Motif ID: Rest

Z-value: 4.394


Transcription factors associated with Rest:

Gene SymbolEntrez IDGene Name
Rest ENSMUSG00000029249.9 Rest

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Restmm10_v2_chr5_+_77266196_77266232-0.654.5e-05Click!


Activity profile for motif Rest.

activity profile for motif Rest


Sorted Z-values histogram for motif Rest

Sorted Z-values for motif Rest



Network of associatons between targets according to the STRING database.



First level regulatory network of Rest

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_-_23890805 80.793 ENSMUST00000004480.3
Sst
somatostatin
chrX_-_73869804 78.490 ENSMUST00000066576.5
ENSMUST00000114430.1
L1cam

L1 cell adhesion molecule

chr19_+_42255704 62.744 ENSMUST00000087123.5
Golga7b
golgi autoantigen, golgin subfamily a, 7B
chr15_-_76521902 51.459 ENSMUST00000164703.1
ENSMUST00000096365.3
Scrt1

scratch homolog 1, zinc finger protein (Drosophila)

chr18_-_31447383 49.245 ENSMUST00000025110.3
Syt4
synaptotagmin IV
chr11_-_35798884 41.279 ENSMUST00000160726.2
Fbll1
fibrillarin-like 1
chr3_-_80802789 41.053 ENSMUST00000107745.1
ENSMUST00000075316.4
Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr2_+_153031852 40.273 ENSMUST00000037235.6
Xkr7
X Kell blood group precursor related family member 7 homolog
chr11_+_80477015 38.589 ENSMUST00000053413.10
ENSMUST00000147694.1
Cdk5r1

cyclin-dependent kinase 5, regulatory subunit 1 (p35)

chr11_+_77930800 38.403 ENSMUST00000093995.3
ENSMUST00000000646.7
Sez6

seizure related gene 6

chr1_+_34579693 31.030 ENSMUST00000052670.8
Amer3
APC membrane recruitment 3
chr4_-_129121234 30.683 ENSMUST00000030572.3
Hpca
hippocalcin
chr9_+_40269430 30.464 ENSMUST00000171835.2
Scn3b
sodium channel, voltage-gated, type III, beta
chr3_-_89764581 28.768 ENSMUST00000029562.3
Chrnb2
cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
chr7_+_51621830 27.869 ENSMUST00000032710.5
Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr6_-_121473630 27.782 ENSMUST00000046373.5
Iqsec3
IQ motif and Sec7 domain 3
chr9_+_40269202 27.671 ENSMUST00000114956.3
ENSMUST00000049941.5
Scn3b

sodium channel, voltage-gated, type III, beta

chr12_+_102554966 27.309 ENSMUST00000021610.5
Chga
chromogranin A
chr7_+_27653906 27.134 ENSMUST00000008088.7
Ttc9b
tetratricopeptide repeat domain 9B
chr2_+_132781278 26.800 ENSMUST00000028826.3
Chgb
chromogranin B
chr12_-_112511136 26.777 ENSMUST00000066791.5
Tmem179
transmembrane protein 179
chr2_+_155775333 26.368 ENSMUST00000029141.5
Mmp24
matrix metallopeptidase 24
chr4_+_101550411 26.055 ENSMUST00000094953.4
ENSMUST00000106933.1
Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr9_+_40269273 25.006 ENSMUST00000176185.1
Scn3b
sodium channel, voltage-gated, type III, beta
chr7_-_81493725 23.581 ENSMUST00000119121.1
Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr7_-_81493883 22.985 ENSMUST00000082090.7
Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr2_-_181314500 22.266 ENSMUST00000103045.3
Stmn3
stathmin-like 3
chr5_-_116591811 21.285 ENSMUST00000076124.5
Srrm4
serine/arginine repetitive matrix 4
chr11_+_74619594 20.646 ENSMUST00000100866.2
E130309D14Rik
RIKEN cDNA E130309D14 gene
chr9_+_108826320 20.397 ENSMUST00000024238.5
Celsr3
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr17_-_91092715 20.363 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
Nrxn1


neurexin I


chr12_+_102949450 19.758 ENSMUST00000179002.1
Unc79
unc-79 homolog (C. elegans)
chrX_+_7638674 19.039 ENSMUST00000128890.1
Syp
synaptophysin
chr11_+_102393403 18.729 ENSMUST00000107105.2
ENSMUST00000107102.1
ENSMUST00000107103.1
ENSMUST00000006750.7
Rundc3a



