Motif ID: Pou6f2_Pou4f2

Z-value: 0.797

Transcription factors associated with Pou6f2_Pou4f2:

Gene SymbolEntrez IDGene Name
Pou4f2 ENSMUSG00000031688.3 Pou4f2
Pou6f2 ENSMUSG00000009734.11 Pou6f2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou4f2mm10_v2_chr8_-_78436640_784366490.575.3e-04Click!
Pou6f2mm10_v2_chr13_-_18382041_183820410.261.5e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Pou6f2_Pou4f2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_-_31949571 5.995 ENSMUST00000064016.5
Gpr17
G protein-coupled receptor 17
chr6_+_63255971 5.675 ENSMUST00000159561.1
ENSMUST00000095852.3
Grid2

glutamate receptor, ionotropic, delta 2

chr2_+_109917639 5.303 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr13_-_56296551 4.876 ENSMUST00000021970.9
Cxcl14
chemokine (C-X-C motif) ligand 14
chr10_+_99263224 3.729 ENSMUST00000020118.4
Dusp6
dual specificity phosphatase 6
chr13_-_81570640 3.471 ENSMUST00000109565.2
Gpr98
G protein-coupled receptor 98
chr5_-_62766153 3.249 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr14_+_27039001 3.194 ENSMUST00000035336.3
Il17rd
interleukin 17 receptor D
chr12_-_56535047 3.090 ENSMUST00000178477.2
Nkx2-1
NK2 homeobox 1
chr5_-_62765618 2.714 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr17_-_49564262 2.575 ENSMUST00000057610.6
Daam2
dishevelled associated activator of morphogenesis 2
chr10_-_70655934 2.535 ENSMUST00000162144.1
ENSMUST00000162793.1
Phyhipl

phytanoyl-CoA hydroxylase interacting protein-like

chr4_+_117849193 2.516 ENSMUST00000132043.2
ENSMUST00000169990.1
Slc6a9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chr1_-_72874877 2.472 ENSMUST00000027377.8
Igfbp5
insulin-like growth factor binding protein 5
chr4_+_117849361 2.445 ENSMUST00000163288.1
Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr1_+_172341197 2.417 ENSMUST00000056136.3
Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr6_+_88724828 2.298 ENSMUST00000089449.2
Mgll
monoglyceride lipase
chr7_-_49636847 2.194 ENSMUST00000032717.6
Dbx1
developing brain homeobox 1
chr19_+_3323301 2.157 ENSMUST00000025835.4
Cpt1a
carnitine palmitoyltransferase 1a, liver
chr6_+_88724667 1.868 ENSMUST00000163271.1
Mgll
monoglyceride lipase
chr12_+_38780284 1.743 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
Etv1


ets variant gene 1


chr3_+_68572245 1.572 ENSMUST00000170788.2
Schip1
schwannomin interacting protein 1
chr12_+_38781093 1.526 ENSMUST00000161513.1
Etv1
ets variant gene 1
chr5_+_135106881 1.357 ENSMUST00000005507.3
Mlxipl
MLX interacting protein-like
chr9_-_37147257 1.275 ENSMUST00000039674.5
ENSMUST00000080754.5
Pknox2

Pbx/knotted 1 homeobox 2

chr2_+_132847719 1.234 ENSMUST00000124836.1
ENSMUST00000154160.1
Crls1

cardiolipin synthase 1

chr12_+_38780817 1.233 ENSMUST00000160856.1
Etv1
ets variant gene 1
chr6_+_125552948 1.228 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
Vwf


Von Willebrand factor homolog


chr13_+_99100698 1.226 ENSMUST00000181742.1
Gm807
predicted gene 807
chr3_-_154328634 1.223 ENSMUST00000167744.1
Lhx8
LIM homeobox protein 8
chr8_-_92355764 1.201 ENSMUST00000180102.1
ENSMUST00000179421.1
ENSMUST00000179222.1
ENSMUST00000179029.1
4933436C20Rik



