Motif ID: Relb

Z-value: 0.678


Transcription factors associated with Relb:

Gene SymbolEntrez IDGene Name
Relb ENSMUSG00000002983.10 Relb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Relbmm10_v2_chr7_-_19629355_196294510.771.9e-07Click!


Activity profile for motif Relb.

activity profile for motif Relb


Sorted Z-values histogram for motif Relb

Sorted Z-values for motif Relb



Network of associatons between targets according to the STRING database.



First level regulatory network of Relb

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_5714490 5.837 ENSMUST00000044009.7
Camk1d
calcium/calmodulin-dependent protein kinase ID
chr15_-_79164477 5.033 ENSMUST00000040019.4
Sox10
SRY-box containing gene 10
chr9_+_64385626 4.073 ENSMUST00000093829.2
ENSMUST00000118485.1
ENSMUST00000164113.1
Megf11


multiple EGF-like-domains 11


chr11_+_90030295 3.477 ENSMUST00000092788.3
Tmem100
transmembrane protein 100
chr2_+_10153563 3.090 ENSMUST00000026886.7
Itih5
inter-alpha (globulin) inhibitor H5
chr9_+_64385675 2.888 ENSMUST00000068967.4
Megf11
multiple EGF-like-domains 11
chr1_+_152399824 2.763 ENSMUST00000044311.8
Colgalt2
collagen beta(1-O)galactosyltransferase 2
chr2_-_5063996 2.611 ENSMUST00000114996.1
Optn
optineurin
chr4_+_129985098 2.465 ENSMUST00000106017.1
ENSMUST00000121049.1
Bai2

brain-specific angiogenesis inhibitor 2

chr4_+_129984833 2.295 ENSMUST00000120204.1
Bai2
brain-specific angiogenesis inhibitor 2
chr2_-_5063932 2.262 ENSMUST00000027986.4
Optn
optineurin
chrX_+_163909132 1.818 ENSMUST00000033734.7
ENSMUST00000112294.2
Ap1s2

adaptor-related protein complex 1, sigma 2 subunit

chr3_-_9610074 1.653 ENSMUST00000041124.7
Zfp704
zinc finger protein 704
chr3_-_107760221 1.563 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
Csf1


colony stimulating factor 1 (macrophage)


chr7_+_99535439 1.301 ENSMUST00000098266.2
ENSMUST00000179755.1
Arrb1

arrestin, beta 1

chrX_+_163908982 1.259 ENSMUST00000069041.8
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr10_-_93310963 1.215 ENSMUST00000151153.1
Elk3
ELK3, member of ETS oncogene family
chr15_-_98677451 1.171 ENSMUST00000120997.1
ENSMUST00000109149.2
ENSMUST00000003451.4
Rnd1


Rho family GTPase 1


chr7_+_99535652 1.138 ENSMUST00000032995.8
ENSMUST00000162404.1
Arrb1

arrestin, beta 1

chr10_-_93311073 1.131 ENSMUST00000008542.5
Elk3
ELK3, member of ETS oncogene family
chr7_+_43463145 1.100 ENSMUST00000107977.1
Vsig10l
ZV-set and immunoglobulin domain containing 10 like
chr7_-_19629355 1.040 ENSMUST00000049912.8
ENSMUST00000094762.3
ENSMUST00000098754.4
Relb


avian reticuloendotheliosis viral (v-rel) oncogene related B


chr7_-_99626936 1.002 ENSMUST00000178124.1
Gm4980
predicted gene 4980
chr14_+_80000292 0.990 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr18_+_37484955 0.985 ENSMUST00000053856.4
Pcdhb17
protocadherin beta 17
chr16_-_55838827 0.939 ENSMUST00000096026.2
ENSMUST00000036273.6
ENSMUST00000114457.1
Nfkbiz


nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta


chrX_+_36112110 0.917 ENSMUST00000033418.7
Il13ra1
interleukin 13 receptor, alpha 1
chr13_+_83732438 0.897 ENSMUST00000182701.1
C130071C03Rik
RIKEN cDNA C130071C03 gene
chr5_+_150259922 0.871 ENSMUST00000087204.5
Fry
furry homolog (Drosophila)
chr7_+_28766747 0.806 ENSMUST00000170068.1
ENSMUST00000072965.4
Sirt2

sirtuin 2

chr12_+_102948843 0.658 ENSMUST00000101099.5
Unc79
unc-79 homolog (C. elegans)
chrX_+_141475385 0.652 ENSMUST00000112931.1
ENSMUST00000112930.1
Col4a5

collagen, type IV, alpha 5

chr4_-_40239779 0.650 ENSMUST00000037907.6
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr16_+_32914094 0.649 ENSMUST00000023491.6
ENSMUST00000170899.1
ENSMUST00000171118.1
ENSMUST00000170201.1
ENSMUST00000165616.1
ENSMUST00000135193.2
Lrch3





leucine-rich repeats and calponin homology (CH) domain containing 3





chr2_-_73485733 0.601 ENSMUST00000102680.1
Wipf1
WAS/WASL interacting protein family, member 1
chr12_-_55492587 0.587 ENSMUST00000021413.7
Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
chr15_-_89429093 0.576 ENSMUST00000170460.1
Chkb
choline kinase beta
chr4_-_101265236 0.560 ENSMUST00000149297.1
ENSMUST00000102781.3
Jak1

