Motif ID: Smad3

Z-value: 1.634


Transcription factors associated with Smad3:

Gene SymbolEntrez IDGene Name
Smad3 ENSMUSG00000032402.6 Smad3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad3mm10_v2_chr9_-_63711969_63711994-0.722.5e-06Click!


Activity profile for motif Smad3.

activity profile for motif Smad3


Sorted Z-values histogram for motif Smad3

Sorted Z-values for motif Smad3



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad3

PNG image of the network

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Top targets:


Showing 1 to 20 of 92 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_22042949 16.791 ENSMUST00000091741.4
 Hist1h2ag
histone cluster 1, H2ag
chr13_+_23533869 16.436 ENSMUST00000073261.2
 Hist1h2af
histone cluster 1, H2af
chr13_-_21833575 13.522 ENSMUST00000081342.5
 Hist1h2ap
histone cluster 1, H2ap
chr13_-_22035589 13.243 ENSMUST00000091742.4
 Hist1h2ah
histone cluster 1, H2ah
chr15_+_81936753 11.828 ENSMUST00000038757.7
 Csdc2
cold shock domain containing C2, RNA binding
chr13_-_21787218 11.297 ENSMUST00000091751.2
 Hist1h2an
histone cluster 1, H2an
chr14_-_62456286 11.018 ENSMUST00000165651.1
ENSMUST00000022501.3
 Gucy1b2

guanylate cyclase 1, soluble, beta 2

chr15_+_81936911 10.588 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding
chr13_+_21810428 9.960 ENSMUST00000091745.5
 Hist1h2ao
histone cluster 1, H2ao
chr13_-_23571151 9.769 ENSMUST00000102969.3
 Hist1h2ae
histone cluster 1, H2ae
chr19_+_5740885 8.227 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr6_-_36811361 7.613 ENSMUST00000101534.1
 Ptn
pleiotrophin
chr11_+_58954675 6.750 ENSMUST00000047697.5
ENSMUST00000108817.3
 Trim17
Hist3h2a
tripartite motif-containing 17
histone cluster 3, H2a
chr1_-_134235420 6.567 ENSMUST00000038191.6
ENSMUST00000086465.4
 Adora1

adenosine A1 receptor

chr13_-_21832194 6.420 ENSMUST00000102979.1
 Hist1h4n
histone cluster 1, H4n
chr2_-_173276144 5.925 ENSMUST00000139306.1
 Pmepa1
prostate transmembrane protein, androgen induced 1
chr15_-_81697256 5.722 ENSMUST00000072910.5
 Chadl
chondroadherin-like
chr13_+_23581563 5.393 ENSMUST00000102968.1
 Hist1h4d
histone cluster 1, H4d
chr11_-_116110211 5.139 ENSMUST00000106441.1
ENSMUST00000021120.5
 Trim47

tripartite motif-containing 47

chr13_-_21750505 4.624 ENSMUST00000102983.1
 Hist1h4k
histone cluster 1, H4k

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 90.4 GO:0006342 chromatin silencing(GO:0006342)
1.4 26.8 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 15.6 GO:0006397 mRNA processing(GO:0006397)
0.4 11.0 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.7 8.5 GO:0002227 innate immune response in mucosa(GO:0002227)
2.7 8.2 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
2.5 7.6 GO:1904395 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.1 7.3 GO:0006334 nucleosome assembly(GO:0006334)
2.2 6.6 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242)
2.1 6.4 GO:0071544 diphosphoinositol polyphosphate metabolic process(GO:0071543) diphosphoinositol polyphosphate catabolic process(GO:0071544)
1.2 5.9 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
1.9 5.7 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
1.5 4.5 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.4 3.9 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 3.7 GO:0098792 xenophagy(GO:0098792)
0.9 3.6 GO:0007039 protein catabolic process in the vacuole(GO:0007039) peptidyl-aspartic acid modification(GO:0018197)
0.0 3.3 GO:0008643 carbohydrate transport(GO:0008643)
1.0 3.1 GO:0042275 error-free postreplication DNA repair(GO:0042275)
0.2 2.9 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 2.9 GO:0071300 cellular response to retinoic acid(GO:0071300)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 82.6 GO:0000786 nucleosome(GO:0000786)
0.1 39.5 GO:0000790 nuclear chromatin(GO:0000790)
0.1 14.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
1.2 11.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 7.6 GO:0031594 neuromuscular junction(GO:0031594)
0.3 6.6 GO:0032279 asymmetric synapse(GO:0032279)
0.1 5.9 GO:0031901 early endosome membrane(GO:0031901)
0.0 5.3 GO:0030133 transport vesicle(GO:0030133)
0.3 4.5 GO:0097449 astrocyte projection(GO:0097449)
0.2 3.9 GO:0005614 interstitial matrix(GO:0005614)
0.1 3.6 GO:0005771 multivesicular body(GO:0005771)
0.0 3.3 GO:0000139 Golgi membrane(GO:0000139)
1.0 3.1 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.1 2.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 2.6 GO:0042734 presynaptic membrane(GO:0042734)
0.1 2.0 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 1.8 GO:0014704 intercalated disc(GO:0014704)
0.1 1.5 GO:0000421 autophagosome membrane(GO:0000421)
0.0 1.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.1 GO:0055038 recycling endosome membrane(GO:0055038)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 62.8 GO:0003677 DNA binding(GO:0003677)
0.1 46.9 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 24.0 GO:0042393 histone binding(GO:0042393)
1.2 11.0 GO:0004383 guanylate cyclase activity(GO:0004383)
0.3 8.2 GO:0050431 transforming growth factor beta binding(GO:0050431)
2.5 7.6 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.9 6.6 GO:0032795 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
1.1 6.4 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.2 6.3 GO:0050699 WW domain binding(GO:0050699)
0.1 5.7 GO:0005518 collagen binding(GO:0005518)
1.5 4.5 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 3.9 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.4 3.6 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116)
0.2 3.6 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.2 3.5 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.1 3.3 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.1 3.2 GO:0030552 cAMP binding(GO:0030552)
0.1 3.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.5 2.6 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.1 2.6 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)