Motif ID: Six3_Six1_Six2

Z-value: 0.611

Transcription factors associated with Six3_Six1_Six2:

Gene SymbolEntrez IDGene Name
Six1 ENSMUSG00000051367.8 Six1
Six2 ENSMUSG00000024134.10 Six2
Six3 ENSMUSG00000038805.9 Six3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six2mm10_v2_chr17_-_85688252_856882750.574.7e-04Click!
Six1mm10_v2_chr12_-_73047179_730471790.567.9e-04Click!
Six3mm10_v2_chr17_+_85620816_856208430.183.3e-01Click!


Activity profile for motif Six3_Six1_Six2.

activity profile for motif Six3_Six1_Six2


Sorted Z-values histogram for motif Six3_Six1_Six2

Sorted Z-values for motif Six3_Six1_Six2



Network of associatons between targets according to the STRING database.



First level regulatory network of Six3_Six1_Six2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_142966709 3.820 ENSMUST00000041317.2
 Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr18_+_56432116 3.606 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr6_-_23248264 3.097 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr9_+_65141154 3.059 ENSMUST00000034961.4
 Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr13_+_43785107 2.568 ENSMUST00000015540.2
 Cd83
CD83 antigen
chr10_-_128180265 2.188 ENSMUST00000099139.1
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr7_-_80115294 1.826 ENSMUST00000107384.3
 Idh2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr3_-_37724321 1.778 ENSMUST00000108105.1
ENSMUST00000079755.4
ENSMUST00000099128.1
 Gm5148


predicted gene 5148


chr9_+_98422961 1.777 ENSMUST00000052068.9
 Rbp1
retinol binding protein 1, cellular
chrX_-_74373260 1.495 ENSMUST00000073067.4
ENSMUST00000037967.5
 Slc10a3

solute carrier family 10 (sodium/bile acid cotransporter family), member 3

chr3_+_130068390 1.389 ENSMUST00000076703.6
 Gm9396
predicted gene 9396
chr15_-_75894474 1.354 ENSMUST00000023237.6
 Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr5_+_140607334 1.061 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr15_-_82244716 1.034 ENSMUST00000089155.4
ENSMUST00000089157.3
 Cenpm

centromere protein M

chr17_+_35241838 0.963 ENSMUST00000173731.1
 Ddx39b
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr17_+_35241746 0.916 ENSMUST00000068056.5
ENSMUST00000174757.1
 Ddx39b

DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B

chr5_+_21543525 0.909 ENSMUST00000035651.4
 Lrrc17
leucine rich repeat containing 17
chr10_+_24595623 0.897 ENSMUST00000176228.1
ENSMUST00000129142.1
 Ctgf

connective tissue growth factor

chr8_-_4275886 0.842 ENSMUST00000003029.7
 Timm44
translocase of inner mitochondrial membrane 44
chrX_+_169685191 0.841 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr15_+_98571004 0.780 ENSMUST00000023728.6
 4930415O20Rik
RIKEN cDNA 4930415O20 gene
chrX_-_74373218 0.768 ENSMUST00000178691.1
ENSMUST00000114146.1
 Ubl4
Slc10a3
ubiquitin-like 4
solute carrier family 10 (sodium/bile acid cotransporter family), member 3
chr4_+_134864536 0.717 ENSMUST00000030627.7
 Rhd
Rh blood group, D antigen
chr3_+_146220955 0.701 ENSMUST00000039164.2
 Lpar3
lysophosphatidic acid receptor 3
chr7_+_30231884 0.687 ENSMUST00000019882.9
 Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr13_+_94083490 0.563 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr9_-_121839460 0.534 ENSMUST00000135986.2
 Ccdc13
coiled-coil domain containing 13
chr4_-_43030440 0.516 ENSMUST00000135660.1
 Stoml2
stomatin (Epb7.2)-like 2
chr19_-_55315980 0.503 ENSMUST00000076891.5
 Zdhhc6
zinc finger, DHHC domain containing 6
chr17_+_40811089 0.483 ENSMUST00000024721.7
 Rhag
Rhesus blood group-associated A glycoprotein
chr13_+_104229366 0.462 ENSMUST00000022227.6
 Cenpk
centromere protein K
chr15_-_76206309 0.457 ENSMUST00000073418.6
ENSMUST00000171634.1
ENSMUST00000076442.5
 Plec


