Motif ID: Pbx2
Z-value: 0.679
Transcription factors associated with Pbx2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Pbx2 | ENSMUSG00000034673.8 | Pbx2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Pbx2 | mm10_v2_chr17_+_34592248_34592329 | -0.91 | 1.3e-13 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 5.4 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.4 | 2.2 | GO:1902847 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949) |
| 0.3 | 1.1 | GO:0008627 | intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627) |
| 0.3 | 1.3 | GO:0030242 | pexophagy(GO:0030242) |
| 0.2 | 3.5 | GO:0032291 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
| 0.2 | 1.3 | GO:0030643 | cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 0.2 | 3.0 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 0.2 | 0.5 | GO:0002678 | positive regulation of chronic inflammatory response(GO:0002678) |
| 0.2 | 1.4 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
| 0.2 | 0.3 | GO:0035633 | maintenance of blood-brain barrier(GO:0035633) |
| 0.2 | 1.0 | GO:0097368 | establishment of Sertoli cell barrier(GO:0097368) |
| 0.1 | 1.1 | GO:0060164 | regulation of timing of neuron differentiation(GO:0060164) |
| 0.1 | 3.5 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
| 0.1 | 0.2 | GO:2000338 | positive regulation of interleukin-23 production(GO:0032747) chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338) |
| 0.1 | 0.4 | GO:0042117 | monocyte activation(GO:0042117) |
| 0.1 | 0.9 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.0 | 0.5 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.0 | 0.4 | GO:0060576 | intestinal epithelial cell development(GO:0060576) |
| 0.0 | 0.2 | GO:0050651 | dermatan sulfate proteoglycan biosynthetic process(GO:0050651) |
| 0.0 | 1.6 | GO:0051926 | negative regulation of calcium ion transport(GO:0051926) |
| 0.0 | 0.8 | GO:0001553 | luteinization(GO:0001553) |
| 0.0 | 0.5 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 0.1 | GO:0016340 | calcium-dependent cell-matrix adhesion(GO:0016340) |
| 0.0 | 0.2 | GO:0090611 | ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611) positive regulation of extracellular exosome assembly(GO:1903553) |
| 0.0 | 0.1 | GO:0042780 | tRNA 3'-end processing(GO:0042780) |
| 0.0 | 0.4 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
| 0.0 | 0.3 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.0 | 0.1 | GO:0006049 | UDP-N-acetylglucosamine catabolic process(GO:0006049) |
| 0.0 | 0.5 | GO:0006301 | postreplication repair(GO:0006301) |
| 0.0 | 0.3 | GO:0046688 | response to copper ion(GO:0046688) |
| 0.0 | 0.3 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.0 | 0.3 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
| 0.0 | 1.8 | GO:0098792 | xenophagy(GO:0098792) |
| 0.0 | 0.4 | GO:2000310 | regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310) |
| 0.0 | 0.1 | GO:0017121 | phospholipid scrambling(GO:0017121) |
| 0.0 | 3.2 | GO:0006869 | lipid transport(GO:0006869) |
| 0.0 | 0.3 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.0 | 0.1 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) regulation of protein heterodimerization activity(GO:0043497) |
| 0.0 | 1.1 | GO:0006665 | sphingolipid metabolic process(GO:0006665) |
| 0.0 | 0.3 | GO:0001782 | B cell homeostasis(GO:0001782) |
| 0.0 | 0.2 | GO:0048266 | behavioral response to pain(GO:0048266) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.2 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418) |
| 0.1 | 1.5 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 2.3 | GO:0043218 | compact myelin(GO:0043218) |
| 0.1 | 0.5 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
| 0.1 | 1.2 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.1 | 1.1 | GO:0034706 | voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706) |
| 0.1 | 0.4 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.0 | 0.3 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.0 | 5.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 1.6 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 6.1 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.2 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.0 | 0.1 | GO:0016011 | dystroglycan complex(GO:0016011) |
| 0.0 | 0.3 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.0 | 0.4 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.0 | 0.5 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 0.4 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.0 | 0.2 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 5.4 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
| 0.4 | 3.0 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 0.3 | 1.3 | GO:0047389 | glycerophosphocholine phosphodiesterase activity(GO:0047389) |
| 0.3 | 3.4 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.3 | 1.6 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.2 | 1.1 | GO:0017040 | ceramidase activity(GO:0017040) |
| 0.1 | 2.2 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.1 | 1.3 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.1 | 0.5 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.1 | 1.1 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.1 | 0.3 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.1 | 0.3 | GO:0008559 | xenobiotic-transporting ATPase activity(GO:0008559) |
| 0.1 | 0.2 | GO:0070976 | TIR domain binding(GO:0070976) |
| 0.1 | 0.2 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
| 0.0 | 5.2 | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances(GO:0042626) |
| 0.0 | 0.8 | GO:0030553 | cGMP binding(GO:0030553) |
| 0.0 | 0.1 | GO:0003997 | acyl-CoA oxidase activity(GO:0003997) palmitoyl-CoA oxidase activity(GO:0016401) |
| 0.0 | 0.2 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
| 0.0 | 0.8 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 1.3 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.0 | 0.1 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.0 | 0.5 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.7 | GO:0008748 | N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693) |
| 0.0 | 3.0 | GO:0005539 | glycosaminoglycan binding(GO:0005539) |
| 0.0 | 0.4 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 0.3 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 0.1 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.0 | 0.3 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
