11_+_50377719 4.220 ENSMUST00000069304.7
ENSMUST00000077817.7
 Hnrnph1

heterogeneous nuclear ribonucleoprotein H1

chr7_+_44816088 4.177 ENSMUST00000057195.9
ENSMUST00000107891.1
 Nup62

nucleoporin 62

chr18_+_80206775 4.074 ENSMUST00000125127.1
ENSMUST00000025463.7
ENSMUST00000145963.1
ENSMUST00000025464.7
 Gm16286

Txnl4a

predicted gene 16286

thioredoxin-like 4A

chr15_-_31601506 4.049 ENSMUST00000161266.1
 Cct5
chaperonin containing Tcp1, subunit 5 (epsilon)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 592 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 23.2 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.3 17.1 GO:0006405 RNA export from nucleus(GO:0006405)
1.2 13.7 GO:1990173 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
1.9 13.0 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
1.2 11.5 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
2.8 11.1 GO:0061626 pharyngeal arch artery morphogenesis(GO:0061626)
1.8 10.7 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 10.4 GO:0006413 translational initiation(GO:0006413)
0.5 9.5 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.2 9.0 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.3 8.8 GO:0007020 microtubule nucleation(GO:0007020)
2.7 8.2 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
1.9 7.8 GO:0006203 dGTP catabolic process(GO:0006203) dATP catabolic process(GO:0046061)
0.3 7.8 GO:0009299 mRNA transcription(GO:0009299)
2.5 7.4 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
1.4 7.2 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.1 7.0 GO:0050691 regulation of defense response to virus by host(GO:0050691)
0.6 6.8 GO:0000012 single strand break repair(GO:0000012)
0.4 6.6 GO:0016180 snRNA processing(GO:0016180)
0.4 6.4 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 290 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 22.3 GO:0005730 nucleolus(GO:0005730)
0.4 19.1 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.9 16.9 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
1.5 14.9 GO:0005642 annulate lamellae(GO:0005642)
1.2 13.7 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.2 12.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 12.3 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.2 10.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 9.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 9.7 GO:0090544 BAF-type complex(GO:0090544)
3.1 9.4 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.2 8.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 8.1 GO:0005643 nuclear pore(GO:0005643)
0.9 7.5 GO:0031415 NatA complex(GO:0031415)
0.3 7.4 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.2 7.4 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.5 7.3 GO:0032039 integrator complex(GO:0032039)
0.1 7.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.4 7.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.4 7.2 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 352 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 85.4 GO:0003723 RNA binding(GO:0003723)
0.1 27.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 18.8 GO:0003743 translation initiation factor activity(GO:0003743)
1.6 18.1 GO:0030957 Tat protein binding(GO:0030957)
0.3 15.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
1.0 13.3 GO:0032554 purine deoxyribonucleotide binding(GO:0032554)
0.1 13.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.2 12.8 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.9 12.1 GO:0017070 U6 snRNA binding(GO:0017070)
0.2 11.7 GO:0003880 protein C-terminal carboxyl O-methyltransferase activity(GO:0003880)
0.0 11.6 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
1.1 10.8 GO:0001055 RNA polymerase II activity(GO:0001055)
0.6 10.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.4 8.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 8.5 GO:0000049 tRNA binding(GO:0000049)
2.7 8.2 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.2 8.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.2 8.1 GO:0003684 damaged DNA binding(GO:0003684)
0.2 7.8 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.4 7.5 GO:0031681 G-protein beta-subunit binding(GO:0031681)