Motif ID: Rfx3_Rfx1_Rfx4

Z-value: 1.608

Transcription factors associated with Rfx3_Rfx1_Rfx4:

Gene SymbolEntrez IDGene Name
Rfx1 ENSMUSG00000031706.6 Rfx1
Rfx3 ENSMUSG00000040929.10 Rfx3
Rfx4 ENSMUSG00000020037.9 Rfx4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rfx1mm10_v2_chr8_+_84066824_840668820.421.4e-02Click!
Rfx4mm10_v2_chr10_+_84756055_84756084-0.392.4e-02Click!
Rfx3mm10_v2_chr19_-_28010995_280110540.212.5e-01Click!


Activity profile for motif Rfx3_Rfx1_Rfx4.

activity profile for motif Rfx3_Rfx1_Rfx4


Sorted Z-values histogram for motif Rfx3_Rfx1_Rfx4

Sorted Z-values for motif Rfx3_Rfx1_Rfx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Rfx3_Rfx1_Rfx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_7919816 18.515 ENSMUST00000041096.3
 Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
chr10_-_81472859 9.510 ENSMUST00000147524.1
ENSMUST00000119060.1
 Celf5

CUGBP, Elav-like family member 5

chr11_-_6606053 9.282 ENSMUST00000045713.3
 Nacad
NAC alpha domain containing
chr18_-_78206408 8.915 ENSMUST00000163367.1
 Slc14a2
solute carrier family 14 (urea transporter), member 2
chr12_+_29528382 6.332 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like
chr10_+_80295930 6.169 ENSMUST00000105359.1
 Apc2
adenomatosis polyposis coli 2
chr3_-_84305385 6.153 ENSMUST00000122849.1
ENSMUST00000132283.1
 Trim2

tripartite motif-containing 2

chr5_+_33983437 5.707 ENSMUST00000114384.1
ENSMUST00000094869.5
ENSMUST00000114383.1
 Gm1673


predicted gene 1673


chr1_+_185454803 5.606 ENSMUST00000061093.6
 Slc30a10
solute carrier family 30, member 10
chr5_+_33983534 5.364 ENSMUST00000114382.1
 Gm1673
predicted gene 1673
chr13_+_55464237 5.313 ENSMUST00000046533.7
 Prr7
proline rich 7 (synaptic)
chr7_-_4546567 4.952 ENSMUST00000065957.5
 Syt5
synaptotagmin V
chr4_+_107830958 4.896 ENSMUST00000106731.2
 Lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr10_+_106470281 4.716 ENSMUST00000029404.9
ENSMUST00000169303.1
 Ppfia2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr19_-_46327121 4.582 ENSMUST00000041391.4
ENSMUST00000096029.5
 Psd

pleckstrin and Sec7 domain containing

chr11_-_61453992 4.404 ENSMUST00000060255.7
ENSMUST00000054927.7
ENSMUST00000102661.3
 Rnf112


ring finger protein 112


chr7_-_140082246 4.336 ENSMUST00000166758.2
 Caly
calcyon neuron-specific vesicular protein
chr7_-_140082489 4.244 ENSMUST00000026541.7
 Caly
calcyon neuron-specific vesicular protein
chr5_+_30814722 4.208 ENSMUST00000114724.1
 Mapre3
microtubule-associated protein, RP/EB family, member 3
chr3_-_89245159 4.173 ENSMUST00000090924.6
 Trim46
tripartite motif-containing 46

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 202 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 18.5 GO:0016486 response to dietary excess(GO:0002021) peptide hormone processing(GO:0016486)
0.6 9.0 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
1.3 8.9 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
0.4 8.7 GO:0048268 clathrin coat assembly(GO:0048268)
2.1 8.3 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.3 8.1 GO:0060074 synapse maturation(GO:0060074)
1.4 7.2 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
1.4 7.1 GO:2000481 positive regulation of cAMP-dependent protein kinase activity(GO:2000481)
0.3 6.9 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.5 6.5 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.6 5.8 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.2 5.6 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
1.4 5.4 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.5 4.9 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.8 4.8 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.4 4.6 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.0 4.6 GO:0007631 feeding behavior(GO:0007631)
0.7 4.5 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.2 4.5 GO:0097120 receptor localization to synapse(GO:0097120)
0.2 4.4 GO:0010738 regulation of protein kinase A signaling(GO:0010738)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 20.3 GO:0005802 trans-Golgi network(GO:0005802)
0.0 15.3 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 12.2 GO:0005769 early endosome(GO:0005769)
0.3 9.6 GO:0035371 microtubule plus-end(GO:0035371)
0.8 9.0 GO:0031258 lamellipodium membrane(GO:0031258)
0.4 7.5 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 6.1 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 5.6 GO:0031225 anchored component of membrane(GO:0031225)
0.3 5.0 GO:0031045 dense core granule(GO:0031045)
0.0 4.9 GO:0016607 nuclear speck(GO:0016607)
0.3 4.8 GO:0097228 sperm principal piece(GO:0097228)
0.2 4.6 GO:0060077 inhibitory synapse(GO:0060077)
0.0 4.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.4 3.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.3 3.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 3.4 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 3.4 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 3.3 GO:0005901 caveola(GO:0005901)
0.0 3.1 GO:0005768 endosome(GO:0005768)
0.2 2.8 GO:0005640 nuclear outer membrane(GO:0005640)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 123 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 18.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 14.1 GO:0008017 microtubule binding(GO:0008017)
0.4 9.0 GO:0045295 gamma-catenin binding(GO:0045295)
1.5 8.9 GO:0015265 urea channel activity(GO:0015265)
0.0 8.9 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
1.4 8.6 GO:0032051 clathrin light chain binding(GO:0032051)
0.4 7.5 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.2 6.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.4 6.3 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.2 5.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.6 5.0 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
1.2 4.9 GO:0038025 reelin receptor activity(GO:0038025)
0.1 4.7 GO:0045296 cadherin binding(GO:0045296)
0.6 4.5 GO:0001618 virus receptor activity(GO:0001618)
0.2 4.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 4.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.4 4.3 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.1 4.2 GO:0030276 clathrin binding(GO:0030276)
0.3 3.8 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.4 3.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)