Motif ID: Smad4

Z-value: 1.046


Transcription factors associated with Smad4:

Gene SymbolEntrez IDGene Name
Smad4 ENSMUSG00000024515.7 Smad4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad4mm10_v2_chr18_-_73703739_737038060.144.3e-01Click!


Activity profile for motif Smad4.

activity profile for motif Smad4


Sorted Z-values histogram for motif Smad4

Sorted Z-values for motif Smad4



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad4

PNG image of the network

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Top targets:


Showing 1 to 20 of 186 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_127534540 4.049 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr13_-_22042949 3.663 ENSMUST00000091741.4
 Hist1h2ag
histone cluster 1, H2ag
chr19_+_5740885 2.867 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr13_-_21832194 2.473 ENSMUST00000102979.1
 Hist1h4n
histone cluster 1, H4n
chr11_-_95514570 2.472 ENSMUST00000058866.7
 Nxph3
neurexophilin 3
chr4_-_148130678 2.092 ENSMUST00000030862.4
 Draxin
dorsal inhibitory axon guidance protein
chr13_+_23581563 1.931 ENSMUST00000102968.1
 Hist1h4d
histone cluster 1, H4d
chr7_-_70360593 1.925 ENSMUST00000032768.7
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr7_-_27181149 1.918 ENSMUST00000071986.6
ENSMUST00000121848.1
 Mia

melanoma inhibitory activity

chr3_+_127633134 1.640 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr14_-_25903100 1.511 ENSMUST00000052286.8
 Plac9a
placenta specific 9a
chr13_+_22043189 1.436 ENSMUST00000110452.1
 Hist1h2bj
histone cluster 1, H2bj
chr18_+_57133065 1.348 ENSMUST00000075770.6
 Megf10
multiple EGF-like-domains 10
chr11_-_89302545 1.254 ENSMUST00000061728.3
 Nog
noggin
chr3_-_96220880 1.178 ENSMUST00000090782.3
 Hist2h2ac
histone cluster 2, H2ac
chr13_-_23551648 1.149 ENSMUST00000102971.1
 Hist1h4f
histone cluster 1, H4f
chr10_-_92164666 1.146 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr10_+_75589363 1.104 ENSMUST00000072217.2
 Ggt5
gamma-glutamyltransferase 5
chr13_+_21735055 1.104 ENSMUST00000087714.4
 Hist1h4j
histone cluster 1, H4j
chr6_+_54040078 1.081 ENSMUST00000127323.2
 Chn2
chimerin (chimaerin) 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.7 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 4.6 GO:0006342 chromatin silencing(GO:0006342)
1.0 2.9 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.1 2.2 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 2.2 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.4 1.9 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 1.9 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 1.6 GO:0021954 central nervous system neuron development(GO:0021954)
0.1 1.4 GO:0030903 notochord development(GO:0030903)
0.0 1.4 GO:0006334 nucleosome assembly(GO:0006334)
0.3 1.3 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.2 1.3 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.2 1.1 GO:0019370 leukotriene biosynthetic process(GO:0019370)
0.1 1.1 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.2 1.0 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.0 0.9 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.9 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.9 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.3 0.8 GO:0015889 cobalamin transport(GO:0015889)
0.1 0.8 GO:2000809 positive regulation of synaptic vesicle clustering(GO:2000809)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.5 GO:0000786 nucleosome(GO:0000786)
0.6 1.9 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.0 1.8 GO:0005581 collagen trimer(GO:0005581)
0.1 1.4 GO:0001891 phagocytic cup(GO:0001891)
0.0 1.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 0.8 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.8 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.6 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.6 GO:0005719 nuclear euchromatin(GO:0005719)
0.2 0.5 GO:0036128 CatSper complex(GO:0036128)
0.1 0.5 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.5 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.5 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.4 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.7 GO:0042393 histone binding(GO:0042393)
0.8 3.0 GO:0050436 microfibril binding(GO:0050436)
0.1 2.9 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.2 1.9 GO:0001972 retinoic acid binding(GO:0001972)
0.0 1.5 GO:0070888 E-box binding(GO:0070888)
0.0 1.3 GO:0019955 cytokine binding(GO:0019955)
0.0 1.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 1.1 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 1.0 GO:0008432 JUN kinase binding(GO:0008432)
0.1 0.8 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.8 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.8 GO:0050699 WW domain binding(GO:0050699)
0.0 0.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 0.7 GO:0030957 Tat protein binding(GO:0030957)
0.1 0.7 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.7 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.6 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.6 GO:0070628 proteasome binding(GO:0070628)
0.0 0.6 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.5 GO:0051861 glycolipid binding(GO:0051861)