Motif ID: Otx1

Z-value: 0.472


Transcription factors associated with Otx1:

Gene SymbolEntrez IDGene Name
Otx1 ENSMUSG00000005917.9 Otx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otx1mm10_v2_chr11_-_22001605_220016310.512.5e-03Click!


Activity profile for motif Otx1.

activity profile for motif Otx1


Sorted Z-values histogram for motif Otx1

Sorted Z-values for motif Otx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Otx1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_3973086 2.278 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
 Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr11_+_94936224 2.040 ENSMUST00000001547.7
 Col1a1
collagen, type I, alpha 1
chr7_-_38271310 1.916 ENSMUST00000032585.6
 Pop4
processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae)
chr5_-_98566762 1.831 ENSMUST00000086912.4
 1700010H22Rik
RIKEN cDNA 1700010H22 gene
chr9_+_108479849 1.780 ENSMUST00000065014.4
 Lamb2
laminin, beta 2
chr1_-_165708088 1.431 ENSMUST00000040357.8
ENSMUST00000097474.3
 Rcsd1

RCSD domain containing 1

chrX_-_48513518 1.339 ENSMUST00000114945.2
ENSMUST00000037349.7
 Aifm1

apoptosis-inducing factor, mitochondrion-associated 1

chr17_+_35861318 1.257 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr16_-_59632520 1.231 ENSMUST00000118438.1
 Arl6
ADP-ribosylation factor-like 6
chr8_-_47675556 1.231 ENSMUST00000125536.1
 Ing2
inhibitor of growth family, member 2
chr2_-_60963192 1.189 ENSMUST00000028347.6
 Rbms1
RNA binding motif, single stranded interacting protein 1
chr12_-_46818749 1.010 ENSMUST00000021438.6
 Nova1
neuro-oncological ventral antigen 1
chr5_-_5749317 0.991 ENSMUST00000015796.2
 Steap1
six transmembrane epithelial antigen of the prostate 1
chr3_+_54481429 0.987 ENSMUST00000091130.3
 Gm5641
predicted gene 5641
chr5_-_37336870 0.972 ENSMUST00000031005.4
 Evc
Ellis van Creveld gene syndrome
chr7_-_79848191 0.959 ENSMUST00000107392.1
 Anpep
alanyl (membrane) aminopeptidase
chr5_-_37336837 0.864 ENSMUST00000114148.1
 Evc
Ellis van Creveld gene syndrome
chr17_+_35861343 0.832 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)
chr4_-_123750236 0.821 ENSMUST00000102636.3
 Akirin1
akirin 1
chr11_+_115564434 0.795 ENSMUST00000021085.4
 Nup85
nucleoporin 85
chr14_-_122913751 0.762 ENSMUST00000160401.1
 Ggact
gamma-glutamylamine cyclotransferase
chr11_+_78346666 0.749 ENSMUST00000100755.3
 Unc119
unc-119 homolog (C. elegans)
chr13_+_21180179 0.710 ENSMUST00000021761.5
 Trim27
tripartite motif-containing 27
chr10_+_61648552 0.693 ENSMUST00000020286.6
 Ppa1
pyrophosphatase (inorganic) 1
chr13_-_60897439 0.686 ENSMUST00000171347.1
ENSMUST00000021884.8
 Ctla2b

cytotoxic T lymphocyte-associated protein 2 beta

chr2_-_144011202 0.684 ENSMUST00000016072.5
ENSMUST00000037875.5
 Rrbp1

ribosome binding protein 1

chr19_-_7039987 0.668 ENSMUST00000025918.7
 Stip1
stress-induced phosphoprotein 1
chr10_+_127642975 0.665 ENSMUST00000092074.5
ENSMUST00000120279.1
 Stat6

signal transducer and activator of transcription 6

chr1_+_131910458 0.660 ENSMUST00000062264.6
 Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr1_+_187215737 0.642 ENSMUST00000160471.1
 Gpatch2
G patch domain containing 2
chr13_+_41016250 0.640 ENSMUST00000021790.5
 Tmem14c
transmembrane protein 14C
chr19_-_6057736 0.606 ENSMUST00000007482.6
 Mrpl49
mitochondrial ribosomal protein L49
chr6_-_136828186 0.601 ENSMUST00000116514.1
 Wbp11
WW domain binding protein 11
chr5_+_15516489 0.597 ENSMUST00000178227.1
 Gm21847
predicted gene, 21847
chr3_-_105960099 0.585 ENSMUST00000118209.1
 Atp5f1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1
chr4_-_42661893 0.576 ENSMUST00000108006.3
 Il11ra2
interleukin 11 receptor, alpha chain 2
chr2_+_28468056 0.573 ENSMUST00000038600.3
 Mrps2
mitochondrial ribosomal protein S2
chr11_-_116274102 0.566 ENSMUST00000106425.3
 Srp68
signal recognition particle 68
chr4_-_41517326 0.561 ENSMUST00000030152.6
ENSMUST00000095126.4
 1110017D15Rik