RIKEN cDNA 4933436C20 gene



chr19_-_19001099 1.110 ENSMUST00000040153.8
ENSMUST00000112828.1
Rorb

RAR-related orphan receptor beta

chr1_+_153665666 1.105 ENSMUST00000111814.1
ENSMUST00000111810.1
Rgs8

regulator of G-protein signaling 8

chr18_-_15063560 1.092 ENSMUST00000168989.1
Kctd1
potassium channel tetramerisation domain containing 1
chrX_+_99975570 1.067 ENSMUST00000113779.1
ENSMUST00000113776.1
ENSMUST00000113775.1
ENSMUST00000113780.1
ENSMUST00000113778.1
ENSMUST00000113781.1
ENSMUST00000113783.1
ENSMUST00000071453.2
ENSMUST00000113777.1
Eda








ectodysplasin-A








chr8_-_67818218 0.978 ENSMUST00000059374.4
Psd3
pleckstrin and Sec7 domain containing 3
chr2_+_71528657 0.964 ENSMUST00000126400.1
Dlx1
distal-less homeobox 1
chr11_-_89538556 0.964 ENSMUST00000169201.1
Ankfn1
ankyrin-repeat and fibronectin type III domain containing 1
chr1_+_153665627 0.960 ENSMUST00000147482.1
Rgs8
regulator of G-protein signaling 8
chr9_+_15239045 0.889 ENSMUST00000034413.6
Vstm5
V-set and transmembrane domain containing 5
chr6_+_29859374 0.832 ENSMUST00000115238.3
Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr6_+_29859686 0.830 ENSMUST00000134438.1
Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr1_+_153665274 0.820 ENSMUST00000152114.1
ENSMUST00000111812.1
Rgs8

regulator of G-protein signaling 8

chr6_+_29859662 0.815 ENSMUST00000128927.2
Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr15_-_50882806 0.800 ENSMUST00000184885.1
Trps1
trichorhinophalangeal syndrome I (human)
chr4_+_115088708 0.794 ENSMUST00000171877.1
ENSMUST00000177647.1
ENSMUST00000106548.2
ENSMUST00000030488.2
Pdzk1ip1



PDZK1 interacting protein 1



chr1_+_153665587 0.793 ENSMUST00000147700.1
Rgs8
regulator of G-protein signaling 8
chr15_+_35371498 0.788 ENSMUST00000048646.7
Vps13b
vacuolar protein sorting 13B (yeast)
chr8_-_61902669 0.766 ENSMUST00000121785.1
ENSMUST00000034057.7
Palld

palladin, cytoskeletal associated protein

chrX_+_16619698 0.725 ENSMUST00000026013.5
Maoa
monoamine oxidase A
chr7_-_116031047 0.720 ENSMUST00000106612.1
Sox6
SRY-box containing gene 6
chr4_+_102589687 0.678 ENSMUST00000097949.4
ENSMUST00000106901.1
Pde4b

phosphodiesterase 4B, cAMP specific

chr6_-_138422898 0.672 ENSMUST00000161450.1
ENSMUST00000163024.1
ENSMUST00000162185.1
Lmo3


LIM domain only 3


chr10_-_92164666 0.669 ENSMUST00000183123.1
ENSMUST00000182033.1
Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr2_-_168767029 0.666 ENSMUST00000075044.3
Sall4
sal-like 4 (Drosophila)
chr10_-_53647080 0.661 ENSMUST00000169866.1
Fam184a
family with sequence similarity 184, member A
chr13_-_102905740 0.632 ENSMUST00000167462.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr13_-_102906046 0.594 ENSMUST00000171791.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr9_-_123678782 0.581 ENSMUST00000170591.1
ENSMUST00000171647.1
Slc6a20a

solute carrier family 6 (neurotransmitter transporter), member 20A

chr16_+_43503607 0.555 ENSMUST00000126100.1
ENSMUST00000123047.1
ENSMUST00000156981.1
Zbtb20


