Motif ID: Rhox4e_Rhox6_Vax2
Z-value: 1.491
Transcription factors associated with Rhox4e_Rhox6_Vax2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Rhox4e | ENSMUSG00000071770.4 | Rhox4e |
Rhox6 | ENSMUSG00000006200.3 | Rhox6 |
Vax2 | ENSMUSG00000034777.1 | Vax2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Vax2 | mm10_v2_chr6_+_83711232_83711288 | -0.21 | 2.4e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.5 | 15.2 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
0.9 | 2.7 | GO:0035633 | maintenance of blood-brain barrier(GO:0035633) |
0.8 | 2.4 | GO:0060489 | establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) |
0.7 | 2.8 | GO:0061738 | late endosomal microautophagy(GO:0061738) |
0.6 | 1.2 | GO:0008627 | intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627) |
0.5 | 5.8 | GO:0036376 | sodium ion export from cell(GO:0036376) |
0.4 | 8.0 | GO:0042541 | hemoglobin biosynthetic process(GO:0042541) |
0.4 | 5.6 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
0.4 | 7.6 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
0.4 | 13.8 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
0.3 | 2.2 | GO:1902035 | positive regulation of hematopoietic stem cell proliferation(GO:1902035) |
0.3 | 0.9 | GO:0060478 | acrosomal vesicle exocytosis(GO:0060478) |
0.3 | 2.4 | GO:0006003 | fructose 2,6-bisphosphate metabolic process(GO:0006003) |
0.3 | 1.4 | GO:0038032 | termination of G-protein coupled receptor signaling pathway(GO:0038032) |
0.3 | 1.4 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) |
0.3 | 1.9 | GO:0021555 | midbrain-hindbrain boundary morphogenesis(GO:0021555) |
0.3 | 2.4 | GO:0016198 | axon choice point recognition(GO:0016198) |
0.3 | 0.8 | GO:0048818 | embryonic nail plate morphogenesis(GO:0035880) positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364) |
0.2 | 5.1 | GO:0007614 | short-term memory(GO:0007614) |
0.2 | 1.4 | GO:1901837 | negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837) |
0.2 | 1.3 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
0.2 | 0.6 | GO:0070543 | response to linoleic acid(GO:0070543) |
0.2 | 0.4 | GO:0003278 | apoptotic process involved in heart morphogenesis(GO:0003278) |
0.2 | 1.7 | GO:0061436 | establishment of skin barrier(GO:0061436) |
0.2 | 3.4 | GO:0007530 | sex determination(GO:0007530) |
0.2 | 0.6 | GO:1904956 | regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041) |
0.2 | 0.9 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
0.2 | 0.8 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
0.2 | 0.9 | GO:0006265 | DNA topological change(GO:0006265) |
0.1 | 0.7 | GO:0035428 | hexose transmembrane transport(GO:0035428) |
0.1 | 2.0 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
0.1 | 0.8 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
0.1 | 0.3 | GO:0072204 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
0.1 | 2.1 | GO:0008340 | determination of adult lifespan(GO:0008340) |
0.1 | 0.5 | GO:0006384 | transcription initiation from RNA polymerase III promoter(GO:0006384) |
0.1 | 0.6 | GO:1901162 | serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162) |
0.1 | 2.0 | GO:0090036 | regulation of protein kinase C signaling(GO:0090036) |
0.1 | 1.2 | GO:0006107 | oxaloacetate metabolic process(GO:0006107) |
0.1 | 0.8 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
0.1 | 0.4 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
0.1 | 0.8 | GO:2000628 | regulation of miRNA metabolic process(GO:2000628) |
0.1 | 0.6 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
0.1 | 2.9 | GO:0035329 | hippo signaling(GO:0035329) |
0.1 | 0.8 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
0.1 | 0.9 | GO:0030497 | fatty acid elongation(GO:0030497) |
0.1 | 4.9 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
0.1 | 0.8 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
0.1 | 2.5 | GO:0022904 | respiratory electron transport chain(GO:0022904) |
0.1 | 0.9 | GO:0006337 | nucleosome disassembly(GO:0006337) protein-DNA complex disassembly(GO:0032986) |
0.1 | 0.8 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
0.1 | 0.4 | GO:0070317 | negative regulation of G0 to G1 transition(GO:0070317) |
0.1 | 0.3 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
0.1 | 0.8 | GO:0080111 | DNA demethylation(GO:0080111) |
0.0 | 0.2 | GO:0070831 | basement membrane assembly(GO:0070831) |
0.0 | 0.5 | GO:0003215 | cardiac right ventricle morphogenesis(GO:0003215) |
0.0 | 1.3 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
