Motif ID: Runx2_Bcl11a

Z-value: 1.008

Transcription factors associated with Runx2_Bcl11a:

Gene SymbolEntrez IDGene Name
Bcl11a ENSMUSG00000000861.9 Bcl11a
Runx2 ENSMUSG00000039153.10 Runx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bcl11amm10_v2_chr11_+_24080664_24080706-0.522.1e-03Click!


Activity profile for motif Runx2_Bcl11a.

activity profile for motif Runx2_Bcl11a


Sorted Z-values histogram for motif Runx2_Bcl11a

Sorted Z-values for motif Runx2_Bcl11a



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx2_Bcl11a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_103827922 3.837 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr8_-_11008458 3.331 ENSMUST00000040514.6
 Irs2
insulin receptor substrate 2
chr12_-_56535047 2.800 ENSMUST00000178477.2
 Nkx2-1
NK2 homeobox 1
chr15_-_37459327 2.546 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr3_-_90514250 2.334 ENSMUST00000107340.1
ENSMUST00000060738.8
 S100a1

S100 calcium binding protein A1

chr9_+_108479849 2.251 ENSMUST00000065014.4
 Lamb2
laminin, beta 2
chr13_+_89540636 2.178 ENSMUST00000022108.7
 Hapln1
hyaluronan and proteoglycan link protein 1
chr1_-_162859684 2.135 ENSMUST00000131058.1
 Fmo1
flavin containing monooxygenase 1
chr11_+_101246960 1.996 ENSMUST00000107282.3
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr3_+_90514435 1.981 ENSMUST00000048138.6
ENSMUST00000181271.1
 S100a13

S100 calcium binding protein A13

chr11_+_87663087 1.791 ENSMUST00000165679.1
 Rnf43
ring finger protein 43
chr11_+_105975204 1.773 ENSMUST00000001964.7
 Ace
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr4_+_144892813 1.744 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr11_+_80183851 1.725 ENSMUST00000017839.2
 Rnf135
ring finger protein 135
chr1_+_9547948 1.653 ENSMUST00000144177.1
 Adhfe1
alcohol dehydrogenase, iron containing, 1
chr9_-_103219823 1.640 ENSMUST00000168142.1
 Trf
transferrin
chr4_-_143299463 1.620 ENSMUST00000119654.1
 Pdpn
podoplanin
chr15_+_3270767 1.616 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr11_+_96849863 1.593 ENSMUST00000018816.7
 Copz2
coatomer protein complex, subunit zeta 2
chr3_+_122419772 1.590 ENSMUST00000029766.4
 Bcar3
breast cancer anti-estrogen resistance 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 275 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 3.8 GO:0021759 globus pallidus development(GO:0021759)
0.1 3.7 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.3 3.6 GO:0061032 visceral serous pericardium development(GO:0061032)
0.3 3.5 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.1 3.4 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.3 3.1 GO:0042572 retinol metabolic process(GO:0042572)
1.0 2.9 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.0 2.8 GO:0098780 mitophagy in response to mitochondrial depolarization(GO:0098779) response to mitochondrial depolarisation(GO:0098780)
0.7 2.6 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.1 2.4 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.6 2.3 GO:1903416 response to glycoside(GO:1903416)
0.1 2.3 GO:0019430 removal of superoxide radicals(GO:0019430)
0.3 2.2 GO:1901387 positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.3 2.2 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.4 2.1 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.3 2.0 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.2 2.0 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.1 2.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 1.9 GO:0009404 toxin metabolic process(GO:0009404)
0.6 1.8 GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.1 GO:0005615 extracellular space(GO:0005615)
0.0 8.8 GO:0005667 transcription factor complex(GO:0005667)
0.0 6.1 GO:0031012 extracellular matrix(GO:0031012)
1.0 3.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 3.6 GO:0072562 blood microparticle(GO:0072562)
0.0 3.3 GO:0030175 filopodium(GO:0030175)
0.0 3.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.8 GO:0043235 receptor complex(GO:0043235)
0.0 2.7 GO:0005901 caveola(GO:0005901)
0.8 2.4 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.1 2.4 GO:0031430 M band(GO:0031430)
0.4 2.3 GO:0043256 laminin complex(GO:0043256)
0.3 2.2 GO:0032009 early phagosome(GO:0032009)
0.0 2.2 GO:0030027 lamellipodium(GO:0030027)
0.2 2.1 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 1.9 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 1.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 1.6 GO:0097433 dense body(GO:0097433)
0.2 1.6 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 1.6 GO:0097225 sperm midpiece(GO:0097225)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 193 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.8 GO:0005158 insulin receptor binding(GO:0005158)
0.0 4.2 GO:0005178 integrin binding(GO:0005178)
0.1 3.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 3.9 GO:0051015 actin filament binding(GO:0051015)
1.0 3.8 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.3 3.8 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.2 3.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.5 3.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.3 3.2 GO:0015250 water channel activity(GO:0015250)
0.1 2.9 GO:0005109 frizzled binding(GO:0005109)
0.6 2.4 GO:0050436 microfibril binding(GO:0050436)
0.4 2.3 GO:0050786 RAGE receptor binding(GO:0050786)
0.2 2.3 GO:0044548 S100 protein binding(GO:0044548)
0.1 2.2 GO:0008009 chemokine activity(GO:0008009)
0.1 2.0 GO:0015026 coreceptor activity(GO:0015026)
0.4 1.9 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 1.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.4 1.8 GO:0070573 tripeptidyl-peptidase activity(GO:0008240) metallodipeptidase activity(GO:0070573)
0.1 1.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.4 1.7 GO:0004528 phosphodiesterase I activity(GO:0004528)