Motif ID: Prox1

Z-value: 0.552


Transcription factors associated with Prox1:

Gene SymbolEntrez IDGene Name
Prox1 ENSMUSG00000010175.7 Prox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prox1mm10_v2_chr1_-_190170671_190170744-0.639.3e-05Click!


Activity profile for motif Prox1.

activity profile for motif Prox1


Sorted Z-values histogram for motif Prox1

Sorted Z-values for motif Prox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prox1

PNG image of the network

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Top targets:


Showing 1 to 20 of 76 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_60144682 3.685 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr5_-_37824580 1.933 ENSMUST00000063116.9
 Msx1
msh homeobox 1
chr19_+_41911851 1.460 ENSMUST00000011896.6
 Pgam1
phosphoglycerate mutase 1
chr4_-_131821516 1.381 ENSMUST00000097860.2
 Ptpru
protein tyrosine phosphatase, receptor type, U
chr18_-_20682963 1.345 ENSMUST00000165229.2
 Gm10269
predicted gene 10269
chr4_+_130913264 1.174 ENSMUST00000156225.1
ENSMUST00000156742.1
 Laptm5

lysosomal-associated protein transmembrane 5

chr19_+_46056539 1.070 ENSMUST00000111899.1
ENSMUST00000099392.3
ENSMUST00000062322.4
 Pprc1


peroxisome proliferative activated receptor, gamma, coactivator-related 1


chr15_-_80014808 1.057 ENSMUST00000000500.6
 Pdgfb
platelet derived growth factor, B polypeptide
chr4_+_140701466 1.044 ENSMUST00000038893.5
ENSMUST00000138808.1
 Rcc2

regulator of chromosome condensation 2

chr17_-_70924958 0.934 ENSMUST00000180468.1
 Gm26510
predicted gene, 26510
chr1_-_169747634 0.858 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr6_+_58640536 0.850 ENSMUST00000145161.1
ENSMUST00000114294.1
 Abcg2

ATP-binding cassette, sub-family G (WHITE), member 2

chr5_-_138187177 0.814 ENSMUST00000110937.1
ENSMUST00000139276.1
ENSMUST00000048698.7
ENSMUST00000123415.1
 Taf6



TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor



chr4_+_130913120 0.768 ENSMUST00000151698.1
 Laptm5
lysosomal-associated protein transmembrane 5
chr19_-_43524462 0.768 ENSMUST00000026196.7
 Got1
glutamate oxaloacetate transaminase 1, soluble
chr6_-_131388417 0.767 ENSMUST00000032309.6
ENSMUST00000087865.2
 Ybx3

Y box protein 3

chr17_+_27839974 0.738 ENSMUST00000071006.7
 Snrpc
U1 small nuclear ribonucleoprotein C
chr19_-_15924560 0.724 ENSMUST00000162053.1
 Psat1
phosphoserine aminotransferase 1
chr4_-_36951223 0.690 ENSMUST00000108122.1
 Lingo2
leucine rich repeat and Ig domain containing 2
chr8_+_31111816 0.688 ENSMUST00000046941.7
 Rnf122
ring finger protein 122

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 1.9 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.5 1.5 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 1.4 GO:0034394 protein localization to cell surface(GO:0034394)
0.4 1.1 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) phenotypic switching(GO:0036166) dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697) glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.3 1.0 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.0 0.9 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.3 0.8 GO:0046618 drug export(GO:0046618)
0.3 0.8 GO:0006106 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.3 0.8 GO:1902219 regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.0 0.8 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.1 0.7 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.7 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 0.6 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.6 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036)
0.0 0.6 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.0 0.6 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.0 0.6 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.2 0.5 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.1 0.5 GO:0036506 maintenance of unfolded protein(GO:0036506) protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.0 0.5 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.0 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.8 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.8 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.8 GO:0005921 gap junction(GO:0005921)
0.1 0.7 GO:0000243 commitment complex(GO:0000243)
0.0 0.6 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.6 GO:0031932 TORC2 complex(GO:0031932)
0.1 0.5 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.4 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.4 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0002039 p53 binding(GO:0002039)
0.5 1.5 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 1.4 GO:0008013 beta-catenin binding(GO:0008013)
0.2 1.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 1.1 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 1.0 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 0.8 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.2 0.8 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.0 0.8 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 0.7 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.7 GO:0008483 transaminase activity(GO:0008483)
0.0 0.6 GO:0070300 phosphatidic acid binding(GO:0070300)
0.1 0.5 GO:1990188 euchromatin binding(GO:1990188)
0.1 0.5 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.1 0.5 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.0 0.5 GO:0016749 N-succinyltransferase activity(GO:0016749)
0.0 0.5 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.3 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.3 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)