Motif ID: Pou2f2_Pou3f1
Z-value: 1.452
Transcription factors associated with Pou2f2_Pou3f1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Pou2f2 | ENSMUSG00000008496.12 | Pou2f2 |
| Pou3f1 | ENSMUSG00000090125.2 | Pou3f1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Pou3f1 | mm10_v2_chr4_+_124657646_124657656 | 0.34 | 5.6e-02 | Click! |
| Pou2f2 | mm10_v2_chr7_-_25132473_25132512 | 0.09 | 6.4e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 8.8 | GO:0017055 | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055) |
| 1.4 | 7.1 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
| 1.2 | 13.9 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 1.0 | 108.9 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.8 | 2.4 | GO:0070269 | pyroptosis(GO:0070269) |
| 0.8 | 5.7 | GO:0034047 | regulation of protein phosphatase type 2A activity(GO:0034047) |
| 0.8 | 4.0 | GO:0035093 | spermatogenesis, exchange of chromosomal proteins(GO:0035093) |
| 0.5 | 2.5 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 0.5 | 1.4 | GO:0021893 | cerebral cortex GABAergic interneuron fate commitment(GO:0021893) |
| 0.5 | 1.8 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.4 | 3.6 | GO:0042095 | interferon-gamma biosynthetic process(GO:0042095) |
| 0.4 | 1.4 | GO:0043973 | histone H3-K4 acetylation(GO:0043973) |
| 0.3 | 2.3 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
| 0.3 | 10.8 | GO:0060074 | synapse maturation(GO:0060074) |
| 0.3 | 1.8 | GO:0035743 | CD4-positive, alpha-beta T cell cytokine production(GO:0035743) T-helper 2 cell cytokine production(GO:0035745) |
| 0.3 | 2.7 | GO:0051152 | positive regulation of smooth muscle cell differentiation(GO:0051152) |
| 0.3 | 2.2 | GO:0006265 | DNA topological change(GO:0006265) |
| 0.3 | 2.1 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.3 | 1.8 | GO:1903715 | regulation of aerobic respiration(GO:1903715) |
| 0.2 | 5.4 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.2 | 7.8 | GO:1900078 | positive regulation of cellular response to insulin stimulus(GO:1900078) |
| 0.2 | 3.5 | GO:0014049 | positive regulation of glutamate secretion(GO:0014049) |
| 0.2 | 1.5 | GO:1904217 | regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222) |
| 0.2 | 0.8 | GO:0090086 | negative regulation of protein deubiquitination(GO:0090086) |
| 0.2 | 1.9 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.2 | 0.5 | GO:0060853 | arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel endothelial cell fate specification(GO:0097101) |
| 0.2 | 0.7 | GO:0046898 | response to cycloheximide(GO:0046898) |
| 0.2 | 17.1 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.2 | 0.9 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 0.1 | 2.4 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
| 0.1 | 4.1 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.1 | 3.3 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 0.4 | GO:2000110 | protein sialylation(GO:1990743) negative regulation of macrophage apoptotic process(GO:2000110) |
| 0.1 | 1.1 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.1 | 0.5 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
| 0.1 | 0.8 | GO:0007379 | segment specification(GO:0007379) |
| 0.1 | 0.5 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.1 | 0.4 | GO:2000255 | negative regulation of male germ cell proliferation(GO:2000255) |
| 0.1 | 1.4 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.1 | 0.6 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.1 | 0.8 | GO:0002115 | store-operated calcium entry(GO:0002115) |
| 0.1 | 4.1 | GO:0010508 | positive regulation of autophagy(GO:0010508) |
| 0.1 | 2.7 | GO:0001541 | ovarian follicle development(GO:0001541) |
| 0.1 | 0.9 | GO:0060065 | uterus development(GO:0060065) |
| 0.0 | 0.5 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
| 0.0 | 0.7 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
| 0.0 | 1.5 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
| 0.0 | 0.5 | GO:0035563 | positive regulation of chromatin binding(GO:0035563) |
| 0.0 | 0.3 | GO:0006983 | ER overload response(GO:0006983) |
| 0.0 | 0.3 | GO:0046085 | adenosine metabolic process(GO:0046085) |
| 0.0 | 0.0 | GO:0090085 | regulation of protein deubiquitination(GO:0090085) |
| 0.0 | 0.1 | GO:0010986 | positive regulation of lipoprotein particle clearance(GO:0010986) |
| 0.0 | 0.7 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.0 | 0.6 | GO:0030262 | cellular component disassembly involved in execution phase of apoptosis(GO:0006921) apoptotic nuclear changes(GO:0030262) |
| 0.0 | 0.4 | GO:0001967 | suckling behavior(GO:0001967) |
| 0.0 | 2.1 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.0 | 2.5 | GO:0007612 | learning(GO:0007612) |
| 0.0 | 0.6 | GO:0016925 | protein sumoylation(GO:0016925) |
| 0.0 | 0.3 | GO:0007097 | nuclear migration(GO:0007097) |
| 0.0 | 0.2 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 0.0 | 0.5 | GO:0050982 | detection of mechanical stimulus(GO:0050982) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 41.3 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.6 | 6.3 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.6 | 2.4 | GO:0061702 | inflammasome complex(GO:0061702) |
| 0.6 | 2.4 | GO:0002111 | BRCA2-BRAF35 complex(GO:0002111) |
| 0.6 | 25.6 | GO:0000786 | nucleosome(GO:0000786) |
| 0.4 | 3.0 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.4 | 2.2 | GO:0001651 | dense fibrillar component(GO:0001651) |
