Motif ID: Smad4

Z-value: 1.046


Transcription factors associated with Smad4:

Gene SymbolEntrez IDGene Name
Smad4 ENSMUSG00000024515.7 Smad4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad4mm10_v2_chr18_-_73703739_737038060.144.3e-01Click!


Activity profile for motif Smad4.

activity profile for motif Smad4


Sorted Z-values histogram for motif Smad4

Sorted Z-values for motif Smad4



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_127534540 4.049 ENSMUST00000095266.2
Nxph4
neurexophilin 4
chr13_-_22042949 3.663 ENSMUST00000091741.4
Hist1h2ag
histone cluster 1, H2ag
chr19_+_5740885 2.867 ENSMUST00000081496.5
Ltbp3
latent transforming growth factor beta binding protein 3
chr13_-_21832194 2.473 ENSMUST00000102979.1
Hist1h4n
histone cluster 1, H4n
chr11_-_95514570 2.472 ENSMUST00000058866.7
Nxph3
neurexophilin 3
chr4_-_148130678 2.092 ENSMUST00000030862.4
Draxin
dorsal inhibitory axon guidance protein
chr13_+_23581563 1.931 ENSMUST00000102968.1
Hist1h4d
histone cluster 1, H4d
chr7_-_70360593 1.925 ENSMUST00000032768.7
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr7_-_27181149 1.918 ENSMUST00000071986.6
ENSMUST00000121848.1
Mia

melanoma inhibitory activity

chr3_+_127633134 1.640 ENSMUST00000029587.7
Neurog2
neurogenin 2
chr14_-_25903100 1.511 ENSMUST00000052286.8
Plac9a
placenta specific 9a
chr13_+_22043189 1.436 ENSMUST00000110452.1
Hist1h2bj
histone cluster 1, H2bj
chr18_+_57133065 1.348 ENSMUST00000075770.6
Megf10
multiple EGF-like-domains 10
chr11_-_89302545 1.254 ENSMUST00000061728.3
Nog
noggin
chr3_-_96220880 1.178 ENSMUST00000090782.3
Hist2h2ac
histone cluster 2, H2ac
chr13_-_23551648 1.149 ENSMUST00000102971.1
Hist1h4f
histone cluster 1, H4f
chr10_-_92164666 1.146 ENSMUST00000183123.1
ENSMUST00000182033.1
Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr10_+_75589363 1.104 ENSMUST00000072217.2
Ggt5
gamma-glutamyltransferase 5
chr13_+_21735055 1.104 ENSMUST00000087714.4
Hist1h4j
histone cluster 1, H4j
chr6_+_54040078 1.081 ENSMUST00000127323.2
Chn2
chimerin (chimaerin) 2
chr2_+_27079371 1.064 ENSMUST00000091233.6
Adamtsl2
ADAMTS-like 2
chr6_+_54039558 1.057 ENSMUST00000046856.7
Chn2
chimerin (chimaerin) 2
chr13_+_23531044 1.030 ENSMUST00000102972.3
Hist1h4h
histone cluster 1, H4h
chr4_+_97772734 0.979 ENSMUST00000152023.1
Nfia
nuclear factor I/A
chr17_+_75178911 0.977 ENSMUST00000112514.1
Ltbp1
latent transforming growth factor beta binding protein 1
chr17_-_29888570 0.967 ENSMUST00000171691.1
Mdga1
MAM domain containing glycosylphosphatidylinositol anchor 1
chr17_+_75178797 0.965 ENSMUST00000112516.1
ENSMUST00000135447.1
Ltbp1

latent transforming growth factor beta binding protein 1

chr19_+_46328179 0.889 ENSMUST00000026256.2
ENSMUST00000177667.1
Fbxl15

F-box and leucine-rich repeat protein 15

chr1_-_173367638 0.837 ENSMUST00000005470.4
ENSMUST00000111220.1
Cadm3

cell adhesion molecule 3

chr8_+_54954728 0.833 ENSMUST00000033915.7
Gpm6a
glycoprotein m6a
chr3_-_116968969 0.824 ENSMUST00000143611.1
ENSMUST00000040097.7
Palmd

