Motif ID: Prrx1_Isx_Prrxl1

Z-value: 0.436

Transcription factors associated with Prrx1_Isx_Prrxl1:

Gene SymbolEntrez IDGene Name
Isx ENSMUSG00000031621.3 Isx
Prrx1 ENSMUSG00000026586.10 Prrx1
Prrxl1 ENSMUSG00000041730.7 Prrxl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prrx1mm10_v2_chr1_-_163289214_1632892350.309.1e-02Click!
Prrxl1mm10_v2_chr14_+_32599922_325999320.009.9e-01Click!


Activity profile for motif Prrx1_Isx_Prrxl1.

activity profile for motif Prrx1_Isx_Prrxl1


Sorted Z-values histogram for motif Prrx1_Isx_Prrxl1

Sorted Z-values for motif Prrx1_Isx_Prrxl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prrx1_Isx_Prrxl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_146121655 3.310 ENSMUST00000039450.4
 Mcoln3
mucolipin 3
chr17_+_27556613 2.590 ENSMUST00000117600.1
ENSMUST00000114888.3
 Hmga1

high mobility group AT-hook 1

chr17_+_27556668 2.584 ENSMUST00000117254.1
ENSMUST00000118570.1
 Hmga1

high mobility group AT-hook 1

chr17_+_27556641 2.441 ENSMUST00000119486.1
ENSMUST00000118599.1
 Hmga1

high mobility group AT-hook 1

chr12_+_79297345 1.827 ENSMUST00000079533.5
ENSMUST00000171210.1
 Rad51b

RAD51 homolog B

chr4_-_134767940 1.343 ENSMUST00000037828.6
 Ldlrap1
low density lipoprotein receptor adaptor protein 1
chr3_+_159839729 1.329 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr8_-_106573461 1.232 ENSMUST00000073722.5
 Gm10073
predicted pseudogene 10073
chr3_+_122419772 1.158 ENSMUST00000029766.4
 Bcar3
breast cancer anti-estrogen resistance 3
chr12_-_57546121 1.150 ENSMUST00000044380.6
 Foxa1
forkhead box A1
chr3_-_59220150 1.108 ENSMUST00000170388.1
 P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr12_-_73047179 1.079 ENSMUST00000050029.7
 Six1
sine oculis-related homeobox 1
chr2_-_67194695 1.066 ENSMUST00000147939.1
 Gm13598
predicted gene 13598
chr15_-_9140374 1.051 ENSMUST00000096482.3
ENSMUST00000110585.2
 Skp2

S-phase kinase-associated protein 2 (p45)

chr2_+_14873656 1.031 ENSMUST00000114718.1
ENSMUST00000114719.1
 Cacnb2

calcium channel, voltage-dependent, beta 2 subunit

chr14_+_73237891 1.015 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr19_+_38395980 0.974 ENSMUST00000054098.2
 Slc35g1
solute carrier family 35, member G1
chr6_-_34317442 0.955 ENSMUST00000154655.1
ENSMUST00000102980.4
 Akr1b3

aldo-keto reductase family 1, member B3 (aldose reductase)

chr18_+_74442551 0.939 ENSMUST00000121875.1
 Myo5b
myosin VB
chr11_+_94936224 0.885 ENSMUST00000001547.7
 Col1a1
collagen, type I, alpha 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.6 GO:0006284 base-excision repair(GO:0006284)
0.0 2.3 GO:0042491 auditory receptor cell differentiation(GO:0042491)
0.5 1.8 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.4 1.8 GO:0032439 endosome localization(GO:0032439)
0.1 1.3 GO:0032367 intracellular cholesterol transport(GO:0032367)
0.1 1.3 GO:0031017 exocrine pancreas development(GO:0031017)
0.1 1.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.4 1.2 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743) alveolar secondary septum development(GO:0061144)
0.0 1.2 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.4 1.1 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.4 1.1 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.1 1.1 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.3 1.0 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.3 1.0 GO:1990034 calcium ion export from cell(GO:1990034)
0.3 1.0 GO:0006059 hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.2 1.0 GO:0015692 vanadium ion transport(GO:0015676) lead ion transport(GO:0015692)
0.1 0.9 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.9 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.9 GO:0006270 DNA replication initiation(GO:0006270)
0.3 0.8 GO:0009106 lipoate metabolic process(GO:0009106)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 7.6 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 2.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.4 1.8 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.3 1.8 GO:0045179 apical cortex(GO:0045179)
0.3 1.3 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 1.3 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 1.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 1.0 GO:0097454 Schwann cell microvillus(GO:0097454)
0.2 1.0 GO:0070826 paraferritin complex(GO:0070826)
0.1 1.0 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.3 0.9 GO:0005584 collagen type I trimer(GO:0005584)
0.1 0.9 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.3 0.8 GO:0031983 vesicle lumen(GO:0031983)
0.1 0.8 GO:0034709 methylosome(GO:0034709)
0.1 0.7 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.6 GO:0005687 U4 snRNP(GO:0005687)
0.1 0.6 GO:0045277 respiratory chain complex IV(GO:0045277)
0.1 0.6 GO:0005916 fascia adherens(GO:0005916)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 7.6 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.3 1.8 GO:0000150 recombinase activity(GO:0000150)
0.0 1.5 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.1 1.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 1.3 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.2 1.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.2 1.0 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.2 1.0 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.1 0.9 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.1 0.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.9 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.8 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.8 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.8 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.8 GO:0016415 octanoyltransferase activity(GO:0016415)
0.1 0.7 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.7 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 0.6 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.1 0.6 GO:0071253 connexin binding(GO:0071253)