Janus kinase 1

chr18_+_36559972 0.512 ENSMUST00000134146.1
Ankhd1
ankyrin repeat and KH domain containing 1
chr4_-_40239700 0.440 ENSMUST00000142055.1
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr6_-_124741374 0.437 ENSMUST00000004389.5
Grcc10
gene rich cluster, C10 gene
chr12_+_111538101 0.393 ENSMUST00000166123.1
Eif5
eukaryotic translation initiation factor 5
chr11_-_84870812 0.389 ENSMUST00000168434.1
Ggnbp2
gametogenetin binding protein 2
chr14_+_55560480 0.353 ENSMUST00000121622.1
ENSMUST00000143431.1
ENSMUST00000150481.1
Dcaf11


DDB1 and CUL4 associated factor 11


chr8_+_46739745 0.344 ENSMUST00000034041.7
Irf2
interferon regulatory factor 2
chr4_+_43631935 0.340 ENSMUST00000030191.8
Npr2
natriuretic peptide receptor 2
chr18_+_36560581 0.300 ENSMUST00000155329.2
Ankhd1
ankyrin repeat and KH domain containing 1
chr7_-_28766469 0.272 ENSMUST00000085851.5
ENSMUST00000032815.4
Nfkbib

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta

chr12_-_54862783 0.270 ENSMUST00000078124.7
Cfl2
cofilin 2, muscle
chr11_-_84870712 0.246 ENSMUST00000170741.1
ENSMUST00000172405.1
ENSMUST00000100686.3
ENSMUST00000108081.2
Ggnbp2



gametogenetin binding protein 2



chr12_+_111166485 0.227 ENSMUST00000139162.1
Traf3
TNF receptor-associated factor 3
chr11_-_84870646 0.221 ENSMUST00000018547.2
Ggnbp2
gametogenetin binding protein 2
chr8_+_72319033 0.215 ENSMUST00000067912.7
Klf2
Kruppel-like factor 2 (lung)
chr14_+_120478443 0.155 ENSMUST00000062117.6
Rap2a
RAS related protein 2a
chr1_+_135132693 0.112 ENSMUST00000049449.4
Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr12_+_111166349 0.109 ENSMUST00000117269.1
Traf3
TNF receptor-associated factor 3
chr12_+_111166413 0.074 ENSMUST00000021706.4
Traf3
TNF receptor-associated factor 3
chr2_+_119972699 0.069 ENSMUST00000066058.7
Mapkbp1
mitogen-activated protein kinase binding protein 1
chr12_-_76369586 0.054 ENSMUST00000176278.1
Zbtb25
zinc finger and BTB domain containing 25
chr12_-_76369385 0.053 ENSMUST00000176187.1
ENSMUST00000167011.1
ENSMUST00000176967.1
Zbtb25


zinc finger and BTB domain containing 25


chr1_+_15287259 0.023 ENSMUST00000175681.1
Kcnb2
potassium voltage gated channel, Shab-related subfamily, member 2
chr11_-_84870188 0.022 ENSMUST00000154915.2
Ggnbp2
gametogenetin binding protein 2
chr1_-_171196229 0.009 ENSMUST00000111332.1
Pcp4l1
Purkinje cell protein 4-like 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.9 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.8 5.8 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.5 1.6 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.4 3.5 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.4 5.0 GO:0048484 enteric nervous system development(GO:0048484)
0.3 2.4 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393) follicle-stimulating hormone signaling pathway(GO:0042699)
0.3 1.1 GO:0009597 detection of virus(GO:0009597)
0.2 7.0 GO:0010842 retina layer formation(GO:0010842)
0.2 0.8 GO:0061428 positive regulation of oocyte development(GO:0060282) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.1 0.9 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1 0.6 GO:0036015 response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.1 3.1 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.1 1.2 GO:0016322 neuron remodeling(GO:0016322)
0.1 0.9 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.1 1.0 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.1 0.6 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 0.7 GO:0048149 behavioral response to ethanol(GO:0048149)
0.1 3.1 GO:0036465 synaptic vesicle recycling(GO:0036465)
0.0 0.3 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.7 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 0.4 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.2 GO:0071499 response to laminar fluid shear stress(GO:0034616) cellular response to laminar fluid shear stress(GO:0071499)
0.0 0.6 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.0 0.4 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 1.0 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.3 GO:0030836 positive regulation of actin filament depolymerization(GO:0030836)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.2 GO:0032486 Rap protein signal transduction(GO:0032486)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.0 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.5 1.6 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.2 2.4 GO:0031143 pseudopodium(GO:0031143)
0.1 0.8 GO:0033010 paranodal junction(GO:0033010)
0.1 0.7 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.1 0.9 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 1.0 GO:0042581 specific granule(GO:0042581)
0.0 0.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 3.1 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.4 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 3.4 GO:0043204 perikaryon(GO:0043204)
0.0 4.9 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.6 4.9 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.6 2.3 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.2 0.8 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739) tubulin deacetylase activity(GO:0042903)
0.1 0.6 GO:0004103 choline kinase activity(GO:0004103)
0.1 5.8 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 0.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 0.6 GO:0005131 growth hormone receptor binding(GO:0005131)
0.1 5.0 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 0.3 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 3.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.4 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 2.8 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.0 0.4 GO:0031996 thioesterase binding(GO:0031996)
0.0 3.1 GO:0008565 protein transporter activity(GO:0008565)
0.0 1.0 GO:0045296 cadherin binding(GO:0045296)
0.0 0.9 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 1.1 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 1.2 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)