palmdelphin

chr12_+_103314944 0.775 ENSMUST00000179363.1
Fam181a
family with sequence similarity 181, member A
chr14_+_57826210 0.752 ENSMUST00000022538.3
Mrp63
mitochondrial ribosomal protein 63
chr1_+_177445660 0.747 ENSMUST00000077225.6
Zbtb18
zinc finger and BTB domain containing 18
chr13_-_23934156 0.747 ENSMUST00000052776.2
Hist1h2ba
histone cluster 1, H2ba
chr10_+_33905015 0.728 ENSMUST00000169670.1
Rsph4a
radial spoke head 4 homolog A (Chlamydomonas)
chr6_+_15720654 0.720 ENSMUST00000101663.3
Mdfic
MyoD family inhibitor domain containing
chr14_-_54577578 0.719 ENSMUST00000054487.8
Ajuba
ajuba LIM protein
chrX_+_56779437 0.699 ENSMUST00000114773.3
Fhl1
four and a half LIM domains 1
chr1_+_187997821 0.696 ENSMUST00000027906.6
Esrrg
estrogen-related receptor gamma
chr1_+_187997835 0.689 ENSMUST00000110938.1
Esrrg
estrogen-related receptor gamma
chr15_+_39076885 0.683 ENSMUST00000067072.3
Cthrc1
collagen triple helix repeat containing 1
chr7_+_45216671 0.670 ENSMUST00000134420.1
Tead2
TEA domain family member 2
chr6_+_54039935 0.661 ENSMUST00000114403.1
Chn2
chimerin (chimaerin) 2
chr2_-_128967725 0.657 ENSMUST00000099385.2
Gm10762
predicted gene 10762
chr10_-_42583628 0.644 ENSMUST00000019938.4
Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr14_+_12189943 0.625 ENSMUST00000119888.1
Ptprg
protein tyrosine phosphatase, receptor type, G
chr7_+_45215753 0.619 ENSMUST00000033060.6
ENSMUST00000155313.1
ENSMUST00000107801.1
Tead2


TEA domain family member 2


chr2_+_152736244 0.607 ENSMUST00000038368.8
ENSMUST00000109824.1
Id1

inhibitor of DNA binding 1

chr15_+_81936753 0.599 ENSMUST00000038757.7
Csdc2
cold shock domain containing C2, RNA binding
chrX_+_99136119 0.593 ENSMUST00000052839.6
Efnb1
ephrin B1
chr15_+_81936911 0.582 ENSMUST00000135663.1
Csdc2
cold shock domain containing C2, RNA binding
chr4_-_95052170 0.562 ENSMUST00000058555.2
Jun
Jun oncogene
chr19_-_23448322 0.552 ENSMUST00000036069.6
Mamdc2
MAM domain containing 2
chr8_-_34146974 0.542 ENSMUST00000033910.8
Leprotl1
leptin receptor overlapping transcript-like 1
chr5_+_19907502 0.537 ENSMUST00000101558.3
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr5_-_137741102 0.533 ENSMUST00000149512.1
Nyap1
neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1
chr4_+_148130883 0.523 ENSMUST00000084129.2
Mad2l2
MAD2 mitotic arrest deficient-like 2
chr18_-_35498856 0.520 ENSMUST00000025215.8
Sil1
endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae)
chr17_-_70851710 0.508 ENSMUST00000166395.2
Tgif1
TGFB-induced factor homeobox 1
chr10_+_91082940 0.503 ENSMUST00000020150.3
Ikbip
IKBKB interacting protein
chr10_+_80150448 0.496 ENSMUST00000153477.1
Midn
midnolin
chr8_+_45658273 0.476 ENSMUST00000153798.1
Sorbs2
sorbin and SH3 domain containing 2
chr4_+_127172866 0.466 ENSMUST00000106094.2
Dlgap3
discs, large (Drosophila) homolog-associated protein 3
chr6_-_83775767 0.463 ENSMUST00000014892.6
Tex261
testis expressed gene 261
chr12_+_76404168 0.451 ENSMUST00000080449.5
Hspa2
heat shock protein 2
chrX_+_10485121 0.443 ENSMUST00000076354.6
ENSMUST00000115526.1
Tspan7

