Motif ID: Prox1

Z-value: 0.552


Transcription factors associated with Prox1:

Gene SymbolEntrez IDGene Name
Prox1 ENSMUSG00000010175.7 Prox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prox1mm10_v2_chr1_-_190170671_190170744-0.639.3e-05Click!


Activity profile for motif Prox1.

activity profile for motif Prox1


Sorted Z-values histogram for motif Prox1

Sorted Z-values for motif Prox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prox1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_60144682 3.685 ENSMUST00000065383.4
E330013P04Rik
RIKEN cDNA E330013P04 gene
chr5_-_37824580 1.933 ENSMUST00000063116.9
Msx1
msh homeobox 1
chr19_+_41911851 1.460 ENSMUST00000011896.6
Pgam1
phosphoglycerate mutase 1
chr4_-_131821516 1.381 ENSMUST00000097860.2
Ptpru
protein tyrosine phosphatase, receptor type, U
chr18_-_20682963 1.345 ENSMUST00000165229.2
Gm10269
predicted gene 10269
chr4_+_130913264 1.174 ENSMUST00000156225.1
ENSMUST00000156742.1
Laptm5

lysosomal-associated protein transmembrane 5

chr19_+_46056539 1.070 ENSMUST00000111899.1
ENSMUST00000099392.3
ENSMUST00000062322.4
Pprc1


peroxisome proliferative activated receptor, gamma, coactivator-related 1


chr15_-_80014808 1.057 ENSMUST00000000500.6
Pdgfb
platelet derived growth factor, B polypeptide
chr4_+_140701466 1.044 ENSMUST00000038893.5
ENSMUST00000138808.1
Rcc2

regulator of chromosome condensation 2

chr17_-_70924958 0.934 ENSMUST00000180468.1
Gm26510
predicted gene, 26510
chr1_-_169747634 0.858 ENSMUST00000027991.5
ENSMUST00000111357.1
Rgs4

regulator of G-protein signaling 4

chr6_+_58640536 0.850 ENSMUST00000145161.1
ENSMUST00000114294.1
Abcg2

ATP-binding cassette, sub-family G (WHITE), member 2

chr5_-_138187177 0.814 ENSMUST00000110937.1
ENSMUST00000139276.1
ENSMUST00000048698.7
ENSMUST00000123415.1
Taf6



TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor



chr4_+_130913120 0.768 ENSMUST00000151698.1
Laptm5
lysosomal-associated protein transmembrane 5
chr19_-_43524462 0.768 ENSMUST00000026196.7
Got1
glutamate oxaloacetate transaminase 1, soluble
chr6_-_131388417 0.767 ENSMUST00000032309.6
ENSMUST00000087865.2
Ybx3

Y box protein 3

chr17_+_27839974 0.738 ENSMUST00000071006.7
Snrpc
U1 small nuclear ribonucleoprotein C
chr19_-_15924560 0.724 ENSMUST00000162053.1
Psat1
phosphoserine aminotransferase 1
chr4_-_36951223 0.690 ENSMUST00000108122.1
Lingo2
leucine rich repeat and Ig domain containing 2
chr8_+_31111816 0.688 ENSMUST00000046941.7
Rnf122
ring finger protein 122
chr2_+_27009926 0.659 ENSMUST00000114005.2
ENSMUST00000114004.1
ENSMUST00000114006.1
ENSMUST00000114007.1
Cacfd1



calcium channel flower domain containing 1



chr14_-_96519067 0.625 ENSMUST00000022666.7
Klhl1
kelch-like 1
chr17_-_34959232 0.622 ENSMUST00000165202.1
ENSMUST00000172753.1
Hspa1b

heat shock protein 1B

chr2_-_92459709 0.620 ENSMUST00000136718.1
ENSMUST00000067631.6
Slc35c1

solute carrier family 35, member C1

chr4_-_133967235 0.607 ENSMUST00000123234.1
Hmgn2
high mobility group nucleosomal binding domain 2
chr11_-_115612878 0.585 ENSMUST00000106506.1
Mif4gd
MIF4G domain containing
chr8_-_85080679 0.575 ENSMUST00000093357.5
Wdr83
WD repeat domain containing 83
chr11_-_115612940 0.566 ENSMUST00000021087.7
Mif4gd
MIF4G domain containing
chr14_-_55944536 0.531 ENSMUST00000022834.6
Cma1
chymase 1, mast cell
chr7_+_127777095 0.527 ENSMUST00000144406.1
Setd1a
SET domain containing 1A
chr9_-_106247730 0.499 ENSMUST00000112524.2
ENSMUST00000074082.6
Alas1

