Motif ID: Pitx2_Otx2

Z-value: 1.964

Transcription factors associated with Pitx2_Otx2:

Gene SymbolEntrez IDGene Name
Otx2 ENSMUSG00000021848.9 Otx2
Pitx2 ENSMUSG00000028023.10 Pitx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otx2mm10_v2_chr14_-_48665098_486652460.698.0e-06Click!
Pitx2mm10_v2_chr3_+_129199878_1291999130.681.6e-05Click!


Activity profile for motif Pitx2_Otx2.

activity profile for motif Pitx2_Otx2


Sorted Z-values histogram for motif Pitx2_Otx2

Sorted Z-values for motif Pitx2_Otx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx2_Otx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_34354119 16.781 ENSMUST00000038406.6
 Akr1b8
aldo-keto reductase family 1, member B8
chr2_+_164562579 15.998 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr17_+_87635974 10.564 ENSMUST00000053577.8
 Epcam
epithelial cell adhesion molecule
chr9_+_119357381 9.691 ENSMUST00000039610.8
 Xylb
xylulokinase homolog (H. influenzae)
chr6_-_88898664 9.525 ENSMUST00000058011.6
 Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr11_-_106998483 9.341 ENSMUST00000124541.1
 Kpna2
karyopherin (importin) alpha 2
chr10_-_77089428 9.173 ENSMUST00000156009.1
 Col18a1
collagen, type XVIII, alpha 1
chr7_-_75782080 8.971 ENSMUST00000181224.1
 AU020206
expressed sequence AU020206
chr19_-_41896132 8.781 ENSMUST00000038677.3
 Rrp12
ribosomal RNA processing 12 homolog (S. cerevisiae)
chr15_+_76879232 7.656 ENSMUST00000023179.5
 Zfp7
zinc finger protein 7
chr10_-_128180265 7.579 ENSMUST00000099139.1
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr1_+_135232045 7.324 ENSMUST00000110798.3
 Gm4204
predicted gene 4204
chr6_-_23248264 7.311 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr17_+_35861318 7.232 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr7_-_143460989 6.869 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr11_-_60811228 6.795 ENSMUST00000018744.8
 Shmt1
serine hydroxymethyltransferase 1 (soluble)
chr7_+_16781341 6.494 ENSMUST00000108496.2
 Slc1a5
solute carrier family 1 (neutral amino acid transporter), member 5
chr17_+_35861343 6.340 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)
chr5_-_134456702 6.318 ENSMUST00000073161.5
ENSMUST00000171794.2
ENSMUST00000111245.2
ENSMUST00000100654.3
ENSMUST00000167084.2
ENSMUST00000100652.3
ENSMUST00000100650.3
ENSMUST00000074114.5
 Gtf2ird1







general transcription factor II I repeat domain-containing 1







chr12_+_109734969 6.308 ENSMUST00000182268.1
ENSMUST00000181543.2
ENSMUST00000183116.1
 Mirg


miRNA containing gene



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 420 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.7 GO:0010466 negative regulation of peptidase activity(GO:0010466)
5.6 16.8 GO:0016095 polyprenol catabolic process(GO:0016095) terpenoid catabolic process(GO:0016115) primary alcohol catabolic process(GO:0034310)
0.7 16.8 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.6 16.2 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.2 11.0 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.3 10.9 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
2.6 10.6 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.6 10.3 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
3.4 10.2 GO:0042732 D-xylose metabolic process(GO:0042732)
0.7 9.5 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
2.9 8.7 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034)
0.8 8.1 GO:0006012 galactose metabolic process(GO:0006012)
0.0 7.9 GO:0000398 RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.1 7.8 GO:0008033 tRNA processing(GO:0008033)
0.2 7.6 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
1.5 7.5 GO:0014886 transition between slow and fast fiber(GO:0014886)
1.2 7.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 7.0 GO:0042254 ribosome biogenesis(GO:0042254)
2.3 6.9 GO:0046166 glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.7 6.9 GO:0015721 bile acid and bile salt transport(GO:0015721)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 208 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 68.3 GO:0070062 extracellular exosome(GO:0070062)
0.5 35.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.6 27.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 20.7 GO:0005730 nucleolus(GO:0005730)
0.3 19.6 GO:0005643 nuclear pore(GO:0005643)
0.2 19.0 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.9 14.5 GO:0005652 nuclear lamina(GO:0005652)
1.3 12.9 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
1.5 12.1 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.4 11.2 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.2 11.0 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 10.2 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 9.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 8.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 8.4 GO:0032587 ruffle membrane(GO:0032587)
0.6 8.2 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.2 8.1 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.8 7.5 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.2 7.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 7.3 GO:0005840 ribosome(GO:0005840)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 300 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 56.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 53.8 GO:0044822 poly(A) RNA binding(GO:0044822)
0.5 21.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
2.8 16.8 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.6 16.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.3 13.2 GO:0016504 peptidase activator activity(GO:0016504)
0.6 12.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.9 12.0 GO:0008301 DNA binding, bending(GO:0008301)
0.8 10.9 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
1.3 10.6 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.6 10.4 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
1.2 9.5 GO:0003688 DNA replication origin binding(GO:0003688)
0.8 9.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.6 9.0 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.3 9.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 8.9 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
2.9 8.7 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 8.2 GO:0005198 structural molecule activity(GO:0005198)
0.1 8.1 GO:0003743 translation initiation factor activity(GO:0003743)
2.6 7.7 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)