Motif ID: Otx1

Z-value: 0.472


Transcription factors associated with Otx1:

Gene SymbolEntrez IDGene Name
Otx1 ENSMUSG00000005917.9 Otx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otx1mm10_v2_chr11_-_22001605_220016310.512.5e-03Click!


Activity profile for motif Otx1.

activity profile for motif Otx1


Sorted Z-values histogram for motif Otx1

Sorted Z-values for motif Otx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Otx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 92 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_3973086 2.278 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
 Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr11_+_94936224 2.040 ENSMUST00000001547.7
 Col1a1
collagen, type I, alpha 1
chr7_-_38271310 1.916 ENSMUST00000032585.6
 Pop4
processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae)
chr5_-_98566762 1.831 ENSMUST00000086912.4
 1700010H22Rik
RIKEN cDNA 1700010H22 gene
chr9_+_108479849 1.780 ENSMUST00000065014.4
 Lamb2
laminin, beta 2
chr1_-_165708088 1.431 ENSMUST00000040357.8
ENSMUST00000097474.3
 Rcsd1

RCSD domain containing 1

chrX_-_48513518 1.339 ENSMUST00000114945.2
ENSMUST00000037349.7
 Aifm1

apoptosis-inducing factor, mitochondrion-associated 1

chr17_+_35861318 1.257 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr16_-_59632520 1.231 ENSMUST00000118438.1
 Arl6
ADP-ribosylation factor-like 6
chr8_-_47675556 1.231 ENSMUST00000125536.1
 Ing2
inhibitor of growth family, member 2
chr2_-_60963192 1.189 ENSMUST00000028347.6
 Rbms1
RNA binding motif, single stranded interacting protein 1
chr12_-_46818749 1.010 ENSMUST00000021438.6
 Nova1
neuro-oncological ventral antigen 1
chr5_-_5749317 0.991 ENSMUST00000015796.2
 Steap1
six transmembrane epithelial antigen of the prostate 1
chr3_+_54481429 0.987 ENSMUST00000091130.3
 Gm5641
predicted gene 5641
chr5_-_37336870 0.972 ENSMUST00000031005.4
 Evc
Ellis van Creveld gene syndrome
chr7_-_79848191 0.959 ENSMUST00000107392.1
 Anpep
alanyl (membrane) aminopeptidase
chr5_-_37336837 0.864 ENSMUST00000114148.1
 Evc
Ellis van Creveld gene syndrome
chr17_+_35861343 0.832 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)
chr4_-_123750236 0.821 ENSMUST00000102636.3
 Akirin1
akirin 1
chr11_+_115564434 0.795 ENSMUST00000021085.4
 Nup85
nucleoporin 85

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.3 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.3 2.0 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 1.9 GO:0006379 mRNA cleavage(GO:0006379)
0.4 1.8 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.1 1.8 GO:0003416 endochondral bone growth(GO:0003416)
0.2 1.4 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.0 1.4 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.1 1.3 GO:1903624 regulation of apoptotic DNA fragmentation(GO:1902510) regulation of DNA catabolic process(GO:1903624)
0.2 1.2 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.2 1.2 GO:0046909 intermembrane transport(GO:0046909)
0.0 1.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.3 1.0 GO:0097461 ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461)
0.1 1.0 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.1 1.0 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 1.0 GO:0050684 regulation of mRNA processing(GO:0050684)
0.1 0.8 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.0 0.8 GO:0048246 macrophage chemotaxis(GO:0048246)
0.2 0.7 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.2 0.7 GO:0002295 T-helper cell lineage commitment(GO:0002295) interleukin-4-mediated signaling pathway(GO:0035771)
0.1 0.7 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 GO:0005652 nuclear lamina(GO:0005652)
0.7 2.0 GO:0005584 collagen type I trimer(GO:0005584)
0.6 1.9 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.3 1.8 GO:0043256 laminin complex(GO:0043256)
0.0 1.8 GO:0036064 ciliary basal body(GO:0036064)
0.0 1.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 1.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.3 1.0 GO:0031983 vesicle lumen(GO:0031983)
0.1 1.0 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 0.8 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.7 GO:0051233 spindle midzone(GO:0051233)
0.0 0.7 GO:0030904 retromer complex(GO:0030904)
0.1 0.6 GO:0002177 manchette(GO:0002177)
0.0 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.6 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.4 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.3 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.2 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.3 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.1 2.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.6 1.9 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.0 1.8 GO:0005178 integrin binding(GO:0005178)
0.4 1.3 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 1.2 GO:0035064 methylated histone binding(GO:0035064)
0.3 1.0 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.2 1.0 GO:0005047 signal recognition particle binding(GO:0005047) endoplasmic reticulum signal peptide binding(GO:0030942)
0.1 1.0 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.3 0.8 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.2 0.8 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 0.7 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 0.7 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.7 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.6 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.5 GO:0004177 aminopeptidase activity(GO:0004177)
0.1 0.4 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.1 0.4 GO:0008142 oxysterol binding(GO:0008142)