tetraspanin 7

chr5_-_92278155 0.442 ENSMUST00000159345.1
ENSMUST00000113102.3
Naaa

N-acylethanolamine acid amidase

chr6_+_108660772 0.441 ENSMUST00000163617.1
Bhlhe40
basic helix-loop-helix family, member e40
chr18_-_84086379 0.438 ENSMUST00000060303.8
Tshz1
teashirt zinc finger family member 1
chr3_-_116968827 0.437 ENSMUST00000119557.1
Palmd
palmdelphin
chr4_+_130055010 0.433 ENSMUST00000123617.1
Col16a1
collagen, type XVI, alpha 1
chr8_-_109251698 0.427 ENSMUST00000079189.3
4922502B01Rik
RIKEN cDNA 4922502B01 gene
chr7_+_82867327 0.427 ENSMUST00000082237.5
Mex3b
mex3 homolog B (C. elegans)
chr2_-_173276144 0.418 ENSMUST00000139306.1
Pmepa1
prostate transmembrane protein, androgen induced 1
chr14_-_57826128 0.415 ENSMUST00000022536.2
Ska3
spindle and kinetochore associated complex subunit 3
chr7_-_30362772 0.412 ENSMUST00000046351.5
Lrfn3
leucine rich repeat and fibronectin type III domain containing 3
chr11_-_5261558 0.410 ENSMUST00000020662.8
Kremen1
kringle containing transmembrane protein 1
chr3_+_96221111 0.406 ENSMUST00000090781.6
Hist2h2be
histone cluster 2, H2be
chr4_+_133011506 0.404 ENSMUST00000105915.1
ENSMUST00000105916.1
Ahdc1

AT hook, DNA binding motif, containing 1

chr5_-_24601961 0.403 ENSMUST00000030791.7
Smarcd3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr11_-_3931960 0.396 ENSMUST00000109990.1
ENSMUST00000020710.4
ENSMUST00000109989.3
ENSMUST00000109991.1
ENSMUST00000109993.2
Tcn2




transcobalamin 2




chr14_-_31168587 0.391 ENSMUST00000036618.7
Stab1
stabilin 1
chr11_-_3931789 0.367 ENSMUST00000109992.1
ENSMUST00000109988.1
Tcn2

transcobalamin 2

chr1_+_152399824 0.366 ENSMUST00000044311.8
Colgalt2
collagen beta(1-O)galactosyltransferase 2
chr2_+_128967383 0.361 ENSMUST00000110320.2
ENSMUST00000110319.2
Zc3h6

zinc finger CCCH type containing 6

chr4_-_117178726 0.358 ENSMUST00000153953.1
ENSMUST00000106436.1
Kif2c

kinesin family member 2C

chr16_-_55283237 0.355 ENSMUST00000036412.3
Zpld1
zona pellucida like domain containing 1
chr4_+_116221633 0.354 ENSMUST00000030464.7
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr7_+_4690760 0.351 ENSMUST00000048248.7
Brsk1
BR serine/threonine kinase 1
chr3_+_89436699 0.347 ENSMUST00000038942.3
ENSMUST00000130858.1
Pbxip1

pre B cell leukemia transcription factor interacting protein 1

chr4_+_128688726 0.333 ENSMUST00000106080.1
Phc2
polyhomeotic-like 2 (Drosophila)
chr7_-_45870928 0.328 ENSMUST00000146672.1
Grin2d
glutamate receptor, ionotropic, NMDA2D (epsilon 4)
chrX_+_136707976 0.320 ENSMUST00000055104.5
Tceal1
transcription elongation factor A (SII)-like 1
chr19_-_40271506 0.318 ENSMUST00000068439.6
Pdlim1
PDZ and LIM domain 1 (elfin)
chr3_+_88607742 0.315 ENSMUST00000175903.1
Arhgef2
rho/rac guanine nucleotide exchange factor (GEF) 2
chr5_+_92683625 0.306 ENSMUST00000168878.1
Shroom3
shroom family member 3
chr11_-_3504766 0.300 ENSMUST00000044507.5
Inpp5j
inositol polyphosphate 5-phosphatase J
chr7_+_110221697 0.296 ENSMUST00000033325.7
Swap70
SWA-70 protein
chr9_+_57940104 0.291 ENSMUST00000043059.7
Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr5_+_111417263 0.287 ENSMUST00000094463.4
Mn1
meningioma 1
chr11_-_69413675 0.287 ENSMUST00000094077.4
Kdm6b
KDM1 lysine (K)-specific demethylase 6B
chrX_-_72274747 0.285 ENSMUST00000064780.3
Gabre
gamma-aminobutyric acid (GABA) A receptor, subunit epsilon
chr7_+_24862193 0.281 ENSMUST00000052897.4
ENSMUST00000170837.2
Gm9844
Gm9844
predicted pseudogene 9844
predicted pseudogene 9844
chr15_-_98728120 0.276 ENSMUST00000003445.6
Fkbp11
FK506 binding protein 11
chr19_+_4097392 0.267 ENSMUST00000174514.1
ENSMUST00000174149.1
Cdk2ap2

