Motif ID: Prox1
Z-value: 0.552
Transcription factors associated with Prox1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Prox1 | ENSMUSG00000010175.7 | Prox1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Prox1 | mm10_v2_chr1_-_190170671_190170744 | -0.63 | 9.3e-05 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 1.9 | GO:0035880 | embryonic nail plate morphogenesis(GO:0035880) |
0.5 | 1.5 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
0.4 | 1.1 | GO:0003104 | positive regulation of glomerular filtration(GO:0003104) negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) phenotypic switching(GO:0036166) dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697) glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262) |
0.3 | 1.0 | GO:0072356 | chromosome passenger complex localization to kinetochore(GO:0072356) |
0.3 | 0.8 | GO:0046618 | drug export(GO:0046618) |
0.3 | 0.8 | GO:0006106 | fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401) |
0.3 | 0.8 | GO:1902219 | regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219) |
0.2 | 0.5 | GO:0035633 | maintenance of blood-brain barrier(GO:0035633) |
0.1 | 0.7 | GO:0006564 | L-serine biosynthetic process(GO:0006564) |
0.1 | 0.6 | GO:0030259 | lipid glycosylation(GO:0030259) |
0.1 | 0.7 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
0.1 | 0.3 | GO:0035616 | histone H2B conserved C-terminal lysine deubiquitination(GO:0035616) |
0.1 | 0.5 | GO:0036506 | maintenance of unfolded protein(GO:0036506) protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) |
0.1 | 0.3 | GO:0010387 | COP9 signalosome assembly(GO:0010387) |
0.1 | 0.2 | GO:0070973 | COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973) |
0.1 | 0.2 | GO:0019042 | viral latency(GO:0019042) |
0.0 | 0.3 | GO:0072610 | interleukin-12 secretion(GO:0072610) regulation of interleukin-12 secretion(GO:2001182) positive regulation of interleukin-12 secretion(GO:2001184) |
0.0 | 0.2 | GO:1990414 | replication-born double-strand break repair via sister chromatid exchange(GO:1990414) |
0.0 | 0.2 | GO:1902775 | mitochondrial large ribosomal subunit assembly(GO:1902775) |
0.0 | 0.5 | GO:0048096 | chromatin-mediated maintenance of transcription(GO:0048096) |
0.0 | 0.6 | GO:0035036 | binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) |
0.0 | 0.1 | GO:0090292 | nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292) |
0.0 | 0.6 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
0.0 | 1.4 | GO:0034394 | protein localization to cell surface(GO:0034394) |
0.0 | 0.1 | GO:0010796 | regulation of multivesicular body size(GO:0010796) |
0.0 | 0.4 | GO:0048268 | clathrin coat assembly(GO:0048268) |
0.0 | 0.9 | GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744) |
0.0 | 0.3 | GO:0002082 | regulation of oxidative phosphorylation(GO:0002082) |
0.0 | 0.5 | GO:0006783 | heme biosynthetic process(GO:0006783) |
0.0 | 0.3 | GO:0006465 | signal peptide processing(GO:0006465) |
0.0 | 0.6 | GO:0021680 | cerebellar Purkinje cell layer development(GO:0021680) |
0.0 | 0.8 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
0.0 | 0.5 | GO:0033209 | tumor necrosis factor-mediated signaling pathway(GO:0033209) |
0.0 | 0.5 | GO:0032611 | interleukin-1 beta production(GO:0032611) |
0.0 | 0.6 | GO:0046580 | negative regulation of Ras protein signal transduction(GO:0046580) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.0 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
0.1 | 0.5 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
0.1 | 0.7 | GO:0000243 | commitment complex(GO:0000243) |
0.1 | 0.8 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
0.0 | 0.6 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
0.0 | 0.6 | GO:0031932 | TORC2 complex(GO:0031932) |
0.0 | 0.8 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
0.0 | 0.8 | GO:0005921 | gap junction(GO:0005921) |
0.0 | 0.4 | GO:0031011 | Ino80 complex(GO:0031011) |
0.0 | 0.1 | GO:0005828 | kinetochore microtubule(GO:0005828) |
0.0 | 0.9 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
0.0 | 0.1 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
0.0 | 0.4 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.5 | GO:0046538 | bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
0.3 | 0.8 | GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) |
0.2 | 1.1 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
0.2 | 0.8 | GO:0008559 | xenobiotic-transporting ATPase activity(GO:0008559) |
0.1 | 0.7 | GO:1990446 | U1 snRNP binding(GO:1990446) |
0.1 | 0.5 | GO:1990188 | euchromatin binding(GO:1990188) |
0.1 | 0.5 | GO:0016668 | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668) |
0.1 | 0.5 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
0.0 | 0.2 | GO:0004165 | dodecenoyl-CoA delta-isomerase activity(GO:0004165) |
0.0 | 0.7 | GO:0008483 | transaminase activity(GO:0008483) |
0.0 | 0.6 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
0.0 | 0.3 | GO:0046974 | histone methyltransferase activity (H3-K9 specific)(GO:0046974) |
0.0 | 0.2 | GO:0009378 | four-way junction helicase activity(GO:0009378) |
0.0 | 0.2 | GO:0043995 | histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972) |
0.0 | 1.9 | GO:0002039 | p53 binding(GO:0002039) |
0.0 | 0.9 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
0.0 | 1.1 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
0.0 | 1.0 | GO:0048365 | Rac GTPase binding(GO:0048365) |
0.0 | 0.3 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
0.0 | 0.5 | GO:0016749 | N-succinyltransferase activity(GO:0016749) |
0.0 | 1.4 | GO:0008013 | beta-catenin binding(GO:0008013) |
0.0 | 0.2 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
0.0 | 0.8 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
0.0 | 0.5 | GO:0004601 | peroxidase activity(GO:0004601) |