Motif ID: Pknox2_Pknox1

Z-value: 0.967

Transcription factors associated with Pknox2_Pknox1:

Gene SymbolEntrez IDGene Name
Pknox1 ENSMUSG00000006705.6 Pknox1
Pknox2 ENSMUSG00000035934.9 Pknox2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pknox1mm10_v2_chr17_+_31564749_315648540.731.7e-06Click!
Pknox2mm10_v2_chr9_-_37147257_371473230.202.7e-01Click!


Activity profile for motif Pknox2_Pknox1.

activity profile for motif Pknox2_Pknox1


Sorted Z-values histogram for motif Pknox2_Pknox1

Sorted Z-values for motif Pknox2_Pknox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pknox2_Pknox1

PNG image of the network

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Top targets:


Showing 1 to 20 of 132 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_78324200 7.034 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr1_+_194619815 6.100 ENSMUST00000027952.5
 Plxna2
plexin A2
chr5_-_109558957 5.662 ENSMUST00000044579.7
 Crlf2
cytokine receptor-like factor 2
chr16_-_11176056 4.876 ENSMUST00000142389.1
ENSMUST00000138185.1
 Zc3h7a

zinc finger CCCH type containing 7 A

chr15_-_100599864 4.766 ENSMUST00000177247.2
ENSMUST00000177505.2
 Pou6f1

POU domain, class 6, transcription factor 1

chr2_-_113758638 3.820 ENSMUST00000099575.3
 Grem1
gremlin 1
chr5_-_134747241 3.504 ENSMUST00000015138.9
 Eln
elastin
chr10_+_41810528 3.502 ENSMUST00000099931.3
 Sesn1
sestrin 1
chr1_-_52727457 3.055 ENSMUST00000156876.1
ENSMUST00000087701.3
 Mfsd6

major facilitator superfamily domain containing 6

chr5_-_138619751 3.010 ENSMUST00000085852.4
ENSMUST00000110905.2
 Zfp68

zinc finger protein 68

chr5_-_138619653 2.989 ENSMUST00000129832.1
 Zfp68
zinc finger protein 68
chr12_-_24493656 2.960 ENSMUST00000073088.2
 Gm16372
predicted pseudogene 16372
chr18_+_49832622 2.901 ENSMUST00000180611.1
 Dmxl1
Dmx-like 1
chr7_-_131410495 2.775 ENSMUST00000121033.1
ENSMUST00000046306.8
 Ikzf5

IKAROS family zinc finger 5

chr2_-_34913976 2.725 ENSMUST00000028232.3
 Phf19
PHD finger protein 19
chr5_+_137553517 2.673 ENSMUST00000136088.1
ENSMUST00000139395.1
ENSMUST00000136565.1
ENSMUST00000149292.1
ENSMUST00000125489.1
 Actl6b




actin-like 6B




chr2_-_31141802 2.671 ENSMUST00000073879.5
ENSMUST00000100208.2
ENSMUST00000100207.2
ENSMUST00000113555.1
ENSMUST00000075326.4
ENSMUST00000113552.2
ENSMUST00000136181.1
 Fnbp1






formin binding protein 1






chr5_-_138619702 2.459 ENSMUST00000063262.4
 Zfp68
zinc finger protein 68
chr2_-_31142002 2.409 ENSMUST00000113560.1
ENSMUST00000113564.2
ENSMUST00000113562.2
 Fnbp1


formin binding protein 1


chr9_-_86880414 2.394 ENSMUST00000074501.5
ENSMUST00000098495.3
ENSMUST00000074468.6
ENSMUST00000036347.6
 Snap91



synaptosomal-associated protein 91




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 7.0 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.6 6.1 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
1.0 5.9 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.9 5.7 GO:0035743 CD4-positive, alpha-beta T cell cytokine production(GO:0035743) T-helper 2 cell cytokine production(GO:0035745)
0.0 4.8 GO:0006897 endocytosis(GO:0006897)
1.3 3.8 GO:1901228 regulation of osteoclast proliferation(GO:0090289) negative regulation of bone mineralization involved in bone maturation(GO:1900158) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228)
0.0 3.6 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.3 3.5 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 3.1 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 3.1 GO:0006333 chromatin assembly or disassembly(GO:0006333)
0.4 2.7 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.0 2.6 GO:0002250 adaptive immune response(GO:0002250)
0.1 2.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 2.3 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.1 2.2 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.3 2.1 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.3 2.0 GO:1905206 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) positive regulation of hydrogen peroxide-induced cell death(GO:1905206)
0.0 1.9 GO:0045638 negative regulation of myeloid cell differentiation(GO:0045638)
0.2 1.5 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.1 1.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 6.1 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 5.2 GO:0005905 clathrin-coated pit(GO:0005905)
0.4 4.7 GO:0061700 GATOR2 complex(GO:0061700)
1.2 3.5 GO:0071953 elastic fiber(GO:0071953)
0.0 3.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 2.7 GO:0016514 SWI/SNF complex(GO:0016514)
0.1 2.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.2 2.4 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 2.3 GO:0031225 anchored component of membrane(GO:0031225)
0.2 2.1 GO:0005642 annulate lamellae(GO:0005642)
0.1 1.4 GO:0043196 varicosity(GO:0043196)
0.1 1.4 GO:0031045 dense core granule(GO:0031045)
0.1 1.1 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 1.1 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 1.0 GO:0070695 FHF complex(GO:0070695)
0.1 1.0 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.2 0.9 GO:0045098 type III intermediate filament(GO:0045098)
0.0 0.8 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.6 GO:0098536 deuterosome(GO:0098536)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 7.0 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.4 6.1 GO:0017154 semaphorin receptor activity(GO:0017154)
1.5 5.9 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.1 5.7 GO:0005125 cytokine activity(GO:0005125)
0.1 5.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.4 3.8 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.1 3.8 GO:0020037 heme binding(GO:0020037)
0.6 3.5 GO:0070728 leucine binding(GO:0070728)
0.1 3.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 2.7 GO:0035064 methylated histone binding(GO:0035064)
0.3 2.4 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 2.4 GO:0017022 myosin binding(GO:0017022)
0.0 2.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.1 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 2.0 GO:0001221 transcription cofactor binding(GO:0001221)
0.4 1.5 GO:0008142 oxysterol binding(GO:0008142)
0.0 1.5 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 1.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 1.4 GO:0004185 serine-type carboxypeptidase activity(GO:0004185) cobalt ion binding(GO:0050897)
0.1 1.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)