RIKEN cDNA 1110017D15 gene

chr9_-_109082372 0.561 ENSMUST00000167504.1
 Tma7
translational machinery associated 7 homolog (S. cerevisiae)
chr1_+_187215501 0.544 ENSMUST00000097443.3
ENSMUST00000065573.7
ENSMUST00000110943.2
ENSMUST00000044812.5
 Gpatch2



G patch domain containing 2



chr1_+_118321834 0.543 ENSMUST00000027626.6
ENSMUST00000112688.3
 Mki67ip

Mki67 (FHA domain) interacting nucleolar phosphoprotein

chr17_-_50094277 0.525 ENSMUST00000113195.1
 Rftn1
raftlin lipid raft linker 1
chr9_-_66975387 0.503 ENSMUST00000034929.6
 Lactb
lactamase, beta
chr10_-_88605017 0.482 ENSMUST00000119185.1
ENSMUST00000121629.1
 Mybpc1

myosin binding protein C, slow-type

chr11_+_100545607 0.456 ENSMUST00000092684.5
ENSMUST00000006976.7
 Ttc25

tetratricopeptide repeat domain 25

chr10_-_93889758 0.453 ENSMUST00000181091.1
ENSMUST00000181217.1
ENSMUST00000047910.8
ENSMUST00000180688.1
 Metap2



methionine aminopeptidase 2



chr11_-_116694802 0.442 ENSMUST00000079545.5
 St6galnac2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr11_-_116274197 0.427 ENSMUST00000021133.9
 Srp68
signal recognition particle 68
chr11_+_3963970 0.425 ENSMUST00000020705.4
ENSMUST00000109985.1
 Pes1

pescadillo homolog 1, containing BRCT domain (zebrafish)

chr4_+_58943575 0.421 ENSMUST00000107554.1
 Zkscan16
zinc finger with KRAB and SCAN domains 16
chr2_-_11603192 0.413 ENSMUST00000040314.5
 Rbm17
RNA binding motif protein 17
chr9_+_68653761 0.406 ENSMUST00000034766.7
 Rora
RAR-related orphan receptor alpha
chr3_+_66985647 0.392 ENSMUST00000162362.1
ENSMUST00000065074.7
 Rsrc1

arginine/serine-rich coiled-coil 1

chr10_+_80054029 0.376 ENSMUST00000097227.3
 Gpx4
glutathione peroxidase 4
chr19_+_5689131 0.356 ENSMUST00000004156.8
 Map3k11
mitogen-activated protein kinase kinase kinase 11
chr2_-_26933781 0.315 ENSMUST00000154651.1
ENSMUST00000015011.3
 Surf4

surfeit gene 4

chr13_+_90089705 0.310 ENSMUST00000012566.8
 Tmem167
transmembrane protein 167
chr17_-_47611449 0.310 ENSMUST00000024783.8
 Bysl
bystin-like
chr4_-_126201117 0.300 ENSMUST00000136157.1
 Thrap3
thyroid hormone receptor associated protein 3
chrX_-_95956890 0.294 ENSMUST00000079987.6
ENSMUST00000113864.2
 Las1l

LAS1-like (S. cerevisiae)

chrM_+_11734 0.286 ENSMUST00000082418.1
 mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr14_-_87141114 0.282 ENSMUST00000168889.1
 Diap3
diaphanous homolog 3 (Drosophila)
chr5_-_62765618 0.279 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr17_+_8165501 0.275 ENSMUST00000097419.3
ENSMUST00000024636.8
 Fgfr1op

Fgfr1 oncogene partner

chr2_-_151980135 0.261 ENSMUST00000062047.5
 Fam110a
family with sequence similarity 110, member A
chr2_+_129800451 0.261 ENSMUST00000165413.2
ENSMUST00000166282.2
 Stk35

serine/threonine kinase 35

chr3_+_66985947 0.257 ENSMUST00000161726.1
ENSMUST00000160504.1
 Rsrc1

arginine/serine-rich coiled-coil 1

chr7_-_100662315 0.221 ENSMUST00000151123.1
ENSMUST00000107047.2
 Plekhb1

pleckstrin homology domain containing, family B (evectins) member 1

chr2_+_154656959 0.204 ENSMUST00000044277.9
 Chmp4b
charged multivesicular body protein 4B
chr7_-_118129567 0.193 ENSMUST00000032888.7
 Arl6ip1
ADP-ribosylation factor-like 6 interacting protein 1
chr5_-_100373484 0.193 ENSMUST00000182433.1
 Sec31a
Sec31 homolog A (S. cerevisiae)
chr10_+_29313164 0.192 ENSMUST00000160399.1
 Echdc1
enoyl Coenzyme A hydratase domain containing 1
chr1_+_133131143 0.161 ENSMUST00000052529.3
 Ppp1r15b
protein phosphatase 1, regulatory (inhibitor) subunit 15b
chr7_-_100662414 0.151 ENSMUST00000079176.6
 Plekhb1
pleckstrin homology domain containing, family B (evectins) member 1
chr10_-_7473361 0.150 ENSMUST00000169796.2
ENSMUST00000177585.1
 Ulbp1

