Motif ID: Onecut1_Cux2

Z-value: 1.194

Transcription factors associated with Onecut1_Cux2:

Gene SymbolEntrez IDGene Name
Cux2 ENSMUSG00000042589.12 Cux2
Cux2 ENSMUSG00000072641.1 Cux2
Onecut1 ENSMUSG00000043013.9 Onecut1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Onecut1mm10_v2_chr9_+_74861888_748619210.521.8e-03Click!
Cux2mm10_v2_chr5_-_122049822_122049882-0.261.5e-01Click!


Activity profile for motif Onecut1_Cux2.

activity profile for motif Onecut1_Cux2


Sorted Z-values histogram for motif Onecut1_Cux2

Sorted Z-values for motif Onecut1_Cux2



Network of associatons between targets according to the STRING database.



First level regulatory network of Onecut1_Cux2

PNG image of the network

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Top targets:


Showing 1 to 20 of 99 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 22.443 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr3_+_102010138 14.765 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr6_+_4755327 10.184 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr14_+_68083853 6.657 ENSMUST00000022639.7
 Nefl
neurofilament, light polypeptide
chr12_+_55598917 4.819 ENSMUST00000051857.3
 Insm2
insulinoma-associated 2
chr19_-_57197496 4.423 ENSMUST00000111544.1
 Ablim1
actin-binding LIM protein 1
chr19_-_57197377 4.094 ENSMUST00000111546.1
 Ablim1
actin-binding LIM protein 1
chr2_-_84775388 4.063 ENSMUST00000023994.3
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr2_-_168767136 4.055 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr9_-_114844090 3.852 ENSMUST00000047013.3
 Cmtm8
CKLF-like MARVEL transmembrane domain containing 8
chr2_-_84775420 3.699 ENSMUST00000111641.1
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr19_-_57197435 3.608 ENSMUST00000111550.1
 Ablim1
actin-binding LIM protein 1
chr19_-_57197556 3.359 ENSMUST00000099294.2
 Ablim1
actin-binding LIM protein 1
chr2_-_168767029 2.906 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr3_+_125404072 2.776 ENSMUST00000173932.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr3_+_125404292 2.709 ENSMUST00000144344.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr2_-_72986716 2.666 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr4_+_62965560 2.529 ENSMUST00000030043.6
ENSMUST00000107415.1
ENSMUST00000064814.5
 Zfp618


zinc finger protein 618


chr2_-_148046896 2.441 ENSMUST00000172928.1
ENSMUST00000047315.3
 Foxa2

forkhead box A2

chr2_+_130277157 2.435 ENSMUST00000028890.8
ENSMUST00000159373.1
 Nop56

NOP56 ribonucleoprotein


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 22.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.5 14.8 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.2 13.8 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 10.2 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
2.6 7.8 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.4 7.0 GO:0001833 inner cell mass cell proliferation(GO:0001833)
2.2 6.7 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.6 3.4 GO:0003383 apical constriction(GO:0003383)
0.0 3.3 GO:0006935 chemotaxis(GO:0006935) taxis(GO:0042330)
0.8 2.4 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.1 2.4 GO:0000154 rRNA modification(GO:0000154)
0.1 2.3 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 2.1 GO:0007498 mesoderm development(GO:0007498)
0.2 2.0 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.2 1.7 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.2 1.7 GO:0051639 actin filament network formation(GO:0051639)
0.0 1.7 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.2 1.6 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.1 1.6 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 1.6 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 7.8 GO:0072562 blood microparticle(GO:0072562)
0.1 7.4 GO:0000792 heterochromatin(GO:0000792)
2.2 6.7 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.4 3.4 GO:0033269 internode region of axon(GO:0033269)
0.3 2.4 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 2.0 GO:0043034 costamere(GO:0043034)
0.4 1.7 GO:0032127 dense core granule membrane(GO:0032127)
0.0 1.7 GO:0043296 apical junction complex(GO:0043296)
0.1 1.6 GO:0005677 chromatin silencing complex(GO:0005677)
0.2 1.5 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 1.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.4 1.4 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.2 1.4 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 1.4 GO:0043679 axon terminus(GO:0043679)
0.0 1.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.3 GO:0055037 recycling endosome(GO:0055037)
0.1 1.2 GO:0045298 tubulin complex(GO:0045298)
0.1 1.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 1.1 GO:0005840 ribosome(GO:0005840)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 22.9 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 15.6 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 14.9 GO:0003677 DNA binding(GO:0003677)
0.2 14.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 13.8 GO:0003779 actin binding(GO:0003779)
0.4 7.1 GO:0001848 complement binding(GO:0001848)
0.3 6.7 GO:0043274 phospholipase binding(GO:0043274)
0.8 5.5 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 4.8 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 3.9 GO:0005125 cytokine activity(GO:0005125)
0.1 3.4 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 2.9 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 2.4 GO:1990226 histone methyltransferase binding(GO:1990226)
0.3 2.0 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 2.0 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.2 1.7 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 1.6 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 1.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 1.5 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 1.5 GO:0045295 gamma-catenin binding(GO:0045295)