RUN domain containing 3A



chr5_-_121009510 18.571 ENSMUST00000079204.5
Rph3a
rabphilin 3A
chr1_-_84696182 17.755 ENSMUST00000049126.6
Dner
delta/notch-like EGF-related receptor
chr2_-_25319095 17.378 ENSMUST00000114318.3
ENSMUST00000114310.3
ENSMUST00000114308.3
ENSMUST00000114317.3
ENSMUST00000028335.6
ENSMUST00000114314.3
ENSMUST00000114307.1
Grin1






glutamate receptor, ionotropic, NMDA1 (zeta 1)






chr13_+_54371340 16.731 ENSMUST00000026985.8
Cplx2
complexin 2
chr2_+_22622183 16.184 ENSMUST00000028123.3
Gad2
glutamic acid decarboxylase 2
chr6_+_8948608 15.777 ENSMUST00000160300.1
Nxph1
neurexophilin 1
chr15_-_76722161 14.552 ENSMUST00000049956.4
Lrrc24
leucine rich repeat containing 24
chrX_-_20920911 14.464 ENSMUST00000081893.6
ENSMUST00000115345.1
Syn1

synapsin I

chr5_+_137030275 13.789 ENSMUST00000041543.8
Vgf
VGF nerve growth factor inducible
chr7_-_27396542 12.829 ENSMUST00000108363.1
Sptbn4
spectrin beta, non-erythrocytic 4
chr6_+_117168535 11.509 ENSMUST00000112866.1
ENSMUST00000112871.1
ENSMUST00000073043.4
Cxcl12


chemokine (C-X-C motif) ligand 12


chr13_-_54749627 10.987 ENSMUST00000099506.1
Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr9_+_59578192 10.817 ENSMUST00000118549.1
ENSMUST00000034840.3
Celf6

CUGBP, Elav-like family member 6

chr9_-_57467985 10.139 ENSMUST00000046587.6
Scamp5
secretory carrier membrane protein 5
chr12_-_84698769 10.131 ENSMUST00000095550.2
Syndig1l
synapse differentiation inducing 1 like
chr17_+_28575718 9.372 ENSMUST00000080780.6
Lhfpl5
lipoma HMGIC fusion partner-like 5
chr2_-_27142429 8.773 ENSMUST00000151224.2
Fam163b
family with sequence similarity 163, member B
chr1_+_81077274 8.148 ENSMUST00000068275.5
ENSMUST00000113494.2
Nyap2

neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2

chr13_-_54749849 7.650 ENSMUST00000135343.1
Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr2_-_180104463 7.454 ENSMUST00000056480.3
Hrh3
histamine receptor H3
chr17_-_83631892 7.307 ENSMUST00000051482.1
Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr11_-_3774706 7.245 ENSMUST00000155197.1
Osbp2
oxysterol binding protein 2
chr7_+_122671378 7.165 ENSMUST00000182563.1
Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr7_+_122671401 6.297 ENSMUST00000182095.1
Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr7_+_63444741 5.954 ENSMUST00000058476.7
Otud7a
OTU domain containing 7A
chr9_-_22085391 5.869 ENSMUST00000179422.1
ENSMUST00000098937.3
ENSMUST00000177967.1
ENSMUST00000180180.1
Ecsit



ECSIT homolog (Drosophila)



chr2_-_25319187 5.775 ENSMUST00000114312.1
Grin1
glutamate receptor, ionotropic, NMDA1 (zeta 1)
chr17_-_72603709 5.610 ENSMUST00000086639.4
Alk
anaplastic lymphoma kinase
chr19_-_45046614 5.535 ENSMUST00000145391.1
Pdzd7
PDZ domain containing 7
chr1_+_81077204 5.144 ENSMUST00000123720.1
Nyap2
neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
chr13_-_23991158 5.000 ENSMUST00000021770.7
Scgn
secretagogin, EF-hand calcium binding protein
chr4_+_15881255 4.034 ENSMUST00000029876.1
Calb1
calbindin 1
chr13_-_105054895 3.861 ENSMUST00000063551.5
Rgs7bp
regulator of G-protein signalling 7 binding protein
chr1_-_193035651 3.676 ENSMUST00000016344.7
Syt14
synaptotagmin XIV
chr2_+_152143552 3.420 ENSMUST00000089112.5
Tcf15
transcription factor 15
chr13_-_56895737 1.963 ENSMUST00000022023.6
ENSMUST00000109871.1
Trpc7