0.0 | 1.1 | GO:0010172 | embryonic body morphogenesis(GO:0010172) |
0.0 | 0.4 | GO:0001675 | acrosome assembly(GO:0001675) |
0.0 | 0.2 | GO:0006041 | glucosamine metabolic process(GO:0006041) |
0.0 | 0.5 | GO:0009303 | rRNA transcription(GO:0009303) |
0.0 | 1.4 | GO:0006418 | tRNA aminoacylation for protein translation(GO:0006418) |
0.0 | 0.4 | GO:0046069 | cGMP catabolic process(GO:0046069) |
0.0 | 0.4 | GO:0006622 | protein targeting to lysosome(GO:0006622) |
0.0 | 2.3 | GO:0051225 | spindle assembly(GO:0051225) |
0.0 | 0.9 | GO:0034605 | cellular response to heat(GO:0034605) |
0.0 | 0.6 | GO:0043171 | peptide catabolic process(GO:0043171) |
0.0 | 0.1 | GO:0002553 | histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553) Golgi reassembly(GO:0090168) |
0.0 | 1.0 | GO:0043029 | T cell homeostasis(GO:0043029) |
0.0 | 0.2 | GO:0048625 | myoblast fate commitment(GO:0048625) |
0.0 | 0.5 | GO:2000036 | regulation of stem cell population maintenance(GO:2000036) |
0.0 | 0.2 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
0.0 | 0.6 | GO:0018345 | protein palmitoylation(GO:0018345) |
0.0 | 0.4 | GO:2000310 | regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310) |
0.0 | 0.5 | GO:0050819 | negative regulation of coagulation(GO:0050819) |
0.0 | 0.5 | GO:0048246 | macrophage chemotaxis(GO:0048246) |
0.0 | 4.9 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
0.0 | 0.6 | GO:0000266 | mitochondrial fission(GO:0000266) |
0.0 | 0.7 | GO:0051693 | actin filament capping(GO:0051693) |
0.0 | 0.9 | GO:0016574 | histone ubiquitination(GO:0016574) |
0.0 | 0.2 | GO:0045717 | negative regulation of fatty acid biosynthetic process(GO:0045717) |
0.0 | 0.6 | GO:0006284 | base-excision repair(GO:0006284) |
0.0 | 0.7 | GO:0015908 | fatty acid transport(GO:0015908) |
0.0 | 0.3 | GO:0034063 | stress granule assembly(GO:0034063) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 5.8 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) dendritic spine neck(GO:0044326) |
0.8 | 2.4 | GO:0043540 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540) |
0.6 | 2.4 | GO:0060187 | cell pole(GO:0060187) |
0.4 | 5.6 | GO:0042555 | MCM complex(GO:0042555) |
0.3 | 1.4 | GO:0097413 | Lewy body(GO:0097413) |
0.3 | 3.8 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
0.3 | 2.0 | GO:0090543 | Flemming body(GO:0090543) |
0.2 | 1.3 | GO:0005726 | perichromatin fibrils(GO:0005726) |
0.2 | 0.8 | GO:0043202 | lysosomal lumen(GO:0043202) |
0.2 | 1.4 | GO:0001740 | Barr body(GO:0001740) |
0.1 | 0.4 | GO:0031417 | NatC complex(GO:0031417) |
0.1 | 0.9 | GO:0033503 | HULC complex(GO:0033503) |
0.1 | 0.5 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
0.1 | 2.4 | GO:0031527 | filopodium membrane(GO:0031527) |
0.1 | 0.9 | GO:0042382 | paraspeckles(GO:0042382) |
0.1 | 1.3 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
0.1 | 0.7 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
0.1 | 1.7 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
0.1 | 0.8 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
0.1 | 1.4 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
0.1 | 1.2 | GO:0034706 | voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706) |
0.1 | 7.6 | GO:0000792 | heterochromatin(GO:0000792) |
0.1 | 0.6 | GO:0000243 | commitment complex(GO:0000243) |
0.1 | 2.2 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
0.1 | 5.1 | GO:0043195 | terminal bouton(GO:0043195) |
0.1 | 0.9 | GO:0071564 | npBAF complex(GO:0071564) |
0.0 | 1.4 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
0.0 | 0.5 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
0.0 | 0.2 | GO:0030689 | preribosome, small subunit precursor(GO:0030688) Noc complex(GO:0030689) |
0.0 | 0.5 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
0.0 | 1.4 | GO:0097440 | apical dendrite(GO:0097440) |
0.0 | 14.9 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
0.0 | 0.4 | GO:0000812 | Swr1 complex(GO:0000812) |
0.0 | 8.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
0.0 | 0.6 | GO:0097539 | ciliary transition fiber(GO:0097539) |
0.0 | 0.5 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
0.0 | 0.8 | GO:0002102 | podosome(GO:0002102) |
0.0 | 2.0 | GO:0005581 | collagen trimer(GO:0005581) |
0.0 | 0.8 | GO:0015030 | Cajal body(GO:0015030) |
0.0 | 0.1 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
0.0 | 1.5 | GO:0070469 | respiratory chain(GO:0070469) |
0.0 | 0.2 | GO:0071664 | beta-catenin-TCF7L2 complex(GO:0070369) catenin-TCF7L2 complex(GO:0071664) |