CDK2-associated protein 2

chr8_-_47352348 0.257 ENSMUST00000110367.2
Stox2
storkhead box 2
chr18_-_52529847 0.255 ENSMUST00000171470.1
Lox
lysyl oxidase
chr5_+_19907774 0.248 ENSMUST00000115267.2
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr17_+_34597852 0.245 ENSMUST00000174496.2
ENSMUST00000015596.3
ENSMUST00000173992.1
Ager


advanced glycosylation end product-specific receptor


chr1_-_16770138 0.244 ENSMUST00000071842.8
Gm5828
predicted gene 5828
chr6_+_147032528 0.243 ENSMUST00000036194.4
Rep15
RAB15 effector protein
chr17_-_25081138 0.238 ENSMUST00000024984.6
Tmem204
transmembrane protein 204
chr5_+_30913398 0.236 ENSMUST00000031055.5
Emilin1
elastin microfibril interfacer 1
chr17_+_46646225 0.229 ENSMUST00000002844.7
ENSMUST00000113429.1
ENSMUST00000113430.1
Mrpl2


mitochondrial ribosomal protein L2


chr5_+_32611171 0.227 ENSMUST00000072311.6
ENSMUST00000168707.2
Yes1

Yamaguchi sarcoma viral (v-yes) oncogene homolog 1

chr7_+_101421691 0.221 ENSMUST00000163751.2
ENSMUST00000084894.7
ENSMUST00000166652.1
Pde2a


phosphodiesterase 2A, cGMP-stimulated


chr6_-_138422898 0.202 ENSMUST00000161450.1
ENSMUST00000163024.1
ENSMUST00000162185.1
Lmo3


LIM domain only 3


chr5_+_7179299 0.201 ENSMUST00000179460.1
Tubb4b-ps1
tubulin, beta 4B class IVB, pseudogene 1
chr11_+_60699718 0.196 ENSMUST00000052346.3
Llgl1
lethal giant larvae homolog 1 (Drosophila)
chr7_-_119895697 0.195 ENSMUST00000059851.6
Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr7_+_101394361 0.186 ENSMUST00000154239.1
ENSMUST00000098243.2
Arap1

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

chr9_+_13621646 0.185 ENSMUST00000034401.8
Maml2
mastermind like 2 (Drosophila)
chr5_-_24445166 0.180 ENSMUST00000115043.1
ENSMUST00000115041.1
Fastk

Fas-activated serine/threonine kinase

chr4_-_129742275 0.175 ENSMUST00000066257.5
Khdrbs1
KH domain containing, RNA binding, signal transduction associated 1
chr11_+_60699758 0.175 ENSMUST00000108719.3
Llgl1
lethal giant larvae homolog 1 (Drosophila)
chr2_+_155940728 0.175 ENSMUST00000109629.1
Gm15557
predicted gene 15557
chr10_+_18845071 0.174 ENSMUST00000019998.7
Perp
PERP, TP53 apoptosis effector
chr11_+_53433299 0.173 ENSMUST00000018382.6
Gdf9
growth differentiation factor 9
chr1_-_133801031 0.165 ENSMUST00000143567.1
Atp2b4
ATPase, Ca++ transporting, plasma membrane 4
chr18_-_52529692 0.153 ENSMUST00000025409.7
Lox
lysyl oxidase
chr2_+_32628390 0.150 ENSMUST00000156578.1
Ak1
adenylate kinase 1
chr4_-_134245579 0.147 ENSMUST00000030644.7
Zfp593
zinc finger protein 593
chr17_-_35162969 0.145 ENSMUST00000174805.1
Prrc2a
proline-rich coiled-coil 2A
chrX_+_18162575 0.144 ENSMUST00000044484.6
ENSMUST00000052368.8
Kdm6a