transient receptor potential cation channel, subfamily C, member 7

chr4_+_129136948 1.935 ENSMUST00000102600.3
Fndc5
fibronectin type III domain containing 5
chr12_-_70347536 1.811 ENSMUST00000110520.2
ENSMUST00000110522.2
ENSMUST00000167755.1
Trim9


tripartite motif-containing 9


chr9_+_122117375 1.226 ENSMUST00000118886.1
Snrk
SNF related kinase
chr15_-_75747922 1.097 ENSMUST00000062002.4
Mafa
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)
chr16_-_37384915 0.805 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
Stxbp5l



syntaxin binding protein 5-like



chr2_+_157456917 0.792 ENSMUST00000109529.1
Src
Rous sarcoma oncogene
chr12_+_113140198 0.719 ENSMUST00000084882.4
Crip2
cysteine rich protein 2
chr8_+_18846251 0.675 ENSMUST00000149565.1
ENSMUST00000033847.4
Agpat5

1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)

chr17_-_25240112 0.298 ENSMUST00000038973.6
ENSMUST00000115154.4
Gnptg

N-acetylglucosamine-1-phosphotransferase, gamma subunit

chr2_-_92401237 0.061 ENSMUST00000050312.2
Mapk8ip1
mitogen-activated protein kinase 8 interacting protein 1
chr15_-_11037968 0.026 ENSMUST00000058007.5
Rxfp3
relaxin family peptide receptor 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
15.4 61.7 GO:0021586 pons maturation(GO:0021586)
10.2 30.7 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
9.6 28.8 GO:0060084 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) synaptic transmission involved in micturition(GO:0060084)
9.2 83.1 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
9.1 27.3 GO:1900736 regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900736)
8.3 41.3 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
7.8 78.5 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
7.4 22.3 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
6.3 19.0 GO:0038003 opioid receptor signaling pathway(GO:0038003) regulation of opioid receptor signaling pathway(GO:2000474)
6.2 49.2 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
4.1 20.4 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
4.0 16.2 GO:0006538 glutamate catabolic process(GO:0006538)
3.9 23.2 GO:0072318 clathrin coat disassembly(GO:0072318)
3.4 20.4 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
3.3 16.7 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
2.9 11.5 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
2.5 7.5 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
2.4 26.4 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
2.3 46.6 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
2.2 41.1 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
2.1 12.8 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
2.0 19.8 GO:0048149 behavioral response to ethanol(GO:0048149)
1.8 38.4 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
1.6 17.8 GO:0007220 Notch receptor processing(GO:0007220)
1.4 27.9 GO:0001504 neurotransmitter uptake(GO:0001504)
1.3 18.7 GO:0030828 positive regulation of cGMP biosynthetic process(GO:0030828)
1.2 6.0 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
1.1 13.8 GO:0043084 penile erection(GO:0043084)
1.1 51.5 GO:2001222 regulation of neuron migration(GO:2001222)
1.1 27.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
1.0 14.9 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.7 10.1 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.6 13.5 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.6 18.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.5 10.8 GO:0071625 vocalization behavior(GO:0071625)
0.5 3.4 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.5 21.3 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.4 27.1 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.3 1.9 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.3 0.8 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.3 1.8 GO:0045955 negative regulation of calcium ion-dependent exocytosis(GO:0045955)
0.2 4.0 GO:0007614 short-term memory(GO:0007614)
0.2 14.6 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.2 14.5 GO:0099643 neurotransmitter secretion(GO:0007269) presynaptic process involved in chemical synaptic transmission(GO:0099531) signal release from synapse(GO:0099643)
0.1 5.9 GO:0051341 regulation of oxidoreductase activity(GO:0051341)
0.1 13.3 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.1 80.8 GO:0030334 regulation of cell migration(GO:0030334)
0.1 26.2 GO:0060828 regulation of canonical Wnt signaling pathway(GO:0060828)
0.1 0.3 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.1 1.1 GO:0007263 nitric oxide mediated signal transduction(GO:0007263)
0.1 2.0 GO:0006828 manganese ion transport(GO:0006828)
0.1 7.2 GO:0007286 spermatid development(GO:0007286)
