Motif ID: Rara

Z-value: 0.689


Transcription factors associated with Rara:

Gene SymbolEntrez IDGene Name
Rara ENSMUSG00000037992.10 Rara

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Raramm10_v2_chr11_+_98927785_989278180.475.6e-03Click!


Activity profile for motif Rara.

activity profile for motif Rara


Sorted Z-values histogram for motif Rara

Sorted Z-values for motif Rara



Network of associatons between targets according to the STRING database.



First level regulatory network of Rara

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_94875600 4.710 ENSMUST00000022195.10
 Otp
orthopedia homolog (Drosophila)
chr6_+_30723541 3.215 ENSMUST00000115127.1
 Mest
mesoderm specific transcript
chr4_-_141599835 3.023 ENSMUST00000141518.1
ENSMUST00000127455.1
ENSMUST00000105784.1
ENSMUST00000147785.1
 Fblim1



filamin binding LIM protein 1



chr17_+_34593388 2.731 ENSMUST00000174532.1
 Pbx2
pre B cell leukemia homeobox 2
chr11_+_98960412 2.156 ENSMUST00000107473.2
 Rara
retinoic acid receptor, alpha
chr4_+_150853919 2.059 ENSMUST00000073600.2
 Errfi1
ERBB receptor feedback inhibitor 1
chr14_-_16575456 1.730 ENSMUST00000063750.6
 Rarb
retinoic acid receptor, beta
chr14_+_55618023 1.508 ENSMUST00000002395.7
 Rec8
REC8 homolog (yeast)
chr12_-_108893197 1.441 ENSMUST00000161154.1
ENSMUST00000161410.1
 Wars

tryptophanyl-tRNA synthetase

chr2_+_5845243 1.392 ENSMUST00000127116.1
 Nudt5
nudix (nucleoside diphosphate linked moiety X)-type motif 5
chr4_-_128609981 1.349 ENSMUST00000141040.1
ENSMUST00000147876.1
ENSMUST00000097877.2
 Zscan20


zinc finger and SCAN domains 20


chr1_-_175692624 1.339 ENSMUST00000027809.7
 Opn3
opsin 3
chr11_+_94629741 1.292 ENSMUST00000021239.6
 Lrrc59
leucine rich repeat containing 59
chr4_+_48045144 1.143 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr11_-_5915124 1.037 ENSMUST00000109823.2
ENSMUST00000109822.1
 Gck

glucokinase

chr4_+_32238950 0.957 ENSMUST00000037416.6
 Bach2
BTB and CNC homology 2
chr12_+_87026564 0.944 ENSMUST00000110187.1
ENSMUST00000156162.1
 Tmem63c

transmembrane protein 63c

chr2_-_5012716 0.924 ENSMUST00000027980.7
 Mcm10
minichromosome maintenance deficient 10 (S. cerevisiae)
chr2_+_5845017 0.897 ENSMUST00000026927.3
ENSMUST00000179748.1
 Nudt5

nudix (nucleoside diphosphate linked moiety X)-type motif 5

chr6_-_6217023 0.875 ENSMUST00000015256.8
 Slc25a13
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
chr3_-_36475688 0.820 ENSMUST00000029266.8
 Anxa5
annexin A5
chr7_+_120635176 0.791 ENSMUST00000033176.5
 Uqcrc2
ubiquinol cytochrome c reductase core protein 2
chr8_-_94876269 0.778 ENSMUST00000046461.7
 Dok4
docking protein 4
chr19_-_7241216 0.750 ENSMUST00000025675.9
 Naa40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr2_+_26319741 0.749 ENSMUST00000066889.6
 Gpsm1
G-protein signalling modulator 1 (AGS3-like, C. elegans)
chrX_+_106187100 0.734 ENSMUST00000081593.6
 Pgk1
phosphoglycerate kinase 1
chr14_+_58070547 0.684 ENSMUST00000165526.1
 Fgf9
fibroblast growth factor 9
chr11_-_50953745 0.653 ENSMUST00000162420.1
ENSMUST00000051159.2
 Prop1

paired like homeodomain factor 1

chr4_+_41348996 0.643 ENSMUST00000072866.5
ENSMUST00000108060.3
 Ubap1

ubiquitin-associated protein 1

chr6_+_91157373 0.591 ENSMUST00000155007.1
 Hdac11
histone deacetylase 11
chr11_-_97700327 0.587 ENSMUST00000018681.7
 Pcgf2
polycomb group ring finger 2
chr8_+_106150359 0.564 ENSMUST00000034377.6
 Pla2g15
phospholipase A2, group XV
chr11_+_4986824 0.546 ENSMUST00000009234.9
ENSMUST00000109897.1
 Ap1b1