lysine (K)-specific demethylase 6A

chr8_-_92356103 0.144 ENSMUST00000034183.3
4933436C20Rik
RIKEN cDNA 4933436C20 gene
chr14_-_54554359 0.140 ENSMUST00000022784.8
Haus4
HAUS augmin-like complex, subunit 4
chr11_-_106160101 0.138 ENSMUST00000045923.3
Limd2
LIM domain containing 2
chrX_+_101383726 0.131 ENSMUST00000119190.1
Gjb1
gap junction protein, beta 1
chr9_-_20898592 0.126 ENSMUST00000004206.8
Eif3g
eukaryotic translation initiation factor 3, subunit G
chr6_-_72958097 0.122 ENSMUST00000114049.1
Tmsb10
thymosin, beta 10
chr10_+_90576777 0.118 ENSMUST00000183136.1
ENSMUST00000182595.1
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr11_-_116110211 0.117 ENSMUST00000106441.1
ENSMUST00000021120.5
Trim47

tripartite motif-containing 47

chr9_-_49798729 0.114 ENSMUST00000166811.2
Ncam1
neural cell adhesion molecule 1
chr5_-_24445254 0.113 ENSMUST00000030800.6
Fastk
Fas-activated serine/threonine kinase
chr2_+_55437100 0.113 ENSMUST00000112633.2
ENSMUST00000112632.1
Kcnj3

potassium inwardly-rectifying channel, subfamily J, member 3

chr5_+_120431770 0.113 ENSMUST00000031591.7
Lhx5
LIM homeobox protein 5
chr2_+_96318014 0.111 ENSMUST00000135431.1
ENSMUST00000162807.2
Lrrc4c

leucine rich repeat containing 4C

chr13_-_115090123 0.106 ENSMUST00000109226.3
Pelo
pelota homolog (Drosophila)
chr12_+_13269111 0.097 ENSMUST00000042953.8
Nbas
neuroblastoma amplified sequence
chr4_+_126677630 0.097 ENSMUST00000030642.2
Psmb2
proteasome (prosome, macropain) subunit, beta type 2
chr9_-_105521147 0.087 ENSMUST00000176770.1
ENSMUST00000085133.6
Atp2c1

ATPase, Ca++-sequestering

chr7_-_89517576 0.084 ENSMUST00000041761.5
Prss23
protease, serine, 23
chr3_+_36552600 0.081 ENSMUST00000029269.5
ENSMUST00000136890.1
Exosc9

exosome component 9

chrX_-_7898950 0.080 ENSMUST00000115655.1
ENSMUST00000156741.1
Pqbp1

polyglutamine binding protein 1

chr7_+_127485221 0.079 ENSMUST00000048896.6
Fbrs
fibrosin
chr3_+_89436736 0.079 ENSMUST00000146630.1
ENSMUST00000145753.1
Pbxip1

pre B cell leukemia transcription factor interacting protein 1

chr11_+_97663366 0.078 ENSMUST00000044730.5
Mllt6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr4_+_116221689 0.076 ENSMUST00000106490.2
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr7_+_117380937 0.074 ENSMUST00000032892.5
Xylt1
xylosyltransferase 1
chr8_+_95825353 0.073 ENSMUST00000074053.4
Gm10094
predicted gene 10094
chr11_-_115419917 0.072 ENSMUST00000106537.1
ENSMUST00000043931.2
ENSMUST00000073791.3
Atp5h


ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d


chr4_+_117835387 0.069 ENSMUST00000169885.1
Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr11_-_102319093 0.069 ENSMUST00000174302.1
ENSMUST00000178839.1
ENSMUST00000006754.7
Ubtf


upstream binding transcription factor, RNA polymerase I


chr17_+_72918298 0.068 ENSMUST00000024857.6
Lbh
limb-bud and heart
chr10_+_90576872 0.066 ENSMUST00000182550.1
ENSMUST00000099364.5
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr1_-_45503282 0.065 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr5_-_124352233 0.064 ENSMUST00000111472.1
Cdk2ap1
CDK2 (cyclin-dependent kinase 2)-associated protein 1
chr14_-_64949838 0.062 ENSMUST00000067843.3
ENSMUST00000176489.1
ENSMUST00000175905.1
ENSMUST00000022544.7
ENSMUST00000175744.1
ENSMUST00000176128.1
Hmbox1





