Motif ID: Rfx5

Z-value: 0.795


Transcription factors associated with Rfx5:

Gene SymbolEntrez IDGene Name
Rfx5 ENSMUSG00000005774.6 Rfx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rfx5mm10_v2_chr3_+_94954075_94954226-0.621.3e-04Click!


Activity profile for motif Rfx5.

activity profile for motif Rfx5


Sorted Z-values histogram for motif Rfx5

Sorted Z-values for motif Rfx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Rfx5

PNG image of the network

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Top targets:


Showing 1 to 20 of 65 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_34263209 4.358 ENSMUST00000040828.5
 H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr7_+_46841475 3.585 ENSMUST00000147535.1
 Ldha
lactate dehydrogenase A
chr7_-_30664986 3.149 ENSMUST00000019697.8
 Haus5
HAUS augmin-like complex, subunit 5
chr17_+_37270214 2.755 ENSMUST00000038580.6
 H2-M3
histocompatibility 2, M region locus 3
chr2_+_122147680 2.711 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr1_-_183147461 2.661 ENSMUST00000171366.1
 Disp1
dispatched homolog 1 (Drosophila)
chr17_+_35861343 2.435 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)
chr17_+_35861318 2.413 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr17_+_35439155 2.305 ENSMUST00000071951.6
ENSMUST00000078205.7
ENSMUST00000116598.3
ENSMUST00000076256.7
 H2-Q7



histocompatibility 2, Q region locus 7



chr8_+_94214567 2.070 ENSMUST00000079961.6
 Nup93
nucleoporin 93
chr7_-_105752193 2.036 ENSMUST00000033184.4
 Tpp1
tripeptidyl peptidase I
chr7_+_100537192 1.905 ENSMUST00000120454.1
 Coa4
cytochrome c oxidase assembly factor 4
chr4_-_35845204 1.809 ENSMUST00000164772.1
ENSMUST00000065173.2
 Lingo2

leucine rich repeat and Ig domain containing 2

chr7_+_100537052 1.756 ENSMUST00000054310.3
 Coa4
cytochrome c oxidase assembly factor 4
chr11_+_98682554 1.737 ENSMUST00000017365.8
 Psmd3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr2_-_152398046 1.733 ENSMUST00000063332.8
ENSMUST00000182625.1
 Sox12

SRY-box containing gene 12

chr17_+_35379608 1.720 ENSMUST00000081435.4
 H2-Q4
histocompatibility 2, Q region locus 4
chr17_-_24886304 1.691 ENSMUST00000044252.5
 Nubp2
nucleotide binding protein 2
chr17_-_34187219 1.662 ENSMUST00000173831.1
 Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr11_+_61505138 1.466 ENSMUST00000102657.3
 B9d1
B9 protein domain 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 4.4 GO:0002339 B cell selection(GO:0002339)
0.3 3.7 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.7 3.6 GO:0019659 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.9 2.8 GO:0002765 immune response-inhibiting signal transduction(GO:0002765)
0.5 2.7 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.2 2.7 GO:0060539 diaphragm development(GO:0060539)
0.0 2.5 GO:0051225 spindle assembly(GO:0051225)
0.1 2.1 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.1 2.0 GO:0043171 peptide catabolic process(GO:0043171)
0.1 1.8 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 1.8 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 1.7 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 1.7 GO:0021510 spinal cord development(GO:0021510)
0.0 1.5 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.3 1.3 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) cytosol to ER transport(GO:0046967) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.4 1.2 GO:0070428 granuloma formation(GO:0002432) negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
0.3 1.2 GO:0021506 anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995)
0.0 1.2 GO:0034341 response to interferon-gamma(GO:0034341)
0.1 1.1 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.2 1.0 GO:2000210 positive regulation of anoikis(GO:2000210)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 7.2 GO:0042611 MHC protein complex(GO:0042611)
0.3 4.8 GO:0005652 nuclear lamina(GO:0005652)
0.6 4.0 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 3.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.3 3.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.4 3.1 GO:0070652 HAUS complex(GO:0070652)
0.0 2.1 GO:0005643 nuclear pore(GO:0005643)
0.2 1.7 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 1.7 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 1.7 GO:0032993 protein-DNA complex(GO:0032993)
0.1 1.5 GO:0036038 MKS complex(GO:0036038)
0.4 1.4 GO:1990111 spermatoproteasome complex(GO:1990111)
0.2 1.3 GO:0042825 TAP complex(GO:0042825)
0.0 1.2 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.3 1.0 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.0 1.0 GO:0031526 brush border membrane(GO:0031526)
0.0 0.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.8 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.7 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.7 GO:0031512 motile primary cilium(GO:0031512)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.3 GO:0046977 TAP binding(GO:0046977)
0.5 4.4 GO:0015643 toxic substance binding(GO:0015643)
0.9 3.6 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.3 2.7 GO:0015197 peptide transporter activity(GO:0015197)
0.0 2.7 GO:0001948 glycoprotein binding(GO:0001948)
0.1 2.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.5 2.0 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.1 1.7 GO:0070628 proteasome binding(GO:0070628)
0.0 1.7 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 1.7 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.5 1.5 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 1.2 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 1.1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.2 1.0 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.1 1.0 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 1.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.9 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.9 GO:0044653 trehalase activity(GO:0015927) dextrin alpha-glucosidase activity(GO:0044653) starch alpha-glucosidase activity(GO:0044654) beta-glucanase activity(GO:0052736) beta-6-sulfate-N-acetylglucosaminidase activity(GO:0052769) glucan endo-1,4-beta-glucosidase activity(GO:0052859)
0.3 0.8 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.8 GO:0030145 manganese ion binding(GO:0030145)