Motif ID: Pbx1_Pbx3

Z-value: 1.227

Transcription factors associated with Pbx1_Pbx3:

Gene SymbolEntrez IDGene Name
Pbx1 ENSMUSG00000052534.9 Pbx1
Pbx3 ENSMUSG00000038718.9 Pbx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pbx1mm10_v2_chr1_-_168431896_168431905-0.832.3e-09Click!
Pbx3mm10_v2_chr2_-_34372004_343720440.392.5e-02Click!


Activity profile for motif Pbx1_Pbx3.

activity profile for motif Pbx1_Pbx3


Sorted Z-values histogram for motif Pbx1_Pbx3

Sorted Z-values for motif Pbx1_Pbx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Pbx1_Pbx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_85688252 15.049 ENSMUST00000024947.7
ENSMUST00000163568.2
 Six2

sine oculis-related homeobox 2

chr9_-_63711969 11.729 ENSMUST00000154323.1
 Smad3
SMAD family member 3
chr14_-_48667508 8.308 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr4_-_3938354 7.549 ENSMUST00000003369.3
 Plag1
pleiomorphic adenoma gene 1
chr12_+_72939724 7.524 ENSMUST00000021519.5
 Six6
sine oculis-related homeobox 6
chr17_-_70853482 6.881 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1
chr19_+_55894508 6.066 ENSMUST00000142291.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr17_+_85620816 5.792 ENSMUST00000175898.2
 Six3
sine oculis-related homeobox 3
chr4_-_43523388 5.557 ENSMUST00000107913.3
ENSMUST00000030184.5
 Tpm2

tropomyosin 2, beta

chr19_+_55741810 5.513 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr3_+_37639985 5.509 ENSMUST00000108107.1
 Spry1
sprouty homolog 1 (Drosophila)
chr13_+_15463837 5.384 ENSMUST00000110510.3
 Gli3
GLI-Kruppel family member GLI3
chr4_-_43523746 5.359 ENSMUST00000150592.1
 Tpm2
tropomyosin 2, beta
chr4_+_3938888 5.326 ENSMUST00000121110.1
ENSMUST00000108386.1
ENSMUST00000149544.1
 Chchd7


coiled-coil-helix-coiled-coil-helix domain containing 7


chr3_+_37639945 5.206 ENSMUST00000108109.1
ENSMUST00000038569.1
 Spry1

sprouty homolog 1 (Drosophila)

chr17_+_47596061 5.195 ENSMUST00000182539.1
 Ccnd3
cyclin D3
chr5_+_103425181 5.045 ENSMUST00000048957.9
 Ptpn13
protein tyrosine phosphatase, non-receptor type 13
chr4_-_43523595 4.843 ENSMUST00000107914.3
 Tpm2
tropomyosin 2, beta
chr1_-_183147461 4.772 ENSMUST00000171366.1
 Disp1
dispatched homolog 1 (Drosophila)
chr19_-_9899450 4.653 ENSMUST00000025562.7
 Incenp
inner centromere protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 182 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 17.1 GO:0048625 myoblast fate commitment(GO:0048625)
3.8 15.0 GO:0097168 condensed mesenchymal cell proliferation(GO:0072137) mesenchymal stem cell proliferation(GO:0097168)
3.9 11.7 GO:0044413 evasion or tolerance of host defenses by virus(GO:0019049) positive regulation of transforming growth factor beta3 production(GO:0032916) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
2.1 10.7 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
3.1 9.2 GO:0097402 neuroblast migration(GO:0097402)
2.1 8.3 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0 7.6 GO:0006936 muscle contraction(GO:0006936)
0.5 7.5 GO:0060736 prostate gland growth(GO:0060736)
0.4 6.9 GO:0038092 nodal signaling pathway(GO:0038092)
0.3 6.7 GO:0035855 megakaryocyte development(GO:0035855)
0.1 6.1 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
1.8 5.4 GO:0060364 frontal suture morphogenesis(GO:0060364)
0.3 5.2 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.1 5.0 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling(GO:0014066)
0.0 4.9 GO:0006281 DNA repair(GO:0006281)
0.4 4.8 GO:0060539 diaphragm development(GO:0060539)
0.0 4.7 GO:0000910 cytokinesis(GO:0000910)
1.5 4.6 GO:0006597 spermine biosynthetic process(GO:0006597)
1.0 4.1 GO:0016259 selenocysteine metabolic process(GO:0016259)
0.3 4.1 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 17.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
1.8 15.8 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 14.0 GO:0005667 transcription factor complex(GO:0005667)
2.3 11.7 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 8.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 5.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 5.6 GO:0005635 nuclear envelope(GO:0005635)
0.1 5.4 GO:0016592 mediator complex(GO:0016592)
0.0 5.0 GO:0030496 midbody(GO:0030496)
0.0 4.8 GO:0005912 adherens junction(GO:0005912)
1.6 4.7 GO:0000801 central element(GO:0000801)
0.0 4.3 GO:0005829 cytosol(GO:0005829)
0.8 4.1 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.3 3.8 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 3.8 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 3.6 GO:0000922 spindle pole(GO:0000922)
0.6 3.5 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 3.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 3.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 3.2 GO:1990391 DNA repair complex(GO:1990391)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 127 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 38.7 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.8 19.0 GO:0045295 gamma-catenin binding(GO:0045295)
0.2 16.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
2.3 11.7 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.6 10.5 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 10.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 10.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.2 9.3 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 8.8 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.4 6.9 GO:0070410 co-SMAD binding(GO:0070410)
0.1 6.5 GO:0005178 integrin binding(GO:0005178)
0.1 6.2 GO:0035064 methylated histone binding(GO:0035064)
0.6 6.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 5.3 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.3 4.8 GO:0015197 peptide transporter activity(GO:0015197)
1.1 4.6 GO:0019808 polyamine binding(GO:0019808)
0.3 4.4 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.4 3.8 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 3.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.3 3.4 GO:0016500 protein-hormone receptor activity(GO:0016500)