Motif ID: Rreb1

Z-value: 0.938


Transcription factors associated with Rreb1:

Gene SymbolEntrez IDGene Name
Rreb1 ENSMUSG00000039087.10 Rreb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rreb1mm10_v2_chr13_+_37826225_378263150.077.0e-01Click!


Activity profile for motif Rreb1.

activity profile for motif Rreb1


Sorted Z-values histogram for motif Rreb1

Sorted Z-values for motif Rreb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Rreb1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_57455898 6.780 ENSMUST00000034023.3
 Scrg1
scrapie responsive gene 1
chrX_+_7919816 4.924 ENSMUST00000041096.3
 Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
chr18_-_31949571 4.163 ENSMUST00000064016.5
 Gpr17
G protein-coupled receptor 17
chr4_+_97777780 3.811 ENSMUST00000107062.2
ENSMUST00000052018.5
ENSMUST00000107057.1
 Nfia


nuclear factor I/A


chr16_-_67620880 3.785 ENSMUST00000114292.1
ENSMUST00000120898.1
 Cadm2

cell adhesion molecule 2

chr12_-_90738438 3.478 ENSMUST00000082432.3
 Dio2
deiodinase, iodothyronine, type II
chr3_-_73056943 3.313 ENSMUST00000059407.7
 Slitrk3
SLIT and NTRK-like family, member 3
chr2_-_33371486 3.303 ENSMUST00000113165.1
 Ralgps1
Ral GEF with PH domain and SH3 binding motif 1
chr4_-_82505274 3.278 ENSMUST00000050872.8
ENSMUST00000064770.2
 Nfib

nuclear factor I/B

chr16_-_67620805 3.228 ENSMUST00000120594.1
 Cadm2
cell adhesion molecule 2
chr4_+_97777606 2.902 ENSMUST00000075448.6
ENSMUST00000092532.6
 Nfia

nuclear factor I/A

chr2_-_33371400 2.894 ENSMUST00000113164.1
ENSMUST00000091039.2
ENSMUST00000042615.6
 Ralgps1


Ral GEF with PH domain and SH3 binding motif 1


chr13_+_43615710 2.819 ENSMUST00000059986.2
 Rnf182
ring finger protein 182
chr17_+_35076902 2.573 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
 Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr5_-_124425907 2.534 ENSMUST00000065263.5
 Sbno1
sno, strawberry notch homolog 1 (Drosophila)
chr3_-_89245159 2.501 ENSMUST00000090924.6
 Trim46
tripartite motif-containing 46
chr2_-_156392829 2.417 ENSMUST00000088578.2
 2900097C17Rik
RIKEN cDNA 2900097C17 gene
chr12_+_81026800 2.405 ENSMUST00000110347.2
ENSMUST00000021564.4
ENSMUST00000129362.1
 Smoc1


SPARC related modular calcium binding 1


chr12_+_29528382 2.383 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like
chr17_+_43568096 2.297 ENSMUST00000167214.1
 Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 145 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.7 GO:0060074 synapse maturation(GO:0060074)
0.2 6.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
1.2 6.2 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.3 4.9 GO:0002021 response to dietary excess(GO:0002021)
0.0 4.9 GO:0006813 potassium ion transport(GO:0006813)
0.5 4.2 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.1 3.8 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.7 3.7 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
1.2 3.6 GO:1902528 regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530)
0.7 3.5 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460)
0.8 3.3 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 3.3 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
0.5 3.1 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.6 3.0 GO:0046684 response to pyrethroid(GO:0046684)
0.2 2.9 GO:0043045 DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.0 2.9 GO:0051017 actin filament bundle assembly(GO:0051017)
0.9 2.7 GO:1904049 regulation of spontaneous neurotransmitter secretion(GO:1904048) negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.1 2.7 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.9 2.6 GO:0090298 positive regulation of fat cell proliferation(GO:0070346) negative regulation of mitochondrial DNA replication(GO:0090298)
0.8 2.5 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.1 GO:0044306 neuron projection terminus(GO:0044306)
0.2 5.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 4.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 4.1 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 3.9 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 3.3 GO:0005802 trans-Golgi network(GO:0005802)
0.0 3.3 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.2 3.0 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
1.0 2.9 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.0 2.8 GO:0005770 late endosome(GO:0005770)
0.5 2.7 GO:1990761 growth cone lamellipodium(GO:1990761)
0.3 2.5 GO:0044327 dendritic spine head(GO:0044327)
0.2 2.3 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.2 2.2 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 2.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 2.2 GO:0019898 extrinsic component of membrane(GO:0019898)
0.1 2.1 GO:0048786 presynaptic active zone(GO:0048786)
0.0 2.1 GO:0031225 anchored component of membrane(GO:0031225)
0.2 2.0 GO:0031091 platelet alpha granule(GO:0031091) extrinsic component of external side of plasma membrane(GO:0031232)
0.3 1.7 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 119 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 6.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 6.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 5.1 GO:0002020 protease binding(GO:0002020)
0.0 4.1 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.1 4.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 3.7 GO:0008026 ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
1.1 3.3 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.1 3.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 3.1 GO:0070412 R-SMAD binding(GO:0070412)
0.5 3.0 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.2 3.0 GO:0031402 sodium ion binding(GO:0031402)
0.1 2.7 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.5 2.6 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 2.5 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.1 2.4 GO:0050840 extracellular matrix binding(GO:0050840)
0.3 2.3 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) calcium-independent phospholipase A2 activity(GO:0047499)
0.0 2.2 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.4 2.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 2.0 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.0 2.0 GO:0030165 PDZ domain binding(GO:0030165)