Motif ID: Pitx1

Z-value: 0.672


Transcription factors associated with Pitx1:

Gene SymbolEntrez IDGene Name
Pitx1 ENSMUSG00000021506.7 Pitx1



Activity profile for motif Pitx1.

activity profile for motif Pitx1


Sorted Z-values histogram for motif Pitx1

Sorted Z-values for motif Pitx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 180 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_64046925 6.282 ENSMUST00000107377.3
 Tnc
tenascin C
chr15_-_79164477 4.960 ENSMUST00000040019.4
 Sox10
SRY-box containing gene 10
chr2_+_14388316 4.800 ENSMUST00000114731.1
ENSMUST00000082290.7
 Slc39a12

solute carrier family 39 (zinc transporter), member 12

chr18_+_73863672 3.887 ENSMUST00000134847.1
 Mro
maestro
chr2_+_102658640 3.058 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr4_+_102589687 2.872 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr16_-_10313940 2.792 ENSMUST00000078357.4
 Emp2
epithelial membrane protein 2
chr1_+_74542881 2.573 ENSMUST00000113749.1
ENSMUST00000067916.6
ENSMUST00000113745.1
ENSMUST00000113747.1
ENSMUST00000113750.1
 Plcd4




phospholipase C, delta 4




chr4_-_137766474 2.033 ENSMUST00000139951.1
 Alpl
alkaline phosphatase, liver/bone/kidney
chr2_+_14388434 1.991 ENSMUST00000133258.1
 Slc39a12
solute carrier family 39 (zinc transporter), member 12
chr15_+_18818895 1.800 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr9_+_44101722 1.799 ENSMUST00000161703.1
ENSMUST00000161381.1
ENSMUST00000034654.7
 Mfrp


membrane-type frizzled-related protein


chr1_-_170110491 1.763 ENSMUST00000027985.2
 Ddr2
discoidin domain receptor family, member 2
chr4_+_144892813 1.755 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr16_+_90831113 1.753 ENSMUST00000037539.7
ENSMUST00000099543.3
 Eva1c

eva-1 homolog C (C. elegans)

chr8_-_46294592 1.737 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr4_+_129960760 1.598 ENSMUST00000139884.1
 1700003M07Rik
RIKEN cDNA 1700003M07 gene
chr5_+_3343893 1.576 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr19_-_36919606 1.534 ENSMUST00000057337.7
 Fgfbp3
fibroblast growth factor binding protein 3
chr2_-_24049389 1.486 ENSMUST00000051416.5
 Hnmt
histamine N-methyltransferase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 6.8 GO:0071578 zinc II ion transmembrane import(GO:0071578)
1.3 6.3 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
0.4 5.0 GO:0048484 enteric nervous system development(GO:0048484)
0.4 4.4 GO:0042572 retinol metabolic process(GO:0042572)
0.5 3.1 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
1.0 3.0 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.2 2.9 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3 2.8 GO:0003093 regulation of glomerular filtration(GO:0003093)
0.1 2.6 GO:0007340 acrosome reaction(GO:0007340)
0.0 2.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 2.2 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.1 2.1 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.7 2.0 GO:1904049 regulation of spontaneous neurotransmitter secretion(GO:1904048) negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.1 2.0 GO:0046677 response to antibiotic(GO:0046677)
0.1 2.0 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.3 1.8 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 1.7 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.2 1.5 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.1 1.5 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.3 1.4 GO:0001561 fatty acid alpha-oxidation(GO:0001561)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.2 GO:0005887 integral component of plasma membrane(GO:0005887)
0.4 6.3 GO:0005614 interstitial matrix(GO:0005614)
0.6 5.0 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 4.0 GO:0031012 extracellular matrix(GO:0031012)
0.1 3.1 GO:0030673 axolemma(GO:0030673)
0.1 3.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 2.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 2.2 GO:0031965 nuclear membrane(GO:0031965)
0.4 2.0 GO:1990761 growth cone lamellipodium(GO:1990761)
0.1 2.0 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 1.8 GO:0005901 caveola(GO:0005901)
0.0 1.5 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.1 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 1.0 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 1.0 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 1.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.3 0.9 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.1 0.8 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
1.0 6.3 GO:0045545 syndecan binding(GO:0045545)
0.8 5.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 4.2 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.8 3.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 3.0 GO:0030332 cyclin binding(GO:0030332)
0.1 2.9 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 2.8 GO:0005178 integrin binding(GO:0005178)
0.0 2.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.5 2.0 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.2 2.0 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 2.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 1.8 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 1.8 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 1.5 GO:1990459 transferrin receptor binding(GO:1990459)
0.1 1.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.5 1.4 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.2 1.4 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.4 1.3 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 1.2 GO:0002162 dystroglycan binding(GO:0002162)