homeobox containing 1





chr15_-_93336800 0.062 ENSMUST00000080299.6
Yaf2
YY1 associated factor 2
chr10_+_91083036 0.055 ENSMUST00000020149.5
Ikbip
IKBKB interacting protein
chr8_-_41016749 0.051 ENSMUST00000117735.1
Mtus1
mitochondrial tumor suppressor 1
chr2_+_119547697 0.050 ENSMUST00000014221.6
ENSMUST00000119172.1
Chp1

calcineurin-like EF hand protein 1

chr10_+_90576708 0.047 ENSMUST00000182430.1
ENSMUST00000182960.1
ENSMUST00000182045.1
ENSMUST00000182083.1
Anks1b



ankyrin repeat and sterile alpha motif domain containing 1B



chr16_-_45158183 0.046 ENSMUST00000114600.1
Slc35a5
solute carrier family 35, member A5
chr5_+_65537267 0.041 ENSMUST00000122141.1
Ube2k
ubiquitin-conjugating enzyme E2K
chr11_-_4160286 0.037 ENSMUST00000093381.4
ENSMUST00000101626.2
Ccdc157

coiled-coil domain containing 157

chr3_-_33143227 0.032 ENSMUST00000108219.1
Pex5l
peroxisomal biogenesis factor 5-like
chr11_-_106160708 0.031 ENSMUST00000106875.1
Limd2
LIM domain containing 2
chr9_+_21424984 0.028 ENSMUST00000172482.1
ENSMUST00000174050.1
Dnm2

