Motif ID: Smad2

Z-value: 0.492


Transcription factors associated with Smad2:

Gene SymbolEntrez IDGene Name
Smad2 ENSMUSG00000024563.9 Smad2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad2mm10_v2_chr18_+_76242135_76242174-0.602.1e-04Click!


Activity profile for motif Smad2.

activity profile for motif Smad2


Sorted Z-values histogram for motif Smad2

Sorted Z-values for motif Smad2



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad2

PNG image of the network

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Top targets:


Showing 1 to 20 of 73 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_12345847 2.232 ENSMUST00000022262.4
 Fezf2
Fez family zinc finger 2
chr8_-_87959560 1.747 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr9_-_119578981 1.663 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr6_-_55175019 1.593 ENSMUST00000003569.5
 Inmt
indolethylamine N-methyltransferase
chr3_+_89136133 1.243 ENSMUST00000047111.6
 Pklr
pyruvate kinase liver and red blood cell
chr7_-_116237767 1.159 ENSMUST00000182834.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr3_+_89136572 1.063 ENSMUST00000107482.3
ENSMUST00000127058.1
 Pklr

pyruvate kinase liver and red blood cell

chr19_+_59458372 0.932 ENSMUST00000062216.3
 Emx2
empty spiracles homeobox 2
chr3_+_127633134 0.853 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chrX_+_99821021 0.777 ENSMUST00000096363.2
 Tmem28
transmembrane protein 28
chr12_+_33147693 0.767 ENSMUST00000077456.6
ENSMUST00000110824.2
 Atxn7l1

ataxin 7-like 1

chr5_-_113800356 0.747 ENSMUST00000160374.1
ENSMUST00000067853.5
 Tmem119

transmembrane protein 119

chr2_+_156863110 0.644 ENSMUST00000029165.3
 1110008F13Rik
RIKEN cDNA 1110008F13 gene
chr7_+_82867327 0.641 ENSMUST00000082237.5
 Mex3b
mex3 homolog B (C. elegans)
chr11_-_116654245 0.624 ENSMUST00000021166.5
 Cygb
cytoglobin
chr7_-_34654342 0.623 ENSMUST00000108069.1
 Kctd15
potassium channel tetramerisation domain containing 15
chr15_-_103251465 0.608 ENSMUST00000133600.1
ENSMUST00000134554.1
ENSMUST00000156927.1
ENSMUST00000149111.1
ENSMUST00000132836.1
 Nfe2




nuclear factor, erythroid derived 2




chr8_-_90908415 0.603 ENSMUST00000098517.1
 Gm6658
predicted gene 6658
chr13_-_78199757 0.586 ENSMUST00000091458.6
 Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr7_-_45052865 0.577 ENSMUST00000057293.6
 Prr12
proline rich 12

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.3 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.4 2.2 GO:1904936 forebrain anterior/posterior pattern specification(GO:0021797) cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.6 1.7 GO:0086017 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) Purkinje myocyte action potential(GO:0086017) membrane depolarization during SA node cell action potential(GO:0086046)
0.0 1.7 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 1.6 GO:0009308 amine metabolic process(GO:0009308)
0.1 1.5 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.2 1.2 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 0.9 GO:0043248 proteasome assembly(GO:0043248)
0.1 0.7 GO:1903012 positive regulation of bone development(GO:1903012)
0.2 0.6 GO:0070844 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.2 0.6 GO:0072697 protein localization to cell cortex(GO:0072697)
0.1 0.6 GO:0015671 oxygen transport(GO:0015671)
0.1 0.6 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.0 0.6 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 0.5 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0 0.5 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.4 GO:0021764 amygdala development(GO:0021764)
0.1 0.4 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.1 0.4 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.4 GO:0032020 ISG15-protein conjugation(GO:0032020)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.7 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 1.2 GO:0005915 zonula adherens(GO:0005915)
0.1 0.9 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.6 GO:0016235 aggresome(GO:0016235)
0.0 0.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.4 GO:0042585 germinal vesicle(GO:0042585)
0.1 0.4 GO:0005827 polar microtubule(GO:0005827)
0.0 0.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.2 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.8 2.3 GO:0004743 pyruvate kinase activity(GO:0004743)
0.2 1.7 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 1.6 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 1.2 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.9 GO:0070888 E-box binding(GO:0070888)
0.2 0.6 GO:0004096 catalase activity(GO:0004096)
0.1 0.6 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.0 0.6 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.6 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.6 GO:0050699 WW domain binding(GO:0050699)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 0.5 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 0.5 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.1 0.4 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.3 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.2 GO:0005095 GTPase inhibitor activity(GO:0005095)