Motif ID: Rela_Rel_Nfkb1

Z-value: 1.176

Transcription factors associated with Rela_Rel_Nfkb1:

Gene SymbolEntrez IDGene Name
Nfkb1 ENSMUSG00000028163.11 Nfkb1
Rel ENSMUSG00000020275.8 Rel
Rela ENSMUSG00000024927.7 Rela

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfkb1mm10_v2_chr3_-_135691512_1356915640.861.1e-10Click!
Relamm10_v2_chr19_+_5637475_5637486-0.029.2e-01Click!


Activity profile for motif Rela_Rel_Nfkb1.

activity profile for motif Rela_Rel_Nfkb1


Sorted Z-values histogram for motif Rela_Rel_Nfkb1

Sorted Z-values for motif Rela_Rel_Nfkb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Rela_Rel_Nfkb1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_103843154 8.417 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr15_-_79164477 7.884 ENSMUST00000040019.4
 Sox10
SRY-box containing gene 10
chr2_-_165234689 6.156 ENSMUST00000065438.6
 Cdh22
cadherin 22
chr7_-_25788635 5.639 ENSMUST00000002677.4
ENSMUST00000085948.4
 Axl

AXL receptor tyrosine kinase

chr2_+_10153563 5.558 ENSMUST00000026886.7
 Itih5
inter-alpha (globulin) inhibitor H5
chr19_+_46304709 4.736 ENSMUST00000073116.5
 Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr13_+_112464070 4.508 ENSMUST00000183663.1
ENSMUST00000184311.1
ENSMUST00000183886.1
 Il6st


interleukin 6 signal transducer


chr6_+_4755327 4.501 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr18_+_4994600 4.272 ENSMUST00000140448.1
 Svil
supervillin
chr6_-_24956106 3.762 ENSMUST00000127247.2
 Tmem229a
transmembrane protein 229A
chr4_+_42240639 3.733 ENSMUST00000117202.2
 Gm10600
predicted gene 10600
chr5_-_37824580 3.653 ENSMUST00000063116.9
 Msx1
msh homeobox 1
chr14_-_70642268 3.439 ENSMUST00000022697.5
 Fgf17
fibroblast growth factor 17
chr8_-_61902669 3.291 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr12_+_79029150 3.154 ENSMUST00000039928.5
 Plekhh1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr11_+_90030295 3.028 ENSMUST00000092788.3
 Tmem100
transmembrane protein 100
chr19_-_58455161 2.947 ENSMUST00000135730.1
ENSMUST00000152507.1
 Gfra1

glial cell line derived neurotrophic factor family receptor alpha 1

chr8_-_122432924 2.707 ENSMUST00000017604.8
 Cyba
cytochrome b-245, alpha polypeptide
chr19_-_58454435 2.687 ENSMUST00000169850.1
 Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr2_-_156839790 2.654 ENSMUST00000134838.1
ENSMUST00000137463.1
ENSMUST00000149275.2
 Gm14230


predicted gene 14230



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 231 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 9.3 GO:0048484 enteric nervous system development(GO:0048484)
1.7 8.4 GO:0015671 oxygen transport(GO:0015671)
0.9 5.6 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.2 5.6 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 5.0 GO:0007519 skeletal muscle tissue development(GO:0007519)
1.6 4.7 GO:0070103 regulation of interleukin-6-mediated signaling pathway(GO:0070103) negative regulation of interleukin-6-mediated signaling pathway(GO:0070104)
0.3 4.5 GO:0002467 germinal center formation(GO:0002467)
0.2 4.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 4.5 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.4 4.3 GO:0008063 Toll signaling pathway(GO:0008063)
0.5 4.2 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
1.2 3.7 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.5 3.7 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.2 3.5 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.3 3.4 GO:0060056 mammary gland involution(GO:0060056)
0.1 3.3 GO:0033622 integrin activation(GO:0033622)
0.9 2.8 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.5 2.6 GO:0045657 positive regulation of monocyte differentiation(GO:0045657)
0.1 2.6 GO:0035082 axoneme assembly(GO:0035082)
0.0 2.6 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 11.3 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 9.4 GO:0031225 anchored component of membrane(GO:0031225)
1.1 8.4 GO:0005833 hemoglobin complex(GO:0005833)
1.0 8.2 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.3 6.7 GO:0043657 host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657)
0.0 6.2 GO:0043209 myelin sheath(GO:0043209)
0.2 6.0 GO:0043034 costamere(GO:0043034)
0.0 5.4 GO:0005667 transcription factor complex(GO:0005667)
0.1 5.0 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
1.5 4.5 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.2 3.8 GO:0002102 podosome(GO:0002102)
0.2 3.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 3.0 GO:0005581 collagen trimer(GO:0005581)
0.6 2.5 GO:0043020 NADPH oxidase complex(GO:0043020)
0.4 2.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 2.3 GO:0016324 apical plasma membrane(GO:0016324)
0.3 2.2 GO:0001520 outer dense fiber(GO:0001520)
0.2 2.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.3 2.1 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 2.1 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 156 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.4 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 10.0 GO:0005178 integrin binding(GO:0005178)
2.1 8.4 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.1 8.1 GO:0051015 actin filament binding(GO:0051015)
0.6 5.6 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 4.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 4.7 GO:0002039 p53 binding(GO:0002039)
0.0 4.7 GO:0005525 GTP binding(GO:0005525)
1.5 4.5 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923) oncostatin-M receptor activity(GO:0004924)
0.1 4.5 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.4 4.3 GO:0031996 thioesterase binding(GO:0031996)
0.1 3.7 GO:0005109 frizzled binding(GO:0005109)
1.1 3.4 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.2 3.4 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 3.2 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 3.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 3.0 GO:0042805 actinin binding(GO:0042805)
0.9 2.8 GO:0016880 acid-ammonia (or amide) ligase activity(GO:0016880)
0.2 2.8 GO:0046977 TAP binding(GO:0046977)
0.0 2.7 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)