dynamin 2

chr3_-_146839365 0.022 ENSMUST00000084614.3
Gm10288
predicted gene 10288
chr15_-_103366763 0.014 ENSMUST00000023128.6
Itga5
integrin alpha 5 (fibronectin receptor alpha)
chr11_+_105975204 0.006 ENSMUST00000001964.7
Ace
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr11_-_106159902 0.004 ENSMUST00000064545.4
Limd2
LIM domain containing 2
chr1_-_143702832 0.003 ENSMUST00000018337.7
Cdc73
cell division cycle 73, Paf1/RNA polymerase II complex component
chrX_+_136270302 0.001 ENSMUST00000113112.1
Ngfrap1
nerve growth factor receptor (TNFRSF16) associated protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.4 7.7 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.4 1.9 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.3 1.3 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.3 0.3 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.3 0.8 GO:0015889 cobalamin transport(GO:0015889)
0.2 1.3 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.2 1.0 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.2 1.1 GO:0019370 leukotriene biosynthetic process(GO:0019370)
0.2 0.5 GO:1901896 positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.1 0.7 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 0.4 GO:0060023 soft palate development(GO:0060023)
0.1 0.7 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 0.3 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.1 0.4 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.1 0.5 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.1 0.6 GO:0021764 amygdala development(GO:0021764)
0.1 0.6 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.1 0.6 GO:0045657 positive regulation of monocyte differentiation(GO:0045657) cellular response to potassium ion starvation(GO:0051365)
0.1 0.4 GO:0072697 protein localization to cell cortex(GO:0072697)
0.1 2.2 GO:0021516 dorsal spinal cord development(GO:0021516)
0.1 0.8 GO:2000809 positive regulation of synaptic vesicle clustering(GO:2000809)
0.1 1.9 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 0.4 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 1.1 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.1 0.2 GO:0097709 connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.1 1.4 GO:0030903 notochord development(GO:0030903)
0.1 0.2 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
0.1 0.4 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 0.5 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 0.6 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.3 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.1 0.2 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241)
0.1 0.2 GO:0010751 regulation of arginine metabolic process(GO:0000821) negative regulation of nitric oxide mediated signal transduction(GO:0010751) negative regulation of cellular amino acid metabolic process(GO:0045763)
0.1 0.7 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.0 0.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.7 GO:0050434 positive regulation of viral transcription(GO:0050434)
0.0 4.6 GO:0006342 chromatin silencing(GO:0006342)
0.0 0.3 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.4 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)
0.0 0.2 GO:0042701 progesterone secretion(GO:0042701)
0.0 0.4 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 0.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.3 GO:0071225 cellular response to muramyl dipeptide(GO:0071225)
0.0 0.6 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 0.2 GO:0002934 desmosome organization(GO:0002934)
0.0 0.9 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.1 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.0 0.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.0 0.2 GO:0036120 cellular response to platelet-derived growth factor stimulus(GO:0036120)
0.0 0.1 GO:0070885 negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.0 0.2 GO:0006172 ADP biosynthetic process(GO:0006172)
0.0 0.9 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.1 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.0 0.3 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0 0.1 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.0 0.3 GO:0033572 transferrin transport(GO:0033572)
0.0 0.3 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.8 GO:0060074 synapse maturation(GO:0060074)
0.0 0.1 GO:0055071 cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071)
0.0 0.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.1 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.9 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.1 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.7 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.0 0.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.4 GO:0033622 integrin activation(GO:0033622)
0.0 0.7 GO:0035082 cilium movement(GO:0003341) axoneme assembly(GO:0035082)
0.0 0.2 GO:0001945 lymph vessel development(GO:0001945)
0.0 1.4 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.7 GO:0021766 hippocampus development(GO:0021766)
0.0 0.1 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.0 0.6 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
0.0 1.6 GO:0021954 central nervous system neuron development(GO:0021954)
0.0 0.3 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.4 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.4 GO:0031572 G2 DNA damage checkpoint(GO:0031572)
0.0 0.4 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.2 GO:0010225 response to UV-C(GO:0010225)
0.0 2.2 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 0.3 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.1 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.0 0.3 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.4 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.2 0.8 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 0.5 GO:0036128 CatSper complex(GO:0036128)
0.1 11.5 GO:0000786 nucleosome(GO:0000786)
0.1 0.5 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 0.2 GO:0044302 dentate gyrus mossy fiber(GO:0044302)
0.1 1.4 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.6 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.4 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.1 GO:0070939 Dsl1p complex(GO:0070939)
0.0 0.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 1.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.8 GO:0005581 collagen trimer(GO:0005581)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.3 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.5 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0070652 HAUS complex(GO:0070652)
0.0 0.8 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.1 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.3 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.6 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.5 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.1 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.0 GO:0050436 microfibril binding(GO:0050436)
0.2 1.9 GO:0001972 retinoic acid binding(GO:0001972)
0.1 2.9 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 0.4 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.8 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.8 GO:0031419 cobalamin binding(GO:0031419)
0.1 0.3 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.1 1.1 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.1 0.2 GO:0036004 GAF domain binding(GO:0036004)
0.1 0.4 GO:0043426 MRF binding(GO:0043426)
0.1 0.7 GO:0030957 Tat protein binding(GO:0030957)
0.1 0.4 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 0.7 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 0.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 0.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.6 GO:0035497 cAMP response element binding(GO:0035497)
0.0 1.0 GO:0008432 JUN kinase binding(GO:0008432)
0.0 7.7 GO:0042393 histone binding(GO:0042393)
0.0 1.5 GO:0070888 E-box binding(GO:0070888)
0.0 0.3 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.6 GO:0070628 proteasome binding(GO:0070628)
0.0 0.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.5 GO:0051861 glycolipid binding(GO:0051861)
0.0 0.1 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.0 0.4 GO:0043747 protein-N-terminal asparagine amidohydrolase activity(GO:0008418) UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity(GO:0008759) iprodione amidohydrolase activity(GO:0018748) (3,5-dichlorophenylurea)acetate amidohydrolase activity(GO:0018749) 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity(GO:0034571) didemethylisoproturon amidohydrolase activity(GO:0034573) N-isopropylacetanilide amidohydrolase activity(GO:0034576) N-cyclohexylformamide amidohydrolase activity(GO:0034781) isonicotinic acid hydrazide hydrolase activity(GO:0034876) cis-aconitamide amidase activity(GO:0034882) gamma-N-formylaminovinylacetate hydrolase activity(GO:0034885) N2-acetyl-L-lysine deacetylase activity(GO:0043747) O-succinylbenzoate synthase activity(GO:0043748) indoleacetamide hydrolase activity(GO:0043864) N-acetylcitrulline deacetylase activity(GO:0043909) N-acetylgalactosamine-6-phosphate deacetylase activity(GO:0047419) diacetylchitobiose deacetylase activity(GO:0052773) chitooligosaccharide deacetylase activity(GO:0052790)
0.0 1.3 GO:0019955 cytokine binding(GO:0019955)
0.0 0.7 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0015410 manganese-transporting ATPase activity(GO:0015410)
0.0 0.4 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.8 GO:0050699 WW domain binding(GO:0050699)
0.0 0.4 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.3 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.0 0.2 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.6 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.4 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.5 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 1.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.1 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.2 GO:0050321 tau-protein kinase activity(GO:0050321)