Motif ID: Six3_Six1_Six2

Z-value: 0.611

Transcription factors associated with Six3_Six1_Six2:

Gene SymbolEntrez IDGene Name
Six1 ENSMUSG00000051367.8 Six1
Six2 ENSMUSG00000024134.10 Six2
Six3 ENSMUSG00000038805.9 Six3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six2mm10_v2_chr17_-_85688252_856882750.574.7e-04Click!
Six1mm10_v2_chr12_-_73047179_730471790.567.9e-04Click!
Six3mm10_v2_chr17_+_85620816_856208430.183.3e-01Click!


Activity profile for motif Six3_Six1_Six2.

activity profile for motif Six3_Six1_Six2


Sorted Z-values histogram for motif Six3_Six1_Six2

Sorted Z-values for motif Six3_Six1_Six2



Network of associatons between targets according to the STRING database.



First level regulatory network of Six3_Six1_Six2

PNG image of the network

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Top targets:


Showing 1 to 20 of 76 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_142966709 3.820 ENSMUST00000041317.2
 Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr18_+_56432116 3.606 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr6_-_23248264 3.097 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr9_+_65141154 3.059 ENSMUST00000034961.4
 Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr13_+_43785107 2.568 ENSMUST00000015540.2
 Cd83
CD83 antigen
chr10_-_128180265 2.188 ENSMUST00000099139.1
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr7_-_80115294 1.826 ENSMUST00000107384.3
 Idh2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr3_-_37724321 1.778 ENSMUST00000108105.1
ENSMUST00000079755.4
ENSMUST00000099128.1
 Gm5148


predicted gene 5148


chr9_+_98422961 1.777 ENSMUST00000052068.9
 Rbp1
retinol binding protein 1, cellular
chrX_-_74373260 1.495 ENSMUST00000073067.4
ENSMUST00000037967.5
 Slc10a3

solute carrier family 10 (sodium/bile acid cotransporter family), member 3

chr3_+_130068390 1.389 ENSMUST00000076703.6
 Gm9396
predicted gene 9396
chr15_-_75894474 1.354 ENSMUST00000023237.6
 Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr5_+_140607334 1.061 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr15_-_82244716 1.034 ENSMUST00000089155.4
ENSMUST00000089157.3
 Cenpm

centromere protein M

chr17_+_35241838 0.963 ENSMUST00000173731.1
 Ddx39b
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr17_+_35241746 0.916 ENSMUST00000068056.5
ENSMUST00000174757.1
 Ddx39b

DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B

chr5_+_21543525 0.909 ENSMUST00000035651.4
 Lrrc17
leucine rich repeat containing 17
chr10_+_24595623 0.897 ENSMUST00000176228.1
ENSMUST00000129142.1
 Ctgf

connective tissue growth factor

chr8_-_4275886 0.842 ENSMUST00000003029.7
 Timm44
translocase of inner mitochondrial membrane 44
chrX_+_169685191 0.841 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.5 3.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.4 2.6 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.0 2.3 GO:0032526 response to retinoic acid(GO:0032526)
0.3 1.9 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.6 1.8 GO:0006097 glyoxylate cycle(GO:0006097)
0.4 1.8 GO:0006776 vitamin A metabolic process(GO:0006776)
0.2 1.2 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.2 1.1 GO:0007386 compartment pattern specification(GO:0007386)
0.3 1.0 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.2 0.9 GO:0048539 bone marrow development(GO:0048539)
0.2 0.9 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.1 0.8 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.8 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 0.7 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.2 0.5 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.2 0.5 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.2 0.5 GO:0048496 maintenance of organ identity(GO:0048496)
0.1 0.5 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.5 GO:0031122 cytoplasmic microtubule organization(GO:0031122)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 2.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 1.9 GO:0005688 U6 snRNP(GO:0005688)
0.0 1.5 GO:0000776 kinetochore(GO:0000776)
0.1 1.0 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.9 GO:0005801 cis-Golgi network(GO:0005801)
0.1 0.7 GO:0061574 ASAP complex(GO:0061574)
0.2 0.5 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 0.5 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.5 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.5 GO:0031143 pseudopodium(GO:0031143)
0.1 0.4 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.4 GO:0001772 immunological synapse(GO:0001772)
0.1 0.3 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.3 GO:0051233 spindle midzone(GO:0051233)
0.0 0.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.2 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.1 GO:0097542 ciliary tip(GO:0097542)
0.0 0.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.6 2.3 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.4 1.9 GO:0030621 U4 snRNA binding(GO:0030621)
0.6 1.8 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.3 1.8 GO:0019841 retinol binding(GO:0019841)
0.1 1.2 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.4 1.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 1.0 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 0.7 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.2 0.5 GO:1901611 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.0 0.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.5 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.4 GO:0047631 adenosine-diphosphatase activity(GO:0043262) ADP-ribose diphosphatase activity(GO:0047631)
0.1 0.3 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 0.3 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.0 0.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.1 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0 0.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)