Motif ID: Snai1_Zeb1_Snai2

Z-value: 2.509

Transcription factors associated with Snai1_Zeb1_Snai2:

Gene SymbolEntrez IDGene Name
Snai1 ENSMUSG00000042821.7 Snai1
Snai2 ENSMUSG00000022676.6 Snai2
Zeb1 ENSMUSG00000024238.7 Zeb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zeb1mm10_v2_chr18_+_5591860_5591902-0.811.2e-08Click!
Snai2mm10_v2_chr16_+_14705832_14705858-0.222.3e-01Click!
Snai1mm10_v2_chr2_+_167538192_1675382100.192.8e-01Click!


Activity profile for motif Snai1_Zeb1_Snai2.

activity profile for motif Snai1_Zeb1_Snai2


Sorted Z-values histogram for motif Snai1_Zeb1_Snai2

Sorted Z-values for motif Snai1_Zeb1_Snai2



Network of associatons between targets according to the STRING database.



First level regulatory network of Snai1_Zeb1_Snai2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_29281977 17.429 ENSMUST00000098604.4
ENSMUST00000108236.3
 Spint2

serine protease inhibitor, Kunitz type 2

chr7_-_30973399 9.616 ENSMUST00000098553.4
ENSMUST00000147431.1
 Lsr

lipolysis stimulated lipoprotein receptor

chr7_-_30973367 9.398 ENSMUST00000108116.3
 Lsr
lipolysis stimulated lipoprotein receptor
chr3_+_75557530 8.979 ENSMUST00000161776.1
ENSMUST00000029423.8
 Serpini1

serine (or cysteine) peptidase inhibitor, clade I, member 1

chr8_+_3631109 8.649 ENSMUST00000004745.8
 Stxbp2
syntaxin binding protein 2
chr7_-_30973464 8.595 ENSMUST00000001279.8
 Lsr
lipolysis stimulated lipoprotein receptor
chr7_-_126704179 8.320 ENSMUST00000106364.1
 Coro1a
coronin, actin binding protein 1A
chr5_-_147076482 8.277 ENSMUST00000016664.7
 Lnx2
ligand of numb-protein X 2
chr4_+_85205417 7.546 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr15_+_98634743 7.381 ENSMUST00000003442.7
 Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
chr5_+_75574916 7.360 ENSMUST00000144270.1
ENSMUST00000005815.6
 Kit

kit oncogene

chr2_+_164562579 7.226 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr13_-_57907587 7.210 ENSMUST00000172326.1
 Spock1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
chr8_+_3587445 7.087 ENSMUST00000057028.7
ENSMUST00000171962.1
 Camsap3

calmodulin regulated spectrin-associated protein family, member 3

chr12_+_112722163 7.074 ENSMUST00000101018.3
ENSMUST00000179041.1
ENSMUST00000092279.6
 Cep170b


centrosomal protein 170B


chr1_-_75219245 7.060 ENSMUST00000079464.6
 Tuba4a
tubulin, alpha 4A
chr19_+_25610533 6.717 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr11_-_67922136 6.546 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chrX_-_158043266 6.489 ENSMUST00000026750.8
ENSMUST00000112513.1
 Cnksr2

connector enhancer of kinase suppressor of Ras 2

chr7_+_44384803 6.473 ENSMUST00000120262.1
 Syt3
synaptotagmin III

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 930 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.2 27.6 GO:1904274 tricellular tight junction assembly(GO:1904274)
3.5 21.0 GO:0032796 uropod organization(GO:0032796)
6.3 19.0 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.7 14.2 GO:1903861 regulation of dendrite extension(GO:1903859) positive regulation of dendrite extension(GO:1903861)
0.5 13.4 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.8 11.7 GO:0046629 gamma-delta T cell activation(GO:0046629)
1.0 11.2 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.4 11.2 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
3.6 10.9 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.4 10.3 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
2.5 10.0 GO:0086042 cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042)
0.9 9.8 GO:1901250 regulation of lung goblet cell differentiation(GO:1901249) negative regulation of lung goblet cell differentiation(GO:1901250)
0.7 9.2 GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577)
0.6 8.3 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.9 8.2 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
2.0 8.0 GO:0002371 dendritic cell cytokine production(GO:0002371)
1.3 7.8 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.8 7.7 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
1.5 7.6 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.5 7.5 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 337 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 28.8 GO:0033268 node of Ranvier(GO:0033268)
4.7 28.3 GO:0061689 tricellular tight junction(GO:0061689)
0.5 25.6 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
1.0 24.3 GO:0001891 phagocytic cup(GO:0001891)
1.0 20.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.4 17.4 GO:0044295 axonal growth cone(GO:0044295)
0.2 16.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 16.5 GO:0045211 postsynaptic membrane(GO:0045211)
0.4 11.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 11.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 11.1 GO:0043195 terminal bouton(GO:0043195)
0.9 9.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
3.1 9.2 GO:0044194 cytolytic granule(GO:0044194)
0.1 9.2 GO:0030427 site of polarized growth(GO:0030427)
0.3 8.7 GO:0060077 inhibitory synapse(GO:0060077)
0.5 8.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 7.7 GO:0005776 autophagosome(GO:0005776)
0.1 7.7 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.5 7.0 GO:0035253 ciliary rootlet(GO:0035253)
0.4 7.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 560 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 27.5 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.7 24.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.5 21.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 20.6 GO:0003735 structural constituent of ribosome(GO:0003735)
1.9 19.3 GO:0032036 myosin heavy chain binding(GO:0032036)
0.7 17.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.5 16.1 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
0.5 15.1 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 13.9 GO:0005518 collagen binding(GO:0005518)
0.6 13.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 12.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 11.7 GO:0008017 microtubule binding(GO:0008017)
1.4 11.3 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.2 10.3 GO:0005179 hormone activity(GO:0005179)
0.3 10.2 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.7 9.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.4 9.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 9.3 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
1.7 8.6 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
0.5 8.6 GO:0050811 GABA receptor binding(GO:0050811)