0.0 | 1.2 | GO:0005657 | replication fork(GO:0005657) |
0.0 | 0.2 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
0.0 | 0.1 | GO:0033093 | Weibel-Palade body(GO:0033093) |
0.0 | 0.1 | GO:0034709 | methylosome(GO:0034709) |
0.0 | 0.4 | GO:0016235 | aggresome(GO:0016235) |
0.0 | 0.4 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
0.0 | 0.8 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
0.0 | 0.6 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
0.0 | 0.9 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
0.0 | 2.0 | GO:0043025 | neuronal cell body(GO:0043025) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 5.8 | GO:0103116 | alpha-D-galactofuranose transporter activity(GO:0103116) |
0.5 | 8.0 | GO:0016594 | glycine binding(GO:0016594) |
0.5 | 1.4 | GO:0047066 | phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066) |
0.4 | 2.4 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
0.3 | 2.4 | GO:0070095 | fructose-6-phosphate binding(GO:0070095) |
0.3 | 0.9 | GO:0019166 | trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166) |
0.3 | 0.9 | GO:0008311 | double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311) |
0.3 | 0.8 | GO:0031686 | A1 adenosine receptor binding(GO:0031686) |
0.3 | 0.8 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
0.2 | 1.2 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
0.2 | 0.6 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
0.2 | 0.6 | GO:0004510 | tryptophan 5-monooxygenase activity(GO:0004510) |
0.2 | 1.3 | GO:0034056 | estrogen response element binding(GO:0034056) |
0.2 | 0.9 | GO:0003917 | DNA topoisomerase type I activity(GO:0003917) |
0.1 | 4.8 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
0.1 | 0.5 | GO:0031727 | CCR2 chemokine receptor binding(GO:0031727) |
0.1 | 0.8 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
0.1 | 2.6 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
0.1 | 0.8 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
0.1 | 5.6 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
0.1 | 1.2 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
0.1 | 0.8 | GO:0045125 | bioactive lipid receptor activity(GO:0045125) |
0.1 | 5.3 | GO:0019842 | vitamin binding(GO:0019842) |
0.1 | 14.2 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
0.1 | 0.6 | GO:1990446 | U1 snRNP binding(GO:1990446) |
0.1 | 0.7 | GO:0034943 | acyl-CoA ligase activity(GO:0003996) 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) very long-chain fatty acid-CoA ligase activity(GO:0031957) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409) |
0.1 | 2.7 | GO:0004601 | peroxidase activity(GO:0004601) |
0.1 | 0.4 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
0.1 | 0.6 | GO:0050897 | cobalt ion binding(GO:0050897) |
0.0 | 0.7 | GO:0005355 | glucose transmembrane transporter activity(GO:0005355) |
0.0 | 1.4 | GO:0002161 | aminoacyl-tRNA editing activity(GO:0002161) |
0.0 | 0.4 | GO:0004526 | ribonuclease P activity(GO:0004526) |
0.0 | 3.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
0.0 | 0.3 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
0.0 | 1.2 | GO:0042162 | telomeric DNA binding(GO:0042162) |
0.0 | 1.4 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
0.0 | 0.5 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
0.0 | 2.6 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
0.0 | 1.1 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
0.0 | 2.6 | GO:0031490 | chromatin DNA binding(GO:0031490) |
0.0 | 0.5 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
0.0 | 0.9 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
0.0 | 0.6 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.0 | 0.4 | GO:0030553 | cGMP binding(GO:0030553) |
0.0 | 1.6 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
0.0 | 0.8 | GO:0016814 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814) |
0.0 | 0.3 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
0.0 | 0.6 | GO:0019706 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) |
0.0 | 0.5 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
0.0 | 1.3 | GO:0015078 | hydrogen ion transmembrane transporter activity(GO:0015078) |
0.0 | 4.4 | GO:0000287 | magnesium ion binding(GO:0000287) |
0.0 | 0.4 | GO:0031491 | nucleosome binding(GO:0031491) |
0.0 | 15.1 | GO:0019904 | protein domain specific binding(GO:0019904) |
0.0 | 12.7 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
0.0 | 0.9 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |