Motif ID: Smad1

Z-value: 1.486


Transcription factors associated with Smad1:

Gene SymbolEntrez IDGene Name
Smad1 ENSMUSG00000031681.8 Smad1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad1mm10_v2_chr8_-_79399513_79399532-0.681.3e-05Click!


Activity profile for motif Smad1.

activity profile for motif Smad1


Sorted Z-values histogram for motif Smad1

Sorted Z-values for motif Smad1



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_55175019 8.351 ENSMUST00000003569.5
 Inmt
indolethylamine N-methyltransferase
chr7_-_103843154 8.285 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chrX_+_73483602 6.951 ENSMUST00000033741.8
ENSMUST00000169489.1
 Bgn

biglycan

chr12_+_109452833 6.456 ENSMUST00000056110.8
 Dlk1
delta-like 1 homolog (Drosophila)
chr2_+_93642307 5.033 ENSMUST00000042078.3
ENSMUST00000111254.1
 Alx4

aristaless-like homeobox 4

chr9_-_114564315 4.935 ENSMUST00000111816.2
 Trim71
tripartite motif-containing 71
chr10_+_79988584 4.805 ENSMUST00000004784.4
ENSMUST00000105374.1
 Cnn2

calponin 2

chr6_-_23248264 4.620 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr17_-_84682932 4.402 ENSMUST00000066175.3
 Abcg5
ATP-binding cassette, sub-family G (WHITE), member 5
chr17_-_32166879 4.351 ENSMUST00000087723.3
 Notch3
notch 3
chr3_+_87948666 4.294 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr19_+_20601958 4.291 ENSMUST00000087638.3
 Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr6_+_4504814 4.279 ENSMUST00000141483.1
 Col1a2
collagen, type I, alpha 2
chr17_+_35439155 3.862 ENSMUST00000071951.6
ENSMUST00000078205.7
ENSMUST00000116598.3
ENSMUST00000076256.7
 H2-Q7



histocompatibility 2, Q region locus 7



chr11_+_32296489 3.780 ENSMUST00000093207.3
 Hba-a2
hemoglobin alpha, adult chain 2
chr2_+_164562579 3.385 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr9_+_119063429 3.381 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr9_+_54764748 3.331 ENSMUST00000034830.8
 Crabp1
cellular retinoic acid binding protein I
chr19_-_24031006 3.309 ENSMUST00000096164.4
 Fam189a2
family with sequence similarity 189, member A2
chr7_-_142576492 3.224 ENSMUST00000140716.1
 H19
H19 fetal liver mRNA

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 772 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 16.0 GO:0042573 retinoic acid metabolic process(GO:0042573)
0.4 10.1 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.3 10.0 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
1.0 9.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
1.7 8.3 GO:0015671 oxygen transport(GO:0015671)
0.1 7.8 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.3 6.7 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
0.6 6.4 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
1.3 6.3 GO:0015705 iodide transport(GO:0015705)
0.4 6.3 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.2 6.3 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.3 5.9 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.1 5.8 GO:0009636 response to toxic substance(GO:0009636)
0.8 5.6 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.1 5.5 GO:0048844 artery morphogenesis(GO:0048844)
1.1 5.3 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.2 5.3 GO:0006270 DNA replication initiation(GO:0006270)
1.7 5.0 GO:0030300 regulation of intestinal cholesterol absorption(GO:0030300)
1.6 4.9 GO:0070366 regulation of hepatocyte differentiation(GO:0070366)
1.2 4.9 GO:0048819 regulation of hair follicle maturation(GO:0048819) regulation of catagen(GO:0051794)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 300 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 28.5 GO:0005667 transcription factor complex(GO:0005667)
0.1 21.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 21.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 21.3 GO:1903561 extracellular organelle(GO:0043230) extracellular vesicle(GO:1903561)
0.2 14.3 GO:0072562 blood microparticle(GO:0072562)
1.7 13.8 GO:0005833 hemoglobin complex(GO:0005833)
0.2 12.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 10.4 GO:0005912 adherens junction(GO:0005912)
0.2 9.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.7 9.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 7.4 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 7.2 GO:0005581 collagen trimer(GO:0005581)
0.4 5.9 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 5.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 5.1 GO:0005643 nuclear pore(GO:0005643)
0.2 4.8 GO:0043218 compact myelin(GO:0043218)
0.1 4.6 GO:0031012 extracellular matrix(GO:0031012)
0.1 4.6 GO:0031526 brush border membrane(GO:0031526)
0.1 4.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
1.4 4.3 GO:0005584 collagen type I trimer(GO:0005584)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 493 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 24.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.4 13.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.3 13.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.3 11.0 GO:0071837 HMG box domain binding(GO:0071837)
0.3 11.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 10.9 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 10.3 GO:0008201 heparin binding(GO:0008201)
2.5 10.0 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.6 8.3 GO:0030881 beta-2-microglobulin binding(GO:0030881)
1.1 6.6 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
1.1 6.5 GO:0016918 retinal binding(GO:0016918)
1.6 6.3 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.2 6.1 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.2 5.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 5.8 GO:0030371 translation repressor activity(GO:0030371)
0.4 5.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
1.1 5.5 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
0.1 5.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 4.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 4.9 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)