adaptor protein complex AP-1, beta 1 subunit

chr2_-_5845164 0.533 ENSMUST00000043864.3
 Cdc123
cell division cycle 123
chrX_+_74254736 0.507 ENSMUST00000096424.4
 Emd
emerin
chr8_-_119778380 0.501 ENSMUST00000049156.5
 Tldc1
TBC/LysM associated domain containing 1
chr14_+_76488436 0.500 ENSMUST00000101618.2
 Tsc22d1
TSC22 domain family, member 1
chr7_-_17056669 0.464 ENSMUST00000037762.4
 Hif3a
hypoxia inducible factor 3, alpha subunit
chr4_+_141444654 0.462 ENSMUST00000006377.6
 Zbtb17
zinc finger and BTB domain containing 17
chr2_-_34754364 0.451 ENSMUST00000142436.1
ENSMUST00000113099.3
ENSMUST00000028224.8
 Gapvd1


GTPase activating protein and VPS9 domains 1


chrX_+_74254782 0.438 ENSMUST00000119197.1
ENSMUST00000088313.4
 Emd

emerin

chr17_-_32388885 0.437 ENSMUST00000087703.5
ENSMUST00000170603.1
 Wiz

widely-interspaced zinc finger motifs

chr3_+_152210458 0.434 ENSMUST00000166984.1
ENSMUST00000106121.1
 Fubp1

far upstream element (FUSE) binding protein 1

chr10_+_19951055 0.415 ENSMUST00000152533.1
 Map3k5
mitogen-activated protein kinase kinase kinase 5
chr9_-_109074049 0.408 ENSMUST00000161521.1
ENSMUST00000045011.2
 Atrip

ATR interacting protein

chrX_-_75874536 0.396 ENSMUST00000033547.7
 Pls3
plastin 3 (T-isoform)
chr10_+_79910856 0.388 ENSMUST00000181321.1
 Gm26602
predicted gene, 26602
chr6_+_18848571 0.383 ENSMUST00000056398.8
 Naa38
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
chr5_+_53590215 0.377 ENSMUST00000037618.6
 Rbpj
recombination signal binding protein for immunoglobulin kappa J region
chr2_+_131262469 0.322 ENSMUST00000150843.1
 Pank2
pantothenate kinase 2
chr2_+_181365384 0.275 ENSMUST00000108807.2
 Zgpat
zinc finger, CCCH-type with G patch domain
chr14_+_20674311 0.274 ENSMUST00000048657.8
 Sec24c
Sec24 related gene family, member C (S. cerevisiae)
chr2_-_181365306 0.270 ENSMUST00000108808.1
ENSMUST00000170190.1
ENSMUST00000127988.1
 Arfrp1


ADP-ribosylation factor related protein 1


chr6_+_115601907 0.260 ENSMUST00000000449.7
 Mkrn2
makorin, ring finger protein, 2
chr7_-_141429351 0.250 ENSMUST00000164387.1
ENSMUST00000137488.1
ENSMUST00000084436.3
 Cend1


cell cycle exit and neuronal differentiation 1


chr9_-_43105718 0.214 ENSMUST00000165665.1
 Arhgef12
Rho guanine nucleotide exchange factor (GEF) 12
chr1_+_134037490 0.214 ENSMUST00000162779.1
 Fmod
fibromodulin
chr7_+_45873127 0.202 ENSMUST00000107718.1
 Kdelr1
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
chr3_-_95015214 0.197 ENSMUST00000128438.1
ENSMUST00000149747.1
ENSMUST00000019482.1
 Zfp687


zinc finger protein 687


chr10_-_89257790 0.195 ENSMUST00000045601.7
 Ano4
anoctamin 4
chr7_-_141429433 0.193 ENSMUST00000124444.1
 Cend1
cell cycle exit and neuronal differentiation 1
chr1_-_36369173 0.189 ENSMUST00000010597.3
 Kansl3
KAT8 regulatory NSL complex subunit 3
chr7_+_17150210 0.176 ENSMUST00000108491.1
ENSMUST00000065540.5
 Ceacam3

carcinoembryonic antigen-related cell adhesion molecule 3

chr3_-_54915867 0.130 ENSMUST00000070342.3
 Sertm1
serine rich and transmembrane domain containing 1
chrX_-_59567348 0.117 ENSMUST00000124402.1
 Fgf13
fibroblast growth factor 13
chr8_+_11556061 0.093 ENSMUST00000054399.4
 Ing1
inhibitor of growth family, member 1
chr13_+_49421229 0.083 ENSMUST00000021817.8
 Ippk
inositol 1,3,4,5,6-pentakisphosphate 2-kinase
chr7_+_45872772 0.079 ENSMUST00000002855.5
ENSMUST00000107719.1
 Kdelr1

