Motif ID: Plag1

Z-value: 0.549


Transcription factors associated with Plag1:

Gene SymbolEntrez IDGene Name
Plag1 ENSMUSG00000003282.3 Plag1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Plag1mm10_v2_chr4_-_3938354_3938401-0.291.0e-01Click!


Activity profile for motif Plag1.

activity profile for motif Plag1


Sorted Z-values histogram for motif Plag1

Sorted Z-values for motif Plag1



Network of associatons between targets according to the STRING database.



First level regulatory network of Plag1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_133498538 3.349 ENSMUST00000125541.1
 Trnp1
TMF1-regulated nuclear protein 1
chr4_-_129121699 2.659 ENSMUST00000135763.1
ENSMUST00000149763.1
ENSMUST00000164649.1
 Hpca


hippocalcin


chr10_+_58813359 2.461 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr3_-_88000350 2.439 ENSMUST00000090971.5
 Bcan
brevican
chr11_+_77930800 2.079 ENSMUST00000093995.3
ENSMUST00000000646.7
 Sez6

seizure related gene 6

chr19_-_5457397 2.024 ENSMUST00000179549.1
 Ccdc85b
coiled-coil domain containing 85B
chr7_-_79386943 2.005 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr7_+_54835959 1.739 ENSMUST00000082373.6
 Luzp2
leucine zipper protein 2
chr13_-_14523178 1.736 ENSMUST00000110516.2
 Hecw1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr4_-_129121889 1.734 ENSMUST00000139450.1
ENSMUST00000125931.1
ENSMUST00000116444.2
 Hpca


hippocalcin


chrX_+_166344692 1.720 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
 Gpm6b





glycoprotein m6b





chr3_+_89520152 1.574 ENSMUST00000000811.7
 Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr16_-_18622403 1.571 ENSMUST00000167388.1
 Gp1bb
glycoprotein Ib, beta polypeptide
chr5_+_117841839 1.542 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr4_-_129121234 1.535 ENSMUST00000030572.3
 Hpca
hippocalcin
chr2_+_170731807 1.506 ENSMUST00000029075.4
 Dok5
docking protein 5
chr7_+_46396439 1.404 ENSMUST00000025202.6
 Kcnc1
potassium voltage gated channel, Shaw-related subfamily, member 1
chr12_+_89812467 1.369 ENSMUST00000110133.2
ENSMUST00000110130.2
 Nrxn3

neurexin III

chrX_+_7919816 1.341 ENSMUST00000041096.3
 Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
chr19_+_29251748 1.323 ENSMUST00000065796.3
ENSMUST00000025705.6
 Jak2

Janus kinase 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 280 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 5.9 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.2 4.5 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.1 4.2 GO:0021696 cerebellar cortex morphogenesis(GO:0021696)
0.6 4.0 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.0 3.2 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.7 2.8 GO:1901204 positive regulation of guanylate cyclase activity(GO:0031284) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
0.6 2.8 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.2 2.7 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.4 2.5 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.1 2.5 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.1 2.3 GO:0010107 potassium ion import(GO:0010107)
0.0 2.2 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.2 2.0 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.1 2.0 GO:0048268 clathrin coat assembly(GO:0048268)
0.4 1.8 GO:0061438 renal system vasculature morphogenesis(GO:0061438) kidney vasculature morphogenesis(GO:0061439)
0.3 1.8 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.3 1.7 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 1.7 GO:0071625 vocalization behavior(GO:0071625)
0.0 1.7 GO:0033344 cholesterol efflux(GO:0033344)
0.5 1.6 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 126 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 6.0 GO:0044327 dendritic spine head(GO:0044327)
0.8 4.0 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 4.0 GO:0031225 anchored component of membrane(GO:0031225)
0.2 3.9 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 3.0 GO:0097440 apical dendrite(GO:0097440)
0.1 3.0 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2 2.8 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 2.7 GO:0031594 neuromuscular junction(GO:0031594)
0.0 2.5 GO:0097060 synaptic membrane(GO:0097060)
0.1 2.3 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 2.3 GO:0034704 calcium channel complex(GO:0034704)
0.0 2.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 2.1 GO:0005614 interstitial matrix(GO:0005614)
0.3 1.9 GO:0008091 spectrin(GO:0008091)
0.1 1.9 GO:0030128 clathrin coat of endocytic vesicle(GO:0030128) clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 1.9 GO:0042734 presynaptic membrane(GO:0042734)
0.1 1.6 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 1.5 GO:0044853 plasma membrane raft(GO:0044853)
0.5 1.4 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 1.4 GO:0030673 axolemma(GO:0030673)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 193 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 4.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.2 3.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.9 2.8 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.3 2.8 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.1 2.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.8 2.4 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.3 2.3 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.2 2.3 GO:0008430 selenium binding(GO:0008430)
0.0 2.3 GO:0005267 potassium channel activity(GO:0005267)
0.5 1.8 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.4 1.8 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.2 1.8 GO:0005131 growth hormone receptor binding(GO:0005131)
0.2 1.7 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.4 1.6 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.3 1.6 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.1 1.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.2 1.5 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 1.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 1.4 GO:0030506 ankyrin binding(GO:0030506)
0.1 1.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)