plectin


chr6_-_115675871 0.457 ENSMUST00000112949.1
 Raf1
v-raf-leukemia viral oncogene 1
chr9_+_104002546 0.450 ENSMUST00000035167.8
ENSMUST00000117054.1
 Nphp3

nephronophthisis 3 (adolescent)

chr5_-_62765618 0.436 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr11_-_101987004 0.423 ENSMUST00000107173.2
ENSMUST00000107172.1
 Dusp3

dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)

chr8_-_106573461 0.419 ENSMUST00000073722.5
 Gm10073
predicted pseudogene 10073
chr1_+_139454747 0.409 ENSMUST00000053364.8
ENSMUST00000097554.3
 Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr5_+_104046869 0.354 ENSMUST00000031250.7
 Nudt9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr12_+_30584429 0.352 ENSMUST00000057151.8
 Tmem18
transmembrane protein 18
chr14_+_57798156 0.349 ENSMUST00000128764.1
 Sap18
Sin3-associated polypeptide 18
chr7_-_101903783 0.346 ENSMUST00000106969.1
 Tomt
transmembrane O-methyltransferase
chr2_-_13271268 0.330 ENSMUST00000137670.1
ENSMUST00000114791.2
 Rsu1

Ras suppressor protein 1

chr14_+_57798182 0.316 ENSMUST00000111269.1
 Sap18
Sin3-associated polypeptide 18
chr7_+_30232310 0.308 ENSMUST00000108193.1
ENSMUST00000108192.1
 Polr2i

polymerase (RNA) II (DNA directed) polypeptide I

chrY_-_6237995 0.293 ENSMUST00000177612.1
 Gm21746
predicted gene, 21746
chr2_-_13271419 0.276 ENSMUST00000028059.2
 Rsu1
Ras suppressor protein 1
chr11_-_69695521 0.267 ENSMUST00000181261.1
 Tnfsf12
tumor necrosis factor (ligand) superfamily, member 12
chr7_-_141168671 0.266 ENSMUST00000106033.3
 Rnh1
ribonuclease/angiogenin inhibitor 1
chr1_+_136467958 0.252 ENSMUST00000047817.6
 Kif14
kinesin family member 14
chr16_-_11203259 0.236 ENSMUST00000119953.1
 Rsl1d1
ribosomal L1 domain containing 1
chr12_+_84773262 0.232 ENSMUST00000021667.5
 Isca2
iron-sulfur cluster assembly 2 homolog (S. cerevisiae)
chr8_+_69832633 0.205 ENSMUST00000131637.2
ENSMUST00000081503.6
 Pbx4

pre B cell leukemia homeobox 4

chr19_+_8764934 0.204 ENSMUST00000184663.1
 Nxf1
nuclear RNA export factor 1
chr2_+_117249725 0.195 ENSMUST00000028825.4
 Fam98b
family with sequence similarity 98, member B
chr2_+_158028481 0.176 ENSMUST00000103123.3
 Rprd1b
regulation of nuclear pre-mRNA domain containing 1B
chr4_+_11758147 0.173 ENSMUST00000029871.5
ENSMUST00000108303.1
 Cdh17

cadherin 17

chr13_-_74292297 0.153 ENSMUST00000109640.1
ENSMUST00000022059.7
 Ahrr

aryl-hydrocarbon receptor repressor

chr1_-_119504736 0.150 ENSMUST00000004565.8
 Ralb
v-ral simian leukemia viral oncogene homolog B (ras related)
chr11_-_99230998 0.147 ENSMUST00000103133.3
 Smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr1_-_118982551 0.147 ENSMUST00000159678.1
 Gli2
GLI-Kruppel family member GLI2
chr7_+_43690418 0.136 ENSMUST00000056329.6
 Klk14
kallikrein related-peptidase 14
chr9_+_72958785 0.134 ENSMUST00000098567.2
ENSMUST00000034734.8
 Dyx1c1

dyslexia susceptibility 1 candidate 1 homolog (human)