aminolevulinic acid synthase 1

chr11_+_72207537 0.499 ENSMUST00000021158.3
Txndc17
thioredoxin domain containing 17
chr17_-_34972124 0.485 ENSMUST00000087328.2
ENSMUST00000179128.1
Hspa1a

heat shock protein 1A

chr2_+_36230426 0.472 ENSMUST00000062069.5
Ptgs1
prostaglandin-endoperoxide synthase 1
chr8_+_85080939 0.450 ENSMUST00000140621.1
BC056474
cDNA sequence BC056474
chr7_+_28716846 0.448 ENSMUST00000108279.2
Fbxo17
F-box protein 17
chr11_+_4986824 0.421 ENSMUST00000009234.9
ENSMUST00000109897.1
Ap1b1

adaptor protein complex AP-1, beta 1 subunit

chr7_-_126861648 0.414 ENSMUST00000129812.1
ENSMUST00000106342.1
Ino80e

INO80 complex subunit E

chr7_+_28716777 0.406 ENSMUST00000032818.6
ENSMUST00000108278.2
Fbxo17

F-box protein 17

chr5_+_139252343 0.374 ENSMUST00000130326.1
Get4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr2_+_27009936 0.339 ENSMUST00000133807.1
Cacfd1
calcium channel flower domain containing 1
chr11_+_120784257 0.336 ENSMUST00000100134.3
Gps1
G protein pathway suppressor 1
chr17_-_83514311 0.328 ENSMUST00000167741.1
ENSMUST00000025095.7
Cox7a2l

cytochrome c oxidase subunit VIIa polypeptide 2-like

chr8_-_85080652 0.328 ENSMUST00000152785.1
Wdr83
WD repeat domain containing 83
chr7_+_24081888 0.319 ENSMUST00000068975.3
Zfp180
zinc finger protein 180
chr4_-_94556737 0.295 ENSMUST00000030313.8
Caap1
caspase activity and apoptosis inhibitor 1
chr15_-_89149557 0.286 ENSMUST00000088823.3
Mapk11
mitogen-activated protein kinase 11
chr17_+_47630690 0.285 ENSMUST00000024779.8
Usp49
ubiquitin specific peptidase 49
chr7_-_80947499 0.285 ENSMUST00000120285.1
Sec11a
SEC11 homolog A (S. cerevisiae)
chr14_-_59440779 0.280 ENSMUST00000111253.2
ENSMUST00000095775.3
ENSMUST00000161459.1
Setdb2


SET domain, bifurcated 2


chr4_+_42950369 0.277 ENSMUST00000084662.5
Dnajb5
DnaJ (Hsp40) homolog, subfamily B, member 5
chrX_-_43274786 0.247 ENSMUST00000016294.7
Tenm1
teneurin transmembrane protein 1
chrX_-_73966329 0.230 ENSMUST00000114372.2
ENSMUST00000033761.6
Hcfc1

host cell factor C1

chr2_+_34406882 0.225 ENSMUST00000113123.1
Mapkap1
mitogen-activated protein kinase associated protein 1
chr12_-_36042476 0.214 ENSMUST00000020896.8
Tspan13
tetraspanin 13
chr17_+_24426676 0.205 ENSMUST00000024946.5
Eci1
enoyl-Coenzyme A delta isomerase 1
chr9_-_110117303 0.197 ENSMUST00000136969.1
Dhx30
DEAH (Asp-Glu-Ala-His) box polypeptide 30
chr19_+_46152505 0.188 ENSMUST00000026254.7
Gbf1
golgi-specific brefeldin A-resistance factor 1
chr2_+_34406845 0.180 ENSMUST00000124443.1
ENSMUST00000113124.1
Mapkap1

mitogen-activated protein kinase associated protein 1

chr5_+_139252314 0.171 ENSMUST00000026976.5
Get4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr2_+_34406949 0.168 ENSMUST00000040459.4
Mapkap1
mitogen-activated protein kinase associated protein 1
chr11_-_115933464 0.160 ENSMUST00000021097.3
Recql5
RecQ protein-like 5
chr18_-_67245818 0.131 ENSMUST00000073054.3
Mppe1
metallophosphoesterase 1
chr5_+_139211934 0.112 ENSMUST00000148772.1
ENSMUST00000110882.1
Sun1

