Motif ID: Rest

Z-value: 4.394


Transcription factors associated with Rest:

Gene SymbolEntrez IDGene Name
Rest ENSMUSG00000029249.9 Rest

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Restmm10_v2_chr5_+_77266196_77266232-0.654.5e-05Click!


Activity profile for motif Rest.

activity profile for motif Rest


Sorted Z-values histogram for motif Rest

Sorted Z-values for motif Rest



Network of associatons between targets according to the STRING database.



First level regulatory network of Rest

PNG image of the network

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Top targets:


Showing 1 to 20 of 81 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_23890805 80.793 ENSMUST00000004480.3
 Sst
somatostatin
chrX_-_73869804 78.490 ENSMUST00000066576.5
ENSMUST00000114430.1
 L1cam

L1 cell adhesion molecule

chr19_+_42255704 62.744 ENSMUST00000087123.5
 Golga7b
golgi autoantigen, golgin subfamily a, 7B
chr15_-_76521902 51.459 ENSMUST00000164703.1
ENSMUST00000096365.3
 Scrt1

scratch homolog 1, zinc finger protein (Drosophila)

chr18_-_31447383 49.245 ENSMUST00000025110.3
 Syt4
synaptotagmin IV
chr11_-_35798884 41.279 ENSMUST00000160726.2
 Fbll1
fibrillarin-like 1
chr3_-_80802789 41.053 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr2_+_153031852 40.273 ENSMUST00000037235.6
 Xkr7
X Kell blood group precursor related family member 7 homolog
chr11_+_80477015 38.589 ENSMUST00000053413.10
ENSMUST00000147694.1
 Cdk5r1

cyclin-dependent kinase 5, regulatory subunit 1 (p35)

chr11_+_77930800 38.403 ENSMUST00000093995.3
ENSMUST00000000646.7
 Sez6

seizure related gene 6

chr1_+_34579693 31.030 ENSMUST00000052670.8
 Amer3
APC membrane recruitment 3
chr4_-_129121234 30.683 ENSMUST00000030572.3
 Hpca
hippocalcin
chr9_+_40269430 30.464 ENSMUST00000171835.2
 Scn3b
sodium channel, voltage-gated, type III, beta
chr3_-_89764581 28.768 ENSMUST00000029562.3
 Chrnb2
cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
chr7_+_51621830 27.869 ENSMUST00000032710.5
 Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr6_-_121473630 27.782 ENSMUST00000046373.5
 Iqsec3
IQ motif and Sec7 domain 3
chr9_+_40269202 27.671 ENSMUST00000114956.3
ENSMUST00000049941.5
 Scn3b

sodium channel, voltage-gated, type III, beta

chr12_+_102554966 27.309 ENSMUST00000021610.5
 Chga
chromogranin A
chr7_+_27653906 27.134 ENSMUST00000008088.7
 Ttc9b
tetratricopeptide repeat domain 9B
chr2_+_132781278 26.800 ENSMUST00000028826.3
 Chgb
chromogranin B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.2 83.1 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.1 80.8 GO:0030334 regulation of cell migration(GO:0030334)
7.8 78.5 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
15.4 61.7 GO:0021586 pons maturation(GO:0021586)
1.1 51.5 GO:2001222 regulation of neuron migration(GO:2001222)
6.2 49.2 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
2.3 46.6 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
8.3 41.3 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
2.2 41.1 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
1.8 38.4 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
10.2 30.7 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
9.6 28.8 GO:0060084 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) synaptic transmission involved in micturition(GO:0060084)
1.4 27.9 GO:0001504 neurotransmitter uptake(GO:0001504)
1.1 27.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
9.1 27.3 GO:1900736 regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900736)
0.4 27.1 GO:0061077 chaperone-mediated protein folding(GO:0061077)
2.4 26.4 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
0.1 26.2 GO:0060828 regulation of canonical Wnt signaling pathway(GO:0060828)
3.9 23.2 GO:0072318 clathrin coat disassembly(GO:0072318)
7.4 22.3 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 137.2 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 133.7 GO:0016020 membrane(GO:0016020)
0.2 99.8 GO:0043025 neuronal cell body(GO:0043025)
0.1 95.4 GO:0005794 Golgi apparatus(GO:0005794)
5.2 83.1 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
1.5 78.6 GO:0044295 axonal growth cone(GO:0044295)
3.3 49.2 GO:0031045 dense core granule(GO:0031045)
4.2 46.6 GO:1904115 axon cytoplasm(GO:1904115)
1.2 45.6 GO:0097440 apical dendrite(GO:0097440)
5.2 41.3 GO:0031428 box C/D snoRNP complex(GO:0031428)
12.9 38.6 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
1.0 31.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
3.1 30.7 GO:0044327 dendritic spine head(GO:0044327)
2.6 28.8 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
1.0 27.8 GO:0060077 inhibitory synapse(GO:0060077)
5.5 27.3 GO:0042583 chromaffin granule(GO:0042583)
0.1 27.1 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.2 26.8 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
5.8 23.2 GO:0044307 dendritic branch(GO:0044307)
0.1 21.2 GO:0030141 secretory granule(GO:0030141)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 92.3 GO:0005179 hormone activity(GO:0005179)
11.9 83.1 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
15.7 78.5 GO:0033691 sialic acid binding(GO:0033691)
0.0 51.7 GO:0046872 metal ion binding(GO:0046872)
0.1 50.5 GO:0005509 calcium ion binding(GO:0005509)
1.6 46.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.6 41.3 GO:0042054 histone methyltransferase activity(GO:0042054)
6.8 41.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
2.3 39.3 GO:0016595 glutamate binding(GO:0016595)
1.7 38.6 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
1.6 35.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.6 31.0 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
2.6 28.8 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
1.7 27.9 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.8 27.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.0 27.1 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.6 26.4 GO:0045296 cadherin binding(GO:0045296)
0.2 26.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 22.3 GO:0015631 tubulin binding(GO:0015631)
0.1 21.3 GO:0003729 mRNA binding(GO:0003729)