chr17_-_36951636 0.132 ENSMUST00000040402.7
ENSMUST00000174711.1
 Ppp1r11

protein phosphatase 1, regulatory (inhibitor) subunit 11

chr17_+_56717759 0.126 ENSMUST00000002452.6
 Ndufa11
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 11
chr9_-_36797273 0.111 ENSMUST00000163192.3
 Ei24
etoposide induced 2.4 mRNA
chr9_-_36797303 0.098 ENSMUST00000115086.5
 Ei24
etoposide induced 2.4 mRNA
chr4_+_133176336 0.090 ENSMUST00000105912.1
 Wasf2
WAS protein family, member 2
chr7_-_126676428 0.077 ENSMUST00000106373.1
 Sult1a1
sulfotransferase family 1A, phenol-preferring, member 1
chr14_+_58893465 0.077 ENSMUST00000079960.1
 Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr2_+_127336152 0.065 ENSMUST00000028846.6
 Dusp2
dual specificity phosphatase 2
chr7_-_126676357 0.062 ENSMUST00000106371.1
ENSMUST00000106372.3
ENSMUST00000155419.1
 Sult1a1


sulfotransferase family 1A, phenol-preferring, member 1


chr8_+_84831522 0.057 ENSMUST00000036734.5
 Gadd45gip1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr8_+_71951038 0.053 ENSMUST00000131237.1
ENSMUST00000136516.1
ENSMUST00000109997.2
ENSMUST00000132848.1
 Zfp961



zinc finger protein 961



chr17_-_53539411 0.021 ENSMUST00000056198.3
 Pp2d1
protein phosphatase 2C-like domain containing 1
chr8_-_86885222 0.001 ENSMUST00000034074.7
 N4bp1
NEDD4 binding protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0006097 glyoxylate cycle(GO:0006097)
0.5 3.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.4 1.8 GO:0006776 vitamin A metabolic process(GO:0006776)
0.4 2.6 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.3 1.0 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.3 1.9 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.2 1.2 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.2 0.9 GO:0048539 bone marrow development(GO:0048539)
0.2 0.9 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.2 1.1 GO:0007386 compartment pattern specification(GO:0007386)
0.2 0.5 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.2 0.5 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.2 0.5 GO:0048496 maintenance of organ identity(GO:0048496)
0.1 0.4 GO:0046032 ADP catabolic process(GO:0046032)
0.1 0.5 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.3 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.1 0.3 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.1 0.4 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 0.8 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 0.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 0.2 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.7 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.1 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.0 0.1 GO:0060032 notochord regression(GO:0060032)
0.0 3.3 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.0 0.4 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 2.3 GO:0032526 response to retinoic acid(GO:0032526)
0.0 0.8 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.1 GO:0007320 insemination(GO:0007320)
0.0 0.2 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0 0.1 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.1 GO:0051923 sulfation(GO:0051923)
0.0 0.2 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.5 GO:0031122 cytoplasmic microtubule organization(GO:0031122)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.9 GO:0005688 U6 snRNP(GO:0005688)
0.2 0.5 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 0.3 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.1 0.4 GO:0036449 microtubule minus-end(GO:0036449)
0.1 0.7 GO:0061574 ASAP complex(GO:0061574)
0.1 1.0 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 3.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.5 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.5 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.5 GO:0031143 pseudopodium(GO:0031143)
0.0 0.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.9 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.2 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.1 GO:0097542 ciliary tip(GO:0097542)
0.0 0.4 GO:0001772 immunological synapse(GO:0001772)
0.0 2.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.3 GO:0051233 spindle midzone(GO:0051233)
0.0 1.5 GO:0000776 kinetochore(GO:0000776)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.6 2.3 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.4 1.9 GO:0030621 U4 snRNA binding(GO:0030621)
0.4 1.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.3 1.8 GO:0019841 retinol binding(GO:0019841)
0.2 0.5 GO:1901611 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.1 0.7 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.3 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.1 1.2 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 0.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.1 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0 0.4 GO:0047631 adenosine-diphosphatase activity(GO:0043262) ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.3 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.0 0.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.0 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.5 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 3.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)