zinc finger and BTB domain containing 20


chrX_-_53269786 0.544 ENSMUST00000114841.1
ENSMUST00000071023.5
Fam122b

family with sequence similarity 122, member B

chr1_-_119053619 0.532 ENSMUST00000062483.8
Gli2
GLI-Kruppel family member GLI2
chr11_+_60537978 0.521 ENSMUST00000044250.3
Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr19_-_32196393 0.520 ENSMUST00000151822.1
Sgms1
sphingomyelin synthase 1
chr1_+_10993452 0.513 ENSMUST00000027056.5
Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chrX_-_59166080 0.504 ENSMUST00000119306.1
Fgf13
fibroblast growth factor 13
chr4_-_58499398 0.496 ENSMUST00000107570.1
Lpar1
lysophosphatidic acid receptor 1
chr8_-_67818284 0.491 ENSMUST00000120071.1
Psd3
pleckstrin and Sec7 domain containing 3
chr16_+_43247278 0.437 ENSMUST00000114691.1
ENSMUST00000079441.6
Zbtb20

zinc finger and BTB domain containing 20

chr2_-_106002008 0.430 ENSMUST00000155811.1
Dnajc24
DnaJ (Hsp40) homolog, subfamily C, member 24
chr16_-_59632520 0.416 ENSMUST00000118438.1
Arl6
ADP-ribosylation factor-like 6
chr2_-_168767136 0.407 ENSMUST00000029061.5
ENSMUST00000103074.1
Sall4

sal-like 4 (Drosophila)

chr19_+_24875679 0.343 ENSMUST00000073080.5
Gm10053
predicted gene 10053
chr2_-_148045891 0.341 ENSMUST00000109964.1
Foxa2
forkhead box A2
chr18_-_88927447 0.308 ENSMUST00000147313.1
Socs6
suppressor of cytokine signaling 6
chr2_+_3114220 0.308 ENSMUST00000072955.5
Fam171a1
family with sequence similarity 171, member A1
chr8_+_4238815 0.307 ENSMUST00000003027.7
ENSMUST00000110999.1
Map2k7

mitogen-activated protein kinase kinase 7

chr4_+_5724304 0.280 ENSMUST00000108380.1
Fam110b
family with sequence similarity 110, member B
chr2_+_96318014 0.272 ENSMUST00000135431.1
ENSMUST00000162807.2
Lrrc4c

leucine rich repeat containing 4C

chrX_+_114474312 0.271 ENSMUST00000113371.1
ENSMUST00000040504.5
Klhl4

kelch-like 4

chr17_+_46681038 0.241 ENSMUST00000002845.6
Mea1
male enhanced antigen 1
chr19_+_16956110 0.223 ENSMUST00000087689.4
Prune2
prune homolog 2 (Drosophila)
chr3_+_76593550 0.221 ENSMUST00000162471.1
Fstl5
follistatin-like 5
chr4_+_150237694 0.211 ENSMUST00000141931.1
Eno1
enolase 1, alpha non-neuron
chr7_+_28881656 0.183 ENSMUST00000066880.4
Capn12
calpain 12
chr2_-_32431104 0.165 ENSMUST00000127961.1
ENSMUST00000136361.1
ENSMUST00000052119.7
Slc25a25


solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25


chr13_-_103764502 0.135 ENSMUST00000074616.5
Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr13_-_38635036 0.132 ENSMUST00000035899.6
Bloc1s5
biogenesis of organelles complex-1, subunit 5, muted
chr10_-_128549125 0.122 ENSMUST00000177163.1
ENSMUST00000176683.1
ENSMUST00000176010.1
Rpl41


