Motif ID: Runx1

Z-value: 0.767


Transcription factors associated with Runx1:

Gene SymbolEntrez IDGene Name
Runx1 ENSMUSG00000022952.10 Runx1



Activity profile for motif Runx1.

activity profile for motif Runx1


Sorted Z-values histogram for motif Runx1

Sorted Z-values for motif Runx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 113 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66801577 6.603 ENSMUST00000168589.1
 Sla
src-like adaptor
chr17_+_3397189 5.229 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr2_+_37516618 3.608 ENSMUST00000065441.6
 Gpr21
G protein-coupled receptor 21
chr4_+_102760294 2.767 ENSMUST00000072481.5
ENSMUST00000156596.1
ENSMUST00000080728.6
ENSMUST00000106882.2
 Sgip1



SH3-domain GRB2-like (endophilin) interacting protein 1



chr2_-_52558539 2.328 ENSMUST00000102760.3
ENSMUST00000102761.2
 Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chr17_-_90455872 2.284 ENSMUST00000174337.1
ENSMUST00000172466.1
 Nrxn1

neurexin I

chr16_+_42907563 2.211 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr10_+_69925954 2.109 ENSMUST00000181974.1
ENSMUST00000182795.1
ENSMUST00000182437.1
 Ank3


ankyrin 3, epithelial


chrX_+_159697308 1.986 ENSMUST00000123433.1
 Sh3kbp1
SH3-domain kinase binding protein 1
chr3_+_96181151 1.922 ENSMUST00000035371.8
 Sv2a
synaptic vesicle glycoprotein 2 a
chr9_+_113812547 1.863 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chr11_+_75531690 1.670 ENSMUST00000149727.1
ENSMUST00000042561.7
ENSMUST00000108433.1
ENSMUST00000143035.1
 Slc43a2



solute carrier family 43, member 2



chr15_-_76090013 1.659 ENSMUST00000019516.4
 Nrbp2
nuclear receptor binding protein 2
chr12_-_25096080 1.582 ENSMUST00000020974.6
 Id2
inhibitor of DNA binding 2
chr7_-_25132473 1.554 ENSMUST00000108418.4
ENSMUST00000108415.3
ENSMUST00000098679.3
ENSMUST00000175774.2
ENSMUST00000108417.3
ENSMUST00000108416.3
ENSMUST00000108414.1
ENSMUST00000108413.1
ENSMUST00000176408.1
 Pou2f2








POU domain, class 2, transcription factor 2








chr1_-_169747634 1.537 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr8_+_105690906 1.442 ENSMUST00000062574.6
 Rltpr
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr3_-_89093358 1.424 ENSMUST00000090929.5
ENSMUST00000052539.6
 Rusc1

RUN and SH3 domain containing 1

chr11_+_75532099 1.407 ENSMUST00000169547.2
 Slc43a2
solute carrier family 43, member 2
chr11_+_116030304 1.401 ENSMUST00000021116.5
ENSMUST00000106452.1
 Unk

unkempt homolog (Drosophila)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.0 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.6 3.6 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 3.6 GO:0015807 L-amino acid transport(GO:0015807)
0.1 2.8 GO:0097320 membrane tubulation(GO:0097320)
0.1 2.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 2.8 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.5 2.3 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.3 2.3 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.2 2.1 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.3 1.9 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091) negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 1.9 GO:0006836 neurotransmitter transport(GO:0006836)
0.3 1.8 GO:0019532 oxalate transport(GO:0019532)
0.3 1.6 GO:0045578 negative regulation of B cell differentiation(GO:0045578) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1 1.6 GO:0048305 immunoglobulin secretion(GO:0048305)
0.0 1.5 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.5 1.4 GO:2000813 negative regulation of barbed-end actin filament capping(GO:2000813)
0.2 1.4 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.1 1.4 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.1 1.4 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 1.3 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.8 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 2.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 2.3 GO:0042734 presynaptic membrane(GO:0042734)
0.1 2.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.6 1.9 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 1.9 GO:0048786 presynaptic active zone(GO:0048786)
0.1 1.4 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 1.3 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 1.3 GO:0005844 polysome(GO:0005844)
0.0 1.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 1.2 GO:0001520 outer dense fiber(GO:0001520)
0.2 1.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 1.0 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.9 GO:0043235 receptor complex(GO:0043235)
0.0 0.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 0.5 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 0.5 GO:0031673 H zone(GO:0031673)
0.1 0.5 GO:0097208 alveolar lamellar body(GO:0097208)
0.1 0.4 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 0.3 GO:1990597 parallel fiber(GO:1990032) AIP1-IRE1 complex(GO:1990597)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.8 GO:0017124 SH3 domain binding(GO:0017124)
0.0 4.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 4.3 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
1.2 3.6 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.1 2.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 2.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 2.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 2.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 2.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 2.1 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 1.9 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 1.8 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 1.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 1.4 GO:1990715 mRNA CDS binding(GO:1990715)
0.1 1.3 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.2 1.2 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.1 1.2 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 1.2 GO:0071889 14-3-3 protein binding(GO:0071889)
0.2 1.1 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.1 1.0 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)