Motif ID: Prop1

Z-value: 1.160


Transcription factors associated with Prop1:

Gene SymbolEntrez IDGene Name
Prop1 ENSMUSG00000044542.3 Prop1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prop1mm10_v2_chr11_-_50953745_509537680.144.4e-01Click!


Activity profile for motif Prop1.

activity profile for motif Prop1


Sorted Z-values histogram for motif Prop1

Sorted Z-values for motif Prop1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prop1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_61804453 5.730 ENSMUST00000048934.8
 Tbr1
T-box brain gene 1
chr14_-_40893222 4.768 ENSMUST00000096000.3
 Sh2d4b
SH2 domain containing 4B
chr4_-_110292719 3.809 ENSMUST00000106601.1
 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chrX_+_170010744 3.130 ENSMUST00000178789.1
 Gm21887
predicted gene, 21887
chr4_-_119492563 3.089 ENSMUST00000049994.7
 Rimkla
ribosomal modification protein rimK-like family member A
chr4_-_87806296 2.974 ENSMUST00000126353.1
ENSMUST00000149357.1
 Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr4_-_82505749 2.797 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr4_-_87806276 2.787 ENSMUST00000148059.1
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr16_-_45693658 2.709 ENSMUST00000114562.2
ENSMUST00000036617.7
 Tmprss7

transmembrane serine protease 7

chr1_-_176807124 2.632 ENSMUST00000057037.7
 Cep170
centrosomal protein 170
chr9_+_118478182 2.612 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478344 2.610 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr18_-_62741387 2.594 ENSMUST00000097557.3
 Spink13
serine peptidase inhibitor, Kazal type 13
chr3_+_94377432 2.538 ENSMUST00000107292.1
 Rorc
RAR-related orphan receptor gamma
chr1_+_107511416 2.471 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr10_+_69925766 2.341 ENSMUST00000182269.1
ENSMUST00000183261.1
ENSMUST00000183074.1
 Ank3


ankyrin 3, epithelial


chrY_+_90785442 2.296 ENSMUST00000177591.1
ENSMUST00000177671.1
ENSMUST00000179077.1
 Erdr1


erythroid differentiation regulator 1


chr10_-_127189981 2.166 ENSMUST00000019611.7
 Arhgef25
Rho guanine nucleotide exchange factor (GEF) 25
chr10_+_69925954 2.151 ENSMUST00000181974.1
ENSMUST00000182795.1
ENSMUST00000182437.1
 Ank3


ankyrin 3, epithelial


chr3_+_94377505 2.150 ENSMUST00000098877.2
 Rorc
RAR-related orphan receptor gamma

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 8.1 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.6 5.8 GO:0007379 segment specification(GO:0007379)
1.1 5.7 GO:0001661 conditioned taste aversion(GO:0001661) amygdala development(GO:0021764)
1.7 5.2 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.2 4.8 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.7 4.7 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.3 4.0 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 4.0 GO:0043488 regulation of mRNA stability(GO:0043488)
1.0 2.9 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.5 2.6 GO:0060467 negative regulation of fertilization(GO:0060467)
0.0 2.3 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.3 2.1 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442)
0.3 2.1 GO:0005513 detection of calcium ion(GO:0005513)
0.7 2.0 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.4 2.0 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.1 2.0 GO:0007614 short-term memory(GO:0007614)
0.2 1.8 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 1.7 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.3 1.6 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.3 1.6 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 8.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 5.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 4.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 4.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.3 3.8 GO:0042788 polysomal ribosome(GO:0042788)
0.0 3.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 3.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 3.0 GO:0005814 centriole(GO:0005814)
1.0 2.9 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 2.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 2.1 GO:0031045 dense core granule(GO:0031045)
0.3 2.0 GO:0005955 calcineurin complex(GO:0005955)
0.0 2.0 GO:0043195 terminal bouton(GO:0043195)
0.0 1.7 GO:0070469 respiratory chain(GO:0070469)
0.2 1.6 GO:0071439 clathrin complex(GO:0071439)
0.0 1.6 GO:0030117 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.3 1.4 GO:0008623 CHRAC(GO:0008623)
0.1 1.3 GO:0042581 specific granule(GO:0042581)
0.0 1.3 GO:0031526 brush border membrane(GO:0031526)
0.2 1.2 GO:0035189 Rb-E2F complex(GO:0035189)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.1 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 6.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 5.7 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 5.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 4.9 GO:0005496 steroid binding(GO:0005496)
1.2 4.7 GO:0008142 oxysterol binding(GO:0008142)
0.1 4.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 3.8 GO:0017091 AU-rich element binding(GO:0017091)
0.1 3.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.4 2.9 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0 2.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 2.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 2.1 GO:0005507 copper ion binding(GO:0005507)
0.3 2.0 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 1.8 GO:0008565 protein transporter activity(GO:0008565)
0.2 1.7 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.1 1.6 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.6 GO:0017124 SH3 domain binding(GO:0017124)
0.0 1.5 GO:0017080 sodium channel regulator activity(GO:0017080)