Motif ID: Pax6

Z-value: 0.601


Transcription factors associated with Pax6:

Gene SymbolEntrez IDGene Name
Pax6 ENSMUSG00000027168.15 Pax6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax6mm10_v2_chr2_+_105668935_1056689500.096.3e-01Click!


Activity profile for motif Pax6.

activity profile for motif Pax6


Sorted Z-values histogram for motif Pax6

Sorted Z-values for motif Pax6



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_103422010 3.870 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr17_+_43568096 2.514 ENSMUST00000167214.1
 Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr7_-_86775860 2.168 ENSMUST00000001824.5
 Folh1
folate hydrolase 1
chr7_-_86775808 2.035 ENSMUST00000107271.3
 Folh1
folate hydrolase 1
chr10_+_94550852 1.499 ENSMUST00000148910.1
ENSMUST00000117460.1
 Tmcc3

transmembrane and coiled coil domains 3

chr15_+_6299781 1.351 ENSMUST00000078019.6
 Dab2
disabled 2, mitogen-responsive phosphoprotein
chr11_-_67965631 1.209 ENSMUST00000021287.5
ENSMUST00000126766.1
 Wdr16

WD repeat domain 16

chr9_+_92250039 1.161 ENSMUST00000093801.3
 Plscr1
phospholipid scramblase 1
chr17_+_43016536 1.120 ENSMUST00000024708.4
 Tnfrsf21
tumor necrosis factor receptor superfamily, member 21
chr5_-_74677792 1.073 ENSMUST00000117525.1
ENSMUST00000153543.1
ENSMUST00000039744.6
ENSMUST00000113531.2
ENSMUST00000121690.1
 Lnx1




ligand of numb-protein X 1




chr7_-_103843154 1.030 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr15_+_6299797 0.999 ENSMUST00000159046.1
ENSMUST00000161040.1
 Dab2

disabled 2, mitogen-responsive phosphoprotein

chr15_+_84669565 0.982 ENSMUST00000171460.1
 Prr5
proline rich 5 (renal)
chr17_-_43543639 0.941 ENSMUST00000178772.1
 Ankrd66
ankyrin repeat domain 66
chr5_-_38480131 0.878 ENSMUST00000143758.1
ENSMUST00000067886.5
 Slc2a9

solute carrier family 2 (facilitated glucose transporter), member 9

chr3_+_65109343 0.837 ENSMUST00000159525.1
ENSMUST00000049230.8
 Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr13_-_24937585 0.766 ENSMUST00000037615.6
 Aldh5a1
aldhehyde dehydrogenase family 5, subfamily A1
chr13_-_113618549 0.739 ENSMUST00000109241.3
 Snx18
sorting nexin 18
chr3_+_98013503 0.733 ENSMUST00000079812.6
 Notch2
notch 2
chr11_+_78328415 0.725 ENSMUST00000048073.8
 Pigs
phosphatidylinositol glycan anchor biosynthesis, class S
chr9_+_15239045 0.671 ENSMUST00000034413.6
 Vstm5
V-set and transmembrane domain containing 5
chr16_+_34784917 0.610 ENSMUST00000023538.8
 Mylk
myosin, light polypeptide kinase
chr11_-_95587691 0.596 ENSMUST00000000122.6
 Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
chr1_+_156040884 0.566 ENSMUST00000060404.4
 Tor1aip2
torsin A interacting protein 2
chr1_-_120120138 0.502 ENSMUST00000112648.1
ENSMUST00000128408.1
 Dbi

diazepam binding inhibitor

chr11_-_115612491 0.473 ENSMUST00000106507.2
 Mif4gd
MIF4G domain containing
chr18_-_34373313 0.455 ENSMUST00000006027.5
 Reep5
receptor accessory protein 5
chr2_-_75981967 0.440 ENSMUST00000099994.3
 Ttc30a1
tetratricopeptide repeat domain 30A1
chr18_+_37447641 0.437 ENSMUST00000052387.3
 Pcdhb14
protocadherin beta 14
chr13_-_53377355 0.427 ENSMUST00000021920.6
 Sptlc1
serine palmitoyltransferase, long chain base subunit 1
chr1_-_138619687 0.415 ENSMUST00000027642.2
 Nek7
NIMA (never in mitosis gene a)-related expressed kinase 7
chr19_+_6400611 0.387 ENSMUST00000113467.1
 Rasgrp2
RAS, guanyl releasing protein 2
chr13_+_64432479 0.367 ENSMUST00000021939.6
 Cdk20
cyclin-dependent kinase 20
chr12_-_45074457 0.356 ENSMUST00000053768.6
 Stxbp6
syntaxin binding protein 6 (amisyn)
chr8_+_105860634 0.341 ENSMUST00000008594.7
 Nutf2
nuclear transport factor 2
chr17_-_57059795 0.334 ENSMUST00000040280.7
 Slc25a23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr2_-_162661075 0.315 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
 Ptprt



