Motif ID: Six4

Z-value: 0.654


Transcription factors associated with Six4:

Gene SymbolEntrez IDGene Name
Six4 ENSMUSG00000034460.8 Six4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six4mm10_v2_chr12_-_73113407_731134560.459.1e-03Click!


Activity profile for motif Six4.

activity profile for motif Six4


Sorted Z-values histogram for motif Six4

Sorted Z-values for motif Six4



Network of associatons between targets according to the STRING database.



First level regulatory network of Six4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 65 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_137314394 5.561 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr6_-_23248264 5.004 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_-_143460989 2.839 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr4_-_134018829 2.393 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chr7_+_29307924 1.895 ENSMUST00000108230.1
ENSMUST00000065181.5
 Dpf1

D4, zinc and double PHD fingers family 1

chr7_-_132317198 1.878 ENSMUST00000080215.5
 Chst15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr7_+_29309429 1.851 ENSMUST00000137848.1
 Dpf1
D4, zinc and double PHD fingers family 1
chr2_-_103797617 1.570 ENSMUST00000028607.6
 Caprin1
cell cycle associated protein 1
chr8_-_84237042 1.556 ENSMUST00000039480.5
 Zswim4
zinc finger SWIM-type containing 4
chr13_+_73626886 1.529 ENSMUST00000022104.7
 Tert
telomerase reverse transcriptase
chr19_+_8764934 1.498 ENSMUST00000184663.1
 Nxf1
nuclear RNA export factor 1
chr8_-_85067982 1.387 ENSMUST00000177563.1
 Gm5741
predicted gene 5741
chr11_+_67078293 1.280 ENSMUST00000108689.1
ENSMUST00000165221.1
ENSMUST00000007301.7
 Myh3


myosin, heavy polypeptide 3, skeletal muscle, embryonic


chr7_+_38183787 1.181 ENSMUST00000067854.8
ENSMUST00000177983.1
 1600014C10Rik

RIKEN cDNA 1600014C10 gene

chr1_-_78968079 1.060 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr13_-_9878998 0.962 ENSMUST00000063093.9
 Chrm3
cholinergic receptor, muscarinic 3, cardiac
chr14_-_89898466 0.941 ENSMUST00000081204.4
 Gm10110
predicted gene 10110
chr6_+_7555053 0.929 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr1_-_180813534 0.912 ENSMUST00000159789.1
ENSMUST00000081026.4
 H3f3a

H3 histone, family 3A

chr12_-_57546121 0.903 ENSMUST00000044380.6
 Foxa1
forkhead box A1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 5.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 2.8 GO:0060065 uterus development(GO:0060065)
0.3 2.4 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 1.9 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 1.9 GO:0019319 hexose biosynthetic process(GO:0019319)
0.0 1.6 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.5 1.5 GO:1900369 negative regulation of RNA interference(GO:1900369) regulation of histone demethylase activity (H3-K4 specific)(GO:1904173)
0.3 1.3 GO:0031509 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.0 1.3 GO:0003009 skeletal muscle contraction(GO:0003009)
0.2 1.0 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.3 0.9 GO:2000852 regulation of corticosterone secretion(GO:2000852)
0.3 0.9 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743) alveolar secondary septum development(GO:0061144)
0.1 0.9 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.0 0.8 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.8 GO:0006400 tRNA modification(GO:0006400)
0.0 0.7 GO:0009206 ATP biosynthetic process(GO:0006754) purine ribonucleoside triphosphate biosynthetic process(GO:0009206)
0.0 0.6 GO:0001522 pseudouridine synthesis(GO:0001522)
0.0 0.6 GO:0000281 mitotic cytokinesis(GO:0000281)
0.1 0.5 GO:0046036 GTP biosynthetic process(GO:0006183) CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036)
0.0 0.5 GO:0051457 maintenance of protein location in nucleus(GO:0051457)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 3.7 GO:0071565 nBAF complex(GO:0071565)
0.1 1.5 GO:0042405 nuclear inclusion body(GO:0042405)
0.1 1.5 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.2 1.3 GO:0001740 Barr body(GO:0001740)
0.1 1.3 GO:0032982 myosin filament(GO:0032982)
0.0 1.0 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.9 GO:0005902 microvillus(GO:0005902)
0.0 0.8 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.6 GO:0001651 dense fibrillar component(GO:0001651) box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.0 0.5 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.4 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.2 GO:0005638 lamin filament(GO:0005638)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.4 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.2 2.8 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 2.4 GO:0035198 miRNA binding(GO:0035198)
0.6 1.9 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.1 1.5 GO:0070034 telomerase RNA binding(GO:0070034)
0.1 1.5 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 1.3 GO:0000146 microfilament motor activity(GO:0000146)
0.0 1.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 1.0 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 0.8 GO:0008193 tRNA guanylyltransferase activity(GO:0008193)
0.0 0.8 GO:0005254 chloride channel activity(GO:0005254)
0.0 0.6 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.6 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.5 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.5 GO:0005112 Notch binding(GO:0005112)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.3 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.3 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116) steroid hormone binding(GO:1990239)