| 0.3 | 5.7 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.3 | 5.4 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.2 | 2.5 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.2 | 73.0 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.1 | 1.8 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.1 | 0.7 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.1 | 5.2 | GO:0005776 | autophagosome(GO:0005776) |
| 0.1 | 3.5 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 4.5 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 0.4 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.0 | 0.8 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.0 | 0.6 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.0 | 1.8 | GO:0000123 | histone acetyltransferase complex(GO:0000123) |
| 0.0 | 0.8 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 1.8 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 0.9 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 0.8 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 0.8 | GO:0016234 | inclusion body(GO:0016234) |
| 0.0 | 1.0 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 2.1 | GO:0005681 | spliceosomal complex(GO:0005681) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 8.8 | GO:0002153 | steroid receptor RNA activator RNA binding(GO:0002153) |
| 0.9 | 5.4 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.7 | 3.7 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.5 | 1.9 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.4 | 2.2 | GO:0003917 | DNA topoisomerase type I activity(GO:0003917) |
| 0.4 | 5.7 | GO:0008601 | protein phosphatase type 2A regulator activity(GO:0008601) |
| 0.2 | 2.1 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
| 0.2 | 2.5 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.2 | 1.4 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.2 | 0.5 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.1 | 0.6 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.1 | 1.4 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.1 | 0.5 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) |
| 0.1 | 1.5 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.1 | 2.7 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 0.7 | GO:0034452 | dynactin binding(GO:0034452) |
| 0.1 | 0.4 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
| 0.1 | 3.8 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 1.8 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
| 0.1 | 0.4 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.1 | 0.7 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.1 | 7.7 | GO:0005496 | steroid binding(GO:0005496) |
| 0.1 | 1.7 | GO:0043747 | protein-N-terminal asparagine amidohydrolase activity(GO:0008418) UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity(GO:0008759) iprodione amidohydrolase activity(GO:0018748) (3,5-dichlorophenylurea)acetate amidohydrolase activity(GO:0018749) 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity(GO:0034571) didemethylisoproturon amidohydrolase activity(GO:0034573) N-isopropylacetanilide amidohydrolase activity(GO:0034576) N-cyclohexylformamide amidohydrolase activity(GO:0034781) isonicotinic acid hydrazide hydrolase activity(GO:0034876) cis-aconitamide amidase activity(GO:0034882) gamma-N-formylaminovinylacetate hydrolase activity(GO:0034885) N2-acetyl-L-lysine deacetylase activity(GO:0043747) O-succinylbenzoate synthase activity(GO:0043748) indoleacetamide hydrolase activity(GO:0043864) N-acetylcitrulline deacetylase activity(GO:0043909) N-acetylgalactosamine-6-phosphate deacetylase activity(GO:0047419) diacetylchitobiose deacetylase activity(GO:0052773) chitooligosaccharide deacetylase activity(GO:0052790) |
| 0.1 | 10.8 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.1 | 0.8 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.1 | 2.4 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.1 | 0.9 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.1 | 0.4 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.1 | 0.6 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.1 | 4.5 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.1 | 29.7 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.1 | 1.8 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 5.9 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.0 | 0.9 | GO:0032183 | SUMO binding(GO:0032183) |
| 0.0 | 1.9 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 3.1 | GO:0016810 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810) |
| 0.0 | 0.6 | GO:0008599 | protein phosphatase type 1 regulator activity(GO:0008599) |
| 0.0 | 1.3 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.0 | 0.0 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 2.9 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 0.2 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 0.0 | 45.7 | GO:0003677 | DNA binding(GO:0003677) |
| 0.0 | 1.9 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
| 0.0 | 0.3 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.0 | 0.1 | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity(GO:0008970) |
| 0.0 | 47.2 | GO:0046872 | metal ion binding(GO:0046872) |
| 0.0 | 1.0 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.0 | 1.4 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 0.0 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
|
|
|