Sad1 and UNC84 domain containing 1

chr11_+_19924354 0.099 ENSMUST00000093299.6
Spred2
sprouty-related, EVH1 domain containing 2
chr6_+_146796041 0.093 ENSMUST00000111639.1
Arntl2
aryl hydrocarbon receptor nuclear translocator-like 2
chr7_-_19458494 0.089 ENSMUST00000085715.5
Mark4
MAP/microtubule affinity-regulating kinase 4
chr6_+_29361410 0.087 ENSMUST00000156163.1
Calu
calumenin
chr6_+_122308684 0.083 ENSMUST00000007602.8
ENSMUST00000112610.1
M6pr

mannose-6-phosphate receptor, cation dependent

chr9_-_64726583 0.080 ENSMUST00000168366.1
Rab11a
RAB11a, member RAS oncogene family
chr12_-_40223149 0.064 ENSMUST00000171553.1
ENSMUST00000001672.5
Ifrd1

interferon-related developmental regulator 1

chr10_-_81496313 0.063 ENSMUST00000118498.1
Ncln
nicalin homolog (zebrafish)
chr10_-_81496329 0.029 ENSMUST00000020463.7
Ncln
nicalin homolog (zebrafish)
chr2_-_26910569 0.023 ENSMUST00000015920.5
ENSMUST00000139815.1
ENSMUST00000102899.3
Med22


mediator complex subunit 22


chr9_+_104569671 0.022 ENSMUST00000057742.8
Cpne4
copine IV
chr2_-_136891363 0.003 ENSMUST00000028730.6
ENSMUST00000110089.2
Mkks

McKusick-Kaufman syndrome


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.5 1.5 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.4 1.1 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) phenotypic switching(GO:0036166) dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697) glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.3 1.0 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.3 0.8 GO:0046618 drug export(GO:0046618)
0.3 0.8 GO:0006106 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.3 0.8 GO:1902219 regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.2 0.5 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.1 0.7 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.6 GO:0030259 lipid glycosylation(GO:0030259)
0.1 0.7 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 0.3 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.1 0.5 GO:0036506 maintenance of unfolded protein(GO:0036506) protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.1 0.3 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.1 0.2 GO:0070973 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.2 GO:0019042 viral latency(GO:0019042)
0.0 0.3 GO:0072610 interleukin-12 secretion(GO:0072610) regulation of interleukin-12 secretion(GO:2001182) positive regulation of interleukin-12 secretion(GO:2001184)
0.0 0.2 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0 0.2 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 0.5 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.6 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036)
0.0 0.1 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.6 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.0 1.4 GO:0034394 protein localization to cell surface(GO:0034394)
0.0 0.1 GO:0010796 regulation of multivesicular body size(GO:0010796)
0.0 0.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.9 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.3 GO:0002082 regulation of oxidative phosphorylation(GO:0002082)
0.0 0.5 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.3 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.6 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.0 0.8 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.5 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.5 GO:0032611 interleukin-1 beta production(GO:0032611)
0.0 0.6 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 0.5 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 0.7 GO:0000243 commitment complex(GO:0000243)
0.1 0.8 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.6 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.6 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.8 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.8 GO:0005921 gap junction(GO:0005921)
0.0 0.4 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.4 GO:0030131 clathrin adaptor complex(GO:0030131)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.3 0.8 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.2 1.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.2 0.8 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.1 0.7 GO:1990446 U1 snRNP binding(GO:1990446)
0.1 0.5 GO:1990188 euchromatin binding(GO:1990188)
0.1 0.5 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.1 0.5 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.0 0.2 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.0 0.7 GO:0008483 transaminase activity(GO:0008483)
0.0 0.6 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.3 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.2 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.2 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 1.9 GO:0002039 p53 binding(GO:0002039)
0.0 0.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 1.1 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 1.0 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.3 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.5 GO:0016749 N-succinyltransferase activity(GO:0016749)
0.0 1.4 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.2 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.8 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.5 GO:0004601 peroxidase activity(GO:0004601)