UL16 binding protein 1

chr1_-_118311132 0.135 ENSMUST00000027623.7
 Tsn
translin
chr4_-_132422484 0.132 ENSMUST00000102568.3
 Phactr4
phosphatase and actin regulator 4
chr15_-_74734313 0.125 ENSMUST00000023260.3
 Lypd2
Ly6/Plaur domain containing 2
chr6_-_148831395 0.125 ENSMUST00000145960.1
 Ipo8
importin 8
chr12_-_27160311 0.123 ENSMUST00000182473.1
ENSMUST00000177636.1
ENSMUST00000183238.1
 Gm9866


predicted gene 9866


chr13_+_93771656 0.101 ENSMUST00000091403.4
 Arsb
arylsulfatase B
chr18_+_80206887 0.089 ENSMUST00000127234.1
 Gm16286
predicted gene 16286
chr19_+_5024006 0.085 ENSMUST00000025826.5
 Slc29a2
solute carrier family 29 (nucleoside transporters), member 2
chr7_-_104950441 0.083 ENSMUST00000179862.1
 Gm5900
predicted pseudogene 5900
chr13_+_21735055 0.080 ENSMUST00000087714.4
 Hist1h4j
histone cluster 1, H4j
chr14_-_87141206 0.074 ENSMUST00000022599.7
 Diap3
diaphanous homolog 3 (Drosophila)
chr7_-_4063195 0.066 ENSMUST00000068865.5
ENSMUST00000086400.6
 Lair1

leukocyte-associated Ig-like receptor 1

chr5_-_100416115 0.046 ENSMUST00000182886.1
ENSMUST00000094578.4
 Sec31a

Sec31 homolog A (S. cerevisiae)

chr14_-_54605908 0.034 ENSMUST00000022786.4
 4931414P19Rik
RIKEN cDNA 4931414P19 gene
chr13_-_21750505 0.022 ENSMUST00000102983.1
 Hist1h4k
histone cluster 1, H4k
chr6_-_88518760 0.006 ENSMUST00000032168.5
 Sec61a1
Sec61 alpha 1 subunit (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.3 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.4 1.8 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.3 1.0 GO:0097461 ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461)
0.3 2.0 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.2 1.2 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.2 0.7 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.2 0.7 GO:0002295 T-helper cell lineage commitment(GO:0002295) interleukin-4-mediated signaling pathway(GO:0035771)
0.2 1.2 GO:0046909 intermembrane transport(GO:0046909)
0.2 1.4 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.1 0.7 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286)
0.1 1.3 GO:1903624 regulation of apoptotic DNA fragmentation(GO:1902510) regulation of DNA catabolic process(GO:1903624)
0.1 0.5 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.4 GO:0097503 sialylation(GO:0097503)
0.1 1.0 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.1 0.4 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.1 1.9 GO:0006379 mRNA cleavage(GO:0006379)
0.1 1.0 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 0.4 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 1.8 GO:0003416 endochondral bone growth(GO:0003416)
0.1 0.8 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.0 0.1 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.2 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.0 0.4 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.7 GO:0046628 positive regulation of insulin receptor signaling pathway(GO:0046628)
0.0 0.5 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.2 GO:0036438 maintenance of lens transparency(GO:0036438) membrane fission(GO:0090148) ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.0 0.6 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.1 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.8 GO:0048246 macrophage chemotaxis(GO:0048246)
0.0 0.2 GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.0 0.3 GO:0000478 endonucleolytic cleavage involved in rRNA processing(GO:0000478)
0.0 1.4 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 0.6 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.6 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.1 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.0 0.4 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 1.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.3 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.3 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 1.0 GO:0050684 regulation of mRNA processing(GO:0050684)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0005584 collagen type I trimer(GO:0005584)
0.6 1.9 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.3 1.0 GO:0031983 vesicle lumen(GO:0031983)
0.3 1.8 GO:0043256 laminin complex(GO:0043256)
0.2 1.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 1.0 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 2.1 GO:0005652 nuclear lamina(GO:0005652)
0.1 0.6 GO:0002177 manchette(GO:0002177)
0.1 0.8 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.4 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.2 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.7 GO:0051233 spindle midzone(GO:0051233)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.7 GO:0030904 retromer complex(GO:0030904)
0.0 1.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.6 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.8 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.2 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.3 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.6 2.3 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.4 1.3 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.3 1.0 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.3 0.8 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.2 0.8 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.2 1.0 GO:0005047 signal recognition particle binding(GO:0005047) endoplasmic reticulum signal peptide binding(GO:0030942)
0.1 0.7 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.1 2.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.4 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.1 0.4 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.3 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.2 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.1 1.0 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.1 GO:0071862 protein phosphatase type 1 activator activity(GO:0071862)
0.0 0.6 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.4 GO:0008932 lytic endotransglycosylase activity(GO:0008932)
0.0 0.4 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.5 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.1 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.1 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189) peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0 1.2 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.8 GO:0005178 integrin binding(GO:0005178)
0.0 0.7 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.7 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)