Motif ID: Rfx5

Z-value: 0.795


Transcription factors associated with Rfx5:

Gene SymbolEntrez IDGene Name
Rfx5 ENSMUSG00000005774.6 Rfx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rfx5mm10_v2_chr3_+_94954075_94954226-0.621.3e-04Click!


Activity profile for motif Rfx5.

activity profile for motif Rfx5


Sorted Z-values histogram for motif Rfx5

Sorted Z-values for motif Rfx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Rfx5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_34263209 4.358 ENSMUST00000040828.5
 H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr7_+_46841475 3.585 ENSMUST00000147535.1
 Ldha
lactate dehydrogenase A
chr7_-_30664986 3.149 ENSMUST00000019697.8
 Haus5
HAUS augmin-like complex, subunit 5
chr17_+_37270214 2.755 ENSMUST00000038580.6
 H2-M3
histocompatibility 2, M region locus 3
chr2_+_122147680 2.711 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr1_-_183147461 2.661 ENSMUST00000171366.1
 Disp1
dispatched homolog 1 (Drosophila)
chr17_+_35861343 2.435 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)
chr17_+_35861318 2.413 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr17_+_35439155 2.305 ENSMUST00000071951.6
ENSMUST00000078205.7
ENSMUST00000116598.3
ENSMUST00000076256.7
 H2-Q7



histocompatibility 2, Q region locus 7



chr8_+_94214567 2.070 ENSMUST00000079961.6
 Nup93
nucleoporin 93
chr7_-_105752193 2.036 ENSMUST00000033184.4
 Tpp1
tripeptidyl peptidase I
chr7_+_100537192 1.905 ENSMUST00000120454.1
 Coa4
cytochrome c oxidase assembly factor 4
chr4_-_35845204 1.809 ENSMUST00000164772.1
ENSMUST00000065173.2
 Lingo2

leucine rich repeat and Ig domain containing 2

chr7_+_100537052 1.756 ENSMUST00000054310.3
 Coa4
cytochrome c oxidase assembly factor 4
chr11_+_98682554 1.737 ENSMUST00000017365.8
 Psmd3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr2_-_152398046 1.733 ENSMUST00000063332.8
ENSMUST00000182625.1
 Sox12

SRY-box containing gene 12

chr17_+_35379608 1.720 ENSMUST00000081435.4
 H2-Q4
histocompatibility 2, Q region locus 4
chr17_-_24886304 1.691 ENSMUST00000044252.5
 Nubp2
nucleotide binding protein 2
chr17_-_34187219 1.662 ENSMUST00000173831.1
 Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr11_+_61505138 1.466 ENSMUST00000102657.3
 B9d1
B9 protein domain 1
chr18_-_51865881 1.422 ENSMUST00000091905.2
 Gm4950
predicted pseudogene 4950
chr5_+_139150211 1.229 ENSMUST00000026975.6
 Heatr2
HEAT repeat containing 2
chr17_+_34305883 1.198 ENSMUST00000074557.8
 H2-Eb1
histocompatibility 2, class II antigen E beta
chr10_-_19011948 1.183 ENSMUST00000105527.1
 Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr8_-_69996326 1.157 ENSMUST00000177851.1
ENSMUST00000065169.4
 Gatad2a

GATA zinc finger domain containing 2A

chr9_+_44773191 1.098 ENSMUST00000147559.1
 Ift46
intraflagellar transport 46
chr12_+_108334341 1.097 ENSMUST00000021684.4
 Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr1_+_134405984 1.010 ENSMUST00000173908.1
 Cyb5r1
cytochrome b5 reductase 1
chr11_+_72441341 0.991 ENSMUST00000045633.5
 Mybbp1a
MYB binding protein (P160) 1a
chr11_-_3539228 0.979 ENSMUST00000075118.3
ENSMUST00000136243.1
ENSMUST00000170588.1
ENSMUST00000020721.8
 Smtn



smoothelin



chr8_+_84969587 0.915 ENSMUST00000109734.1
ENSMUST00000005292.8
 Prdx2

peroxiredoxin 2

chr5_-_36830647 0.913 ENSMUST00000031002.3
 Man2b2
mannosidase 2, alpha B2
chr3_-_95882031 0.888 ENSMUST00000161994.1
 Gm129
predicted gene 129
chr7_-_45092130 0.876 ENSMUST00000148175.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr18_+_60803838 0.799 ENSMUST00000050487.8
ENSMUST00000097563.2
ENSMUST00000167610.1
 Cd74


CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)


chr13_+_24831661 0.798 ENSMUST00000038039.2
 Tdp2
tyrosyl-DNA phosphodiesterase 2
chr2_-_128687354 0.797 ENSMUST00000110332.1
ENSMUST00000110333.1
ENSMUST00000014499.3
 Anapc1


anaphase promoting complex subunit 1


chr5_-_125294107 0.715 ENSMUST00000127148.1
 Scarb1
scavenger receptor class B, member 1
chr10_-_7663245 0.697 ENSMUST00000163085.1
ENSMUST00000159917.1
 Pcmt1

protein-L-isoaspartate (D-aspartate) O-methyltransferase 1

chr17_+_34187789 0.677 ENSMUST00000041633.8
 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr4_-_116627921 0.633 ENSMUST00000030456.7
 Nasp
nuclear autoantigenic sperm protein (histone-binding)
chr17_+_34187545 0.626 ENSMUST00000170086.1
 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr6_-_29165003 0.614 ENSMUST00000007993.9
 Rbm28
RNA binding motif protein 28
chr8_-_89187560 0.600 ENSMUST00000093326.2
 Gm5356
predicted pseudogene 5356
chrX_-_160138375 0.530 ENSMUST00000033662.8
 Pdha1
pyruvate dehydrogenase E1 alpha 1
chr7_-_45091713 0.500 ENSMUST00000141576.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr17_+_24886643 0.496 ENSMUST00000117890.1
ENSMUST00000168265.1
ENSMUST00000120943.1
ENSMUST00000068508.6
ENSMUST00000119829.1
 Spsb3




splA/ryanodine receptor domain and SOCS box containing 3




chr17_+_34398802 0.429 ENSMUST00000114175.1
ENSMUST00000078615.5
ENSMUST00000139063.1
ENSMUST00000097348.2
 BC051142



cDNA sequence BC051142



chr3_-_95882193 0.423 ENSMUST00000159863.1
ENSMUST00000159739.1
ENSMUST00000036418.3
 Gm129


predicted gene 129


chr10_-_123196916 0.390 ENSMUST00000020334.7
 Usp15
ubiquitin specific peptidase 15
chr1_+_136676413 0.368 ENSMUST00000181491.1
 Gm19705
predicted gene, 19705
chr10_-_7663569 0.346 ENSMUST00000162606.1
 Pcmt1
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
chr14_+_55618023 0.331 ENSMUST00000002395.7
 Rec8
REC8 homolog (yeast)
chr14_+_111675113 0.258 ENSMUST00000042767.7
 Slitrk5
SLIT and NTRK-like family, member 5
chr9_+_44773027 0.215 ENSMUST00000125877.1
 Ift46
intraflagellar transport 46
chr7_-_101921186 0.201 ENSMUST00000106965.1
ENSMUST00000106968.1
ENSMUST00000106967.1
 Lrrc51


leucine rich repeat containing 51


chr19_-_8819278 0.190 ENSMUST00000088092.5
 Ttc9c
tetratricopeptide repeat domain 9C
chr19_-_8819314 0.178 ENSMUST00000096751.4
 Ttc9c
tetratricopeptide repeat domain 9C
chr7_-_101921175 0.170 ENSMUST00000098236.2
 Lrrc51
leucine rich repeat containing 51
chr8_+_27042555 0.152 ENSMUST00000033875.8
ENSMUST00000098851.4
 Prosc

