Motif ID: Rad21_Smc3

Z-value: 0.951

Transcription factors associated with Rad21_Smc3:

Gene SymbolEntrez IDGene Name
Rad21 ENSMUSG00000022314.9 Rad21
Smc3 ENSMUSG00000024974.10 Smc3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smc3mm10_v2_chr19_+_53600377_53600435-0.551.0e-03Click!
Rad21mm10_v2_chr15_-_51991679_51991760-0.115.4e-01Click!


Activity profile for motif Rad21_Smc3.

activity profile for motif Rad21_Smc3


Sorted Z-values histogram for motif Rad21_Smc3

Sorted Z-values for motif Rad21_Smc3



Network of associatons between targets according to the STRING database.



First level regulatory network of Rad21_Smc3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_74442551 6.821 ENSMUST00000121875.1
 Myo5b
myosin VB
chr18_+_74442500 6.508 ENSMUST00000074157.6
 Myo5b
myosin VB
chr13_+_98354234 6.000 ENSMUST00000105098.3
 Foxd1
forkhead box D1
chr2_-_166155272 5.992 ENSMUST00000088086.3
 Sulf2
sulfatase 2
chr2_+_167538192 5.529 ENSMUST00000052631.7
 Snai1
snail homolog 1 (Drosophila)
chr4_+_63215402 5.493 ENSMUST00000036300.6
 Col27a1
collagen, type XXVII, alpha 1
chr19_-_10240689 5.134 ENSMUST00000088013.5
 Myrf
myelin regulatory factor
chr8_+_119446719 4.584 ENSMUST00000098363.3
 Necab2
N-terminal EF-hand calcium binding protein 2
chr10_-_31445921 4.532 ENSMUST00000000305.5
 Tpd52l1
tumor protein D52-like 1
chr2_-_158146385 4.512 ENSMUST00000103122.3
 Tgm2
transglutaminase 2, C polypeptide
chr4_+_100095791 4.432 ENSMUST00000039630.5
 Ror1
receptor tyrosine kinase-like orphan receptor 1
chr13_-_53286052 4.122 ENSMUST00000021918.8
 Ror2
receptor tyrosine kinase-like orphan receptor 2
chr2_+_26586607 3.950 ENSMUST00000174211.1
ENSMUST00000145575.2
ENSMUST00000173920.1
 Egfl7


EGF-like domain 7


chr3_-_84155762 3.878 ENSMUST00000047368.6
 Mnd1
meiotic nuclear divisions 1 homolog (S. cerevisiae)
chr9_+_66158206 3.740 ENSMUST00000034944.2
 Dapk2
death-associated protein kinase 2
chr6_-_87335758 3.472 ENSMUST00000042025.9
 Antxr1
anthrax toxin receptor 1
chr12_-_56536895 3.394 ENSMUST00000001536.8
 Nkx2-1
NK2 homeobox 1
chr10_+_3973086 3.357 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
 Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr13_-_113046357 3.339 ENSMUST00000022282.3
 Gpx8
glutathione peroxidase 8 (putative)
chr14_+_33319703 3.303 ENSMUST00000111955.1
 Arhgap22
Rho GTPase activating protein 22

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 226 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 13.3 GO:0032439 endosome localization(GO:0032439)
3.1 9.3 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
2.1 8.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
2.0 6.0 GO:0072076 nephrogenic mesenchyme development(GO:0072076)
1.1 5.5 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.0 5.4 GO:0051321 meiotic cell cycle(GO:0051321)
1.8 5.3 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.6 5.1 GO:0032286 central nervous system myelin maintenance(GO:0032286)
1.5 4.5 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.9 4.4 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.7 4.3 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.1 4.3 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 4.2 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.8 4.1 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.2 4.1 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.4 3.9 GO:0032825 positive regulation of natural killer cell differentiation(GO:0032825)
1.2 3.7 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
1.2 3.5 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.1 3.5 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
1.1 3.4 GO:0021759 globus pallidus development(GO:0021759)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 13.7 GO:0045179 apical cortex(GO:0045179)
0.0 9.1 GO:0031012 extracellular matrix(GO:0031012)
0.0 8.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 6.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 6.2 GO:0005667 transcription factor complex(GO:0005667)
0.4 5.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 4.9 GO:0005769 early endosome(GO:0005769)
0.1 4.7 GO:0005844 polysome(GO:0005844)
0.0 4.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 4.0 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 3.8 GO:0009925 basal plasma membrane(GO:0009925)
0.0 3.8 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 3.7 GO:0005838 proteasome regulatory particle(GO:0005838)
0.4 3.5 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.3 3.5 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 3.2 GO:0000242 pericentriolar material(GO:0000242)
0.1 3.2 GO:0005902 microvillus(GO:0005902)
0.0 3.2 GO:0005925 focal adhesion(GO:0005925)
0.1 3.1 GO:0005581 collagen trimer(GO:0005581)
0.2 3.0 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 166 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 9.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 9.7 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
3.1 9.3 GO:0004454 ketohexokinase activity(GO:0004454)
1.6 8.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 7.8 GO:0046982 protein heterodimerization activity(GO:0046982)
0.3 6.1 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.5 6.0 GO:0008301 DNA binding, bending(GO:0008301)
0.2 5.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.7 5.1 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 4.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 4.9 GO:0005096 GTPase activator activity(GO:0005096)
0.0 4.6 GO:0008234 cysteine-type peptidase activity(GO:0008234)
1.1 4.5 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.2 4.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 4.3 GO:0005112 Notch binding(GO:0005112)
0.2 3.8 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.4 3.5 GO:0008097 5S rRNA binding(GO:0008097)
0.8 3.4 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0 3.4 GO:0005125 cytokine activity(GO:0005125)