protein tyrosine phosphatase, receptor type, T



chr5_-_18360384 0.301 ENSMUST00000074694.5
 Gnai1
guanine nucleotide binding protein (G protein), alpha inhibiting 1
chr2_+_163602331 0.275 ENSMUST00000152135.1
 Ttpal
tocopherol (alpha) transfer protein-like
chr17_+_25366550 0.263 ENSMUST00000069616.7
 Tpsb2
tryptase beta 2
chr2_-_105904484 0.260 ENSMUST00000122965.1
 Elp4
elongation protein 4 homolog (S. cerevisiae)
chr6_-_88045190 0.258 ENSMUST00000113596.1
ENSMUST00000113600.3
 Rab7

RAB7, member RAS oncogene family

chr8_-_80880479 0.252 ENSMUST00000034150.8
 Gab1
growth factor receptor bound protein 2-associated protein 1
chr4_-_139832920 0.246 ENSMUST00000174681.1
 Pax7
paired box gene 7
chr19_+_34290653 0.240 ENSMUST00000025691.5
ENSMUST00000112472.2
 Fas

Fas (TNF receptor superfamily member 6)

chr1_-_195131536 0.220 ENSMUST00000075451.6
 Cr1l
complement component (3b/4b) receptor 1-like
chr19_-_57118981 0.215 ENSMUST00000111528.1
ENSMUST00000111529.1
ENSMUST00000104902.2
 Ablim1


actin-binding LIM protein 1


chr11_+_45852031 0.213 ENSMUST00000109261.3
ENSMUST00000109260.1
 Clint1

clathrin interactor 1

chr5_+_112255813 0.206 ENSMUST00000031286.6
ENSMUST00000131673.1
ENSMUST00000112375.1
 Crybb1


crystallin, beta B1


chr1_+_156040909 0.192 ENSMUST00000065648.8
ENSMUST00000097526.2
 Tor1aip2

torsin A interacting protein 2

chr4_+_129820702 0.190 ENSMUST00000165853.1
 Ptp4a2
protein tyrosine phosphatase 4a2
chr8_+_31150307 0.186 ENSMUST00000098842.2
 Tti2
TELO2 interacting protein 2
chr17_-_6827990 0.178 ENSMUST00000181895.1
 Gm2885
predicted gene 2885
chr9_+_50775347 0.165 ENSMUST00000159576.1
 Alg9
asparagine-linked glycosylation 9 (alpha 1,2 mannosyltransferase)
chr15_-_35938186 0.151 ENSMUST00000014457.8
 Cox6c
cytochrome c oxidase subunit VIc
chr16_-_22857514 0.143 ENSMUST00000004576.6
 Tbccd1
TBCC domain containing 1
chr19_-_57118897 0.134 ENSMUST00000111526.1
 Ablim1
actin-binding LIM protein 1
chr7_+_97453204 0.133 ENSMUST00000050732.7
ENSMUST00000121987.1
 Kctd14

potassium channel tetramerisation domain containing 14

chr6_+_123229843 0.128 ENSMUST00000112554.2
ENSMUST00000024118.4
ENSMUST00000117130.1
 Clec4n


C-type lectin domain family 4, member n


chr7_+_75610038 0.123 ENSMUST00000125771.1
 Akap13
A kinase (PRKA) anchor protein 13
chr3_-_36613285 0.122 ENSMUST00000108155.1
 Bbs7
Bardet-Biedl syndrome 7 (human)
chr7_-_12775658 0.111 ENSMUST00000046245.5
 Zscan18
zinc finger and SCAN domain containing 18
chrX_+_36795642 0.104 ENSMUST00000016463.3
 Slc25a5
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5
chr2_+_105904629 0.101 ENSMUST00000037499.5
 Immp1l
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr7_+_12897800 0.089 ENSMUST00000055528.4
ENSMUST00000117189.1
ENSMUST00000120809.1
ENSMUST00000119989.1
 Zscan22