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1

chr9_+_54586450 0.020 ENSMUST00000167866.1
 Idh3a
isocitrate dehydrogenase 3 (NAD+) alpha
chr1_-_163403627 0.018 ENSMUST00000045138.4
 Gorab
golgin, RAB6-interacting
chr4_-_152318458 0.006 ENSMUST00000170820.1
ENSMUST00000076183.5
 Rnf207

ring finger protein 207


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.7 2.1 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.5 1.4 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.4 1.3 GO:0018298 protein-chromophore linkage(GO:0018298)
0.4 5.4 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.4 1.1 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.3 1.0 GO:0034287 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.3 1.7 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.2 0.9 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.2 3.0 GO:0033623 regulation of integrin activation(GO:0033623)
0.2 0.8 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.2 0.5 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.2 2.3 GO:0009191 ribonucleoside diphosphate catabolic process(GO:0009191)
0.1 0.4 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
0.1 1.5 GO:0007141 male meiosis I(GO:0007141)
0.1 0.4 GO:0072554 arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel lumenization(GO:0072554) blood vessel endothelial cell fate specification(GO:0097101) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of heart induction(GO:1901321) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.1 0.6 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 3.2 GO:0010883 regulation of lipid storage(GO:0010883)
0.1 2.7 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 0.8 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 0.2 GO:0061588 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylserine scrambling(GO:0061589) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.1 0.4 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.1 0.7 GO:0060484 lung-associated mesenchyme development(GO:0060484)
0.0 0.9 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.3 GO:1904251 regulation of bile acid metabolic process(GO:1904251)
0.0 0.4 GO:1904707 positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.0 0.3 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.6 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.5 GO:0007398 ectoderm development(GO:0007398)
0.0 0.9 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.3 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.5 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.1 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0 0.4 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.2 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.0 0.6 GO:0014003 oligodendrocyte development(GO:0014003)
0.0 0.7 GO:0006094 gluconeogenesis(GO:0006094)
0.0 0.1 GO:0006020 inositol metabolic process(GO:0006020)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0000798 nuclear cohesin complex(GO:0000798) nuclear meiotic cohesin complex(GO:0034991)
0.2 0.9 GO:0031298 replication fork protection complex(GO:0031298)
0.1 0.4 GO:0031417 NatC complex(GO:0031417)
0.1 0.8 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 0.4 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 0.4 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 0.6 GO:0000813 ESCRT I complex(GO:0000813)
0.1 1.0 GO:0045180 basal cortex(GO:0045180)
0.1 0.6 GO:0001739 sex chromatin(GO:0001739)
0.1 0.9 GO:0005652 nuclear lamina(GO:0005652)
0.0 1.3 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 2.0 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.5 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.9 GO:0014704 intercalated disc(GO:0014704)
0.0 4.5 GO:0005667 transcription factor complex(GO:0005667)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.4 1.3 GO:0009881 photoreceptor activity(GO:0009881)
0.3 2.3 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.2 2.2 GO:0001972 retinoic acid binding(GO:0001972)
0.2 0.9 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.2 3.0 GO:0031005 filamin binding(GO:0031005)
0.2 0.7 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.2 1.6 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.2 1.0 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396)
0.1 0.9 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 1.7 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 3.2 GO:0052771 coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.1 0.3 GO:0046923 ER retention sequence binding(GO:0046923)
0.1 0.3 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 0.8 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.6 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.1 0.6 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.6 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.2 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.7 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.9 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.7 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.6 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.7 GO:0034945 dihydrolipoamide branched chain acyltransferase activity(GO:0004147) palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity(GO:0008951) serine O-acyltransferase activity(GO:0016412) O-succinyltransferase activity(GO:0016750) sinapoyltransferase activity(GO:0016752) O-sinapoyltransferase activity(GO:0016753) peptidyl-lysine N6-myristoyltransferase activity(GO:0018030) peptidyl-lysine N6-palmitoyltransferase activity(GO:0018031) benzoyl acetate-CoA thiolase activity(GO:0018711) 3-hydroxybutyryl-CoA thiolase activity(GO:0018712) 3-ketopimelyl-CoA thiolase activity(GO:0018713) N-palmitoyltransferase activity(GO:0019105) acyl-CoA N-acyltransferase activity(GO:0019186) protein-cysteine S-myristoyltransferase activity(GO:0019705) glucosaminyl-phosphotidylinositol O-acyltransferase activity(GO:0032216) ergosterol O-acyltransferase activity(GO:0034737) lanosterol O-acyltransferase activity(GO:0034738) naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity(GO:0034848) 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity(GO:0034851) 2-methylhexanoyl-CoA C-acetyltransferase activity(GO:0034915) butyryl-CoA 2-C-propionyltransferase activity(GO:0034919) 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity(GO:0034945) L-2-aminoadipate N-acetyltransferase activity(GO:0043741) keto acid formate lyase activity(GO:0043806) azetidine-2-carboxylic acid acetyltransferase activity(GO:0046941) peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0052858) acetyl-CoA:L-lysine N6-acetyltransferase(GO:0090595)
0.0 0.2 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 1.1 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.5 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.8 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 2.1 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.4 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)