proline synthetase co-transcribed

chr6_-_83831736 0.086 ENSMUST00000058383.8
 Paip2b
poly(A) binding protein interacting protein 2B
chr19_+_32757497 0.078 ENSMUST00000013807.7
 Pten
phosphatase and tensin homolog
chr17_+_34135182 0.031 ENSMUST00000042121.9
 H2-DMa
histocompatibility 2, class II, locus DMa
chr4_+_107968332 0.025 ENSMUST00000106713.3
 Slc1a7
solute carrier family 1 (glutamate transporter), member 7
chr6_+_94500313 0.003 ENSMUST00000061118.8
 Slc25a26
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.4 GO:0002339 B cell selection(GO:0002339)
0.9 2.8 GO:0002765 immune response-inhibiting signal transduction(GO:0002765)
0.7 3.6 GO:0019659 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.5 2.7 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.4 1.2 GO:0070428 granuloma formation(GO:0002432) negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
0.3 3.7 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.3 1.3 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) cytosol to ER transport(GO:0046967) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.3 1.2 GO:0021506 anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995)
0.2 2.7 GO:0060539 diaphragm development(GO:0060539)
0.2 0.7 GO:0015920 regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920)
0.2 0.8 GO:0002606 positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.2 1.0 GO:2000210 positive regulation of anoikis(GO:2000210)
0.1 2.1 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.1 1.1 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 0.9 GO:0002536 respiratory burst involved in inflammatory response(GO:0002536) negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.1 0.9 GO:0006013 mannose metabolic process(GO:0006013)
0.1 0.4 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.1 1.7 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 0.1 GO:1901630 negative regulation of presynaptic membrane organization(GO:1901630)
0.1 0.5 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 2.0 GO:0043171 peptide catabolic process(GO:0043171)
0.1 1.8 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 1.0 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.0 0.7 GO:0001539 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.0 0.6 GO:0043486 histone exchange(GO:0043486)
0.0 0.3 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 0.8 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 2.5 GO:0051225 spindle assembly(GO:0051225)
0.0 0.3 GO:0021756 striatum development(GO:0021756)
0.0 1.7 GO:0021510 spinal cord development(GO:0021510)
0.0 1.5 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.0 1.8 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.2 GO:0034341 response to interferon-gamma(GO:0034341)
0.0 1.0 GO:0016126 sterol biosynthetic process(GO:0016126)
0.0 0.0 GO:0002636 positive regulation of germinal center formation(GO:0002636)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.0 GO:0042613 MHC class II protein complex(GO:0042613)
0.5 7.2 GO:0042611 MHC protein complex(GO:0042611)
0.4 3.1 GO:0070652 HAUS complex(GO:0070652)
0.4 1.4 GO:1990111 spermatoproteasome complex(GO:1990111)
0.3 1.0 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.3 4.8 GO:0005652 nuclear lamina(GO:0005652)
0.3 3.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 1.7 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.2 1.3 GO:0042825 TAP complex(GO:0042825)
0.1 1.7 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 1.5 GO:0036038 MKS complex(GO:0036038)
0.1 0.5 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.1 0.3 GO:0000798 nuclear cohesin complex(GO:0000798) nuclear meiotic cohesin complex(GO:0034991)
0.1 3.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.7 GO:0031528 microvillus membrane(GO:0031528)
0.0 1.2 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.7 GO:0031512 motile primary cilium(GO:0031512)
0.0 0.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 2.1 GO:0005643 nuclear pore(GO:0005643)
0.0 0.8 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.0 GO:0031526 brush border membrane(GO:0031526)
0.0 1.7 GO:0032993 protein-DNA complex(GO:0032993)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.6 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.5 2.0 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.5 1.5 GO:0008158 hedgehog receptor activity(GO:0008158)
0.5 4.4 GO:0015643 toxic substance binding(GO:0015643)
0.4 5.3 GO:0046977 TAP binding(GO:0046977)
0.3 0.8 GO:0042289 MHC class II protein binding(GO:0042289)
0.3 2.7 GO:0015197 peptide transporter activity(GO:0015197)
0.2 0.7 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.2 1.0 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.1 1.0 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 2.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.5 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.1 1.7 GO:0070628 proteasome binding(GO:0070628)
0.1 0.9 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 1.2 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 1.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 1.1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.9 GO:0044653 trehalase activity(GO:0015927) dextrin alpha-glucosidase activity(GO:0044653) starch alpha-glucosidase activity(GO:0044654) beta-glucanase activity(GO:0052736) beta-6-sulfate-N-acetylglucosaminidase activity(GO:0052769) glucan endo-1,4-beta-glucosidase activity(GO:0052859)
0.0 0.5 GO:0042605 peptide antigen binding(GO:0042605)
0.0 1.7 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 1.7 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 2.7 GO:0001948 glycoprotein binding(GO:0001948)
0.0 0.4 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.6 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.8 GO:0030145 manganese ion binding(GO:0030145)
0.0 0.1 GO:0010997 anaphase-promoting complex binding(GO:0010997)