zinc finger and SCAN domain containing 22



chr15_-_101850778 0.080 ENSMUST00000023790.3
 Krt1
keratin 1
chr5_+_123907175 0.079 ENSMUST00000023869.8
 Denr
density-regulated protein
chr10_-_53694823 0.078 ENSMUST00000171807.1
 Fam184a
family with sequence similarity 184, member A
chr4_-_70410422 0.073 ENSMUST00000144099.1
 Cdk5rap2
CDK5 regulatory subunit associated protein 2
chr1_+_43092588 0.063 ENSMUST00000039080.3
 8430432A02Rik
RIKEN cDNA 8430432A02 gene
chr15_-_35938009 0.063 ENSMUST00000156915.1
 Cox6c
cytochrome c oxidase subunit VIc
chr8_-_57962564 0.058 ENSMUST00000098757.3
 Galntl6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr12_+_112976471 0.027 ENSMUST00000165079.1
ENSMUST00000002880.6
 Btbd6

BTB (POZ) domain containing 6

chr13_-_66905322 0.027 ENSMUST00000021993.4
 Uqcrb
ubiquinol-cytochrome c reductase binding protein
chr16_-_52452654 0.019 ENSMUST00000168071.1
 Alcam
activated leukocyte cell adhesion molecule
chr13_-_43480973 0.013 ENSMUST00000144326.2
 Ranbp9
RAN binding protein 9
chr11_+_60699718 0.011 ENSMUST00000052346.3
 Llgl1
lethal giant larvae homolog 1 (Drosophila)
chr6_-_145048809 0.009 ENSMUST00000032402.5
 Bcat1
branched chain aminotransferase 1, cytosolic

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.5 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.5 2.3 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.4 1.2 GO:0010911 regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912) phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.4 1.1 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) negative regulation of interleukin-10 secretion(GO:2001180)
0.3 0.8 GO:0006083 acetate metabolic process(GO:0006083)
0.2 0.7 GO:0035622 intrahepatic bile duct development(GO:0035622) cholangiocyte proliferation(GO:1990705)
0.2 1.0 GO:0015671 oxygen transport(GO:0015671)
0.2 0.6 GO:0035864 response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865)
0.2 0.6 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.2 0.7 GO:0061724 lipophagy(GO:0061724)
0.1 4.2 GO:0006760 folic acid-containing compound metabolic process(GO:0006760)
0.1 0.7 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.1 0.3 GO:0097274 urea homeostasis(GO:0097274)
0.1 0.7 GO:0036089 cleavage furrow formation(GO:0036089)
0.1 0.5 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.1 0.9 GO:0046415 urate metabolic process(GO:0046415)
0.1 0.8 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.1 0.8 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0 0.2 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.0 0.4 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.2 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.1 GO:0051661 maintenance of centrosome location(GO:0051661) maintenance of Golgi location(GO:0051684)
0.0 0.2 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0 0.3 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0 0.1 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0 0.1 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.3 GO:0070102 interleukin-6-mediated signaling pathway(GO:0070102)
0.0 0.1 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.0 0.4 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.0 0.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 1.0 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.0 0.2 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.1 GO:0032790 ribosome disassembly(GO:0032790)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.3 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.2 2.5 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.1 0.8 GO:1990635 proximal dendrite(GO:1990635)
0.1 1.0 GO:0005833 hemoglobin complex(GO:0005833)
0.1 0.7 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 0.4 GO:0035339 SPOTS complex(GO:0035339)
0.1 1.0 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.3 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.2 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.3 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 0.6 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.4 GO:0000145 exocyst(GO:0000145)
0.0 0.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.1 GO:0071817 MMXD complex(GO:0071817)
0.0 0.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.0 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 0.1 GO:0034464 BBSome(GO:0034464)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.3 4.2 GO:0016805 dipeptidase activity(GO:0016805)
0.3 2.5 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) calcium-independent phospholipase A2 activity(GO:0047499)
0.3 2.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.3 1.0 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.1 1.2 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 0.4 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758)
0.1 0.5 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.1 2.0 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.8 GO:0070402 NADPH binding(GO:0070402)
0.0 0.3 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.8 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.3 GO:0045294 alpha-catenin binding(GO:0045294) delta-catenin binding(GO:0070097)
0.0 0.8 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.7 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.7 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.2 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.3 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)