ribosomal protein L41


chr1_+_143777263 0.119 ENSMUST00000018333.6
Uchl5
ubiquitin carboxyl-terminal esterase L5
chr18_+_54990280 0.118 ENSMUST00000181538.1
Gm4221
predicted gene 4221
chr4_+_150237211 0.108 ENSMUST00000133839.1
Eno1
enolase 1, alpha non-neuron
chr14_-_69805524 0.096 ENSMUST00000022665.2
Rhobtb2
Rho-related BTB domain containing 2
chrM_+_7005 0.093 ENSMUST00000082405.1
mt-Co2
mitochondrially encoded cytochrome c oxidase II
chrX_-_51018011 0.080 ENSMUST00000053593.7
Rap2c
RAP2C, member of RAS oncogene family
chr18_+_57468478 0.069 ENSMUST00000091892.2
Ctxn3
cortexin 3
chr10_-_128549102 0.066 ENSMUST00000176906.1
Rpl41
ribosomal protein L41
chr17_+_34592248 0.062 ENSMUST00000038149.6
Pbx2
pre B cell leukemia homeobox 2
chr8_-_84662841 0.057 ENSMUST00000060427.4
Ier2
immediate early response 2

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
1.7 5.0 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
1.6 4.9 GO:2000501 natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
1.2 3.7 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
1.0 3.1 GO:0021759 globus pallidus development(GO:0021759)
0.8 2.4 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.7 6.0 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.6 4.2 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.4 5.7 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.4 1.1 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.4 2.5 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.3 1.4 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
0.3 1.0 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
0.3 2.5 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.3 3.7 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.2 0.7 GO:0042420 dopamine catabolic process(GO:0042420)
0.2 0.6 GO:0036233 glycine import(GO:0036233)
0.2 1.1 GO:0046549 retinal cone cell development(GO:0046549)
0.2 2.2 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.2 1.2 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.2 2.7 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 4.5 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 0.5 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.1 0.5 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 1.0 GO:0050957 equilibrioception(GO:0050957)
0.1 0.7 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1 1.6 GO:0001553 luteinization(GO:0001553)
0.1 0.5 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.5 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.1 0.4 GO:0046909 intermembrane transport(GO:0046909)
0.1 1.1 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 1.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 0.8 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.1 GO:0032474 otolith morphogenesis(GO:0032474)
0.0 0.7 GO:0001780 neutrophil homeostasis(GO:0001780) regulation of high voltage-gated calcium channel activity(GO:1901841)
0.0 0.1 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.0 0.8 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 1.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.3 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.0 1.2 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.0 1.8 GO:0007368 determination of left/right symmetry(GO:0007368)
0.0 0.1 GO:0048853 forebrain morphogenesis(GO:0048853)
0.0 1.2 GO:0030168 platelet activation(GO:0030168)
0.0 0.6 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.2 GO:0002021 response to dietary excess(GO:0002021)
0.0 0.4 GO:0032781 positive regulation of ATPase activity(GO:0032781)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.5 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.3 4.2 GO:0043196 varicosity(GO:0043196)
0.2 1.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 1.2 GO:0001674 female germ cell nucleus(GO:0001674)
0.2 2.4 GO:0097449 astrocyte projection(GO:0097449)
0.1 3.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 2.0 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 4.9 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.1 0.5 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.5 GO:0097542 ciliary tip(GO:0097542)
0.0 0.8 GO:0002102 podosome(GO:0002102)
0.0 0.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.1 GO:0005581 collagen trimer(GO:0005581)
0.0 5.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 3.5 GO:0098793 presynapse(GO:0098793)
0.0 0.1 GO:0031083 BLOC-1 complex(GO:0031083)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.9 5.5 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.8 2.4 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.4 5.3 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.4 2.2 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.4 1.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.4 2.5 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.3 4.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.3 2.5 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.3 3.1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.2 1.2 GO:0008808 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572)
0.2 5.7 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.2 0.7 GO:0051378 primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378)
0.2 4.9 GO:0008009 chemokine activity(GO:0008009)
0.1 1.2 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 0.5 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.1 0.5 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 6.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 4.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 3.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 1.3 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 2.1 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 3.2 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 0.4 GO:0008198 ferrous iron binding(GO:0008198)
0.0 0.7 GO:0030552 cAMP binding(GO:0030552)
0.0 0.3 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 2.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 3.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)