0.1 5.6 GO:0000187 activation of MAPK activity(GO:0000187)
0.0 7.3 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.0 5.0 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)
0.0 3.7 GO:0006906 vesicle fusion(GO:0006906)
0.0 10.1 GO:0009607 response to biotic stimulus(GO:0009607)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.7 GO:0006639 neutral lipid metabolic process(GO:0006638) acylglycerol metabolic process(GO:0006639)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
12.9 38.6 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
5.8 23.2 GO:0044307 dendritic branch(GO:0044307)
5.5 27.3 GO:0042583 chromaffin granule(GO:0042583)
5.2 83.1 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
5.2 41.3 GO:0031428 box C/D snoRNP complex(GO:0031428)
4.2 46.6 GO:1904115 axon cytoplasm(GO:1904115)
4.2 16.7 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
3.3 49.2 GO:0031045 dense core granule(GO:0031045)
3.1 30.7 GO:0044327 dendritic spine head(GO:0044327)
3.0 137.2 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
2.6 28.8 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
2.1 12.8 GO:0008091 spectrin(GO:0008091)
1.9 9.4 GO:0032426 stereocilium tip(GO:0032426)
1.8 5.5 GO:0002141 stereocilia ankle link(GO:0002141)
1.5 78.6 GO:0044295 axonal growth cone(GO:0044295)
1.2 45.6 GO:0097440 apical dendrite(GO:0097440)
1.0 31.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
1.0 27.8 GO:0060077 inhibitory synapse(GO:0060077)
0.3 13.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 20.4 GO:0042734 presynaptic membrane(GO:0042734)
0.3 13.8 GO:0030667 secretory granule membrane(GO:0030667)
0.2 7.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 26.8 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.2 99.8 GO:0043025 neuronal cell body(GO:0043025)
0.2 2.0 GO:0005801 cis-Golgi network(GO:0005801)
0.1 21.2 GO:0030141 secretory granule(GO:0030141)
0.1 27.1 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 11.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 5.6 GO:0044297 cell body(GO:0044297)
0.1 95.4 GO:0005794 Golgi apparatus(GO:0005794)
0.0 6.7 GO:0043209 myelin sheath(GO:0043209)
0.0 1.8 GO:0008021 synaptic vesicle(GO:0008021)
0.0 133.7 GO:0016020 membrane(GO:0016020)
0.0 0.7 GO:0005938 cell cortex(GO:0005938)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
15.7 78.5 GO:0033691 sialic acid binding(GO:0033691)
11.9 83.1 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
6.8 41.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
6.2 18.7 GO:0030249 guanylate cyclase regulator activity(GO:0030249)
2.6 28.8 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
2.3 39.3 GO:0016595 glutamate binding(GO:0016595)
1.9 18.6 GO:0042301 phosphate ion binding(GO:0042301)
1.7 27.9 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
1.7 20.4 GO:0097109 neuroligin family protein binding(GO:0097109)
1.7 38.6 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
1.6 35.8 GO:0017075 syntaxin-1 binding(GO:0017075)
1.6 92.3 GO:0005179 hormone activity(GO:0005179)
1.6 46.4 GO:0001786 phosphatidylserine binding(GO:0001786)
1.2 7.5 GO:0015464 acetylcholine receptor activity(GO:0015464)
1.0 11.5 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
1.0 27.1 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.8 27.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.6 41.3 GO:0042054 histone methyltransferase activity(GO:0042054)
0.6 31.0 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.6 17.8 GO:0005112 Notch binding(GO:0005112)
0.6 26.4 GO:0045296 cadherin binding(GO:0045296)
0.3 13.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.3 12.8 GO:0030507 spectrin binding(GO:0030507)
0.3 7.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 6.0 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.2 26.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.2 14.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 19.4 GO:0051219 phosphoprotein binding(GO:0051219)
0.2 3.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 2.0 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 7.2 GO:0015485 cholesterol binding(GO:0015485)
0.1 0.3 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 4.0 GO:0043178 alcohol binding(GO:0043178)
0.1 50.5 GO:0005509 calcium ion binding(GO:0005509)
0.1 21.3 GO:0003729 mRNA binding(GO:0003729)
0.1 5.9 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.1 5.6 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.1 22.3 GO:0015631 tubulin binding(GO:0015631)
0.0 0.7 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 51.7 GO:0046872 metal ion binding(GO:0046872)
0.0 5.5 GO:0046982 protein heterodimerization activity(GO:0046982)