Motif ID: Runx3

Z-value: 0.466


Transcription factors associated with Runx3:

Gene SymbolEntrez IDGene Name
Runx3 ENSMUSG00000070691.4 Runx3



Activity profile for motif Runx3.

activity profile for motif Runx3


Sorted Z-values histogram for motif Runx3

Sorted Z-values for motif Runx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 76 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_20181773 1.871 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr3_-_154330543 1.534 ENSMUST00000184966.1
ENSMUST00000177846.2
 Lhx8

LIM homeobox protein 8

chr13_-_22041352 1.045 ENSMUST00000102977.2
 Hist1h4i
histone cluster 1, H4i
chr13_-_23551648 0.791 ENSMUST00000102971.1
 Hist1h4f
histone cluster 1, H4f
chr2_-_71546745 0.732 ENSMUST00000024159.6
 Dlx2
distal-less homeobox 2
chrX_+_99136119 0.696 ENSMUST00000052839.6
 Efnb1
ephrin B1
chr7_+_141216626 0.694 ENSMUST00000141804.1
ENSMUST00000148975.1
 Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr7_-_78783026 0.649 ENSMUST00000032841.5
 Mrpl46
mitochondrial ribosomal protein L46
chr11_-_89302545 0.643 ENSMUST00000061728.3
 Nog
noggin
chr13_-_23698454 0.571 ENSMUST00000102967.1
 Hist1h4c
histone cluster 1, H4c
chr17_+_27556668 0.539 ENSMUST00000117254.1
ENSMUST00000118570.1
 Hmga1

high mobility group AT-hook 1

chr17_+_27556641 0.536 ENSMUST00000119486.1
ENSMUST00000118599.1
 Hmga1

high mobility group AT-hook 1

chr13_+_21735055 0.526 ENSMUST00000087714.4
 Hist1h4j
histone cluster 1, H4j
chr17_+_27556613 0.515 ENSMUST00000117600.1
ENSMUST00000114888.3
 Hmga1

high mobility group AT-hook 1

chr11_-_5878207 0.512 ENSMUST00000102922.3
 Pold2
polymerase (DNA directed), delta 2, regulatory subunit
chr18_-_47368446 0.485 ENSMUST00000076043.6
ENSMUST00000135790.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr17_+_30005029 0.478 ENSMUST00000057897.7
 Zfand3
zinc finger, AN1-type domain 3
chr6_-_100671126 0.471 ENSMUST00000089245.6
ENSMUST00000113312.2
ENSMUST00000170667.1
 Shq1


SHQ1 homolog (S. cerevisiae)


chr13_-_21832194 0.470 ENSMUST00000102979.1
 Hist1h4n
histone cluster 1, H4n
chr13_+_51645232 0.459 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.1 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.2 2.0 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 1.6 GO:0006284 base-excision repair(GO:0006284)
0.0 1.5 GO:0021884 forebrain neuron development(GO:0021884)
0.2 0.7 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
0.0 0.7 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.2 0.6 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.2 0.5 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.0 0.5 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 0.4 GO:0003195 tricuspid valve development(GO:0003175) tricuspid valve morphogenesis(GO:0003186) tricuspid valve formation(GO:0003195) right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 0.4 GO:1902416 positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216)
0.0 0.4 GO:0046036 CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036)
0.1 0.3 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.1 0.3 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.0 0.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.3 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 0.3 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.3 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.2 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 0.2 GO:0009235 cobalamin metabolic process(GO:0009235)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 GO:0000786 nucleosome(GO:0000786)
0.2 1.6 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.3 1.5 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 0.5 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.5 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.4 GO:0045120 pronucleus(GO:0045120)
0.1 0.3 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.3 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 0.2 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.0 0.2 GO:0030677 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.0 0.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.2 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.1 GO:0070652 HAUS complex(GO:0070652)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 GO:0042393 histone binding(GO:0042393)
0.2 2.0 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.2 1.6 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 1.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.7 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.5 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 0.4 GO:0003883 CTP synthase activity(GO:0003883)
0.0 0.4 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 0.3 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.2 GO:0098634 protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.2 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.0 0.2 GO:0043842 Kdo transferase activity(GO:0043842)
0.0 0.2 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.2 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.2 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.2 GO:0008242 omega peptidase activity(GO:0008242)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)